Alpha Subunit: RNLPVATPDP GMFPCLHHSQ NLLRAVSNML QKARQTLEFY PCTSEEIDHE DITKDKTSTV EACLPLELTK NESCLNSRET SFITNGSCLA SRKTSFMMAL CLSSIYEDLK MYQVEFKTMN AKLLMDPKRQ IFLDQNMLAV IDELMQALNF NSETVPQKSS LEEPDFYKTK IKLCILLHAF RIRAVTIDRV MSYLNAS Beta Subunit: RKGPPAALTL PRVQCRASRY PIAVDCSWTL PPAPNSTSPV SFIATYRLGM AARGHSWPCL QQTPTSTSCT ITDVQLFSMA PYVLNVTAVH PWGSSSSFVP FITEHIIKPD PPEGVRLSPL AERQLQVQWE PPGSWPFPEI FSLKYWIRYK RQGAARFHRV GPIEATSFIL RAVRPRARYY VQVAAQDLTD YGELSDWSLP ATATMSLGK

Molecular weight

45.8 kDa

Class

Recombinant

Type

Protein

Purity

≥ 90% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

Measured by its ability to inhibit proliferative activity of PBMCs.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Amount

2 µg

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Ambient

Product Specific Information

200-37-100UG will be provided as 2 x 50 µg (200-37-50UG).

200-37-1MG will be provided as 20 x 50 µg (200-37-50UG).

200-37-250UG will be provided as 5 x 50 µg (200-37-50UG).

200-37-500UG will be provided as 5 x 100 µg (200-37-50UG).

Recombinant Recombinant Human IL-35 expressed in HEK293 cells contains 406 amino acid residues and has a calculated molecular weight of 45.8 kDa.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IL-35, or Interleukin 35 is a cytokine belonging to the IL12 family, that is produced by regulatory T cells. It is a dimeric protein composed of IL-12-alpha and IL-27-beta chains. Members of this class of cytokines are important in influencing T helper cell differentiation and supressing inflammatory response. IL-35 is known to induce proliferation of regulatory T cells, and reduce the activity of helper Th17 cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Bioinformatics

Protein Aliases: CLMF p35; cytotoxic lymphocyte maturation factor 1, p35; cytotoxic lymphocyte maturation factor 35 kDa subunit; IL-12, subunit p35; IL12p35; il35; IL35 subunit; ILN; Interleukin; interleukin 12, p35; interleukin 12A (natural killer cell stimulatory factor 1, cytotoxic lymphocyte maturation factor 1, p35); interleukin-12 alpha chain; Interleukin-35; NF cell stimulatory factor chain 1; NK cell stimulatory factor chain 1; NKSF/CLMF; IL12p35; 35kD

Human IL-35 Recombinant Protein, PeproTech®

Product Details

200-37-2UG

Control (Ctrl)

In vitro Assay (In vitro)

Miscellaneous PubMed (Misc)

Bioactivity (Bioactivity)

Species

Published species

Expression System

Amino acid sequence