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Invitrogen
Human CELSR3 (aa 3191-3267) Control Fragment Recombinant Protein
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Product Details
RP-103474
Product Specifications
Species
Human
Expression System
E. coli
Amino acid sequence
LDSLSRSSNSREQLDQVPSRHPSREALGPLPQLLRAREDSVSGPSHGPSTEQLDILSSILASFNSSALSSVQSSSTP
Tag
His-ABP-tag
Class
Recombinant
Type
Protein
Purity
>80% by SDS-PAGE and Coomassie blue staining
Conjugate
Form
Liquid
Concentration
≥5.0 mg/mL
Purification
purified
Storage buffer
PBS/1M urea, pH 7.4
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
Highest antigen sequence indentity to the following orthologs: Mouse (94%), Rat (94%).
This recombinant protein control fragment may be used for blocking experiments. In IHC/ICC and WB experiments, we recommend a 100x molar excess of the protein fragment control based on the concentration and the molecular weight. Pre-incubate the antibody-protein control fragment mixture for 30 min at room temperature.
Target Information
CELSR3 is a member of the flamingo subfamily, part of the cadherin superfamily. The flamingo subfamily consists of nonclassic-type cadherins; a subpopulation that does not interact with catenins. The flamingo cadherins are located at the plasma membrane and have nine cadherin domains, seven epidermal growth factor-like repeats and two laminin A G-type repeats in their ectodomain. They also have seven transmembrane domains, a characteristic unique to this subfamily. It is postulated that these proteins are receptors involved in contact-mediated communication, with cadherin domains acting as homophilic binding regions and the EGF-like domains involved in cell adhesion and receptor-ligand interactions. The specific function of this particular member has not been determined.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: adhesion G protein-coupled receptor C3; anchor protein; Cadherin EGF LAG seven-pass G-type receptor 3; Cadherin family member 11; cadherin, EGF LAG seven-pass G-type receptor 3 (flamingo homolog, Drosophila); EGF-like protein 1; EGF-like-domain, multiple 1; Epidermal growth factor-like protein 1; Flamingo homolog 1; hFmi1; Megf3; Multiple EGF-like domains protein 2; Multiple epidermal growth factor-like domains protein 2
Gene Aliases: ADGRC3; CDHF11; CELSR3; EGFL1; FMI1; HFMI1; KIAA0812; MEGF2; RESDA1
UniProt ID: (Human) Q9NYQ7
Entrez Gene ID: (Human) 1951
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