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Invitrogen
Human CD27 Ligand (TNFSF7, CD70) Fc Chimera Recombinant Protein
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Product Details
A42566
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human CD70, amino acids Gln39-Pro193 (Accession # NP_001243.1) with an N-terminal Fc-tag
Tag
Fc-tag
Molecular weight
45.5 kDa
Class
Recombinant
Type
Protein
Purity
>90% by SDS-PAGE
Endotoxin concentration
<1.0 EU/µg
Activity
Measured by its binding ability in a functional ELISA. Immobilized Human CD27 His at 2 µg/mL (100 µL/well) can bind Human CD27 Ligand (TNFSF7, CD70) Fc Chimera Recombinant Protein, the EC50 of Human CD70 hFc is 15-60 ng/mL.
Conjugate
Form
Lyophilized
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C or -80°C if preferred
Shipping conditions
Ambient
Product Specific Information
Reconstitution: Dissolve the protein in sterile double distilled water to a concentration of 0.2 mg/mL or lower. It is recommended that the protein be aliquoted and be used as soon as possible. Store aliquots under sterile conditions at -20°C. Avoid repeated freeze-thaw cycles.
Target Information
The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin synthesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD27 ligand; CD27-L; CD70; CD70 antigen; Ki-24 antigen; surface antigen CD70; tumor necrosis factor ligand 8A; Tumor necrosis factor ligand superfamily member 7; type II transmembrane protein; unnamed protein product
Gene Aliases: CD27-L; CD27L; CD27LG; CD70; LPFS3; TNFSF7; TNLG8A
UniProt ID: (Human) P32970
Entrez Gene ID: (Human) 970
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