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Invitrogen
Human DR3 Synthetic Peptide
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Product Details
PEP-0015
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Amount
50 µg
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 16 amino amino terminus of human DR3.
PEP-0015 can be used as a blocking peptide with polyclonal antibody PA5-19886.
Target Information
DR3/TNFRSF25 is a member of the TNF-receptor superfamily. This receptor is expressed preferentially in the tissues enriched in lymphocytes, and it may play a role in regulating lymphocyte homeostasis. This receptor has been shown to stimulate NF-kappa B activity and regulate cell apoptosis. The signal transduction of this receptor is mediated by various death domain containing adaptor proteins. Knockout studies in mice suggested the role of DR3/TNFRSF25 in the removal of self-reactive T cells in the thymus. Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported, most of which are potentially secreted molecules. The alternative splicing of this gene in B and T cells encounters a programmed change upon T-cell activation, which predominantly produces full-length, membrane bound isoforms, and is thought to be involved in controlling lymphocyte proliferation induced by T-cell activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: Apo-3; apoptosis inducing receptor; Apoptosis-inducing receptor AIR; Apoptosis-mediating receptor DR3; Apoptosis-mediating receptor TRAMP; death domain receptor 3 soluble form; Death receptor 3; death receptor beta; DR3 beta; Guanine nucleotide exchange factor 720; LARD; LARD-11; NGFR family member; LARD-1a; membrane protein; LARD-1b; membrane protein; LARD-2; LARD-3; LARD-4; LARD-5; LARD-8; NGFR family member; LARD-9; NGFR family member; Lymphocyte-associated receptor of death; PH domain-containing family G member 5; Pleckstrin homology domain-containing family G member 5; Protein WSL; Protein WSL-1; RP4-650H14.2; sDR3 beta; Tumor necrosis factor receptor superfamily member 25; tumor necrosis factor receptor superfamily, member 12 (translocating chain-association membrane protein); unnamed protein product
Gene Aliases: APO-3; APO3; DDR3; DR3; GEF720; LARD; PLEKHG5; TNFRSF12; TNFRSF25; TR3; TRAMP; UNQ455/PRO779; WSL; WSL-1; WSL-LR; WSL1
UniProt ID: (Human) Q93038
Entrez Gene ID: (Human) 8718
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