Product References
Lineage-tracing hematopoietic stem cell origins in vivo to efficiently make human HLF+ HOXA+ hematopoietic progenitors from pluripotent stem cells.
Developmental cell
Fowler JL,Zheng SL,Nguyen A,Chen A,Xiong X,Chai T,Chen JY,Karigane D,Banuelos AM,Niizuma K,Kayamori K,Nishimura T,Cromer MK,Gonzalez-Perez D,Mason C,Liu DD,Yilmaz L,Miquerol L,Porteus MH,Luca VC,Majeti R,Nakauchi H,Red-Horse K,Weissman IL,Ang LT,Loh KM
300-23 was used in In vitro experiments to non-invasive genetic lineage tracing in mouse embryos pinpoints that artery endothelial cells generate hematopoietic stem cells.
Mon May 06 00:00:00 UTC 2024
Venetoclax triggers sublethal apoptotic signaling in venetoclax-resistant acute myeloid leukemia cells and induces vulnerability to PARP inhibition and azacitidine.
Cell death & disease
Tambe M,Unterberger S,Kriegbaum MC,Vänttinen I,Olgac EJ,Vähä-Koskela M,Kontro M,Wennerberg K,Heckman CA
300-23 was used in Cell Culture to identify a new vulnerability in acquired venetoclax-resistant AML cells and identify PARP inhibition as a potential therapeutic approach to overcome acquired venetoclax resistance in AML.
Wed Oct 16 00:00:00 UTC 2024
LucFlow: A method to measure Luciferase reporter expression in single cells.
PloS one
Nooti S,Naylor M,Long T,Groll B
300-23 was used in Cell Culture to develop a Luciferase Reporter Assay using Flow-Cytometry (LucFlow), which measures reporter expression in single cells immunostained for Luciferase.
Wed Nov 01 00:00:00 UTC 2023
Analyzing mitochondrial respiration of human induced pluripotent stem cell-derived myeloid progenitors using Seahorse technology.
STAR protocols
Fan Y,Mizoguchi Y,Tatematsu M,Linder MI,Frenz S,Choi J,Klein C
300-23 was used in Cell Culture to describe a protocol to analyze and to quantify key parameters of mitochondrial respiration of iPSC-derived myeloid progenitors by the Seahorse XFe96 Analyzer.
Fri Mar 17 00:00:00 UTC 2023
C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.
iScience
Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y
300-23 was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.
Fri Oct 20 00:00:00 UTC 2023
Targeting a Tumor-Specific Epitope on Podocalyxin Increases Survival in Human Tumor Preclinical Models.
Frontiers in oncology
Canals Hernaez D,Hughes MR,Li Y,Mainero Rocca I,Dean P,Brassard J,Bell EM,Samudio I,Mes-Masson AM,Narimatsu Y,Clausen H,Blixt O,Roskelley CD,McNagny KM
300-23 was used in Sample Preparation (FC/FACS) to use an array of glycosylation defective cell lines to define the PODO447 reactive epitope and reveal it as an O-linked core 1 glycan presented in the context of the Podxl peptide backbone.
Sat Jul 16 00:00:00 UTC 2022
A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.
RNA (New York, N.Y.)
Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF
300-23 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.
Thu Sep 01 00:00:00 UTC 2022
Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy.
Cell reports
Chang Y,Syahirah R,Wang X,Jin G,Torregrosa-Allen S,Elzey BD,Hummel SN,Wang T,Li C,Lian X,Deng Q,Broxmeyer HE,Bao X
300-23 was used in Cell Culture to establish a robust platform for massive production of CAR neutrophils, paving the way to myeloid cell-based therapeutic strategies that would boost current cancer-treatment approaches.
Tue Jul 19 00:00:00 UTC 2022
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.
JCI insight
Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA
300-23 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.
Wed Jun 08 00:00:00 UTC 2022
CXCL4-RNA Complexes Circulate in Systemic Sclerosis and Amplify Inflammatory/Pro-Fibrotic Responses by Myeloid Dendritic Cells.
International journal of molecular sciences
Pietraforte I,Butera A,Gaddini L,Mennella A,Palazzo R,Campanile D,Stefanantoni K,Riccieri V,Lande R,Frasca L
300-23 was used in Cell Culture to support a role for CXCL4-RNA complexes, besides CXCL4-DNA complexes, in immune amplification via the modulation of myeloid DC effector functions in SSc and also during normal immune responses.
Fri Dec 30 00:00:00 UTC 2022
SHMT2 promotes tumor growth through VEGF and MAPK signaling pathway in breast cancer.
American journal of cancer research
Xie SY,Shi DB,Ouyang Y,Lin F,Chen XY,Jiang TC,Xia W,Guo L,Lin HX
300-23 was used in In vitro experiments to indicate that SHMT2 plays a critical role in regulating breast cancer growth through MAPK, and VEGF signaling pathways.
Tue Aug 16 00:00:00 UTC 2022
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation.
Cancer cell
Cheng Y,Xie W,Pickering BF,Chu KL,Savino AM,Yang X,Luo H,Nguyen DT,Mo S,Barin E,Velleca A,Rohwetter TM,Patel DJ,Jaffrey SR,Kharas MG
300-23 was used in In vitro experiments to investigate How N6-Methyladenosine dictates its diverse molecular and cellular effects in leukemias.
Mon Jul 12 00:00:00 UTC 2021
Dissecting ELANE neutropenia pathogenicity by human HSC gene editing.
Cell stem cell
Rao S,Yao Y,Soares de Brito J,Yao Q,Shen AH,Watkinson RE,Kennedy AL,Coyne S,Ren C,Zeng J,Serbin AV,Studer S,Ballotti K,Harris CE,Luk K,Stevens CS,Armant M,Pinello L,Wolfe SA,Chiarle R,Shimamura A,Lee B,Newburger PE,Bauer DE
Thu May 06 00:00:00 UTC 2021
ATF3 coordinates serine and nucleotide metabolism to drive cell cycle progression in acute myeloid leukemia.
Molecular cell
Di Marcantonio D,Martinez E,Kanefsky JS,Huhn JM,Gabbasov R,Gupta A,Krais JJ,Peri S,Tan Y,Skorski T,Dorrance A,Garzon R,Goldman AR,Tang HY,Johnson N,Sykes SM
300-23 was used in In vitro experiments to investigate the role of ATF3 expression on cell cycle progression in acute myeloid leukemia.
Thu Jul 01 00:00:00 UTC 2021
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.
Science translational medicine
Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N
Wed Jun 16 00:00:00 UTC 2021
Enhanced cytarabine-induced killing in OGG1-deficient acute myeloid leukemia cells.
Proceedings of the National Academy of Sciences of the United States of America
Owen N,Minko IG,Moellmer SA,Cammann SK,Lloyd RS,McCullough AK
Tue Mar 16 00:00:00 UTC 2021
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι.
