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          • Home
          • › Search Tool
          • › Search Results
          • › Hs00608023_m1
          See other BCL2 GE Assays ›
          Gene Symbol:
          BCL2
          Gene Name:
          BCL2, apoptosis regulator
          Gene Aliases:
          Bcl-2, PPP1R50
          Chromosome Location:
          Chr.18: 63123346 - 63319778 on Build GRCh38
          Species:
          Human
          Species Specific ID (Flybase ID):
          -
          Assay ID Hs00608023_m1
          Size
          Availability Inventoried
          Catalog # 4331182
          Price 2,694.00
          Your Price
          Online offer:
          2694.0
          Check your price ›
          • Genomic Map
          • Assay Details
          • More Information
          • Citations (11)

          Genomic Map

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          Assay Details

          Gene Symbol: BCL2
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_000633.2 NP_000624.2 2 - 3 1081 81
          GenBank mRNA BC027258.1 - 2 - 3 977 4511027 81
          EU287875.1 - 1 - 2 588 81
          M13994.1 - 1 - 2 2046 81
          M14745.1 - 1 - 2 619 81
          X06487.1 - 2 - 3 1474 81

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          More Information


          Set Membership:

          Ambion siRNA available Amplicon length between 71 and 85 Apoptosis 3' Most Mammalian Gene Collection Homo sapiens Human Androgen Panel Human Hedgehog Pathway Human NFkB Pathway Human Apoptosis Inventoried Human_Nfkb Human_Apoptosis Human_Androgen Human_Hedgehog Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene BCL2

          Gene Ontology Categories:

          Function(s) Process(es)

          protein polyubiquitination
          ossification
          ovarian follicle development
          metanephros development
          branching involved in ureteric bud morphogenesis
          behavioral fear response
          B cell homeostasis
          release of cytochrome c from mitochondria
          regulation of cell-matrix adhesion
          lymphoid progenitor cell differentiation
          B cell lineage commitment
          response to ischemia
          renal system process
          protein dephosphorylation
          melanin metabolic process
          regulation of nitrogen utilization
          apoptotic process
          humoral immune response
          cellular response to DNA damage stimulus
          actin filament organization
          axonogenesis
          female pregnancy
          cell aging
          male gonad development
          extrinsic apoptotic signaling pathway via death domain receptors
          intrinsic apoptotic signaling pathway in response to DNA damage
          intrinsic apoptotic signaling pathway in response to oxidative stress
          response to radiation
          response to toxic substance
          post-embryonic development
          response to iron ion
          response to UV-B
          response to gamma radiation
          regulation of gene expression
          negative regulation of autophagy
          negative regulation of calcium ion transport into cytosol
          regulation of glycoprotein biosynthetic process
          mesenchymal cell development
          positive regulation of neuron maturation
          positive regulation of smooth muscle cell migration
          cell growth
          peptidyl-serine phosphorylation
          peptidyl-threonine phosphorylation
          cochlear nucleus development
          gland morphogenesis
          regulation of transmembrane transporter activity
          negative regulation of ossification
          positive regulation of cell growth
          negative regulation of cell growth
          melanocyte differentiation
          negative regulation of cell migration
          positive regulation of B cell proliferation
          hair follicle morphogenesis
          axon regeneration
          regulation of protein stability
          endoplasmic reticulum calcium ion homeostasis
          glomerulus development
          negative regulation of cellular pH reduction
          negative regulation of myeloid cell apoptotic process
          T cell differentiation in thymus
          positive regulation of peptidyl-serine phosphorylation
          negative regulation of osteoblast proliferation
          response to cytokine
          response to nicotine
          organ growth
          positive regulation of multicellular organism growth
          B cell proliferation
          cellular response to glucose starvation
          response to drug
          response to hydrogen peroxide
          T cell homeostasis
          negative regulation of apoptotic process
          positive regulation of catalytic activity
          CD8-positive, alpha-beta T cell lineage commitment
          regulation of protein homodimerization activity
          regulation of protein heterodimerization activity
          negative regulation of neuron apoptotic process
          ear development
          regulation of viral genome replication
          positive regulation of melanocyte differentiation
          negative regulation of retinal cell programmed cell death
          regulation of mitochondrial membrane permeability
          focal adhesion assembly
          spleen development
          thymus development
          digestive tract morphogenesis
          oocyte development
          positive regulation of skeletal muscle fiber development
          pigment granule organization
          homeostasis of number of cells within a tissue
          B cell receptor signaling pathway
          response to glucocorticoid
          neuron apoptotic process
          defense response to virus
          regulation of mitochondrial membrane potential
          negative regulation of mitochondrial depolarization
          regulation of calcium ion transport
          transmembrane transport
          intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
          cellular response to organic substance
          cellular response to hypoxia
          reactive oxygen species metabolic process
          extrinsic apoptotic signaling pathway in absence of ligand
          positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
          negative regulation of G1/S transition of mitotic cell cycle
          negative regulation of reactive oxygen species metabolic process
          negative regulation of anoikis
          negative regulation of apoptotic signaling pathway
          negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
          negative regulation of intrinsic apoptotic signaling pathway
          positive regulation of intrinsic apoptotic signaling pathway
          protease binding
          protein binding
          transcription factor binding
          channel activity
          channel inhibitor activity
          ubiquitin protein ligase binding
          identical protein binding
          protein homodimerization activity
          sequence-specific DNA binding
          protein heterodimerization activity
          BH3 domain binding
          protein phosphatase 2A binding

