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Human BTLA Fc Recombinant Protein, PeproTech®
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Product Details
310-43-250UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
CHO cells
Amino acid sequence
KESCDVQLYI KRQSEHSILA GDPFELECPV KYCANRPHVT WCKLNGTTCV KLEDRQTSWK EEKNISFFIL HFEPVLPNDN GSYRCSANFQ SNLIESHSTT LYVTDVKSAS ERPSKDEMAS GGPKSCDKTH TCPPCPAPEL LGGPSVFLFP PKPKDTLMIS RTPEVTCVVV DVSHEDPEVK FNWYVDGVEV HNAKTKPREE QYNSTYRVVS VLTVLHQDWL NGKEYKCKVS NKALPAPIEK TISKAKGQPR EPQVYTLPPS RDELTKNQVS LTCLVKGFYP SDIAVEWESN GQPENNYKTT PPVLDSDGSF FLYSKLTVDK SRWQQGNVFS CSVMHEALHN HYTQKSLSLS PGK
Tag
Fc-tag
Molecular weight
39.8 kDa
Class
Recombinant
Type
Protein
Purity
≥ 95% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by its ability to bind recombinant Murine HVEM Fc in a functional ELISA.
Conjugate
Form
Lyophilized
Amount
250 µg
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
PeproTech's CHO cell-derived Recombinant Human BTLA Fc is a glycosylated, disulfide-linked homodimer of 353-amino-acid-residues whose monomer consists of a 120-amino-acid portion of the extracellular domain fused to the 231-amino-acid length Fc portion of human IgG by two glycine residues. The calculated molecular weight of monomeric CHO cell-derived Recombinant Human BTLA Fc is 39.8 kDa; however, due to glycosylation, it migrates at an apparent molecular weight of approximately 50-55 kDa by SDS-PAGE analysis under reducing conditions.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
BTLA or B and T-lymphocyte attenuator is a member of the co-inhibitory receptors of the CD28 superfamily. BTLA is a lymphocyte inhibitory receptor which inhibits lymphocytes during immunes responses. BTLA is constitutively expressed on most CD4+ and CD8+ T cells and its expression progressively decreases upon T cell activation. It remains expressed on Th1 cells, but not Th2 cells. BTLA is a unique co-receptor that interacts with the tumor necrosis factor receptor superfamily member herpesvirus entry mediator (HVEM). This interation is an important pathway regulating lymphocyte activation and/or homeostasis in the immune response.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: B and T lymphocyte associated; B and T lymphocyte associated protein; B- and T-lymphocyte attenuator; B- and T-lymphocyte-associated protein; BTLA; BTLA_HUMAN; CD272; CD272 antigen; FLJ16065; MGC129743; unnamed protein product
Gene Aliases: BTLA; BTLA1; CD272
UniProt ID: (Human) Q7Z6A9
Entrez Gene ID: (Human) 151888
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