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Abnova
SOCS2 Recombinant Rabbit Monoclonal Antibody
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Product Details
RAB01903
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human SOCS2.
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 0.05% BSA, 40% glycerol, 150mM NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10 and interferon (IFN)-gamma. The protein encoded by this gene is found to interact with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R), and thus is thought to be involved in the regulation of IGF1R mediated cell signaling. Knockout studies in mice also suggested a regulatory role of this gene in IGF-1 related growth control.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CIS-2; Cytokine-inducible SH2 protein 2; SOCS-2; SSI-2; STAT-induced STAT inhibitor 2; Suppressor of cytokine signaling 2; unnamed protein product
Gene Aliases: CIS2; Cish2; SOCS-2; SOCS2; SSI-2; SSI2; STATI2
UniProt ID: (Human) O14508
Entrez Gene ID: (Human) 8835
regulation of cell growth
JAK-STAT cascade
lactation
regulation of signal transduction
negative regulation of signal transduction
protein ubiquitination
cytokine-mediated signaling pathway
response to estradiol
cellular response to hormone stimulus
intracellular signal transduction
erythropoietin-mediated signaling pathway
regulation of multicellular organism growth
negative regulation of multicellular organism growth
negative regulation of apoptotic process
proteasome-mediated ubiquitin-dependent protein catabolic process
positive regulation of neuron differentiation
negative regulation of JAK-STAT cascade
growth hormone receptor signaling pathway
JAK-STAT cascade involved in growth hormone signaling pathway
negative regulation of growth hormone receptor signaling pathway
mammary gland alveolus development
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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