Proceedings of the National Academy of Sciences of the United States of America
Zhang Y,Chen Y,Li Y,Huang F,Luo B,Yuan Y,Xia B,Ma X,Yang T,Yu F,Liu J,Liu B,Song Z,Chen J,Yan S,Wu L,Pan T,Zhang X,Li R,Huang W,He X,Xiao F,Zhang J,Zhang H
Tue Jun 08 00:00:00 UTC 2021
Granulocyte colony-stimulating factor directly acts on mouse lymphoid-biased but not myeloid-biased hematopoietic stem cells.
Haematologica
Xie M,Zhang S,Dong F,Zhang Q,Wang J,Wang C,Zhu C,Zhang S,Luo B,Wu P,Ema H
300-23 was used in Cell Culture to investigate whether granulocyte colony-stimulating factor directly stimulates hematopoietic stem cells to change their cell cycle state and fate.
Tue Jun 01 00:00:00 UTC 2021
Engraftment characterization of risk-stratified AML in NSGS mice.
Blood advances
Díaz de la Guardia R,Velasco-Hernandez T,Gutiérrez-Agüera F,Roca-Ho H,Molina O,Nombela-Arrieta C,Bataller A,Fuster JL,Anguita E,Vives S,Zamora L,Nomdedeu J,Gómez-Casares MT,Ramírez-Orellana M,Lapillonne H,Ramos-Mejia V,Rodríguez-Manzaneque JC,Bueno C,Lopez-Millan B,Menéndez P
Tue Dec 14 00:00:00 UTC 2021
Dendritic cells loaded with exosomes derived from cancer stem cell-enriched spheroids as a potential immunotherapeutic option.
Journal of cellular and molecular medicine
Naseri M,Zöller M,Hadjati J,Ghods R,Ranaei Pirmardan E,Kiani J,Eini L,Bozorgmehr M,Madjd Z
Thu Apr 01 00:00:00 UTC 2021
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Transfusion
Cunningham S,Hackstein H
Tue Jun 01 00:00:00 UTC 2021
Enhancer recruitment of transcription repressors RUNX1 and TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid leukemia.
Cell reports
Simeoni F,Romero-Camarero I,Camera F,Amaral FMR,Sinclair OJ,Papachristou EK,Spencer GJ,Lie-A-Ling M,Lacaud G,Wiseman DH,Carroll JS,Somervaille TCP
Tue Sep 21 00:00:00 UTC 2021
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages.
Science advances
Trizzino M,Zucco A,Deliard S,Wang F,Barbieri E,Veglia F,Gabrilovich D,Gardini A
Fri Jan 01 00:00:00 UTC 2021
Implication of TIGIT+ human memory B cells in immune regulation.
Nature communications
Hasan MM,Nair SS,O'Leary JG,Thompson-Snipes L,Nyarige V,Wang J,Park W,Stegall M,Heilman R,Klintmalm GB,Joo H,Oh S
Tue Mar 09 00:00:00 UTC 2021
Altered Neuronal Support and Inflammatory Response in Bipolar Disorder Patient-Derived Astrocytes.
Stem cell reports
Vadodaria KC,Mendes APD,Mei A,Racha V,Erikson G,Shokhirev MN,Oefner R,Heard KJ,McCarthy MJ,Eyler L,Kelsoe JR,Santos R,Marchetto MC,Gage FH
Tue Apr 13 00:00:00 UTC 2021
TNF-α Regulated Endometrial Stroma Secretome Promotes Trophoblast Invasion.
Frontiers in immunology
You Y,Stelzl P,Joseph DN,Aldo PB,Maxwell AJ,Dekel N,Liao A,Whirledge S,Mor G
300-23 was used in In vitro experiments to provide a new insight into the complexity of the implantation process and reveal the importance of inflammation for embryo implantation.
Fri Dec 24 00:00:00 UTC 2021
Neutrophils require SKAP2 for reactive oxygen species production following C-type lectin and Candida stimulation.
iScience
Nguyen GT,Xu S,Adams W,Leong JM,Bunnell SC,Mansour MK,Sykes DB,Mecsas J
Fri Aug 20 00:00:00 UTC 2021
Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy.
Nature communications
Bent EH,Millán-Barea LR,Zhuang I,Goulet DR,Fröse J,Hemann MT
Thu Oct 28 00:00:00 UTC 2021
Ectopic humanized mesenchymal niche in mice enables robust engraftment of myelodysplastic stem cells.
Blood cancer discovery
Mian SA,Abarrategi A,Kong KL,Rouault-Pierre K,Wood H,Oedekoven CA,Smith AE,Batsivari A,Ariza-McNaughton L,Johnson P,Snoeks T,Mufti GJ,Bonnet D
300-23 was used in Cell Culture to show that human microenvironment but not mouse is essential to MDS-SCs homing and engraftment.
Mon Mar 01 00:00:00 UTC 2021
Iron control of erythroid microtubule cytoskeleton as a potential target in treatment of iron-restricted anemia.
Nature communications
Goldfarb AN,Freeman KC,Sahu RK,Elagib KE,Holy M,Arneja A,Polanowska-Grabowska R,Gru AA,White Z,Khalil S,Kerins MJ,Ooi A,Leitinger N,Luckey CJ,Delehanty LL
Fri Mar 12 00:00:00 UTC 2021
Immune suppressive activity of myeloid-derived suppressor cells in cancer requires inactivation of the type I interferon pathway.
Nature communications
Alicea-Torres K,Sanseviero E,Gui J,Chen J,Veglia F,Yu Q,Donthireddy L,Kossenkov A,Lin C,Fu S,Mulligan C,Nam B,Masters G,Denstman F,Bennett J,Hockstein N,Rynda-Apple A,Nefedova Y,Fuchs SY,Gabrilovich DI
Fri Mar 19 00:00:00 UTC 2021
Single-cell transcriptome of bronchoalveolar lavage fluid reveals sequential change of macrophages during SARS-CoV-2 infection in ferrets.
Nature communications
Lee JS,Koh JY,Yi K,Kim YI,Park SJ,Kim EH,Kim SM,Park SH,Ju YS,Choi YK,Park SH
Tue Jul 27 00:00:00 UTC 2021
The Expression of NTAL and Its Protein Interactors Is Associated With Clinical Outcomes in Acute Myeloid Leukemia.
Molecular & cellular proteomics : MCP
Thomé CH,Ferreira GA,Pereira-Martins DA,Augusto Dos Santos G,Almeida-Silveira DR,Weinhäuser I,Antônio de Souza G,Houtsma R,Schuringa JJ,Rego EM,Faça VM
Mon Mar 21 00:00:00 UTC 2022
The Use of Induced Pluripotent Stem Cells to Study the Effects of Adenosine Deaminase Deficiency on Human Neutrophil Development.
