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Invitrogen
Human ABRA1 Synthetic Peptide
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Product Details
PEP-0529
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 15 amino acids near the amino terminus of human CCDC98.
PEP-0529 can be used as a blocking peptide with polyclonal antibody PA5-20412.
Target Information
CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: abraxas protein; BRCA1 associated A-complex protein; BRCA1-A complex subunit Abraxas 1; coiled-coil domain containing 98; Coiled-coil domain-containing protein 98; family with sequence similarity 175 member A; FLJ11520; FLJ12642; FLJ13614; Protein FAM175A; unnamed protein product
Gene Aliases: ABRA1; ABRAXAS1; CCDC98; FAM175A; UNQ496/PRO1013
UniProt ID: (Human) Q6UWZ7
Entrez Gene ID: (Human) 84142
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