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Invitrogen
Human Bub1 Synthetic Peptide
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Product Details
PEP-0498
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 19 amino acids near the amino terminus of human Bub1.
PEP-0498 can be used as a blocking peptide with polyclonal antibody PA5-20381.
Target Information
The BUB1 gene encodes a serine/threonine-protein kinase that is integral to the spindle assembly checkpoint, a crucial mechanism ensuring proper chromosome alignment and segregation during mitosis. BUB1 is involved in detecting and correcting errors in kinetochore-microtubule attachments, which is vital for maintaining genomic stability. It acts by delaying the onset of anaphase until all chromosomes are correctly attached to the spindle apparatus. BUB1 is recruited to kinetochores in early mitosis, where it phosphorylates several substrates to activate other checkpoint proteins, such as BUBR1 and MAD2, thereby preventing premature progression through mitosis. Mutations or aberrations in the expression levels of BUB1 are often associated with aneuploidy and chromosomal instability, contributing to cancer progression. BUB1 is thus considered a potential target for cancer therapeutics, aiming to exploit its role in the mitotic checkpoint to selectively eliminate tumor cells through checkpoint bypass or mitotic arrest.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: BUB1 budding uninhibited by benzimidazoles 1 homolog; BUB1A; budding uninhibited by benzimidazoles 1 homolog; hBUB1; huBUB1; HuBub1; putative serine/threonine-protein kinase; Mitotic checkpoint serine/threonine-protein kinase BUB1; mitotic spindle checkpoint kinase; protein kinase; putative serine/threonine-protein kinase; unnamed protein product
Gene Aliases: BUB1; BUB1A; BUB1L; hBUB1; MCPH30
UniProt ID: (Human) O43683
Entrez Gene ID: (Human) 699
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