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Product Details
PEP-0717
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 15 amino acids near the amino terminus of human ACVR1C
PEP-0717 can be used as a blocking peptide with polyclonal antibody PA5-20597.
Target Information
ACVR1C, a serine/threonine protein kinase, is a type I receptor for the TGFB family of signaling molecules. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors. ACVR1C is a receptor for activin AB, activin B and NODAL. This protein plays a role in cell differentiation, growth arrest and apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: activin A receptor type IC; activin A receptor, type IC; Activin receptor type IC; Activin receptor type-1C; Activin receptor-like kinase 7; ACTR-IC; ACTRI; ACVR1A; ACVR1C; ACVRLK2; ALK-7; ALK2; FOP; TSRI
Gene Aliases: ACVR1C; ACVRLK7; ALK7
UniProt ID: (Human) Q8NER5
Entrez Gene ID: (Human) 130399
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