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          Citations (11)

          The silencing mediator of retinoic acid and thyroid hormone receptor (SMRT) corepressor is required for full estrogen receptor alpha transcriptional activity.
          Authors
          Peterson TJ, Karmakar S, Pace MC, Gao T, Smith CL
          Journal
          Mol Cell Biol - Page No 5933 (Sat Sep 01 00:00:00 EDT 2007)
          Volume (Year)
          27 (2007)
          Product Usage
          -
          Bax, Bak and mitochondrial oxidants are involved in hypoxia-reoxygenation-induced apoptosis in human placenta.
          Authors
          Hung TH, Chen SF, Liou JD, Hsu JJ, Li MJ, Yeh YL, Hsieh TT
          Journal
          Placenta - Page No 565 (Tue Jul 01 00:00:00 EDT 2008)
          Volume (Year)
          29 (2008)
          Product Usage
          -
          The role of Bcl-x(L) protein in nucleotide excision repair-facilitated cell protection against cisplatin-induced apoptosis.
          Authors
          Lomonaco SL, Xu XS, Wang G
          Journal
          Dna Cell Biol - Page No 285 (Mon Jun 01 00:00:00 EDT 2009)
          Volume (Year)
          28 (2009)
          Product Usage
          -
          1,25-dihydroxyvitamin D3 enhances the apoptotic activity of MDM2 antagonist nutlin-3a in acute myeloid leukemia cells expressing wild-type p53.
          Authors
          Thompson T, Andreeff M, Studzinski GP, Vassilev LT
          Journal
          Mol Cancer Ther - Page No 1158 (Sat May 01 00:00:00 EDT 2010)
          Volume (Year)
          9 (2010)
          Product Usage
          -
          Cyclin-dependent kinase 1 inhibitor RO-3306 enhances p53-mediated Bax activation and mitochondrial apoptosis in AML.
          Authors
          Kojima K, Shimanuki M, Shikami M, Andreeff M, Nakakuma H
          Journal
          Cancer Sci - Page No 1128 (Mon Jun 01 00:00:00 EDT 2009)
          Volume (Year)
          100 (2009)
          Product Usage
          -
          Differential effects of concomitant use of vitamins C and E on trophoblast apoptosis and autophagy between normoxia and hypoxia-reoxygenation.
          Authors
          Hung TH, Chen SF, Li MJ, Yeh YL, Hsieh TT
          Journal
          Plos One - Page No e12202 (Fri Jan 01 00:00:00 EST 2010)
          Volume (Year)
          5 (2010)
          Product Usage
          -
          Gene expression analysis of immunostained endothelial cells isolated from formaldehyde-fixated paraffin embedded tumors using laser capture microdissection--a technical report.
          Authors
          Kaneko T, Okiji T, Kaneko R, Suda H, Nor JE
          Journal
          Microsc Res Tech - Page No 908 (Tue Dec 01 00:00:00 EST 2009)
          Volume (Year)
          72 (2009)
          Product Usage
          -
          eIF4E activation is commonly elevated in advanced human prostate cancers and significantly related to reduced patient survival.
          Authors
          Graff JR, Konicek BW, Lynch RL, Dumstorf CA, Dowless MS, McNulty AM, Parsons SH, Brail LH, Colligan BM, Koop JW, Hurst BM, Deddens JA, Neubauer BL, Stancato LF, Carter HW, Douglass LE, Carter JH
          Journal
          Cancer Res - Page No 3866 (Fri May 01 00:00:00 EDT 2009)
          Volume (Year)
          69 (2009)
          Product Usage
          -
          Molecular markers implicating early malignant events in cervical carcinogenesis.
          Authors
          Koskimaa HM, Kurvinen K, Costa S, Syrjanen K, Syrjanen S
          Journal
          Cancer Epidemiol Biomarkers Prev - Page No 2003 (Sun Aug 01 00:00:00 EDT 2010)
          Volume (Year)
          19 (2010)
          Product Usage
          -
          IFNgamma restores breast cancer sensitivity to fulvestrant by regulating STAT1, IFN regulatory factor 1, NF-kappaB, BCL2 family members, and signaling to caspase-dependent apoptosis.
          Authors
          Ning Y, Riggins RB, Mulla JE, Chung H, Zwart A, Clarke R
          Journal
          Mol Cancer Ther - Page No 1274 (Sat May 01 00:00:00 EDT 2010)
          Volume (Year)
          9 (2010)
          Product Usage
          -
          Co-inhibition of BCL-W and BCL2 restores antiestrogen sensitivity through BECN1 and promotes an autophagy-associated necrosis.
          Authors
          Crawford AC, Riggins RB, Shajahan AN, Zwart A, Clarke R
          Journal
          Plos One - Page No e8604 (Fri Jan 01 00:00:00 EST 2010)
          Volume (Year)
          5 (2010)
          Product Usage
          -

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