Frontiers in immunology
Tsui M,Min W,Ng S,Dobbs K,Notarangelo LD,Dror Y,Grunebaum E
300-23 was used in Cell Culture to study the characterization of neutrophil developmental abnormalities and the mechanisms contributing to them to demonstrate the important role of adenosine deaminase (ADA) in the development and function of neutrophils while clarifying the mechanisms responsible for the neutrophil abnormalities in ADA-deficient patients.
Mon Dec 27 00:00:00 UTC 2021
The Folate Cycle Enzyme MTHFR Is a Critical Regulator of Cell Response to MYC-Targeting Therapies.
Cancer discovery
Su A,Ling F,Vaganay C,Sodaro G,Benaksas C,Dal Bello R,Forget A,Pardieu B,Lin KH,Rutter JC,Bassil CF,Fortin G,Pasanisi J,Antony-Debré I,Alexe G,Benoist JF,Pruvost A,Pikman Y,Qi J,Schlageter MH,Micol JB,Roti G,Cluzeau T,Dombret H,Preudhomme C,Fenouille N,Benajiba L,Golan HM,Stegmaier K,Lobry C,Wood KC,Itzykson R,Puissant A
300-23 was used in Cell Culture to investigate the effects of MTHFR for its therapeutic effects on acute myeloid leukemia.
Tue Dec 01 00:00:00 UTC 2020
Glucocorticoids enhance the antileukemic activity of FLT3 inhibitors in FLT3-mutant acute myeloid leukemia.
Blood
Gebru MT,Atkinson JM,Young MM,Zhang L,Tang Z,Liu Z,Lu P,Dower CM,Chen L,Annageldiyev C,Sharma A,Imamura Kawasawa Y,Zhao Z,Miller BA,Claxton DF,Wang HG
Thu Aug 27 00:00:00 UTC 2020
Mesenchymal niche remodeling impairs hematopoiesis via stanniocalcin 1 in acute myeloid leukemia.
The Journal of clinical investigation
Waclawiczek A,Hamilton A,Rouault-Pierre K,Abarrategi A,Albornoz MG,Miraki-Moud F,Bah N,Gribben J,Fitzgibbon J,Taussig D,Bonnet D
Mon Jun 01 00:00:00 UTC 2020
A stress-responsive enhancer induces dynamic drug resistance in acute myeloid leukemia.
The Journal of clinical investigation
Williams MS,Amaral FM,Simeoni F,Somervaille TC
Mon Mar 02 00:00:00 UTC 2020
IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.
Proceedings of the National Academy of Sciences of the United States of America
Panda SK,Wigerblad G,Jiang L,Jiménez-Andrade Y,Iyer VS,Shen Y,Boddul SV,Guerreiro-Cacais AO,Raposo B,Kasza Z,Wermeling F
Tue Feb 11 00:00:00 UTC 2020
IL-4 controls activated neutrophil FcγR2b expression and migration into inflamed joints.
Proceedings of the National Academy of Sciences of the United States of America
Panda SK,Wigerblad G,Jiang L,Jiménez-Andrade Y,Iyer VS,Shen Y,Boddul SV,Guerreiro-Cacais AO,Raposo B,Kasza Z,Wermeling F
Tue Feb 11 00:00:00 UTC 2020
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.
Science signaling
Gómez V,Eykyn TR,Mustapha R,Flores-Borja F,Male V,Barber PR,Patsialou A,Green R,Panagaki F,Li CW,Fruhwirth GO,Ros S,Brindle KM,Ng T
Tue Oct 06 00:00:00 UTC 2020
Combination of a mitogen-activated protein kinase inhibitor with the tyrosine kinase inhibitor pacritinib combats cell adhesion-based residual disease and prevents re-expansion of FLT3-ITD acute myeloid leukaemia.
British journal of haematology
Zabkiewicz J,Lazenby M,Edwards G,Bygrave CA,Omidvar N,Zhuang L,Knapper S,Guy C,Hills RK,Burnett AK,Alvares CL
Thu Oct 01 00:00:00 UTC 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 UTC 2020
Functional annotation of genetic associations by transcriptome-wide association analysis provides insights into neutrophil development regulation.
Communications biology
Yao Y,Yang J,Qin Q,Tang C,Li Z,Chen L,Li K,Ren C,Chen L,Rao S
Fri Dec 18 00:00:00 UTC 2020
DPP8/9 inhibitors activate the CARD8 inflammasome in resting lymphocytes.
Cell death & disease
Johnson DC,Okondo MC,Orth EL,Rao SD,Huang HC,Ball DP,Bachovchin DA
Fri Aug 14 00:00:00 UTC 2020
Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution.
Cell reports
Jordan PM,Gerstmeier J,Pace S,Bilancia R,Rao Z,Börner F,Miek L,Gutiérrez-Gutiérrez Ó,Arakandy V,Rossi A,Ialenti A,González-Estévez C,Löffler B,Tuchscherr L,Serhan CN,Werz O
300-23 was used in Cell Culture to investigate the role of α-hemolysin from Staphylococcus aureus in the activation of specialized pro-resolving mediators.
Tue Oct 13 00:00:00 UTC 2020
The transcription factor C/EBPβ orchestrates dendritic cell maturation and functionality under homeostatic and malignant conditions.
Proceedings of the National Academy of Sciences of the United States of America
Scholz F,Grau M,Menzel L,Graband A,Zapukhlyak M,Leutz A,Janz M,Lenz G,Rehm A,Höpken UE
Tue Oct 20 00:00:00 UTC 2020
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway.
Scientific reports
Krotova K,Khodayari N,Oshins R,Aslanidi G,Brantly ML
Mon Sep 28 00:00:00 UTC 2020
Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.
Immunity
Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H
Tue Nov 19 00:00:00 UTC 2019
Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome.
Cancer cell
Labuhn M,Perkins K,Matzk S,Varghese L,Garnett C,Papaemmanuil E,Metzner M,Kennedy A,Amstislavskiy V,Risch T,Bhayadia R,Samulowski D,Hernandez DC,Stoilova B,Iotchkova V,Oppermann U,Scheer C,Yoshida K,Schwarzer A,Taub JW,Crispino JD,Weiss MJ,Hayashi Y,Taga T,Ito E,Ogawa S,Reinhardt D,Yaspo ML,Campbell PJ,Roberts I,Constantinescu SN,Vyas P,Heckl D,Klusmann JH
Mon Aug 12 00:00:00 UTC 2019
Reprogramming identifies functionally distinct stages of clonal evolution in myelodysplastic syndromes.
Blood
Hsu J,Reilly A,Hayes BJ,Clough CA,Konnick EQ,Torok-Storb B,Gulsuner S,Wu D,Becker PS,Keel SB,Abkowitz JL,Doulatov S
Thu Jul 11 00:00:00 UTC 2019
Distinct Molecular Trajectories Converge to Induce Naive Pluripotency.
