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NeoBiotechnologies

HLA-Pan (MHC II) Recombinant Rabbit Monoclonal Antibody (HLA-Pan, 2967R)

View all (27) HLA-DR/DP/DQ antibodies

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HLA-Pan (MHC II) Recombinant Rabbit Monoclonal Antibody (HLA-Pan, 2967R)

Product Details

RBM1-2967-P1ABX

Applications
Tested Dilution
Publications

Western Blot (WB)

1-2 µg/mL
-

Immunohistochemistry (Paraffin) (IHC (P))

1-2 µg/mL
-

Immunocytochemistry (ICC/IF)

1-2 µg/mL
-

Flow Cytometry (Flow)

1-2 µg/10^6 cells
-

Peptide Array (Array)

Assay-dependent
-
Product Specifications

Species Reactivity

Human

Host/Isotype

Rabbit / IgG

Expression System

HEK293 cells

Class

Recombinant Monoclonal

Type

Antibody

Clone

HLA-Pan, 2967R

Immunogen

Non-T, non-B human acute lymphoblastic leukemia REH6 cell line
3D Epitope / Immunogen

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1 mg/mL

Amount

100 µg

Purification

Protein A/G

Storage buffer

PBS, pH 7.4

Contains

no preservative

Storage conditions

-20°C or -80°C if preferred

Shipping conditions

Ambient (domestic); Wet ice (international)

Product Specific Information

Antibody is tested in direct ELISA (For coating use Ab at 2-5 µg/mL.

Immunohistochemistry (PFA fixed): incubate antibody for 30 min RT. Staining of formalin-fixed tissues requires heating tissue sections in 10mM Tris with 1mM EDTA, pH 9.0, for 45 min at 95 degrees C followed by cooling at RT for 20 minutes.

Target Information

MHC class II molecules are transmembrane glycoproteins composed of an alpha chain (36 kDa) and a beta chain (27 kDa). They are expressed primarily on antigen presenting cells such as B lymphocytes, monocytes, macrophages, thymic epithelial cells and activated T lymphocytes. Three loci, DR, DQ and DP, encode the major expressed products of the human class II region. The human MHC class II molecules bind intracellularly processed peptides and present them to T-helper cells. They therefore have a critical role in the initiation of the immune response.

HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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Bioinformatics

Protein Aliases: cell surface glycoprotein; integral membrane protein; class II HLA histocompatibility antigen; DP beta 1 domain protein; DR beta-5; DR2-beta-2; DR7 beta-chain glycoprotein; DRB1; DRB52; DRw53 beta-chain glycoprotein; Dw2; ERLA-005; FLJ75017; FLJ76359; histocompatibility antigen HLA-DR alpha; HLA class II histocompatibility antigen, DP beta 1 chain; HLA class II histocompatibility antigen, DP(W4) beta chain; HLA class II histocompatibility antigen, DQ beta 1 chain; HLA class II histocompatibility antigen, DR alpha chain; HLA class II histocompatibility antigen, DR beta 3 chain; HLA class II histocompatibility antigen, DR beta 4 chain; HLA class II histocompatibility antigen, DR beta 5 chain; HLA class II histocompatibility antigen, DR-1 beta chain; HLA class II histocompatibility antigen, DR-5 beta chain; HLA class II histocompatibility antigen, DRB1 beta chain; HLA DP4 beta-chain; HLA DRB3; HLA-D; HLA-DP histocompatibility type, beta-1 subunit; HLA-DQ; HLA-DQ-beta-1 cell surface glycoprotein; HLA-DQB1; HLA-DR; HLA-DR alpha-chain; hla-dr antigen alpha chain; hla-dr antigen beta chain; hla-dr antigen heavy chain; HLA-DR-alpha chain precursor; HLA-DR-beta chain; HLA-DR11-14N allele; HLA-DRA; HLA-DRB1; human leucocyte antigen; human leucocyte antigen DRB1; human leucocyte antigen DRB3; Human leukocyte antigen DRB1; leukocyte antigen; light chain; lymphocyte antigen DRB1; major histocompatibility complex, class II, DRB3; MHC Class 2; MHC class II; MHC class II antigen; MHC class II antigen DPB1; MHC class II antigen DQB1; MHC class II antigen DR beta 3 chain; MHC class II antigen DRA; MHC class II antigen DRB3; MHC class II antigen DRB4; MHC class II antigen DRB5; MHC class II antigen HLA-DQ-beta-1; MHC class II DQ beta chain; MHC class II DQ-beta protein precursor; MHC class II DQ3.1ER protein; MHC class II DR beta chain; MHC class II HLA-DP-beta-1; MHC class II HLA-DQ beta glycoprotein; MHC class II HLA-DR beta 1 chain; MHC class II HLA-DR beta 3 chain; MHC class II HLA-DR4 protein; MHC class II HLA-DR4/w53 protein; MHC class II protein; MHC DQ beta protein precursor; MHC DQ-beta chain; MHC DQw1-beta surface glycoprotein; MHC DR beta protein precursor; MHC DR-beta; MHC DR7-beta-1 chain; MHC DR7-beta-2 chain; MHC HLA DPB1; MHC HLA DR5 cell surface glycoprotein beta chain precursor; MHC HLA-D; MHC HLA-DC-beta chain precursor; MHC HLA-DPw4b-beta chain precursor; MHC HLA-DQ-beta cell surface glycoprotein; MHC HLA-DQ-beta chain precursor old gene name 'HLA-DQB'; MHC HLA-DQ-beta precursor; MHC HLA-DQB1-beta protein; MHC HLA-DR-beta chain; MHC HLA-DR-beta chain precursor; MHC HLA-DR-beta chain precursor old gene name 'HLA-DRA1'; MHC HLA-DR-beta surface glycoprotein; MHC HLA-DR-beta-1 chain; MHC HLA-DR-beta-1 precursor; MHC HLA-DR-beta-2 precursor; MHC HLA-DR1-beta; MHC HLA-DR2 (non-Dw2/non-Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw12)a glycoprotein beta-chain; MHC HLA-DR2(Dw12)b glycoprotein beta-chain; MHC HLA-DR2(Dw2)a glycoprotein beta-chain; MHC HLA-DR2(Dw2)b glycoprotein beta-chain; MHC HLA-DR2(non-Dw2/non-Dw12)a glycoprotein beta-chain; MHC HLA-DRQ-beta chain; MHC HLA-DRw10-beta-2 protein precursor; MHC HLA-SB-beta chain I; MHC II HLA; SB-beta chain; unnamed protein product; XXbac-BPG161M6.1

