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Abnova
PLA2G2A Recombinant Rabbit Monoclonal Antibody
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Product Details
RAB01922
Product Specifications
Species Reactivity
Human,
Mouse,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human PLA2G2A.
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 150mM NaCl, 0.05% BSA, 40% glycerol
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids and lysophospholipids, and thought to participate in the regulation of the phospholipid metabolism in biomembranes. Several alternatively spliced transcript variants with different 5' UTRs have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 3.1.1.4; EF; Enhancing factor; eted enzyme type IIA phospholipase A2; GIIC sPLA2; Group IIA phospholipase A2; modifier of Min1; non-pancreatic secreted type II phospholipase A2; Non-pancreatic secretory phospholipase A2; NPS-PLA2; Phosphatidylcholine 2-acylhydrolase 2A; phospholipase A2, group IIA (platelets, synovial fluid); Phospholipase A2, membrane associated; PLA2BPLA2; PLA2G2A; PLA2LPLA2S; platelet phospholipase A2; secretory group II phospholipase A2; synovial phospholipase A-2 (EC 3.1.1.4); unnamed protein product
Gene Aliases: EF; MOM1; PLA2; PLA2B; PLA2G2A; PLA2L; PLA2S; PLAS1; RASF-A; sPLA2; sPla2-IIA
UniProt ID: (Human) P14555, (Rat) P14423, (Mouse) P31482
Entrez Gene ID: (Human) 5320, (Rat) 29692, (Mouse) 18780
lipid metabolic process
phospholipid metabolic process
inflammatory response
positive regulation of macrophage derived foam cell differentiation
lipid catabolic process
killing of cells of other organism
low-density lipoprotein particle remodeling
intestinal stem cell homeostasis
angiotensin-activated signaling pathway
negative regulation of T cell proliferation
defense response to bacterium
phosphatidylethanolamine metabolic process
phosphatidylcholine metabolic process
phosphatidylglycerol metabolic process
phosphatidic acid metabolic process
arachidonic acid secretion
positive regulation of inflammatory response
defense response to Gram-positive bacterium
positive regulation of ERK1 and ERK2 cascade
regulation of neutrophil activation
negative regulation of cell proliferation
somatic stem cell population maintenance
regulation of cell proliferation
regulation of epithelial cell proliferation
negative regulation of epithelial cell proliferation
regulation of growth
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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