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Gibco
Human GDF-15/MIC-1 Recombinant Protein, PeproTech®
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Product Details
120-28C-20UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Dog,
Human,
Mouse
Expression System
CHO cells
Amino acid sequence
ARNGDHCPLG PGRCCRLHTV RASLEDLGWA DWVLSPREVQ VTMCIGACPS QFRAANMHAQ IKTSLHRLKP DTVPAPCCVP ASYNPMVLIQ KTDTGVSLQT YDDLLAKDCH CI
Molecular weight
24.6 kDa
Class
Recombinant
Type
Protein
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by its ability to inhibit alkaline phosphatase activity in differentiating MC3T3/E1 osteoblastcells. The expected ED50 for this effect is 75-200 ng/ml.
Conjugate
Form
Lyophilized
Amount
20 µg
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Human GDF-15/MIC-1 is a disulfide linked homodimeric protein consisting of two 112 amino acid polypeptide chains. The calculated molecular weight of Recombinant Human GDF-15/MIC-1 is 24.6 kDa.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
GDF-15 belongs to the TGF-beta cytokine family, whose members play an important role during prenatal development and postnatal growth, and the remodeling and maintenance of a variety of tissues and organs. GDF-15 is expressed predominantly in the placenta and, to a much lesser extent, in various other tissues. The presence of GDF-15 in amniotic fluid and its elevated levels in the sera of pregnant women suggest GDF-15's involvement in gestation and embryonic development. GDF-15 generally exerts tumor suppressive activities and is one of the predominant factors produced and secreted in response to activation of the p53 pathway. Interestingly, the serum level of GDF-15 is positively correlated with neoplastic progression of several tumor types, including certain colorectal, pancreatic, and prostate cancers.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: GDF-15; Growth/differentiation factor 15; Macrophage inhibitory cytokine 1; MIC-1; NAG-1; NAG1; non-steroidal anti-inflammatory drug-activated gene-1; NRG-1; NSAID (nonsteroidal anti-inflammatory drug)-activated protein 1; NSAID-activated gene 1 protein; NSAID-regulated gene 1 protein; PDF; Placental bone morphogenetic protein; Placental TGF-beta; Prostate differentiation factor; PTGF-beta; TGF-b superfamily cytokine; unnamed protein product
Gene Aliases: GDF-15; GDF15; HG; MIC-1; MIC1; NAG-1; PDF; PLAB; PTGFB
UniProt ID: (Human) Q99988
Entrez Gene ID: (Human) 9518
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