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Invitrogen
beta-2 Adaptin Synthetic Peptide
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Product Details
PEP-293
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
1 mg/mL
Amount
50 µg
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
This peptide corresponds to amino acids I(588) HRKHLPIHHGSTDAGDSP (606) of human beta Adaptin 2 and can be used as a blocking peptide with polyclonal antibody PA1-1066. This sequence is identical in human, mouse, rat and bovine.
Target Information
Clathrin-mediated endocytosis is the pathway by which many receptors for nutrients and hormones are internalized to be recycled or down-regulated. During formation of clathrin coated membranes, clathrin co-assembles with heterotetrameric molecules known as assembly polypeptides (APs) or adaptors which form a layer of protein coat between the clathrin lattice and the membrane. There are two characterized adaptors AP1 and AP2. AP1 is associated with clathrin coated vesicles at the trans-Golgi network and AP2 is associated with the endocytic clathrin coated vesicles at the plasma membrane and has been shown to specifically interact with Shc and EGF receptor. AP2 is composed of four subunits, two separate ~100 kDa gene products with similar domain structures (alpha and beta adaptin) and a ~50 and ~17 kDa subunit. There are two alpha-adaptin genes, alpha A and alpha C which have a tissue specific pattern of expression.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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