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Gibco
Human I-309 (CCL1) Recombinant Protein, PeproTech®
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Product Details
300-37-10UG
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Published species
Bacteria,
Human,
Mouse,
Non-human primate
Expression System
E. coli
Amino acid sequence
SKSMQVPFSR CCFSFAEQEI PLRAILCYRN TSSICSNEGL IFKLKRGKEA CALDTVGWVQ RHRKMLRHCP SKRK
Molecular weight
8.5 kDa
Class
Recombinant
Type
Protein
Purity
≥ 98% by SDS-PAGE gel and HPLC analyses.
Endotoxin concentration
<1 EU/µg
Activity
Determined by its ability to chemoattract human monocytes population using a concentration range of 10.0-30.0 ng/ml.
Conjugate
Form
Lyophilized
Purification
purified
Contains
no preservative
Storage conditions
-20°C
Shipping conditions
Ambient
Product Specific Information
Recombinant Human I-309 is an 8.5 kDa protein consisting of 74 amino acid residues that include six cysteine residues, of which four are the highly conserved cysteine residues present in CC chemokines. Unlike some CC chemokines, whose biologically active form in solution is a non-disulfide-linked dimer, the biologically active form of I-309 is monomeric.
This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis
Target Information
This gene is one of several cytokine genes clustered on the q-arm of chromosome 17. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The protein encoded by this gene is structurally related to the CXC subfamily of cytokines. Members of this subfamily are characterized by two cysteines separated by a single amino acid. This cytokine is secreted by activated T cells and displays chemotactic activity for monocytes but not for neutrophils. It binds to the chemokine receptor CCR8.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Bioinformatics
Protein Aliases: C-C motif chemokine 1; CCL 1; chemokine (C-C motif) ligand 1; inflammatory cytokine I-309; small inducible cytokine A1 (I-309, homologous to mouse Tca-3); Small-inducible cytokine A1; T lymphocyte-secreted protein I-309
Gene Aliases: CCL1; I-309; P500; SCYA1; SISe; TCA3
UniProt ID: (Human) P22362
Entrez Gene ID: (Human) 6346
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