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Invitrogen
HDAC4 Synthetic Peptide
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Product Details
PEP-095
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Lyophilized
Concentration
4.8 mg/mL
Amount
50 µg
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
This peptide corresponds to amino acids M(1)SSQSHPDGLSGRDQPVE(18) of human HDAC4 and can be used as a blocking peptide with polyclonal antibody PA1-863.
Target Information
Histone deacetylase 4 (HDAC4) is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC4 is also involved in muscle maturation via its interaction with the myocyte enhancer factors such as MEF2A, MEF2C and MEF2D. It is also involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer. Mutations to the HDAC4 gene have been found in Brachydactyly-mental retardation syndrome (BDMR).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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