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This peptide corresponds to 15 amino acids near the amino terminus of human CCDC98.
PEP-0529 can be used as a blocking peptide with polyclonal antibody PA5-20412.
CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
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Protein Aliases: abraxas protein; BRCA1-A complex subunit Abraxas 1; coiled-coil domain containing 98; Coiled-coil domain-containing protein 98; family with sequence similarity 175, member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A
Gene Aliases: ABRA1; ABRAXAS1; CCDC98; FAM175A; UNQ496/PRO1013
UniProt ID: (Human) Q6UWZ7
Entrez Gene ID: (Human) 84142
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