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Invitrogen
TIMP1 Polyclonal Antibody
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FIGURE: 1 / 7
TIMP1 Antibody (PA5-99559) in IHC (P)
Immunohistochemistry analysis of TIMP1 in rat ovary tissue. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with TIMP1 polyclonal antibody (Product # PA5-99559) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-99559
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Published species
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human TIMP1(Accession P01033), corresponding to amino acid residues A74-F124.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total TIMP1.
Target Information
TIMP1 (metalloproteinase inhibitor 1) is a metalloproteinase inhibitor that functions by forms one-to-one complexes with target metallproteinases, such as collagenases, and irreversible inactivates them by binding to their catalytic zinc cofactor. TIMP1 acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP14, and MMP16. It also functions as a growth factor that regulates cell differenation, migration, and cell death. TIMP1 activates cellular signaling cascades via CD63 and ITGB1.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: Collagenase inhibitor; Collagenase inhibitor 16C8 fibroblast; EPA; epididymis secretory sperm binding protein; erythroid potentiating activity; Erythroid-potentiating activity; Fibroblast collagenase inhibitor; FLJ90373; Metalloproteinase inhibitor; Metalloproteinase inhibitor 1; MMP inhibitor; prefibroblast collagenase inhibitor; RP1-230G1.3; TIMP; TIMP 1; TIMP-1; TIMP1; tissue inhibitor of metallopeptidase 1; tissue inhibitor of metalloproteinase 1; tissue inhibitor of metalloproteinase-1; Tissue inhibitor of metalloproteinases 1; TPA-induced protein; TPA-S1; unnamed protein product
Gene Aliases: CLGI; EPA; EPO; HCI; TIMP; TIMP-1; TIMP1; TPA-S1
UniProt ID: (Human) P01033, (Rat) P30120, (Mouse) P12032
Entrez Gene ID: (Human) 7076, (Rat) 116510, (Mouse) 21857
connective tissue replacement involved in inflammatory response wound healing
signal transduction
positive regulation of cell proliferation
response to hormone
negative regulation of endopeptidase activity
response to cytokine
negative regulation of apoptotic process
negative regulation of catalytic activity
response to peptide hormone
negative regulation of membrane protein ectodomain proteolysis
cartilage development
cellular response to UV-A
negative regulation of trophoblast cell migration
cellular response to peptide
negative regulation of metallopeptidase activity
regulation of integrin-mediated signaling pathway
cell activation
steroid biosynthetic process
aging
response to organic substance
wound healing
negative regulation of peptidase activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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