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Abnova
ANGPT1 Recombinant Rabbit Monoclonal Antibody
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Product Details
RAB01740
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human ANGPT1.
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 150mM NaCl, 0.05% BSA, 40% glycerol
Contains
0.01% sodium azide
Storage conditions
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ANG-1; Angiopoietin-1; KIAA0003; ligand for the TIE2 receptor; unnamed protein product
Gene Aliases: AGP1; AGPT; AGPT-1; ANG1; ANGPT1; HAE5; KIAA0003
UniProt ID: (Human) Q15389
Entrez Gene ID: (Human) 284
angiogenesis
blood vessel development
in utero embryonic development
regulation of endothelial cell proliferation
sprouting angiogenesis
positive regulation of receptor internalization
negative regulation of cytokine production involved in immune response
negative regulation of cell adhesion
transmembrane receptor protein tyrosine kinase signaling pathway
activation of transmembrane receptor protein tyrosine kinase activity
blood coagulation
positive regulation of endothelial cell migration
positive regulation of gene expression
regulation of skeletal muscle satellite cell proliferation
hemopoiesis
cell differentiation
negative regulation of blood coagulation
heparin biosynthetic process
positive regulation of protein ubiquitination
cell-substrate adhesion
regulation of tumor necrosis factor production
protein localization to cell surface
negative regulation of protein import into nucleus
negative regulation of apoptotic process
negative regulation of vascular permeability
regulation of I-kappaB kinase/NF-kappaB signaling
negative regulation of neuron apoptotic process
positive regulation of blood vessel endothelial cell migration
positive regulation of cell adhesion
Tie signaling pathway
positive regulation of peptidyl-tyrosine phosphorylation
positive regulation of coagulation
positive chemotaxis
positive regulation of multicellular organismal process
neuron apoptotic process
positive regulation of protein kinase B signaling
positive regulation of ERK1 and ERK2 cascade
glomerulus vasculature development
negative regulation of vascular endothelial growth factor signaling pathway
positive regulation of maintenance of permeability of blood-brain barrier
negative regulation of endothelial cell apoptotic process
regulation of macrophage migration inhibitory factor signaling pathway
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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