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Gibco
Human/Mouse/Rat GDF-11 Recombinant Protein, PeproTech®
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Product Details
120-11-20UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human,
Mouse,
Rat
Published species
Human,
Mouse,
Rat
Expression System
E. coli
Amino acid sequence
NLGLDCDEHS SESRCCRYPL TVDFEAFGWD WIIAPKRYKA NYCSGQCEYM FMQKYPHTHL VQQANPRGSA GPCCTPTKMS PINMLYFNDK QQIIYGKIPG MVVDRCGCS
Molecular weight
25 kDa
Class
Recombinant
Type
Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Assay 1: Determined by its ability to inhibit induced alkaline phosphatase production by ATDC-5 chondrogenic cells. The expected ED50 for this effect is 0.08-0.10 ug/ml. Assay 2: Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1cells. The ED50 for this effect is 8-10 ng/ml.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
120-11-1MG will be provided as 2 x 500 µg (120-11-500UG).
Recombinant Human/Murine/Rat GDF-11 is a 25.0 kDa disulfide-linked homodimer containing two 109 amino acid polypeptide chains. It is highly homologous to myostatin/GDF-8, sharing 90% amino acid sequence identity.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
GDF11 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice and Xenopus suggest that this protein is involved in mesodermal formation and neurogenesis during embryonic development.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: BMP-11; Bone morphogenetic protein 11; GDF-11; Growth/differentiation factor 11
Gene Aliases: BMP-11; BMP11; GDF11
UniProt ID: (Human) O95390, (Mouse) Q9Z1W4, (Rat) Q9Z217
Entrez Gene ID: (Human) 10220, (Mouse) 14561, (Rat) 29454
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