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Highest antigen sequence indentity to the following orthologs: Mouse (75%), Rat (75%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-67104. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
The ATP5MF gene encodes the ATP synthase membrane subunit F, which is a part of the mitochondrial ATP synthase complex (Complex V). This complex plays a crucial role in the process of oxidative phosphorylation, where ADP is converted to ATP, the primary energy currency of the cell. The ATP synthase complex consists of two main domains: the F1 catalytic core and the F0 proton channel. ATP5MF is a component of the F0 domain, helping to form the membrane channel that facilitates proton translocation across the mitochondrial membrane. This proton translocation is essential for driving the synthesis of ATP. Mutations or dysfunction in the ATP5MF gene can lead to mitochondrial disorders, which can have significant implications for cellular energy production and are associated with various metabolic and neurodegenerative diseases.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ATP synthase f chain, mitochondrial; ATP synthase F(0) complex subunit f, mitochondrial; ATP synthase membrane subunit f; ATP synthase, H+ transporting, mitochondrial F0 complex, subunit f; ATP synthase, H+ transporting, mitochondrial Fo complex subunit F2; ATP5J2; F1F0-type ATPase subunit f; F1Fo-ATP synthase complex Fo membrane domain f subunit; F1Fo-ATPase synthase f subunit
Gene Aliases: ATP5J2; ATP5JL; ATP5MF
UniProt ID: (Human) P56134
Entrez Gene ID: (Human) 9551
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