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TEM-1 beta-lactamase is the most widespread enzyme to confer beta-lactam antibiotic resistance to gram-negative bacteria. It is a monomeric protein that requires no metals or cofactors for activity. TEM-1 beta-lactamase efficiently hydrolyzes most penicillin and cephalosporin substrates, including nitrocefin and fluorescent derivates. This protein is intended to be used as a positive control for enzyme-dependent substrate hydrolysis and for use on immunoblots. Other uses include kinetic studies with novel substrates or identification of inhibitors of beta-lactamase as part of an antimicrobial program.
1165 micromoles of penicillin G hydrolyzed per minute per milligram of total
protein.
CD248 (CD248 Molecule) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include calcium ion binding and extracellular matrix binding. An important paralog of this gene is CD93. CD248 may play a role in tumor angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 2610111G01Rik; CD164 sialomucin-like 1; CD248; CD248 antigen, endosialin; CD248 molecule, endosialin; Endosialin; MGC119478; MGC119479; Tumor endothelial marker 1
Gene Aliases: CD164L1; CD248; TEM1
UniProt ID: (Human) Q9HCU0
Entrez Gene ID: (Human) 57124
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