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Invitrogen
Human CDK2/cyclin O, GST Tag Recombinant Protein
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Product Details
PV6287
Product Specifications
Species
Human
Expression System
Baculovirus
Amino acid sequence
1-264
Tag
GST-tag
Molecular weight
60.2-64.4 kDa
Class
Recombinant
Type
Protein
Conjugate
Form
Liquid
Concentration
See Label
Purification
purified
Storage buffer
50mM tris HCl, pH 7.5, with 25% glycerol, 150mM NaCl, 0.1mM PMSF, 0.1mM EDTA, 0.25mM DTT, 10mM glutathione
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Recombinant full-length human CDK2/Cyclin O was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag.
• Validated in LanthaScreen™ Kinase Binding Assay
• Protocols available for simple use and optimized performance
• Multiple pack sizes available for convenient use
Related Product:
LanthaScreen™ Eu Kinase Binding Assay
Protein Form: Recombinant
The gene accession number for the subunits (CDK2/Cyclin O) are NP_001789.2 and NP_066970.3.
Target Information
CDK2, or Cyclin-Dependent Kinase 2, is a key member of the cyclin-dependent kinase family, which is essential for regulating cell cycle progression. CDK2 is particularly important for the transition from the G1 phase to the S phase and for the progression through the S phase of the cell cycle.
Cyclin O is a regulatory subunit that binds to CDK2, activating its kinase activity. The binding of Cyclin O to CDK2 is necessary for the proper functioning of CDK2, as cyclins regulate the activation and specificity of CDKs.
Together, the CDK2/Cyclin O complex is involved in regulating the cell cycle, although its specific roles and target substrates are less well-characterized compared to other CDK2/cyclin complexes. The CDK2/Cyclin O complex is thought to contribute to various cellular processes, including DNA replication and repair mechanisms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: cdc2-related protein kinase; Cell division protein kinase 2; cyclin domain containing; cyclin U; Cyclin-dependent kinase 2; Cyclin-O; p33 protein kinase
Gene Aliases: CCNO; CCNU; CDK2; CDKN2; CILD29; p33(CDK2); UDG2
UniProt ID: (Human) P22674, (Human) P24941
Entrez Gene ID: (Human) 10309, (Human) 1017
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