Cell stem cell
Stuart HT,Stirparo GG,Lohoff T,Bates LE,Kinoshita M,Lim CY,Sousa EJ,Maskalenka K,Radzisheuskaya A,Malcolm AA,Alves MRP,Lloyd RL,Nestorowa S,Humphreys P,Mansfield W,Reik W,Bertone P,Nichols J,Göttgens B,Silva JCR
300-23 was used in Cell Culture to propose that fine-tuned regulation of this transition factor" underpins multidimensional access to naive pluripotency
Thu Sep 05 00:00:00 UTC 2019
Inhibition of mitochondrial translation overcomes venetoclax resistance in AML through activation of the integrated stress response.
Science translational medicine
Sharon D,Cathelin S,Mirali S,Di Trani JM,Yanofsky DJ,Keon KA,Rubinstein JL,Schimmer AD,Ketela T,Chan SM
300-23 was used in Cell Culture to investigate if inactivation of genes involved in mitochondrial translation restores sensitivity to venetoclax in resistant acute myeloid leukemia cells.
Wed Oct 30 00:00:00 UTC 2019
Downregulation of the histone methyltransferase SETD2 promotes imatinib resistance in chronic myeloid leukaemia cells.
Cell proliferation
Sheng Y,Ji Z,Zhao H,Wang J,Cheng C,Xu W,Wang X,He Y,Liu K,Li L,Voeltzel T,Maguer-Satta V,Gao WQ,Zhu HH
Mon Jul 01 00:00:00 UTC 2019
Mebendazole for Differentiation Therapy of Acute Myeloid Leukemia Identified by a Lineage Maturation Index.
Scientific reports
Li Y,Thomas D,Deutzmann A,Majeti R,Felsher DW,Dill DL
Thu Nov 14 00:00:00 UTC 2019
All-trans retinoic acid enhances, and a pan-RAR antagonist counteracts, the stem cell promoting activity of EVI1 in acute myeloid leukemia.
Cell death & disease
Nguyen CH,Bauer K,Hackl H,Schlerka A,Koller E,Hladik A,Stoiber D,Zuber J,Staber PB,Hoelbl-Kovacic A,Purton LE,Grebien F,Wieser R
Tue Dec 10 00:00:00 UTC 2019
DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia.
Nature medicine
Johnson DC,Taabazuing CY,Okondo MC,Chui AJ,Rao SD,Brown FC,Reed C,Peguero E,de Stanchina E,Kentsis A,Bachovchin DA
300-23 was used in Cell Culture to identify an activator of CARD8 in human cells and indicate that its activation by small-molecule DPP8/9 inhibitors represents a new potential therapeutic strategy for AML.
Wed Aug 01 00:00:00 UTC 2018
Regulation of embryonic haematopoietic multipotency by EZH1.
Nature
Vo LT,Kinney MA,Liu X,Zhang Y,Barragan J,Sousa PM,Jha DK,Han A,Cesana M,Shao Z,North TE,Orkin SH,Doulatov S,Xu J,Daley GQ
Thu Jan 25 00:00:00 UTC 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 UTC 2018
Genetic Inactivation of CD33 in Hematopoietic Stem Cells to Enable CAR T Cell Immunotherapy for Acute Myeloid Leukemia.
Cell
Kim MY,Yu KR,Kenderian SS,Ruella M,Chen S,Shin TH,Aljanahi AA,Schreeder D,Klichinsky M,Shestova O,Kozlowski MS,Cummins KD,Shan X,Shestov M,Bagg A,Morrissette JJD,Sekhri P,Lazzarotto CR,Calvo KR,Kuhns DB,Donahue RE,Behbehani GK,Tsai SQ,Dunbar CE,Gill S
Thu May 31 00:00:00 UTC 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
Mon Apr 02 00:00:00 UTC 2018
Ribonuclease inhibitor 1 regulates erythropoiesis by controlling GATA1 translation.
The Journal of clinical investigation
Chennupati V,Veiga DF,Maslowski KM,Andina N,Tardivel A,Yu EC,Stilinovic M,Simillion C,Duchosal MA,Quadroni M,Roberts I,Sankaran VG,MacDonald HR,Fasel N,Angelillo-Scherrer A,Schneider P,Hoang T,Allam R
Mon Apr 02 00:00:00 UTC 2018
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.
Developmental cell
Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T
300-23 was used in Cell Culture to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.
Mon Feb 05 00:00:00 UTC 2018
Soluble PD-1 ligands regulate T-cell function in Waldenstrom macroglobulinemia.
Blood advances
Jalali S,Price-Troska T,Paludo J,Villasboas J,Kim HJ,Yang ZZ,Novak AJ,Ansell SM
Tue Aug 14 00:00:00 UTC 2018
A revised road map for the commitment of human cord blood CD34-negative hematopoietic stem cells.
Nature communications
Sumide K,Matsuoka Y,Kawamura H,Nakatsuka R,Fujioka T,Asano H,Takihara Y,Sonoda Y
Wed Jun 06 00:00:00 UTC 2018
Consequences of cathepsin C inactivation for membrane exposure of proteinase 3, the target antigen in autoimmune vasculitis.
The Journal of biological chemistry
Seren S,Rashed Abouzaid M,Eulenberg-Gustavus C,Hirschfeld J,Nasr Soliman H,Jerke U,N'Guessan K,Dallet-Choisy S,Lesner A,Lauritzen C,Schacher B,Eickholz P,Nagy N,Szell M,Croix C,Viaud-Massuard MC,Al Farraj Aldosari A,Ragunatha S,Ibrahim Mostafa M,Giampieri F,Battino M,Cornillier H,Lorette G,Stephan JL,Goizet C,Pedersen J,Gauthier F,Jenne DE,Marchand-Adam S,Chapple IL,Kettritz R,Korkmaz B
Fri Aug 10 00:00:00 UTC 2018
Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation.
Scientific reports
Biechonski S,Olender L,Zipin-Roitman A,Yassin M,Aqaqe N,Marcu-Malina V,Rall-Scharpf M,Trottier M,Meyn MS,Wiesmüller L,Beider K,Raz Y,Grisaru D,Nagler A,Milyavsky M
Tue Apr 17 00:00:00 UTC 2018
Targeting the Extracellular Signal-Regulated Kinase 5 Pathway to Suppress Human Chronic Myeloid Leukemia Stem Cells.
Stem cell reports
Tusa I,Cheloni G,Poteti M,Gozzini A,DeSouza NH,Shan Y,Deng X,Gray NS,Li S,Rovida E,Dello Sbarba P
Tue Oct 09 00:00:00 UTC 2018
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.
Scientific reports
MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH
Tue May 22 00:00:00 UTC 2018
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.
Scientific reports
MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH
Tue May 22 00:00:00 UTC 2018
MLL-fusion-driven leukemia requires SETD2 to safeguard genomic integrity.
Nature communications
Skucha A,Ebner J,Schmöllerl J,Roth M,Eder T,César-Razquin A,Stukalov A,Vittori S,Muhar M,Lu B,Aichinger M,Jude J,Müller AC,Győrffy B,Vakoc CR,Valent P,Bennett KL,Zuber J,Superti-Furga G,Grebien F
Fri May 18 00:00:00 UTC 2018
Chronic myeloid leukaemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal.
