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Invitrogen
Human CtIP Synthetic Peptide
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Product Details
PEP-1077
Product Specifications
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
50 µg
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 15 amino acids near the center of human RBBP8.
PEP-1077 can be used as a blocking peptide with polyclonal antibody PA5-20963.
Target Information
CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription. Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor. This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation. Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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