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Invitrogen
Human ACE2 (aa18-740) Fc Chimera Recombinant Protein
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Product Details
RP-87702
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human ACE2, amino acids Gln18-Ser740 with a C-terminal Fc-tag
Tag
Fc-tag
Molecular weight
110 kDa
Class
Recombinant
Type
Protein
Purity
>95% by SDS-PAGE
Endotoxin concentration
<0.1 EU/µg
Activity
Measured by its binding ability in a functional ELISA. Immobilized SARS-CoV-2 Spike RBD at 1 µg/mL (100 µL/well) can bind Human ACE2 with a linear range of 0.01-2.4 ng/mL.
Conjugate
Form
Lyophilized
Concentration
0.1-0.5 mg/mL
Amount
100 µg
Purification
purified
Storage buffer
PBS, pH 7.4
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Wet ice
Product Specific Information
Animal Origin Free
Storage and Reconstitution: Store the lyophilized protein at -20°C to -80°C for long term. Reconstitute to a concentration of 0.1-0.5 mg/mL in sterile distilled water. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week.
Target Information
Angiotensin-converting enzyme 2 (ACE2) plays a central role in vascular, renal, and myocardial physiology. In contrast to its homolog ACE, ACE2 expression is restricted to heart, kidney, and testis. Recently. ACE2 has also been shown to be a functional receptor of the SARS coronavirus. The normal function of ACE2 is to convert the inactive vasoconstrictor angiotensin I (AngI) to Ang1-9 and the active form AngII to Ang1-7, unlike ACE, which converts AngI to AngII. While the role of these vasoactive peptides is not well understood, lack of ACE2 expression in ace2-/ace2- mice leads to severely reduced cardiac contractility, indicating its importance in regulating heart function.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: ACE 2; ACE-related carboxypeptidase; ACE2; ACEH; angiotensin I converting enzyme (peptidyl-dipeptidase A) 2; angiotensin I converting enzyme 2; Angiotensin-converting enzyme 2; Angiotensin-converting enzyme homolog; Angiotensin-converting enzyme-related carboxypeptidase; Metalloprotease MPROT15; peptidyl-dipeptidase A; sACE2; N-terminally-truncated natural isoform; unnamed protein product; zinc metalloprotease
Gene Aliases: ACE2; ACEH; UNQ868/PRO1885
UniProt ID: (Human) Q9BYF1
Entrez Gene ID: (Human) 59272
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