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Gene Aliases: CELIAC1; DPB1; DR4; DRB1; DRB3; DRB4; DRB5; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DQB; HLA-DQB1; HLA-DR1B; HLA-DR3B; HLA-DR4B; HLA-DRA; HLA-DRA1; HLA-DRB; HLA-DRB1; HLA-DRB3; HLA-DRB3*; HLA-DRB4; HLA-DRB4*; HLA-DRB5; HLA-DRB5*; IDDM1; SS1

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UniProt ID: (Human) P79608, (Human) P01920, (Human) P01903, (Human) P01911, (Human) P79483, (Human) P13762, (Human) Q30154

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Entrez Gene ID: (Human) 3115, (Human) 3119, (Human) 3122, (Human) 3123, (Human) 3125, (Human) 3126, (Human) 3127

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Function(s)
protein binding MHC class II protein complex binding peptide antigen binding MHC class II receptor activity polysaccharide binding T cell receptor binding structural constituent of cytoskeleton CD4 receptor binding
Process(es)
adaptive immune response immune system process peptide antigen assembly with MHC class II protein complex antigen processing and presentation of peptide or polysaccharide antigen via MHC class II immune response antigen processing and presentation antigen processing and presentation of exogenous peptide antigen via MHC class II positive regulation of interferon-gamma production positive regulation of T cell proliferation positive regulation of immune response T cell receptor signaling pathway positive regulation of T cell activation positive regulation of T cell mediated cytotoxicity myeloid dendritic cell antigen processing and presentation antigen processing and presentation of endogenous peptide antigen via MHC class II positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation positive regulation of memory T cell differentiation regulation of T-helper cell differentiation cognition positive regulation of CD4-positive, alpha-beta T cell activation positive regulation of T cell mediated immune response to tumor cell signal transduction humoral immune response positive regulation of protein phosphorylation inflammatory response to antigenic stimulus negative regulation of inflammatory response to antigenic stimulus cytoskeleton organization epidermis development detection of bacterium macrophage differentiation regulation of interleukin-10 production regulation of interleukin-4 production negative regulation of interferon-gamma production positive regulation of kinase activity positive regulation of insulin secretion involved in cellular response to glucose stimulus T-helper 1 type immune response negative regulation of T cell proliferation positive regulation of I-kappaB kinase/NF-kappaB signaling positive regulation of MAPK cascade positive regulation of monocyte differentiation positive regulation of transcription, DNA-templated positive regulation of viral entry into host cell protein tetramerization positive regulation of ERK1 and ERK2 cascade
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