Cell death & disease
Toofan P,Busch C,Morrison H,O'Brien S,Jørgensen H,Copland M,Wheadon H
Tue Sep 11 00:00:00 UTC 2018
Restoration of TET2 Function Blocks Aberrant Self-Renewal and Leukemia Progression.
Cell
Cimmino L,Dolgalev I,Wang Y,Yoshimi A,Martin GH,Wang J,Ng V,Xia B,Witkowski MT,Mitchell-Flack M,Grillo I,Bakogianni S,Ndiaye-Lobry D,Martín MT,Guillamot M,Banh RS,Xu M,Figueroa ME,Dickins RA,Abdel-Wahab O,Park CY,Tsirigos A,Neel BG,Aifantis I
Thu Sep 07 00:00:00 UTC 2017
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Cell
Spencer DH,Russler-Germain DA,Ketkar S,Helton NM,Lamprecht TL,Fulton RS,Fronick CC,O'Laughlin M,Heath SE,Shinawi M,Westervelt P,Payton JE,Wartman LD,Welch JS,Wilson RK,Walter MJ,Link DC,DiPersio JF,Ley TJ
Thu Feb 23 00:00:00 UTC 2017
JAK1/2 and BCL2 inhibitors synergize to counteract bone marrow stromal cell-induced protection of AML.
Blood
Karjalainen R,Pemovska T,Popa M,Liu M,Javarappa KK,Majumder MM,Yadav B,Tamborero D,Tang J,Bychkov D,Kontro M,Parsons A,Suvela M,Mayoral Safont M,Porkka K,Aittokallio T,Kallioniemi O,McCormack E,Gjertsen BT,Wennerberg K,Knowles J,Heckman CA
Thu Aug 10 00:00:00 UTC 2017
Gene silencing and a novel monoallelic expression pattern in distinct CD177 neutrophil subsets.
The Journal of experimental medicine
Eulenberg-Gustavus C,Bähring S,Maass PG,Luft FC,Kettritz R
Mon Jul 03 00:00:00 UTC 2017
Anti-SIRPα antibody immunotherapy enhances neutrophil and macrophage antitumor activity.
Proceedings of the National Academy of Sciences of the United States of America
Ring NG,Herndler-Brandstetter D,Weiskopf K,Shan L,Volkmer JP,George BM,Lietzenmayer M,McKenna KM,Naik TJ,McCarty A,Zheng Y,Ring AM,Flavell RA,Weissman IL
Tue Dec 05 00:00:00 UTC 2017
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Oncogene
Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW
300-23 was used in In vitro experiments to study the specific tumor microenvironment (TME) which most actively control cancer cell plasticity for metastasis.
Thu Jul 13 00:00:00 UTC 2017
KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.
Nature communications
Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J
Fri Nov 10 00:00:00 UTC 2017
The combination of CHK1 inhibitor with G-CSF overrides cytarabine resistance in human acute myeloid leukemia.
Nature communications
Di Tullio A,Rouault-Pierre K,Abarrategi A,Mian S,Grey W,Gribben J,Stewart A,Blackwood E,Bonnet D
Wed Nov 22 00:00:00 UTC 2017
Nuclear Factor Erythroid 2 Regulates Human HSC Self-Renewal and T Cell Differentiation by Preventing NOTCH1 Activation.
Stem cell reports
Di Tullio A,Passaro D,Rouault-Pierre K,Purewal S,Bonnet D
Tue Jul 11 00:00:00 UTC 2017
Selective Inhibitors of Histone Deacetylases 1 and 2 Synergize with Azacitidine in Acute Myeloid Leukemia.
PloS one
Min C,Moore N,Shearstone JR,Quayle SN,Huang P,van Duzer JH,Jarpe MB,Jones SS,Yang M
300-23 was used in Sample Preparation (FC/FACS) to support the clinical evaluation of selective HDAC1/2 inhibitors in combination with azacitidine in AML patients.
Tue Aug 15 00:00:00 UTC 2017
Targeting MTHFD2 in acute myeloid leukemia.
The Journal of experimental medicine
Pikman Y,Puissant A,Alexe G,Furman A,Chen LM,Frumm SM,Ross L,Fenouille N,Bassil CF,Lewis CA,Ramos A,Gould J,Stone RM,DeAngelo DJ,Galinsky I,Clish CB,Kung AL,Hemann MT,Vander Heiden MG,Banerji V,Stegmaier K
Mon Jun 27 00:00:00 UTC 2016
CDKIs p18(INK4c) and p57(Kip2) are involved in quiescence of CML leukemic stem cells after treatment with TKI.
Cell cycle (Georgetown, Tex.)
Moreno-Lorenzana D,Avilés-Vazquez S,Sandoval Esquivel MA,Alvarado-Moreno A,Ortiz-Navarrete V,Torres-Martínez H,Ayala-Sánchez M,Mayani H,Chavez-Gonzalez A
300-23 was used in Sample Preparation (FC/FACS) to analyze the cell cycle status, levels of several CDKIs and the subcellular localization of such molecules in different Chronic Myeloid Leukemia (CML) cell lines, as well as primary CD34(+)CD38(-)lin(-) LSC and HSC to understand the role of Cyclin Dependent Kinase Inhibitors in CML LSC permanence after tyrosine kinase inhibitor (TKI) treatment.
Mon May 02 00:00:00 UTC 2016
Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency.
Stem cell reports
Mucci A,Kunkiel J,Suzuki T,Brennig S,Glage S,Kühnel MP,Ackermann M,Happle C,Kuhn A,Schambach A,Trapnell BC,Hansen G,Moritz T,Lachmann N
Tue Aug 09 00:00:00 UTC 2016
BIM mediates synergistic killing of B-cell acute lymphoblastic leukemia cells by BCL-2 and MEK inhibitors.
Cell death & disease
Korfi K,Smith M,Swan J,Somervaille TC,Dhomen N,Marais R
Thu Apr 07 00:00:00 UTC 2016
Acetylation of C/EBPα inhibits its granulopoietic function.
Nature communications
Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG
Wed Mar 23 00:00:00 UTC 2016
Acetylation of C/EBPα inhibits its granulopoietic function.
Nature communications
Bararia D,Kwok HS,Welner RS,Numata A,Sárosi MB,Yang H,Wee S,Tschuri S,Ray D,Weigert O,Levantini E,Ebralidze AK,Gunaratne J,Tenen DG
Wed Mar 23 00:00:00 UTC 2016
Semi-automated closed system manufacturing of lentivirus gene-modified haematopoietic stem cells for gene therapy.
Nature communications
Adair JE,Waters T,Haworth KG,Kubek SP,Trobridge GD,Hocum JD,Heimfeld S,Kiem HP
Thu Oct 20 00:00:00 UTC 2016
DNMT3A R882 mutants interact with polycomb proteins to block haematopoietic stem and leukaemic cell differentiation.
