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Invitrogen
MPP5 Polyclonal Antibody
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FIGURE: 1 / 12
MPP5 Antibody (PA5-99990) in IHC (P)
Immunohistochemistry analysis of MPP5 in human normal tissues adjacent to colorectal cancer. The sample was formaldehyde fixed and a heat mediated antigen retrieval step in citrate buffer was performed. Samples were incubated with MPP5 polyclonal antibody (Product # PA5-99990) using a dilution of 1:100 (4°C overnight) followed by HRP conjugated anti-Rabbit secondary antibody.
Product Details
PA5-99990
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Class
Polyclonal
Type
Antibody
Immunogen
A synthesized peptide derived from human MPP5(Accession Q8N3R9), corresponding to amino acid residues S588-Y638.
Conjugate
Form
Liquid
Concentration
1 mg/mL
Amount
100 µg
Purification
Affinity chromatography
Storage buffer
PBS, pH 7.4, with 50% glycerol
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Ambient (domestic); Wet ice (international)
RRID
Product Specific Information
Antibody detects endogenous levels of total MPP5.
Target Information
MPP5 (Membrane Protein, Palmitoylated 5) plays a critical role in neurogenesis and hematopoiesis. This protein is crucial for establishing and maintaining cell polarity in epithelial cells and neurons. It is involved in the Par-3 complex, which contributes to maintaining tight junctions in epithelial cells. Mutations in MPP5 have been associated with severe neurologic impairments, including global developmental delay (GDD) and behavioral changes. In animal models, MPP5 is highly involved in the early differentiation of multipotent progenitors and supports long-term lineage-specific contributions, primarily in myeloid and lymphoid cells. MPP5 variants disrupt normal cellular function, leading to profound developmental and functional abnormalities.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: FLJ12615; MAGUK p55 subfamily member 5; membrane palmitoylated protein 5; membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 5); Membrane protein, palmitoylated 5; membrane protein, palmitoylated 5 (MAGUK p55 subfamily member 5); palmitoylated 5; protein associated with lin seven 1; Protein associated with Lin-7 1; protein associated with LIN7 1, MAGUK family member; Protein PALS1; stardust; unnamed protein product
Gene Aliases: 3830420B02Rik; AI255216; AI644496; MPP5; PALS1
UniProt ID: (Mouse) Q9JLB2, (Rat) B4F7E7, (Human) Q8N3R9
Entrez Gene ID: (Mouse) 56217, (Rat) 314259, (Human) 64398
morphogenesis of an epithelial sheet
plasma membrane organization
peripheral nervous system myelin maintenance
myelin assembly
protein localization to myelin sheath abaxonal region
nucleotide phosphorylation
establishment of protein localization to plasma membrane
protein localization
gene expression
establishment or maintenance of polarity of embryonic epithelium
regulation of transforming growth factor beta receptor signaling pathway
central nervous system neuron development
cerebral cortex development
establishment or maintenance of epithelial cell apical/basal polarity
generation of neurons
protein localization to plasma membrane
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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