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Abnova
PRMT1 Recombinant Rabbit Monoclonal Antibody
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FIGURE: 1 / 2
PRMT1 Antibody (RAB01983) in IHC (P)
Immunohistochemical staining (Formalin/PFA-fixed paraffin-embedded sections) of human breast cancer with PRMT1 recombinant monoclonal antibody, clone R08-3H8 (Product # RAB01983). High-pressure and temperature Sodium Citrate pH 6.0 was used for antigen retrieval.
Product Details
RAB01983
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Rat
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human PRMT1.
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 150mM NaCl, 0.05% BSA
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
PRMT1 is a member of the protein arginine N-methyltransferase (PRMT) family. Arginine methylation is an irreversible post translational modification which has been implicated in RNA processing and trafficking, receptor-mediated signaling, and transcription. At least three types of PRMT enzymes have been identified in mammalian cells. These enzymes have been shown to have essential regulatory functions by methylation of key proteins in several fundamental areas. These proteins include nuclear proteins, IL enhancer binding factor, nuclear factors, cell cycle proteins, signal transduction proteins, apoptosis proteins, and viral proteins. The mammalian PRMT family currently consists of 7 members that share two large domains of homology. Increased expression of PRMT1 may play a role in various types of cancer.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: heterogeneous nuclear ribonucleoprotein methyltransferase 1-like 2; heterogeneous nuclear ribonucleoproteins methyltransferase-like 2; highly conserved protein 1; Histone-arginine N-methyltransferase PRMT1; HMT1 (hnRNP methyltransferase, S. cerevisiae)-like 2; HRMT1L2; Interferon receptor 1-bound protein 4; Protein arginine N-methyltransferase 1; protein arginine N-methyltransferase 1 isoform 10; protein arginine N-methyltransferase 1 isoform 11; protein arginine N-methyltransferase 1 isoform 12; protein arginine N-methyltransferase 1 isoform 13; protein arginine N-methyltransferase 1 isoform 14; protein arginine N-methyltransferase 1 isoform 15; protein arginine N-methyltransferase 1 isoform 16; protein arginine N-methyltransferase 1 isoform 17; protein arginine N-methyltransferase 1 isoform 18; protein arginine N-methyltransferase 1 isoform 19; protein arginine N-methyltransferase 1 isoform 20; protein arginine N-methyltransferase 1 isoform 21; protein arginine N-methyltransferase 1 isoform 22; protein arginine N-methyltransferase 1 isoform 23; protein arginine N-methyltransferase 1 isoform 24; protein arginine N-methyltransferase 1 isoform 25; protein arginine N-methyltransferase 1 isoform 26; protein arginine N-methyltransferase 1 isoform 27; protein arginine N-methyltransferase 1 isoform 28; protein arginine N-methyltransferase 1 isoform 29; protein arginine N-methyltransferase 1 isoform 30; protein arginine N-methyltransferase 1 isoform 31; protein arginine N-methyltransferase 1 isoform 32; protein arginine N-methyltransferase 1 isoform 33; protein arginine N-methyltransferase 1 isoform 34; protein arginine N-methyltransferase 1 isoform 35; protein arginine N-methyltransferase 1 isoform 36; protein arginine N-methyltransferase 1 isoform 37; protein arginine N-methyltransferase 1 isoform 38; protein arginine N-methyltransferase 1 isoform 39; protein arginine N-methyltransferase 1 isoform 4; protein arginine N-methyltransferase 1 isoform 40; protein arginine N-methyltransferase 1 isoform 41; protein arginine N-methyltransferase 1 isoform 42; protein arginine N-methyltransferase 1 isoform 43; protein arginine N-methyltransferase 1 isoform 44; protein arginine N-methyltransferase 1 isoform 45; protein arginine N-methyltransferase 1 isoform 46; protein arginine N-methyltransferase 1 isoform 47; protein arginine N-methyltransferase 1 isoform 48; protein arginine N-methyltransferase 1 isoform 5; protein arginine N-methyltransferase 1 isoform 6; protein arginine N-methyltransferase 1 isoform 7; protein arginine N-methyltransferase 1 isoform 8; protein arginine N-methyltransferase 1 isoform 9; unnamed protein product
Gene Aliases: ANM1; HCP1; HMT2; HRMT1L2; IR1B4; PRMT1
UniProt ID: (Human) Q99873, (Rat) Q63009
Entrez Gene ID: (Human) 3276, (Rat) 60421
RNA binding
protein binding
methyltransferase activity
N-methyltransferase activity
protein methyltransferase activity
methyl-CpG binding
protein-arginine N-methyltransferase activity
transferase activity
enzyme binding
protein-arginine omega-N monomethyltransferase activity
protein-arginine omega-N asymmetric methyltransferase activity
histone methyltransferase activity
identical protein binding
histone methyltransferase activity (H4-R3 specific)
mitogen-activated protein kinase p38 binding
GATOR1 complex binding
histone H4 methyltransferase activity
S-adenosyl-L-methionine binding
histone-arginine N-methyltransferase activity
S-adenosylmethionine-dependent methyltransferase activity
[cytochrome c]-arginine N-methyltransferase activity
snoRNP binding
poly(A) RNA binding
protein modifying enzyme
double-strand break repair via homologous recombination
in utero embryonic development
chromatin remodeling
regulation of transcription, DNA-templated
protein methylation
cellular response to DNA damage stimulus
cell surface receptor signaling pathway
positive regulation of cell proliferation
RNA splicing
negative regulation of translation
peptidyl-arginine methylation
viral protein processing
BMP signaling pathway
regulation of BMP signaling pathway
negative regulation of BMP signaling pathway
neuron projection development
cellular response to nutrient levels
methylation
cellular response to amino acid starvation
TORC1 signaling
positive regulation of erythrocyte differentiation
regulation of megakaryocyte differentiation
negative regulation of megakaryocyte differentiation
positive regulation of translation
negative regulation of translational initiation
negative regulation of JNK cascade
positive regulation of hemoglobin biosynthetic process
cardiac muscle tissue development
protein homooligomerization
cellular response to methionine
protein localization to lysosome
membraneless organelle assembly
positive regulation of p38MAPK cascade
negative regulation of TORC1 signaling
positive regulation of TORC1 signaling
positive regulation of double-strand break repair via homologous recombination
negative regulation of double-strand break repair via homologous recombination
histone methylation
peptidyl-arginine methylation, to asymmetrical-dimethyl arginine
peptidyl-arginine N-methylation
peptidyl-arginine omega-N-methylation
histone H4-R3 methylation
liver regeneration
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Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
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