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Abnova

PAK1 Recombinant Rabbit Monoclonal Antibody

View all (34) PAK1 antibodies

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Product Details

RAB01807

Applications
Tested Dilution
Publications

Western Blot (WB)

1:500-1:1,000
-

Immunohistochemistry (Paraffin) (IHC (P))

1:50-1:100
-

Immunocytochemistry (ICC/IF)

1:50-1:200
-

Immunoprecipitation (IP)

1:20
-
Product Specifications

Species Reactivity

Hamster, Human, Mouse, Rat

Host/Isotype

Rabbit / IgG

Expression System

CHO cells

Class

Recombinant Monoclonal

Type

Antibody

Immunogen

Synthetic peptide corresponding to human PAK1.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Purification

Affinity chromatography

Storage buffer

50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA

Contains

0.01% sodium azide

Storage conditions

-20°C, Avoid Freeze/Thaw Cycles

Shipping conditions

Ambient (domestic); Wet ice (international)

Target Information

PAK1 is a serine/threonine kinase that is a target for restenosis, cancer, and immunosuppression treatment. These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK1 regulates cell motility and morphology.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: activated protein kinase alpha; ADRB2; alpha pak; Alpha-PAK; CDC42/RAC effector kinase PAK-A; EC 2.7.11.1; kinase PAK1; MGC130000; MGC130001; p21 (CDKN1A)-activated kinase 1; p21 protein (Cdc42/Rac)-activated kinase 1; p21-activated kinase 1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast); p21/Cdc42/Rac1-activated kinase 1 (yeast Ste20-related); p65-PAK; p68-PAK; PAK 1; PAK-1; PAK1B; protein kinase; Protein kinase MUK2; Serine/threonine-protein kinase PAK 1; STE20 homolog, yeast; unnamed protein product

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Gene Aliases: alpha-PAK; AW045634; I79_024882; IDDMSSD; p65-PAK; PAK-1; PAK1; Paka; PAKalpha

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UniProt ID: (Human) Q13153, (Rat) P35465

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Entrez Gene ID: (Human) 5058, (Mouse) 18479, (Chinese hamster) 100767503, (Rat) 29431

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Function(s)
nucleotide binding catalytic activity protein kinase activity protein serine/threonine kinase activity protein binding collagen binding ATP binding kinase activity transferase activity protein kinase binding small GTPase binding identical protein binding gamma-tubulin binding protein serine kinase activity transferase activity, transferring phosphorus-containing groups Rac GTPase binding MAP kinase kinase kinase activity
Process(es)
response to hypoxia positive regulation of protein phosphorylation protein phosphorylation exocytosis apoptotic process Rho protein signal transduction regulation of mitotic cell cycle neuromuscular junction development metabolic process response to organic substance regulation of gene expression phosphorylation dendrite development cell migration amygdala development signal transduction by protein phosphorylation actin cytoskeleton organization stress-activated protein kinase signaling cascade actin cytoskeleton reorganization activation of protein kinase activity cellular response to insulin stimulus regulation of actin cytoskeleton organization positive regulation of peptidyl-serine phosphorylation positive regulation of intracellular estrogen receptor signaling pathway wound healing regulation of apoptotic process receptor clustering regulation of MAPK cascade positive regulation of JUN kinase activity protein autophosphorylation branching morphogenesis of an epithelial tube neuron projection morphogenesis positive regulation of stress fiber assembly negative regulation of cell proliferation involved in contact inhibition dendritic spine development gamma-aminobutyric acid secretion, neurotransmission glutamate secretion, neurotransmission cellular response to organic cyclic compound observational learning regulation of long-term synaptic potentiation MAPK cascade activation of MAPKK activity mitotic cell cycle small GTPase mediated signal transduction axonogenesis intracellular signal transduction stimulatory C-type lectin receptor signaling pathway chromatin remodeling cellular response to DNA damage stimulus transmembrane receptor protein tyrosine kinase signaling pathway positive regulation of cell proliferation cellular response to starvation positive regulation of fibroblast migration cerebellum development establishment of cell polarity positive regulation of cell migration positive regulation of microtubule polymerization Fc-gamma receptor signaling pathway involved in phagocytosis positive regulation of axon extension positive regulation of insulin receptor signaling pathway hepatocyte growth factor receptor signaling pathway ephrin receptor signaling pathway regulation of axonogenesis negative regulation of cell growth involved in cardiac muscle cell development positive regulation of microtubule nucleation positive regulation of protein targeting to membrane regulation of actin filament organization protein localization to cytoplasmic stress granule positive regulation of vascular smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell migration
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If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*

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