Nature communications
Koya J,Kataoka K,Sato T,Bando M,Kato Y,Tsuruta-Kishino T,Kobayashi H,Narukawa K,Miyoshi H,Shirahige K,Kurokawa M
Thu Mar 24 00:00:00 UTC 2016
Real-time deformability cytometry: on-the-fly cell mechanical phenotyping.
Nature methods
Otto O,Rosendahl P,Mietke A,Golfier S,Herold C,Klaue D,Girardo S,Pagliara S,Ekpenyong A,Jacobi A,Wobus M,Töpfner N,Keyser UF,Mansfeld J,Fischer-Friedrich E,Guck J
Sun Mar 01 00:00:00 UTC 2015
Aberrant splicing of genes involved in haemoglobin synthesis and impaired terminal erythroid maturation in SF3B1 mutated refractory anaemia with ring sideroblasts.
British journal of haematology
Conte S,Katayama S,Vesterlund L,Karimi M,Dimitriou M,Jansson M,Mortera-Blanco T,Unneberg P,Papaemmanuil E,Sander B,Skoog T,Campbell P,Walfridsson J,Kere J,Hellström-Lindberg E
Sun Nov 01 00:00:00 UTC 2015
Induction of the proapoptotic tumor suppressor gene Cell Adhesion Molecule 1 by chemotherapeutic agents is repressed in therapy resistant acute myeloid leukemia.
Molecular carcinogenesis
Fisser MC,Rommer A,Steinleitner K,Heller G,Herbst F,Wiese M,Glimm H,Sill H,Wieser R
Tue Dec 01 00:00:00 UTC 2015
Generation of a High Number of Healthy Erythroid Cells from Gene-Edited Pyruvate Kinase Deficiency Patient-Specific Induced Pluripotent Stem Cells.
Stem cell reports
Garate Z,Quintana-Bustamante O,Crane AM,Olivier E,Poirot L,Galetto R,Kosinski P,Hill C,Kung C,Agirre X,Orman I,Cerrato L,Alberquilla O,Rodriguez-Fornes F,Fusaki N,Garcia-Sanchez F,Maia TM,Ribeiro ML,Sevilla J,Prosper F,Jin S,Mountford J,Guenechea G,Gouble A,Bueren JA,Davis BR,Segovia JC
Tue Dec 08 00:00:00 UTC 2015
Serial analysis of 38 proteins during the progression of human breast tumor in mice using an antibody colocalization microarray.
Molecular & cellular proteomics : MCP
Li H,Bergeron S,Annis MG,Siegel PM,Juncker D
Wed Apr 01 00:00:00 UTC 2015
SF3B1 mutant MDS-initiating cells may arise from the haematopoietic stem cell compartment.
Nature communications
Mian SA,Rouault-Pierre K,Smith AE,Seidl T,Pizzitola I,Kizilors A,Kulasekararaj AG,Bonnet D,Mufti GJ
Tue Dec 08 00:00:00 UTC 2015
AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.
Cell death & disease
Six E,Lagresle-Peyrou C,Susini S,De Chappedelaine C,Sigrist N,Sadek H,Chouteau M,Cagnard N,Fontenay M,Hermine O,Chomienne C,Reynier P,Fischer A,André-Schmutz I,Gueguen N,Cavazzana M
Thu Aug 13 00:00:00 UTC 2015
Heme-mediated SPI-C induction promotes monocyte differentiation into iron-recycling macrophages.
Cell
Haldar M,Kohyama M,So AY,Kc W,Wu X,Briseño CG,Satpathy AT,Kretzer NM,Arase H,Rajasekaran NS,Wang L,Egawa T,Igarashi K,Baltimore D,Murphy TL,Murphy KM
Thu Mar 13 00:00:00 UTC 2014
Monoclonal antibody targeting of IL-3 receptor α with CSL362 effectively depletes CML progenitor and stem cells.
Blood
Nievergall E,Ramshaw HS,Yong AS,Biondo M,Busfield SJ,Vairo G,Lopez AF,Hughes TP,White DL,Hiwase DK
Thu Feb 20 00:00:00 UTC 2014
Rapamycin relieves lentiviral vector transduction resistance in human and mouse hematopoietic stem cells.
Blood
Wang CX,Sather BD,Wang X,Adair J,Khan I,Singh S,Lang S,Adams A,Curinga G,Kiem HP,Miao CH,Rawlings DJ,Torbett BE
Thu Aug 07 00:00:00 UTC 2014
Ponatinib overcomes FGF2-mediated resistance in CML patients without kinase domain mutations.
Blood
Traer E,Javidi-Sharifi N,Agarwal A,Dunlap J,English I,Martinez J,Tyner JW,Wong M,Druker BJ
Thu Mar 06 00:00:00 UTC 2014
CD33 target validation and sustained depletion of AML blasts in long-term cultures by the bispecific T-cell-engaging antibody AMG 330.
Blood
Krupka C,Kufer P,Kischel R,Zugmaier G,Bögeholz J,Köhnke T,Lichtenegger FS,Schneider S,Metzeler KH,Fiegl M,Spiekermann K,Baeuerle PA,Hiddemann W,Riethmüller G,Subklewe M
Thu Jan 16 00:00:00 UTC 2014
Clonal Dominance With Retroviral Vector Insertions Near the ANGPT1 and ANGPT2 Genes in a Human Xenotransplant Mouse Model.
Molecular therapy. Nucleic acids
Haemmerle R,Phaltane R,Rothe M,Schröder S,Schambach A,Moritz T,Modlich U
Tue Oct 07 00:00:00 UTC 2014
Generation of functional, antigen-specific CD8+ human T cells from cord blood stem cells using exogenous Notch and tetramer-TCR signaling.
Stem cells (Dayton, Ohio)
Fernandez I,Ooi TP,Roy K
Wed Jan 01 00:00:00 UTC 2014
CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.
Blood
Casucci M,Nicolis di Robilant B,Falcone L,Camisa B,Norelli M,Genovese P,Gentner B,Gullotta F,Ponzoni M,Bernardi M,Marcatti M,Saudemont A,Bordignon C,Savoldo B,Ciceri F,Naldini L,Dotti G,Bonini C,Bondanza A
Thu Nov 14 00:00:00 UTC 2013
SGN-CD33A: a novel CD33-targeting antibody-drug conjugate using a pyrrolobenzodiazepine dimer is active in models of drug-resistant AML.
Blood
Kung Sutherland MS,Walter RB,Jeffrey SC,Burke PJ,Yu C,Kostner H,Stone I,Ryan MC,Sussman D,Lyon RP,Zeng W,Harrington KH,Klussman K,Westendorf L,Meyer D,Bernstein ID,Senter PD,Benjamin DR,Drachman JG,McEarchern JA
Thu Aug 22 00:00:00 UTC 2013
Genomic instability may originate from imatinib-refractory chronic myeloid leukemia stem cells.
