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Human GITR/TNFRSF18 Fc Recombinant Protein, PeproTech®
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Product Details
310-22R-500UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
CHO cells
Amino acid sequence
QRPTGGPGCG PGRLLLGTGT DARCCRVHTT RCCRDYPGEE CCSEWDCMCV QPEFHCGDPC CTTCRHHPCP PGQGVQSQGK FSFGFQCIDC ASGTFSGGHE GHCKPWTDCT QFGFLTVFPG NKTHNAVCVP GSPPAEGGPK SCDKTHTCPP CPAPELLGGP SVFLFPPKPK DTLMISRTPE VTCVVVDVSH EDPEVKFNWY VDGVEVHNAK TKPREEQYNS TYRVVSVLTV LHQDWLNGKE YKCKVSNKAL PAPIEKTISK AKGQPREPQV YTLPPSRDEL TKNQVSLTCL VKGFYPSDIA VEWESNGQPE NNYKTTPPVL DSDGSFFLYS KLTVDKSRWQ QGNVFSCSVM HEALHNHYTQ KSLSLSPGK
Tag
Fc-tag
Molecular weight
40.6 kDa
Class
Recombinant
Type
Protein
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by its ability to bind recombinant human GITR Ligand/TNFSF18 in a functional ELISA.
Conjugate
Form
Lyophilized
Amount
500 µg
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
PeproTech's CHO cell-derived Recombinant Human GITR/TNFRSF18 Fc is a glycosylated, disulfide-linked homodimer of 738 amino-acid-residues whose monomer consists of a 136-amino-acid extracellular domain fused to the 231-amino-acid length Fc portion of human IgG by two glycine residues. The calculated molecular weight of monomeric CHO cell-derived Recombinant Human GITR/TNFRSF18 Fc is 40.6 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 45-50 kDa by SDS-PAGE analysis under reducing conditions.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25 (+)CD4 (+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Activation-inducible TNFR family receptor; AITR; CD357; GITR; TNF receptor homolog; similar to murine glucocorticoid-induced TNFR-related protein; Glucocorticoid-induced TNFR-related protein; PRO364; TNF receptor superfamily activation-inducible protein; Tumor necrosis factor receptor superfamily member 18; UNQ319; variant (4) contains an extra coding segment, which leads to a frame shift, compared to variant 1 and 3; resulting protein (isoform 4) contains a transmembrane domain (identical to variant 1 and 3) and a longer cytoplasmic domain with a sequence different
Gene Aliases: AITR; CD357; ENERGEN; GITR; GITR-D; TNFRSF18; UNQ319/PRO364
UniProt ID: (Human) Q9Y5U5
Entrez Gene ID: (Human) 8784
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