Search
Abnova
HMGCR Recombinant Rabbit Monoclonal Antibody
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promotions']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.viewpromo']}}
{{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.promocode']}}: {{promo.promoCode}} {{promo.promoTitle}} {{promo.promoDescription}}. {{$productOrderCtrl.translations['antibody.pdp.commerceCard.promotion.learnmore']}}
Additional Information:
{{banner.description}}
Product Details
RAB02214
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human,
Mouse
Host/Isotype
Rabbit
/ IgG
Expression System
CHO cells
Class
Recombinant Monoclonal
Type
Antibody
Immunogen
Synthetic peptide corresponding to human HMGCR.
Conjugate
Form
Liquid
Purification
Affinity chromatography
Storage buffer
50mM tris glycine, pH 7.4, with 40% glycerol, 0.05% BSA, 150mM NaCl
Contains
0.01% sodium azide
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Ambient (domestic); Wet ice (international)
Target Information
3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGCR) is a key enzyme in the mevalonate pathway, which is critical for the biosynthesis of cholesterol and other isoprenoids. HMGCR catalyzes the conversion of HMG-CoA to mevalonate, a rate-limiting step in the production of cholesterol. Due to its central role in cholesterol synthesis, HMGCR is a primary target for statin drugs, which are used to lower cholesterol levels and reduce the risk of cardiovascular disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
References (0)
Have you cited this product in a publication?
Let us know so we can reference it here.
Bioinformatics
Protein Aliases: 3-hydroxy-3-methylglutaryl CoA reductase (NADPH); 3-hydroxy-3-methylglutaryl coenzyme A reductase; 3-hydroxy-3-methylglutaryl-CoA reductase; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; HMDH; HMG CoA reductase; HMG CoAR; HMG-CoA reductase; hydroxymethylglutaryl-CoA reductase; MGC103269; unnamed protein product
Gene Aliases: HMG-CoAR; HMGCR; LDLCQ3; LGMDR28; MYPLG; Red
UniProt ID: (Human) P04035, (Mouse) Q01237
Entrez Gene ID: (Human) 3156, (Mouse) 15357
hydroxymethylglutaryl-CoA reductase (NADPH) activity
protein binding
oxidoreductase activity
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
GTPase regulator activity
NADP binding
NADPH binding
coenzyme A binding
hydroxymethylglutaryl-CoA reductase activity
protein homodimerization activity
coenzyme binding
protein phosphatase 2A binding
oxidoreductase
reductase
metabolite interconversion enzyme
lipid metabolic process
steroid biosynthetic process
cholesterol biosynthetic process
steroid metabolic process
cholesterol metabolic process
isoprenoid biosynthetic process
visual learning
coenzyme A metabolic process
sterol biosynthetic process
negative regulation of protein catabolic process
negative regulation of protein secretion
long-term synaptic potentiation
regulation of ERK1 and ERK2 cascade
negative regulation of beta-amyloid clearance
ubiquinone metabolic process
positive regulation of cell proliferation
embryo development
negative regulation of striated muscle cell apoptotic process
positive regulation of cardiac muscle cell apoptotic process
positive regulation of stress-activated MAPK cascade
negative regulation of apoptotic process
negative regulation of MAP kinase activity
negative regulation of vasodilation
positive regulation of skeletal muscle tissue development
positive regulation of smooth muscle cell proliferation
protein tetramerization
oxidation-reduction process
negative regulation of wound healing
negative regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of ERK1 and ERK2 cascade
Disclaimer
Clicking the images or links will redirect you to a website hosted by BenchSci that provides third-party scientific content. Neither the content nor the BenchSci technology and processes for selection have been evaluated by us; we are providing them as-is and without warranty of any kind, including for use or application of the Thermo Fisher Scientific products presented.
Performance Guarantee
If an Invitrogen™ antibody doesn't perform as described on our website or datasheet,we'll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Learn more
We're here to help
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.
Contact tech support