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Gibco
Human ApoE4 Recombinant Protein, PeproTech®
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Product Details
350-04-100UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Human,
Mouse,
Rat
Expression System
E. coli
Amino acid sequence
MKVEQAVETE PEPELRQQTE WQSGQRWELA LGRFWDYLRW VQTLSEQVQE ELLSSQVTQE LRALMDETMK ELKAYKSELE EQLTPVAEET RARLSKELQA AQARLGADME DVRGRLVQYR GEVQAMLGQS TEELRVRLAS HLRKLRKRLL RDADDLQKRL AVYQAGAREG AERGLSAIRE RLGPLVEQGR VRAATVGSLA GQPLQERAQA WGERLRARME EMGSRTRDRL DEVKEQVAEV RAKLEEQAQQ IRLQAEAFQA RLKSWFEPLV EDMQRQWAGL VEKVQAAVGT SAAPVPSDNH
Molecular weight
34.4 kDa
Class
Recombinant
Type
Protein
Purity
≥ 90% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Conjugate
Form
Lyophilized
Amount
100 µg
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
350-04-1MG will be provided as 2 x 500 µg (350-04-500UG).
Recombinant Human ApoE4 is a 34.4 kDa protein containing 300 amino acid residues.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
ApoE belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solubilization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in the liver and brain, and to some extent in almost every organ. ApoE is an important constituent of all plasma lipoproteins. Its interaction with specific ApoE receptor enables uptake of chylomicron remnants by liver cells, which is an essential step during normal lipid metabolism. It also binds with the LDL receptor (apo B/E). Defects in ApoE are a cause of hyperlipoproteinemia type III. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. Individuals heterozygous for the ApoE4 allele are at higher risk of late-onset Alzheimer's disease.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: APO-E; Apolipoprotein E; Apolipoprotein E3; unnamed protein product
Gene Aliases: AD2; APO-E; APOE; ApoE4; LDLCQ5; LPG
UniProt ID: (Human) P02649
Entrez Gene ID: (Human) 348
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