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          • › Rn00565158_m1
          See other LEP GE Assays ›
          Gene Symbol:
          Lep
          Gene Name:
          leptin
          Gene Aliases:
          OB, obese
          Chromosome Location:
          Chr.4: 56337695 - 56351818 on Build Rnor_6.0
          Species:
          Rat
          Species Specific ID (Flybase ID):
          -
          Assay ID Rn00565158_m1
          Best Coverage
          Size
          Availability Inventoried
          Catalog # 4331182
          Price
          Your Price
          Online offer:
          Check your price ›
          • Genomic Map
          • Assay Details
          • More Information
          • Citations (1)

          Genomic Map

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          Assay Details

          Gene Symbol: Lep
          Interrogated Sequence Translated Protein Exon Boundary Assay Location IMAGE Clone ID Amplicon Length
          RefSeq NM_013076.3 NP_037208.1 1 - 2 194 92
          XM_008762762.1 XP_008760984.1 1 - 2 282 92
          GenBank mRNA D45862.1 - 2 - 3 206 92
          D49653.1 - 1 - 2 175 92
          S78586.1 - 1 - 2 146 92
          U48849.1 - 1 - 2 107 92

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          More Information


          Updated Mapping Information

          This assay targets the same location as RTA transcript cluster(s) TC0400000505.rn.1

          Set Membership:

          Ambion siRNA available Amplicon length between 86 and 100 3' Most Recommended Assay Rattus norvegicus 1700 Inventoried Probe spans exons

          Matching Ambion siRNAs:

          Click here to find siRNAs for Gene Lep

          Panther Classification:

          Molecular Function -

          peptide hormone

          Gene Ontology Categories:

          Function(s) Process(es)

          negative regulation of transcription from RNA polymerase II promoter
          ovulation from ovarian follicle
          response to hypoxia
          positive regulation of cytokine production
          placenta development
          regulation of protein phosphorylation
          response to dietary excess
          cardiac muscle hypertrophy
          glucose metabolic process
          regulation of gluconeogenesis
          energy reserve metabolic process
          glycerol biosynthetic process
          lipid metabolic process
          fatty acid beta-oxidation
          JAK-STAT cascade
          tyrosine phosphorylation of STAT protein
          female pregnancy
          response to nutrient
          circadian rhythm
          cholesterol metabolic process
          bile acid metabolic process
          regulation of blood pressure
          positive regulation of cell proliferation
          adult feeding behavior
          fatty acid catabolic process
          negative regulation of metabolic process
          regulation of metabolic process
          cAMP-mediated signaling
          central nervous system neuron development
          insulin secretion
          regulation of intestinal cholesterol absorption
          negative regulation of appetite
          response to insulin
          response to vitamin E
          leptin-mediated signaling pathway
          positive regulation of luteinizing hormone secretion
          positive regulation of peroxisome proliferator activated receptor signaling pathway
          intracellular signal transduction
          bone mineralization involved in bone maturation
          positive regulation of protein import into nucleus
          hormone metabolic process
          positive regulation of tyrosine phosphorylation of Stat3 protein
          glucose homeostasis
          eating behavior
          negative regulation of apoptotic process
          positive regulation of ion transport
          positive regulation of MAPK cascade
          regulation of fat cell differentiation
          positive regulation of myeloid cell differentiation
          negative regulation of vasoconstriction
          positive regulation of JAK-STAT cascade
          positive regulation of insulin receptor signaling pathway
          positive regulation of follicle-stimulating hormone secretion
          positive regulation of developmental growth
          regulation of insulin secretion
          regulation of steroid biosynthetic process
          leukocyte tethering or rolling
          regulation of lipoprotein lipid oxidation
          adipose tissue development
          negative regulation of cartilage development
          negative regulation of glucagon secretion
          cellular response to L-ascorbic acid
          cellular response to retinoic acid
          regulation of protein localization to nucleus
          positive regulation of STAT protein import into nucleus
          positive regulation of reactive oxygen species metabolic process
          negative regulation of glutamine transport
          positive regulation of hepatic stellate cell activation
          cytokine activity
          hormone activity
          growth factor activity
          peptide hormone receptor binding

          MicroArray Probes:

          Agilent Affymetrix ABI Illumina

          Array Name Probe IDs Targets Target Type
          Agilent Whole Rat Genome Microarray 4x44K v2 A_64_P085566 - -
          Agilent SurePrint G3 Rat CGH Microarray 1x1M 491899 - -
          Agilent Whole Rat Genome Microarray 4x44K v3 A_64_P085566 - -
          Agilent Whole Rat Genome Microarray 4x44K v3 A_64_P085566 - -
          Agilent SurePrint G3 Rat GE 8x60K Microarray A_64_P085566 - -
          SurePrint G3 Rat Gene Expression Microarray G4131A A_44_P402536 - -
          Agilent Rat Genome CGH Microarray 105A (G4436A) 92914 - -
          Agilent Rat Genome CGH Microarray 105A (G4436A) 54483 - -
          Array Name Probe IDs Targets Target Type
          Affymetrix Rat Gene 1.0 ST Array 10854088 - -
          Affymetrix Rat Gene 1.0 ST Array 10854089 - -
          Affymetrix Rat Gene 1.1 ST Array 10854086 - -
          Rat Genome 230 2.0 Array 1387748_at - -
          Rat Genome 230 2.0 Array 1387748_PM_at - -
          Affymetrix HT Rat Focus Array 1387748_at - -
          Affymetrix HT Rat Focus Array 1387748_PM_at - -
          Affymetrix Rat Clariom S Assay PSR0400003533.rn.1 TC0400000505.rn.1 RTA TC
          Affymetrix Rat Clariom S Assay PSR0400003532.rn.1 TC0400000505.rn.1 RTA TC
          Affymetrix Rat Clariom S Assay PSR0400003531.rn.1 TC0400000505.rn.1 RTA TC
          Rat Expression Set 230 1387748_at - -
          Rat Expression Set 230 1387748_PM_at - -
          Affymetrix Rat Gene 1.0 ST Array 10854086 - -
          Rat Genome U34 Set D45862_at - -
          Rat Genome U34 Set D45862_g_at - -
          Rat Genome U34 Set D49653_s_at - -
          Rat Genome U34 Set D49653_s_at - -
          Rat Genome U34 Set D45862_g_at - -
          Array Name Probe IDs Targets Target Type
          ABI Rat Genome Survey Microarray 21177605 - -
          Array Name Probe IDs Targets Target Type
          Illumina ratRef-12 v1.0 expression beadchip ILMN_1361844 - -
          RatRef-12 Expression BeadChip ILMN_51605 - -

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          Citations (1)

          Early postnatal oestradiol exposure causes insulin resistance and signs of inflammation in circulation and skeletal muscle.
          Authors
          Alexanderson C, Eriksson E, Stener-Victorin E, Lonn M, Holmang A
          Journal
          J Endocrinol - Page No 49 (Wed Apr 01 00:00:00 EDT 2009)
          Volume (Year)
          201 (2009)
          Product Usage
          -

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