Product References
SAA suppresses α-PD-1 induced anti-tumor immunity by driving TH2 polarization in lung adenocarcinoma.
Cell death & disease
Wang X,Wen S,Du X,Zhang Y,Yang X,Zou R,Feng B,Fu X,Jiang F,Zhou G,Liu Z,Zhu W,Ma R,Feng J,Shen B
300-53 was used in In vitro experiments to indicate that cancer stem cells secreted SAA have significant biological impact to promote treatment resistant and tumor fibrosis by driving cancer stemness transformation and type 2 immunity polarization via P2X7 receptor.
Sat Nov 04 00:00:00 EDT 2023
Citrullinated fibrinogen-SAAs complex causes vascular metastagenesis.
Nature communications
Han Y,Tomita T,Kato M,Ashihara N,Higuchi Y,Matoba H,Wang W,Hayashi H,Itoh Y,Takahashi S,Kurita H,Nakayama J,Okumura N,Hiratsuka S
300-53 was used in In vitro experiments to demonstrate that post-translational citrullination of fibrinogen creates a metastatic niche in the vulnerable spots.
Thu Aug 24 00:00:00 EDT 2023
Subversion of Serotonin Receptor Signaling in Osteoblasts by Kynurenine Drives Acute Myeloid Leukemia.
Cancer discovery
Galán-Díez M,Borot F,Ali AM,Zhao J,Gil-Iturbe E,Shan X,Luo N,Liu Y,Huang XP,Bisikirska B,Labella R,Kurland I,Roth BL,Quick M,Mukherjee S,Rabadán R,Carroll M,Raza A,Kousteni S
300-53 was used in In vivo experiments to investigate the mechanisms involved in acute myeloid leukemia using patient-derived xenografts, and patient samples.
Fri Apr 01 00:00:00 EDT 2022
Effects of serum amyloid protein A on influenza A virus replication and viral interactions with neutrophils.
Journal of leukocyte biology
White MR,Hsieh IN,De Luna X,Hartshorn KL
Thu Jul 01 00:00:00 EDT 2021
SAA1/TLR2 axis directs chemotactic migration of hepatic stellate cells responding to injury.
iScience
Getachew A,Abbas N,You K,Yang Z,Hussain M,Huang X,Cheng Z,Tan S,Tao J,Yu X,Chen Y,Yang F,Pan T,Xu Y,Xu G,Zhuang Y,Wu F,Li Y
Fri May 21 00:00:00 EDT 2021
Enterocytes, fibroblasts and myeloid cells synergize in anti-bacterial and anti-viral pathways with IL22 as the central cytokine.
Communications biology
Klooster JPT,Bol-Schoenmakers M,van Summeren K,van Vliet ALW,de Haan CAM,van Kuppeveld FJM,Verkoeijen S,Pieters R
300-53 was used in In vitro experiments to indicate that IL22 contributes to the innate responses against both bacteria and viruses.
Thu May 27 00:00:00 EDT 2021
Dysfunctional high-density lipoprotein activates toll-like receptors via serum amyloid A in vascular smooth muscle cells.
Scientific reports
Schuchardt M,Prüfer N,Tu Y,Herrmann J,Hu XP,Chebli S,Dahlke K,Zidek W,van der Giet M,Tölle M
Mon Mar 04 00:00:00 EST 2019
COOH-terminal SAA1 peptides fail to induce chemokines but synergize with CXCL8 and CCL3 to recruit leukocytes via FPR2.
Blood
De Buck M,Gouwy M,Berghmans N,Opdenakker G,Proost P,Struyf S,Van Damme J
Thu Jan 25 00:00:00 EST 2018
Bacterial Lipoproteins Constitute the TLR2-Stimulating Activity of Serum Amyloid A.
Journal of immunology (Baltimore, Md. : 1950)
Burgess EJ,Hoyt LR,Randall MJ,Mank MM,Bivona JJ,Eisenhauer PL,Botten JW,Ballif BA,Lam YW,Wargo MJ,Boyson JE,Ather JL,Poynter ME
Mon Oct 15 00:00:00 EDT 2018
Mechanisms of selective delivery of xanthophylls to retinal pigment epithelial cells by human lipoproteins.
Journal of lipid research
Thomas SE,Harrison EH
Sat Oct 01 00:00:00 EDT 2016
Serum amyloid A chemoattracts immature dendritic cells and indirectly provokes monocyte chemotaxis by induction of cooperating CC and CXC chemokines.
European journal of immunology
Gouwy M,De Buck M,Pörtner N,Opdenakker G,Proost P,Struyf S,Van Damme J
300-53 was used in In vitro experiments to demonstrate that the serum amyloid A (SAA)-α isoform also chemoattracts monocyte-derived immature dendritic cells (DCs) in the Boyden and µ-slide chemotaxis assay and that its chemotactic activity for monocytes and DCs was indirectly mediated via rapid chemokine induction.
Thu Jan 01 00:00:00 EST 2015
Inflammatory remodeling of the HDL proteome impairs cholesterol efflux capacity.
Journal of lipid research
Vaisar T,Tang C,Babenko I,Hutchins P,Wimberger J,Suffredini AF,Heinecke JW
Sat Aug 01 00:00:00 EDT 2015
Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils.
Journal of leukocyte biology
De Buck M,Berghmans N,Pörtner N,Vanbrabant L,Cockx M,Struyf S,Opdenakker G,Proost P,Van Damme J,Gouwy M
Tue Dec 01 00:00:00 EST 2015
Serum amyloid A1α induces paracrine IL-8/CXCL8 via TLR2 and directly synergizes with this chemokine via CXCR2 and formyl peptide receptor 2 to recruit neutrophils.
Journal of leukocyte biology
De Buck M,Berghmans N,Pörtner N,Vanbrabant L,Cockx M,Struyf S,Opdenakker G,Proost P,Van Damme J,Gouwy M
Tue Dec 01 00:00:00 EST 2015
Serum amyloid A and inflammation in diabetic kidney disease and podocytes.
Laboratory investigation; a journal of technical methods and pathology
Anderberg RJ,Meek RL,Hudkins KL,Cooney SK,Alpers CE,Leboeuf RC,Tuttle KR
Sun Mar 01 00:00:00 EST 2015
Ex vivo and in vitro effect of serum amyloid a in the induction of macrophage M2 markers and efferocytosis of apoptotic neutrophils.
Journal of immunology (Baltimore, Md. : 1950)
Sun L,Zhou H,Zhu Z,Yan Q,Wang L,Liang Q,Ye RD
300-53 was used in In vivo experiments to suggest a potential role for SAA to alter macrophage phenotype and modulate macrophage functions through an MyD88-dependent mechanism that involves IRF4-mediated transcription.
Fri May 15 00:00:00 EDT 2015
Extracellular acidosis is a novel danger signal alerting innate immunity via the NLRP3 inflammasome.
The Journal of biological chemistry
Rajamäki K,Nordström T,Nurmi K,Åkerman KE,Kovanen PT,Öörni K,Eklund KK
Fri May 10 00:00:00 EDT 2013
Endogenous Acute Phase Serum Amyloid A Lacks Pro-Inflammatory Activity, Contrasting the Two Recombinant Variants That Activate Human Neutrophils through Different Receptors.
Frontiers in immunology
Christenson K,Björkman L,Ahlin S,Olsson M,Sjöholm K,Karlsson A,Bylund J
300-53 was used in In vitro experiments to study whether endogenous acute phase serum amyloid A (SAA) mediates pro-inflammatory effects.
Tue Apr 30 00:00:00 EDT 2013