Gibco

Human IFN-omega Recombinant Protein, PeproTech®

Human IFN-omega Protein in Functional Assay (Functional)

FIGURE: 1 / 1

Human IFN-omega Protein (300-02J-100UG) in Functional

Bioassay analysis of Human IFN-omega Recombinant Protein, PeproTech® (Product # 300-02J-1MG).

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Product Details

300-02J-100UG

Applications

Tested Dilution

Publications

ELISA (ELISA)

View 1 publication 1 publication

Functional Assay (Functional)

Assay-dependent

In vitro Assay (IV)

View 4 publications 4 publications

Product Specifications

Species

Human

Published species

Human, Mouse

Expression System

E. coli

Amino acid sequence

CDLPQNHGLL SRNTLVLLHQ MRRISPFLCL KDRRDFRFPQ EMVKGSQLQK AHVMSVLHEM LQQIFSLFHT ERSSAAWNMT LLDQLHTGLH QQLQHLETCL LQVVGEGESA GAISSPALTL RRYFQGIRVY LKEKKYSDCA WEVVRMEIMK SLFLSTNMQE RLRSKDRDLG SS

Molecular weight

19.9 kDa

Class

Recombinant

Type

Protein

Purity

≥ 98% by SDS-PAGE gel and HPLC analyses.

Endotoxin concentration

<1 EU/µg

Activity

The ED50 was determined by a cytotoxicity assay using Human TF-1 cells is ≤ 0.01 ng/ml, corresponding to a specific activity of ≥ 1 x 10^8 units/mg.

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Lyophilized

Purification

purified

Contains

no preservative

Storage conditions

-20°C

Shipping conditions

Ambient

Product Specific Information

Recombinant Human IFN-omega is a 19.9 kDa protein consisting of 172 amino acid residues.

This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

Target Information

IFN-omega is a type I interferon that can be induced by virus-infected leukocytes. Members of the type I interferon family, which includes IFN-alpha, IFN-beta, and IFN-omega, signal through the IFNAR-1/IFNAR-2 receptor complex, and exert antiviral and antiproliferative activities. IFN-omega exhibits about 75% sequence homology with IFN-alpha, and contains two conserved disulfide bonds that are necessary for full biological activity.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

Product References

Alpha-Soluble NSF Attachment Protein Prevents the Cleavage of the SARS-CoV-2 Spike Protein by Functioning as an Interferon-Upregulated Furin Inhibitor.

mBio

Wang J,Luo J,Wen Z,Wang X,Shuai L,Zhong G,Wang C,Sun Z,Chen W,Ge J,Liu R,Wang X,Bu Z

Tue Feb 22 00:00:00 EST 2022

Detection of interferon alpha protein reveals differential levels and cellular sources in disease.

The Journal of experimental medicine

Rodero MP,Decalf J,Bondet V,Hunt D,Rice GI,Werneke S,McGlasson SL,Alyanakian MA,Bader-Meunier B,Barnerias C,Bellon N,Belot A,Bodemer C,Briggs TA,Desguerre I,Frémond ML,Hully M,van den Maagdenberg AMJM,Melki I,Meyts I,Musset L,Pelzer N,Quartier P,Terwindt GM,Wardlaw J,Wiseman S,Rieux-Laucat F,Rose Y,Neven B,Hertel C,Hayday A,Albert ML,Rozenberg F,Crow YJ,Duffy D

Mon May 01 00:00:00 EDT 2017

Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.

The Journal of clinical investigation

Walter JE,Rosen LB,Csomos K,Rosenberg JM,Mathew D,Keszei M,Ujhazi B,Chen K,Lee YN,Tirosh I,Dobbs K,Al-Herz W,Cowan MJ,Puck J,Bleesing JJ,Grimley MS,Malech H,De Ravin SS,Gennery AR,Abraham RS,Joshi AY,Boyce TG,Butte MJ,Nadeau KC,Balboni I,Sullivan KE,Akhter J,Adeli M,El-Feky RA,El-Ghoneimy DH,Dbaibo G,Wakim R,Azzari C,Palma P,Cancrini C,Capuder K,Condino-Neto A,Costa-Carvalho BT,Oliveira JB,Roifman C,Buchbinder D,Kumanovics A,Franco JL,Niehues T,Schuetz C,Kuijpers T,Yee C,Chou J,Masaad MJ,Geha R,Uzel G,Gelman R,Holland SM,Recher M,Utz PJ,Browne SK,Notarangelo LD

Mon Nov 02 00:00:00 EST 2015

Mining the human autoantibody repertoire: isolation of potent IL17A-neutralizing monoclonal antibodies from a patient with thymoma.

mAbs

Beerli RR,Bauer M,Fritzer A,Rosen LB,Buser RB,Hanner M,Maudrich M,Nebenfuehr M,Toepfer JA,Mangold S,Bauer A,Holland SM,Browne SK,Meinke A

300-02J was used in In vitro experiments to demonstrate that the human autoantibody repertoire can be mined for antibodies with high therapeutic potential for clinical development.

Tue Sep 01 00:00:00 EDT 2015

Antiviral responses in mouse embryonic stem cells: differential development of cellular mechanisms in type I interferon production and response.

The Journal of biological chemistry

Wang R,Wang J,Acharya D,Paul AM,Bai F,Huang F,Guo YL

Fri Sep 05 00:00:00 EDT 2014

Bioinformatics

Protein Aliases: IFN o; IFN ω; IFN-omega 1, interferon omega-1; IFNo; IFNomega; IFNW; IFNω; Interferon alpha-II-1; Interferon o; Interferon OMEGA; Interferon omega-1; Interferon ω; interferon, omega 1