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Product Details
PEP-1453
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Dry ice
Product Specific Information
This peptide corresponds to 15 amino acid peptide near the carboxy terminus of human CRIM2.
PEP-1453 can be used as a blocking peptide with polyclonal antibody PA5-34411.
Target Information
CRIM2, also known as Kielin/chordin-like protein (KCP), is a novel enhancer of BMP signaling. It binds to BMP7, a morphogen that is important for kidney development and part of the kidney's physiological response to repair of acute kidney injury, enhancing its binding to its receptor. Because of this, CRIM2 has been suggested as a potential antifibrotic therapy in acute and chronic kidney injury. CRIM2 can also interact directly with either activin or TGF-Beta1, suppressing activin- and TGF-Beta1-dependent transcription.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CRIM-2; cysteine rich BMP regulator 2 (chordin-like); Cysteine-rich BMP regulator 2; Cysteine-rich motor neuron 2 protein; KCP-1; kielin; Kielin/chordin-like protein; Kielin/chordin-like protein 1
Gene Aliases: CRIM2; KCP; KCP1; NET67
UniProt ID: (Human) Q6ZWJ8
Entrez Gene ID: (Human) 375616
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