Assay Details

Gene Symbol: Nos2
Interrogated Sequence		Translated Protein	Exon Boundary	Assay Location	IMAGE Clone ID	Amplicon Length
RefSeq	NM_010927.3	NP_035057.1	4 - 5	487		70
GenBank mRNA	AF065919.1	-	4 - 5	484		70
	AF065920.1	-	4 - 5	484		70
	AF065921.2	-	4 - 5	484		70
	AF065922.2	-	3 - 4	357		70
	AF065923.2	-	3 - 4	357		70
	AY090567.1	-	3 - 4	307		70
	BC062378.1	-	4 - 5	496	4978648	70
	M84373.1	-	4 - 5	488		70
	M87039.1	-	4 - 5	559		70
	M92649.1	-	4 - 5	495		70
	U43428.1	-	4 - 5	375		70

More Information

Updated Mapping Information

This assay targets the same location as MTA transcript cluster(s) TC1100001171.mm.1

Set Membership:

Ambion siRNA available

Amplicon length less than or equal to 70

Mammalian Gene Collection

Mus musculus

Mouse Immune Response

1700

Inventoried

Mouse_Immune_Response

Probe spans exons

Matching Ambion siRNAs:

Click here to find siRNAs for Gene Nos2

Panther Classification:

Molecular Function -

oxidoreductase

Gene Ontology Categories:

Function(s) Process(es)

MicroArray Probes:

Affymetrix ABI

Citations (37)

TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis.

Authors: Liese J, Schleicher U, Bogdan C
Journal: Eur J Immunol - Page No 3424 (Sat Dec 01 00:00:00 EST 2007)
Volume (Year): 37 (2007)
Product Usage: -

Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis.

Authors: Chowdhry S, Nazmy MH, Meakin PJ, Dinkova-Kostova AT, Walsh SV, Tsujita T, Dillon JF, Ashford ML, Hayes JD
Journal: Free Radic Biol Med - Page No 357 (Fri Jan 15 00:00:00 EST 2010)
Volume (Year): 48 (2010)
Product Usage: -

Fucoxanthin regulates adipocytokine mRNA expression in white adipose tissue of diabetic/obese KK-Ay mice.

Authors: Hosokawa M, Miyashita T, Nishikawa S, Emi S, Tsukui T, Beppu F, Okada T, Miyashita K
Journal: Arch Biochem Biophys - Page No 17 (Wed Dec 01 00:00:00 EST 2010)
Volume (Year): 504 (2010)
Product Usage: -

Cytokine-mediated control of lipopolysaccharide-induced activation of small intestinal epithelial cells.

Authors: Lotz M, Konig T, Menard S, Gutle D, Bogdan C, Hornef MW
Journal: Immunology - Page No 306 (Thu Nov 01 00:00:00 EDT 2007)
Volume (Year): 122 (2007)
Product Usage: -

Immortalized mouse articular cartilage cell lines retain chondrocyte phenotype and respond to both anabolic factor BMP-2 and pro-inflammatory factor IL-1.

Authors: Majumdar MK, Chockalingam PS, Bhat RA, Sheldon R, Keohan C, Blanchet T, Glasson S, Morris EA
Journal: J Cell Physiol - Page No 68 (Tue Apr 01 00:00:00 EDT 2008)
Volume (Year): 215 (2008)
Product Usage: -

Cytokines, signaling pathways, and effector molecules required for the control of Leishmania (Viannia) braziliensis in mice.

Authors: Rocha FJ, Schleicher U, Mattner J, Alber G, Bogdan C
Journal: Infect Immun - Page No 3823 (Wed Aug 01 00:00:00 EDT 2007)
Volume (Year): 75 (2007)
Product Usage: -

Nitric oxide synthase modulates CFA-induced thermal hyperalgesia through cytokine regulation in mice.

Authors: Chen Y, Boettger MK, Reif A, Schmitt A, Uceyler N, Sommer C
Journal: Mol Pain - Page No 13 (Fri Jan 01 00:00:00 EST 2010)
Volume (Year): 6 (2010)
Product Usage: -

High mobility group box 1 protein is released by neural cells upon different stresses and worsens ischemic neurodegeneration in vitro and in vivo.

