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Invitrogen
Human C8orf48 Control Fragment Recombinant Protein
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Product Details
RP-93868
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
DFLTRIGEAHQDFPRLSDDPRIIWKRLTEKSHIRYSGFERSETEQKMQRDGNSACHLPFSLPFLKRLTLIKPELVIVNDNV
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (41%), Rat (41%).
This recombinant protein control fragment may be used for blocking experiments with the corresponding antibody, PA5-55618. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
The C8orf48 gene has been identified as a critical biomarker in colorectal cancer (CRC). Research indicates that C8orf48 plays a significant role in inhibiting tumorigenesis by regulating key signaling pathways. This gene is negatively associated with KRAS, BRAF, and MAP2K2 in normal colorectal tissues and negatively correlated with MAP2K2 in CRC tissues. These associations suggest that C8orf48 may function as a tumor suppressor by modulating pathways involved in cell proliferation, migration, and invasion. The gene's expression and methylation profiles have been extensively studied using data from The Cancer Genome Atlas (TCGA), and functional assays have confirmed its inhibitory effects on CRC cell growth. Additionally, C8orf48 has been identified as a direct target of miR-556, further elucidating its regulatory mechanisms. The findings underscore the potential of C8orf48 as a novel target for CRC prediction and therapy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Uncharacterized protein C8orf48
Gene Aliases: C8orf48
UniProt ID: (Human) Q96LL4
Entrez Gene ID: (Human) 157773
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