Blood
Bolton-Gillespie E,Schemionek M,Klein HU,Flis S,Hoser G,Lange T,Nieborowska-Skorska M,Maier J,Kerstiens L,Koptyra M,Müller MC,Modi H,Stoklosa T,Seferynska I,Bhatia R,Holyoake TL,Koschmieder S,Skorski T
Thu May 16 00:00:00 UTC 2013
MASL1 induces erythroid differentiation in human erythropoietin-dependent CD34+ cells through the Raf/MEK/ERK pathway.
Blood
Kumkhaek C,Aerbajinai W,Liu W,Zhu J,Uchida N,Kurlander R,Hsieh MM,Tisdale JF,Rodgers GP
Thu Apr 18 00:00:00 UTC 2013
Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP.
Blood
Gupta M,Maurer MJ,Wellik LE,Law ME,Han JJ,Ozsan N,Micallef IN,Dogan A,Witzig TE
Thu Nov 22 00:00:00 UTC 2012
Stress hematopoiesis reveals abnormal control of self-renewal, lineage bias, and myeloid differentiation in Mll partial tandem duplication (Mll-PTD) hematopoietic stem/progenitor cells.
Blood
Zhang Y,Yan X,Sashida G,Zhao X,Rao Y,Goyama S,Whitman SP,Zorko N,Bernot K,Conway RM,Witte D,Wang QF,Tenen DG,Xiao Z,Marcucci G,Mulloy JC,Grimes HL,Caligiuri MA,Huang G
Thu Aug 02 00:00:00 UTC 2012
GILZ inhibits the mTORC2/AKT pathway in BCR-ABL(+) cells.
Oncogene
Joha S,Nugues AL,Hétuin D,Berthon C,Dezitter X,Dauphin V,Mahon FX,Roche-Lestienne C,Preudhomme C,Quesnel B,Idziorek T
Thu Mar 15 00:00:00 UTC 2012
Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice.
Journal of immunology (Baltimore, Md. : 1950)
Tanaka S,Saito Y,Kunisawa J,Kurashima Y,Wake T,Suzuki N,Shultz LD,Kiyono H,Ishikawa F
Fri Jun 15 00:00:00 UTC 2012
Development of mature and functional human myeloid subsets in hematopoietic stem cell-engrafted NOD/SCID/IL2rγKO mice.
Journal of immunology (Baltimore, Md. : 1950)
Tanaka S,Saito Y,Kunisawa J,Kurashima Y,Wake T,Suzuki N,Shultz LD,Kiyono H,Ishikawa F
Fri Jun 15 00:00:00 UTC 2012
Human haemato-endothelial precursors: cord blood CD34+ cells produce haemogenic endothelium.
PloS one
Pelosi E,Castelli G,Martin-Padura I,Bordoni V,Santoro S,Conigliaro A,Cerio AM,De Santis Puzzonia M,Marighetti P,Biffoni M,Alonzi T,Amicone L,Alcalay M,Bertolini F,Testa U,Tripodi M
Tue May 21 00:00:00 UTC 2013
Micro-RNA30c negatively regulates REDD1 expression in human hematopoietic and osteoblast cells after gamma-irradiation.
PloS one
Li XH,Ha CT,Fu D,Xiao M
Thu May 09 00:00:00 UTC 2013
Distinct regulation of c-myb gene expression by HoxA9, Meis1 and Pbx proteins in normal hematopoietic progenitors and transformed myeloid cells.
Blood cancer journal
Dassé E,Volpe G,Walton DS,Wilson N,Del Pozzo W,O'Neill LP,Slany RK,Frampton J,Dumon S
Fri Jun 01 00:00:00 UTC 2012
Inhibition of TET2-mediated conversion of 5-methylcytosine to 5-hydroxymethylcytosine disturbs erythroid and granulomonocytic differentiation of human hematopoietic progenitors.
Blood
Pronier E,Almire C,Mokrani H,Vasanthakumar A,Simon A,da Costa Reis Monte Mor B,Massé A,Le Couédic JP,Pendino F,Carbonne B,Larghero J,Ravanat JL,Casadevall N,Bernard OA,Droin N,Solary E,Godley LA,Vainchenker W,Plo I,Delhommeau F
Thu Sep 01 00:00:00 UTC 2011
Single-cell phospho-specific flow cytometric analysis demonstrates biochemical and functional heterogeneity in human hematopoietic stem and progenitor compartments.
Blood
Gibbs KD,Gilbert PM,Sachs K,Zhao F,Blau HM,Weissman IL,Nolan GP,Majeti R
Thu Apr 21 00:00:00 UTC 2011
Bcr-Abl ubiquitination and Usp9x inhibition block kinase signaling and promote CML cell apoptosis.
Blood
Sun H,Kapuria V,Peterson LF,Fang D,Bornmann WG,Bartholomeusz G,Talpaz M,Donato NJ
Thu Mar 17 00:00:00 UTC 2011
Production of the plasma-cell survival factor a proliferation-inducing ligand (APRIL) peaks in myeloid precursor cells from human bone marrow.
Blood
Matthes T,Dunand-Sauthier I,Santiago-Raber ML,Krause KH,Donze O,Passweg J,McKee T,Huard B
Thu Aug 18 00:00:00 UTC 2011
Combined effects of hematopoietic progenitor cell mobilization from bone marrow by granulocyte colony stimulating factor and AMD3100 and chemotaxis into the brain using stromal cell-derived factor-1α in an Alzheimer's disease mouse model.
Stem cells (Dayton, Ohio)
Shin JW,Lee JK,Lee JE,Min WK,Schuchman EH,Jin HK,Bae JS
Fri Jul 01 00:00:00 UTC 2011
Ubiquitin fusion expression and tissue-dependent targeting of hG-CSF in transgenic tobacco.
BMC biotechnology
Tian L,Sun SS
Tue Oct 11 00:00:00 UTC 2011
Ubiquitin fusion expression and tissue-dependent targeting of hG-CSF in transgenic tobacco.
BMC biotechnology
Tian L,Sun SS
Tue Oct 11 00:00:00 UTC 2011
Hypoxia selects bortezomib-resistant stem cells of chronic myeloid leukemia.
PloS one
Tanturli M,Giuntoli S,Barbetti V,Rovida E,Dello Sbarba P
Fri Feb 11 00:00:00 UTC 2011
Granulocyte colony stimulating factor attenuates inflammation in a mouse model of amyotrophic lateral sclerosis.
Journal of neuroinflammation
Pollari E,Savchenko E,Jaronen M,Kanninen K,Malm T,Wojciechowski S,Ahtoniemi T,Goldsteins G,Giniatullina R,Giniatullin R,Koistinaho J,Magga J
Tue Jun 28 00:00:00 UTC 2011
Specific cellular signal-transduction responses to in vivo combination therapy with ATRA, valproic acid and theophylline in acute myeloid leukemia.