Authors: Faraco G, Fossati S, Bianchi ME, Patrone M, Pedrazzi M, Sparatore B, Moroni F, Chiarugi A
Journal: J Neurochem - Page No 590 (Mon Oct 01 00:00:00 EDT 2007)
Volume (Year): 103 (2007)
Product Usage: -

Congenital NOS2 deficiency prevents impairment of hypoxic pulmonary vasoconstriction in murine ventilator-induced lung injury.

Authors: Liu R, Hotta Y, Graveline AR, Evgenov OV, Buys ES, Bloch KD, Ichinose F, Zapol WM
Journal: Am J Physiol Lung Cell Mol Physiol - Page No L1300 (Thu Nov 01 00:00:00 EDT 2007)
Volume (Year): 293 (2007)
Product Usage: -

Inducible nitric oxide synthase and estradiol exhibit complementary neuroprotective roles after ischemic brain injury.

Authors: Brown CM, Dela Cruz CD, Yang E, Wise PM
Journal: Exp Neurol - Page No 782 (Tue Apr 01 00:00:00 EDT 2008)
Volume (Year): 210 (2008)
Product Usage: -

Central administration of lipopolysaccharide induces depressive-like behavior in vivo and activates brain indoleamine 2,3 dioxygenase in murine organotypic hippocampal slice cultures.

Authors: Fu X, Zunich SM, O'Connor JC, Kavelaars A, Dantzer R, Kelley KW
Journal: J Neuroinflammation - Page No 43 (Fri Jan 01 00:00:00 EST 2010)
Volume (Year): 7 (2010)
Product Usage: -

Mutant alpha-synuclein overexpression mediates early proinflammatory activity.

Authors: Su X, Federoff HJ, Maguire-Zeiss KA
Journal: Neurotox Res - Page No 238 (Thu Oct 01 00:00:00 EDT 2009)
Volume (Year): 16 (2009)
Product Usage: -

Low-Intensity Pulsed Ultrasound Modulates Shear Stress Induced PGHS-2 Expression and PGE(2) Synthesis in MLO-Y4 Osteocyte-Like Cells.

Authors: Saini V, Yadav S, McCormick S
Journal: Ann Biomed Eng - Page No (Sat Sep 04 00:00:00 EDT 2010)
Volume (Year): (2010)
Product Usage: -

Differential involvement of RelB in morphine-induced modulation of chemotaxis, NO, and cytokine production in murine macrophages and lymphocytes.

Authors: Martucci C, Franchi S, Lattuada D, Panerai AE, Sacerdote P
Journal: J Leukoc Biol - Page No 344 (Mon Jan 01 00:00:00 EST 2007)
Volume (Year): 81 (2007)
Product Usage: -

Endothelial nitric oxide synthase deficiency in mice results in reduced chondrocyte proliferation and endochondral bone growth.

Authors: Yan Q, Feng Q, Beier F
Journal: Arthritis Rheum - Page No 2013 (Thu Jul 01 00:00:00 EDT 2010)
Volume (Year): 62 (2010)
Product Usage: -

Adiponectin upregulates ferritin heavy chain in skeletal muscle cells.

Authors: Ikegami Y, Inukai K, Imai K, Sakamoto Y, Katagiri H, Kurihara S, Awata T, Katayama S
Journal: Diabetes - Page No 61 (Thu Jan 01 00:00:00 EST 2009)
Volume (Year): 58 (2009)
Product Usage: -

Pioglitazone protects the myocardium against ischemia-reperfusion injury in eNOS and iNOS knockout mice.

Authors: Ye Y, Lin Y, Manickavasagam S, Perez-Polo JR, Tieu BC, Birnbaum Y
Journal: Am J Physiol Heart Circ Physiol - Page No H2436 (Mon Dec 01 00:00:00 EST 2008)
Volume (Year): 295 (2008)
Product Usage: -

Suppressive effects of alloxanthin and diatoxanthin from Halocynthia roretzi on LPS-induced expression of pro-inflammatory genes in RAW264.7 cells.

