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Product Details
PEP-0568
Applications
Tested Dilution
Publications
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Shipping conditions
Wet ice
Product Specific Information
This peptide corresponds to 17 amino acids near the carboxy terminus of human Grik5.
PEP-0568 can be used as a blocking peptide with polyclonal antibody PA5-20451.
Target Information
Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. Grik5, also known as kainate-preferring glutamate recptor subunit KA2, belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Grik5 is highly homologous to the related ionotrophic glutamate receptor Grik4 (also known as KA1). Like Grik4, Grik5 does not form homomeric channels, but instead forms heteromers with Grik2. In Grik2- but not Grik1-null mice, Grik5 surface expression is greatly reduced in neurons, indicating that Grik2/Grik5 heteromers are required for exit from the endoplasmic reticulum to the cell surface.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EAA2; Excitatory amino acid receptor 2; GluK5; glutamate receptor; Glutamate receptor ionotropic, kainate 5; Glutamate receptor KA-2; glutamate receptor KA2; glutamate receptor, ionotropic, kainate 5; KA2
Gene Aliases: EAA2; GluK5; GRIK2; GRIK5; KA2
UniProt ID: (Human) Q16478
Entrez Gene ID: (Human) 2901
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