Blood cancer journal
Skavland J,Jørgensen KM,Hadziavdic K,Hovland R,Jonassen I,Bruserud O,Gjertsen BT
Tue Feb 01 00:00:00 UTC 2011
Comparative study of hematopoietic differentiation between human embryonic stem cell lines.
PloS one
Melichar H,Li O,Ross J,Haber H,Cado D,Nolla H,Robey EA,Winoto A
Fri Oct 21 00:00:00 UTC 2011
DNA damage-mediated induction of a chemoresistant niche.
Cell
Gilbert LA,Hemann MT
Fri Oct 29 00:00:00 UTC 2010
β-Catenin mediates the establishment and drug resistance of MLL leukemic stem cells.
Cancer cell
Yeung J,Esposito MT,Gandillet A,Zeisig BB,Griessinger E,Bonnet D,So CW
Tue Dec 14 00:00:00 UTC 2010
The transcription factor Gfi1 regulates G-CSF signaling and neutrophil development through the Ras activator RasGRP1.
Blood
de la Luz Sierra M,Sakakibara S,Gasperini P,Salvucci O,Jiang K,McCormick PJ,Segarra M,Stone J,Maric D,Zhu J,Qian X,Lowy DR,Tosato G
Thu May 13 00:00:00 UTC 2010
Interferon-gamma and tumor necrosis factor-alpha induce an immunoinhibitory molecule, B7-H1, via nuclear factor-kappaB activation in blasts in myelodysplastic syndromes.
Blood
Kondo A,Yamashita T,Tamura H,Zhao W,Tsuji T,Shimizu M,Shinya E,Takahashi H,Tamada K,Chen L,Dan K,Ogata K
Thu Aug 19 00:00:00 UTC 2010
Iron control of erythroid development by a novel aconitase-associated regulatory pathway.
Blood
Bullock GC,Delehanty LL,Talbot AL,Gonias SL,Tong WH,Rouault TA,Dewar B,Macdonald JM,Chruma JJ,Goldfarb AN
Thu Jul 08 00:00:00 UTC 2010
miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.
Journal of immunology (Baltimore, Md. : 1950)
Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H
Sat May 01 00:00:00 UTC 2010
Intensive chemotherapy for acute myeloid leukemia differentially affects circulating TC1, TH1, TH17 and TREG cells.
BMC immunology
Ersvaer E,Liseth K,Skavland J,Gjertsen BT,Bruserud Ø
Fri Jul 09 00:00:00 UTC 2010
Protein-arginine methyltransferase 1 suppresses megakaryocytic differentiation via modulation of the p38 MAPK pathway in K562 cells.
The Journal of biological chemistry
Chang YI,Hua WK,Yao CL,Hwang SM,Hung YC,Kuan CJ,Leou JS,Lin WJ
Fri Jul 02 00:00:00 UTC 2010
Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states.
BMC systems biology
Felli N,Cianetti L,Pelosi E,Carè A,Liu CG,Calin GA,Rossi S,Peschle C,Marziali G,Giuliani A
Wed Jun 16 00:00:00 UTC 2010
Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease.
Nature
Gu Y,Harley IT,Henderson LB,Aronow BJ,Vietor I,Huber LA,Harley JB,Kilpatrick JR,Langefeld CD,Williams AH,Jegga AG,Chen J,Wills-Karp M,Arshad SH,Ewart SL,Thio CL,Flick LM,Filippi MD,Grimes HL,Drumm ML,Cutting GR,Knowles MR,Karp CL
Thu Apr 23 00:00:00 UTC 2009
The preferentially expressed antigen in melanoma (PRAME) inhibits myeloid differentiation in normal hematopoietic and leukemic progenitor cells.
Blood
Oehler VG,Guthrie KA,Cummings CL,Sabo K,Wood BL,Gooley T,Yang T,Epping MT,Shou Y,Pogosova-Agadjanyan E,Ladne P,Stirewalt DL,Abkowitz JL,Radich JP
Thu Oct 08 00:00:00 UTC 2009
NFI-A directs the fate of hematopoietic progenitors to the erythroid or granulocytic lineage and controls beta-globin and G-CSF receptor expression.
Blood
Starnes LM,Sorrentino A,Pelosi E,Ballarino M,Morsilli O,Biffoni M,Santoro S,Felli N,Castelli G,De Marchis ML,Mastroberardino G,Gabbianelli M,Fatica A,Bozzoni I,Nervi C,Peschle C
Thu Aug 27 00:00:00 UTC 2009
Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.
Blood
Kandilci A,Grosveld GC
Thu Aug 20 00:00:00 UTC 2009
Functional involvement of RINF, retinoid-inducible nuclear factor (CXXC5), in normal and tumoral human myelopoiesis.
Blood
Pendino F,Nguyen E,Jonassen I,Dysvik B,Azouz A,Lanotte M,Ségal-Bendirdjian E,Lillehaug JR
Thu Apr 02 00:00:00 UTC 2009
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells.
Blood
Eberhard Y,McDermott SP,Wang X,Gronda M,Venugopal A,Wood TE,Hurren R,Datti A,Batey RA,Wrana J,Antholine WE,Dick JE,Schimmer AD
Thu Oct 01 00:00:00 UTC 2009
The TEL-AML1 leukemia fusion gene dysregulates the TGF-beta pathway in early B lineage progenitor cells.
The Journal of clinical investigation
Ford AM,Palmi C,Bueno C,Hong D,Cardus P,Knight D,Cazzaniga G,Enver T,Greaves M
Wed Apr 01 00:00:00 UTC 2009
Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H
Wed Jul 01 00:00:00 UTC 2009
A kinase-dead allele of Lyn attenuates autoimmune disease normally associated with Lyn deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Verhagen AM,Wallace ME,Goradia A,Jones SA,Croom HA,Metcalf D,Collinge JE,Maxwell MJ,Hibbs ML,Alexander WS,Hilton DJ,Kile BT,Starr R
Sun Feb 15 00:00:00 UTC 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 UTC 2009
Acadesine kills chronic myelogenous leukemia (CML) cells through PKC-dependent induction of autophagic cell death.
PloS one
Robert G,Ben Sahra I,Puissant A,Colosetti P,Belhacene N,Gounon P,Hofman P,Bost F,Cassuto JP,Auberger P
Wed Nov 18 00:00:00 UTC 2009
TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha.
Journal of immunology (Baltimore, Md. : 1950)
Andrade RM,Wessendarp M,Portillo JA,Yang JQ,Gomez FJ,Durbin JE,Bishop GA,Subauste CS
Tue Nov 01 00:00:00 UTC 2005
Stem cell factor can stimulate the formation of eosinophils by two types of murine eosinophil progenitor cells.
Stem cells (Dayton, Ohio)
Metcalf D,Mifsud S,Di Rago L
Wed Mar 12 00:00:00 UTC 2003