Authors: Konishi I, Hosokawa M, Sashima T, Maoka T, Miyashita K
Journal: J Oleo Sci - Page No 181 (Tue Jan 01 00:00:00 EST 2008)
Volume (Year): 57 (2008)
Product Usage: -

Endogenous interleukin-10 inhibits angiotensin II-induced vascular dysfunction.

Authors: Didion SP, Kinzenbaw DA, Schrader LI, Chu Y, Faraci FM
Journal: Hypertension - Page No 619 (Tue Sep 01 00:00:00 EDT 2009)
Volume (Year): 54 (2009)
Product Usage: -

Psychological stress suppresses innate IFN-gamma production via glucocorticoid receptor activation: reversal by the anxiolytic chlordiazepoxide.

Authors: Curtin NM, Boyle NT, Mills KH, Connor TJ
Journal: Brain Behav Immun - Page No 535 (Fri May 01 00:00:00 EDT 2009)
Volume (Year): 23 (2009)
Product Usage: -

Differential roles of nitric oxide synthase isozymes in cardiotoxicity and mortality following chronic doxorubicin treatment in mice.

Authors: Deng S, Kruger A, Schmidt A, Metzger A, Yan T, Godtel-Armbrust U, Hasenfuss G, Brunner F, Wojnowski L
Journal: Naunyn Schmiedebergs Arch Pharmacol - Page No 25 (Wed Jul 01 00:00:00 EDT 2009)
Volume (Year): 380 (2009)
Product Usage: -

Modulation by budesonide of DNA methylation and mRNA expression in mouse lung tumors.

Authors: Pereira MA, Tao L, Liu Y, Li L, Steele VE, Lubet RA
Journal: Int J Cancer - Page No 1150 (Thu Mar 01 00:00:00 EST 2007)
Volume (Year): 120 (2007)
Product Usage: -

Enhanced production of nitric oxide, reactive oxygen species, and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages.

Authors: Yanagisawa N, Shimada K, Miyazaki T, Kume A, Kitamura Y, Sumiyoshi K, Kiyanagi T, Iesaki T, Inoue N, Daida H
Journal: Lipids Health Dis - Page No 48 (Tue Jan 01 00:00:00 EST 2008)
Volume (Year): 7 (2008)
Product Usage: -

Purple carrot (Daucus carota L.) polyacetylenes decrease lipopolysaccharide-induced expression of inflammatory proteins in macrophage and endothelial cells.

Authors: Metzger BT, Barnes DM, Reed JD
Journal: J Agric Food Chem - Page No 3554 (Wed May 28 00:00:00 EDT 2008)
Volume (Year): 56 (2008)
Product Usage: -

Both TLR2 and TLR4 are required for the effective immune response in Staphylococcus aureus-induced experimental murine brain abscess.

Authors: Stenzel W, Soltek S, Sanchez-Ruiz M, Akira S, Miletic H, Schluter D, Deckert M
Journal: Am J Pathol - Page No 132 (Tue Jan 01 00:00:00 EST 2008)
Volume (Year): 172 (2008)
Product Usage: -

The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol.

Authors: Brown CM, Choi E, Xu Q, Vitek MP, Colton CA
Journal: Neurobiol Aging - Page No 1783 (Mon Dec 01 00:00:00 EST 2008)
Volume (Year): 29 (2008)
Product Usage: -

The involvement of nitric oxide in the enhanced expression of mu-opioid receptors during intestinal inflammation in mice.

Authors: Pol O, Sasaki M, Jimenez N, Dawson VL, Dawson TM, Puig MM
Journal: Br J Pharmacol - Page No 758 (Fri Jul 01 00:00:00 EDT 2005)
Volume (Year): 145 (2005)
Product Usage: -

Psychological stress reactivates dextran sulfate sodium-induced chronic colitis in mice.

Authors: Melgar S, Engstrom K, Jagervall A, Martinez V
Journal: Stress - Page No 348 (Tue Jan 01 00:00:00 EST 2008)
Volume (Year): 11 (2008)
Product Usage: -

Arginine supplementation induces myoblast fusion via augmentation of nitric oxide production.

