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Invitrogen
PDE4B/PDE4C/PDE4D Polyclonal Antibody
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Product Details
PA5-99682
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human PDE4B(Accession Q07343), corresponding to amino acid residues G36-A86.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total PDE4B/C/D.
Target Information
This gene is a member of the type IV, cyclic AMP (cAMP)-specific, cyclic nucleotide phosphodiesterase (PDE) family. The encoded protein regulates the cellular concentrations of cyclic nucleotides and thereby play a role in signal transduction. Altered activity of this protein has been associated with schizophrenia and bipolar affective disorder. Alternative splicing and the use of alternative promoters results in multiple transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: 3',5'-cyclic-AMP phosphodiesterase 4B; 3',5'-cyclic-AMP phosphodiesterase 4C; 3',5'-cyclic-AMP phosphodiesterase 4D; alternatively spliced; cAMP specific rolipram-sensitive phosphodiesterase; cAMP specific rolipram-sensitive phosphosdiesterase; cAMP-specific 3',5'-cyclic phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4C; cAMP-specific 3',5'-cyclic phosphodiesterase 4D; cAMP-specific phosphodiesterase 4B; cAMP-specific phosphodiesterase 4C; cAMP-specific phosphodiesterase 4D; cAMP-specific phosphodiesterase PDE4D6; cyclic AMP specific phosphodiesterase PDE4D5A; DPDE1; DPDE3; DPDE4; dunce; dunce-like phosphodiesterase E1; dunce-like phosphodiesterase E4; PDE21; PDE32; PDE43; PDE4B5; phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila); phosphodiesterase 4C, cAMP-specific (phosphodiesterase E1 dunce homolog, Drosophila); phosphodiesterase 4D, cAMP-specific (phosphodiesterase E3 dunce homolog, Drosophila); testicular tissue protein Li 136; unnamed protein product
Gene Aliases: 9630011N22Rik; ACRDYS2; DPDE1; DPDE3; DPDE4; dunce; E130301F19Rik; HSPDE4D; PDE21; PDE43; PDE4B; PDE4C; PDE4D; PDE4DN2; PDEIVB; R74983; STRK1
UniProt ID: (Human) Q07343, (Human) Q08493, (Human) Q08499, (Mouse) Q3UEI1, (Mouse) Q01063
Entrez Gene ID: (Human) 5142, (Human) 5143, (Human) 5144, (Mouse) 18578, (Mouse) 110385, (Mouse) 238871
3',5'-cyclic-nucleotide phosphodiesterase activity
3',5'-cyclic-AMP phosphodiesterase activity
calcium channel regulator activity
protein binding
phosphoric diester hydrolase activity
hydrolase activity
cAMP binding
gamma-tubulin binding
ion channel binding
metal ion binding
3',5'-cyclic-GMP phosphodiesterase activity
enzyme binding
receptor regulator activity
beta-2 adrenergic receptor binding
ATPase binding
scaffold protein binding
heterocyclic compound binding
drug binding
phosphodiesterase
neutrophil homeostasis
cAMP catabolic process
signal transduction
neutrophil chemotaxis
positive regulation of interferon-gamma production
positive regulation of interleukin-2 production
T cell receptor signaling pathway
leukocyte migration
cellular response to lipopolysaccharide
cellular response to xenobiotic stimulus
cellular response to epinephrine stimulus
negative regulation of adrenergic receptor signaling pathway
regulation of cardiac muscle cell contraction
negative regulation of cAMP/PKA signal transduction
negative regulation of relaxation of cardiac muscle
regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
regulation of heart rate
positive regulation of heart rate
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum
positive regulation of interleukin-5 production
negative regulation of heart contraction
establishment of endothelial barrier
cellular response to cAMP
adrenergic receptor signaling pathway
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway
regulation of cell communication by electrical coupling involved in cardiac conduction
smooth muscle contraction
cellular response to drug
regulation of high voltage-gated calcium channel activity
negative regulation of insulin secretion
aging
negative regulation of peptidyl-serine phosphorylation
multicellular organism growth
regulation of ryanodine-sensitive calcium-release channel activity
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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