Authors: Long JH, Lira VA, Soltow QA, Betters JL, Sellman JE, Criswell DS
Journal: J Muscle Res Cell Motil - Page No 577 (Sun Jan 01 00:00:00 EST 2006)
Volume (Year): 27 (2006)
Product Usage: -

Small interfering RNA (siRNA) delivery into murine bone marrow-derived macrophages by electroporation.

Authors: Wiese M, Castiglione K, Hensel M, Schleicher U, Bogdan C, Jantsch J
Journal: J Immunol Methods - Page No 102 (Sun Feb 28 00:00:00 EST 2010)
Volume (Year): 353 (2010)
Product Usage: -

Regulation of the inflammatory response to Staphylococcus aureus-induced brain abscess by interleukin-10.

Authors: Stenzel W, Dahm J, Sanchez-Ruiz M, Miletic H, Hermann M, Courts C, Schwindt H, Utermohlen O, Schluter D, Deckert M
Journal: J Neuropathol Exp Neurol - Page No 1046 (Thu Dec 01 00:00:00 EST 2005)
Volume (Year): 64 (2005)
Product Usage: -

Expression profiles of proliferative and antiapoptotic genes in sporadic and colitis-related mouse colon cancer models.

Authors: Svec J, Ergang P, Mandys V, Kment M, Pacha J
Journal: Int J Exp Pathol - Page No 44 (Mon Feb 01 00:00:00 EST 2010)
Volume (Year): 91 (2010)
Product Usage: -

PKC412 (CGP41251) modulates the proliferation and lipopolysaccharide-induced inflammatory responses of RAW 264.7 macrophages.

Authors: Miyatake K, Inoue H, Hashimoto K, Takaku H, Takata Y, Nakano S, Yasui N, Itakura M
Journal: Biochem Biophys Res Commun - Page No 115 (Fri Aug 17 00:00:00 EDT 2007)
Volume (Year): 360 (2007)
Product Usage: -

Intra-colonic administration of the TLR7 agonist R-848 induces an acute local and systemic inflammation in mice.

Authors: Karlsson A, Jagervall K, Utkovic H, Karlsson L, Rehnstrom E, Fredin MF, Gillberg PG, Jansson L, Michaelsson E, Melgar S
Journal: Biochem Biophys Res Commun - Page No 242 (Fri Mar 07 00:00:00 EST 2008)
Volume (Year): 367 (2008)
Product Usage: -

Discrepancy between the in vitro and in vivo effects of murine mesenchymal stem cells on T-cell proliferation and collagen-induced arthritis.

Authors: Schurgers E, Kelchtermans H, Mitera T, Geboes L, Matthys P
Journal: Arthritis Res Ther - Page No R31 (Fri Jan 01 00:00:00 EST 2010)
Volume (Year): 12 (2010)
Product Usage: -

IL-4(-/-) mice with lethal Mesocestoides corti infections--reduced Th2 cytokines and alternatively activated macrophages.

Authors: O'Connell AE, Kerepesi LA, Vandergrift GL, Herbert DR, VAN Winkle TJ, Hooper DC, Pearce EJ, Abraham D
Journal: Parasite Immunol - Page No 741 (Tue Dec 01 00:00:00 EST 2009)
Volume (Year): 31 (2009)
Product Usage: -

Immortalized cell lines from mouse xiphisternum preserve chondrocyte phenotype.

Authors: Majumdar MK, Chockalingam PS, Bhat RA, Sheldon R, Keohan C, Blanchet T, Glasson S, Morris EA
Journal: J Cell Physiol - Page No 551 (Wed Nov 01 00:00:00 EST 2006)
Volume (Year): 209 (2006)
Product Usage: -

Availability	Inventoried
Catalog #	4331182
Price	284.00
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Array Name	Probe IDs	Targets	Target Type
Affymetrix Mouse Clariom S Array	PSR1100010918.mm.1	NM_010927.4	Refseq
Affymetrix Mouse Clariom S Array	PSR1100010918.mm.1	TC1100001171.mm.1	MTA TC

System Message

Genomic Map