Product References
Reversion of breast epithelial polarity alterations caused by obesity.
NPJ breast cancer
Holmes J,Gaber M,Jenks MZ,Wilson A,Loy T,Lepetit C,Vitolins MZ,Herbert BS,Cook KL,Vidi PA
100-11 was used in In vitro experiments to show that obesity and/or dietary factors modulate tissue markers of risk.
Tue May 09 00:00:00 EDT 2023
A Cell-Based Assessment of the Muscle Anabolic Potential of Blue Whiting (Micromesistius poutassou) Protein Hydrolysates.
International journal of molecular sciences
Shekoohi N,Amigo-Benavent M,Wesley Peixoto da Fonseca G,Harnedy-Rothwell PA,FitzGerald RJ,Carson BP
100-11 was used in Cell Culture to investigate the impact of three different Blue whiting protein hydrolysates (BWPH-X, Y and Z) on growth, proliferation and muscle protein synthesis (MPS) in skeletal muscle (C2C12) myotubes.
Thu Jan 19 00:00:00 EST 2023
Differentiation state and culture conditions impact neural stem/progenitor cell-derived extracellular vesicle bioactivity.
Biomaterials science
Dutta D,Pirolli NH,Levy D,Tsao J,Seecharan N,Wang Z,Xu X,Jia X,Jay SM
100-11 was used in In vitro experiments to assess whether oligodendrocyte precursor cells and immature oligodendrocytes, which are further differentiated than neural progenitor/stem cells (NPSCs) and which both give rise to mature myelinating oligodendrocytes, could yield extracellular vesicles with neurotherapeutic properties comparable or superior to those from NPSCs.
Tue Aug 08 00:00:00 EDT 2023
ANGPTL2 binds MAG to efficiently enhance oligodendrocyte differentiation.
Cell & bioscience
Chen L,Yu Z,Xie L,He X,Mu X,Chen C,Yang W,Tong X,Liu J,Gao Z,Sun S,Xu N,Lu Z,Zheng J,Zhang Y
100-11 was used in Cell Culture to demonstrate an unexpected cross-talk between the environmental protein (ANGPTL2) and its surface receptor (MAG) in the regulation of oligodendrocyte differentiation, which may benefit the treatment of many demyelination disorders, including multiple sclerosis.
Tue Feb 28 00:00:00 EST 2023
C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.
iScience
Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y
100-11 was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.
Fri Oct 20 00:00:00 EDT 2023
The quality and quantity media-cultured mononuclear cell transplantation is safe and effective in ischemic hindlimb mouse model.
JVS-vascular science
Chinchalongporn W,Chruewkamlow N,Sermsathanasawadi N,Vorateera K,Jintaworn S,Wongwanit C,Ruangsetakit C
100-11 was used in Cell Culture to investigate in vitro proangiogenic and anti-inflammatory phenotypes and functions and the in vivo efficacy and safety of quality and quantity (QQ) media-cultured mononuclear cells (MNCs) compared with standard cultured MNCs from the peripheral blood of patients with chronic limb-threatening ischemia (CLTI) with atheosclerotic risk factors.
Tue Nov 14 00:00:00 EST 2023
Three-dimensional co-culture platform of human induced pluripotent stem cell-derived oligodendrocyte lineage cells and neurons for studying myelination.
STAR protocols
von der Bey M,De Cicco S,Zach S,Hengerer B,Ercan-Herbst E
100-11 was used in In vitro experiments to describe steps to differentiate hiPSCs into cortical neurons and oligodendrocyte lineage cells on 3D nanofibers.
Fri Mar 17 00:00:00 EDT 2023
A cholinergic neuroskeletal interface promotes bone formation during postnatal growth and exercise.
Cell stem cell
Gadomski S,Fielding C,García-García A,Korn C,Kapeni C,Ashraf S,Villadiego J,Toro RD,Domingues O,Skepper JN,Michel T,Zimmer J,Sendtner R,Dillon S,Poole KES,Holdsworth G,Sendtner M,Toledo-Aral JJ,De Bari C,McCaskie AW,Robey PG,Méndez-Ferrer S
100-11 was used in Cell Culture to uncover a cholinergic neuro-osteocyte interface that regulates skeletogenesis and skeletal turnover through bone-anabolic effects.
Thu Apr 07 00:00:00 EDT 2022
Long-term corneal recovery by simultaneous delivery of hPSC-derived corneal endothelial precursors and nicotinamide.
The Journal of clinical investigation
Li Z,Duan H,Jia Y,Zhao C,Li W,Wang X,Gong Y,Dong C,Ma B,Dou S,Zhang B,Li D,Cao Y,Xie L,Zhou Q,Shi W
Tue Jan 04 00:00:00 EST 2022
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
EMBO reports
Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB
100-11 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.
Thu Feb 03 00:00:00 EST 2022
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
EMBO reports
Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB
100-11 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.
Thu Feb 03 00:00:00 EST 2022
Growth factors-based platelet lysate rejuvenates skin against ageing through NF-κB signalling pathway: In vitro and in vivo mechanistic and clinical studies.
Cell proliferation
Li T,Lu H,Zhou L,Jia M,Zhang L,Wu H,Shan L
Fri Apr 01 00:00:00 EDT 2022
IGF-1 regulates astrocytic phagocytosis and inflammation through the p110α isoform of PI3K in a sex-specific manner.
Glia
Pinto-Benito D,Paradela-Leal C,Ganchala D,de Castro-Molina P,Arevalo MA
100-11 was used in Cell Culture to investigate IGF-1 regulation of phagocytosis via PI3K.
Wed Jun 01 00:00:00 EDT 2022
Patient-specific, re-engineered cardiomyocyte model confirms the circumstance-dependent arrhythmia risk associated with the African-specific common SCN5A polymorphism p.S1103Y: Implications for the increased sudden deaths observed in black individuals during the COVID-19 pandemic.
Heart rhythm
Hamrick SK,John Kim CS,Tester DJ,Giudicessi JR,Ackerman MJ
100-11 was used in Cell Culture to ascertain the effects of acidosis and hydroxychloroquine (HCQ) on the action potential duration (APD) in a patient-specific induced pluripotent stem cell-derived cardiomyocyte (iPSC-CM) model of p.S1103Y-SCN5A.
Sun May 01 00:00:00 EDT 2022
A dual role for the RNA helicase DHX34 in NMD and pre-mRNA splicing and its function in hematopoietic differentiation.
RNA (New York, N.Y.)
Hug N,Aitken S,Longman D,Raab M,Armes H,Mann AR,Rio-Machin A,Fitzgibbon J,Rouault-Pierre K,Cáceres JF
100-11 was used in In vitro experiments to investigate NMD factors and the role of DNX34 in the spliceosome.
Thu Sep 01 00:00:00 EDT 2022
Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.
JID innovations : skin science from molecules to population health
Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH
100-11 was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.
Sat Jan 01 00:00:00 EST 2022
Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
Cancer discovery
Fonteneau G,Redding A,Hoag-Lee H,Sim ES,Heinrich S,Gaida MM,Grabocka E
100-11 was used in In vitro experiments to show that stress adaptation via the phase-separation organelles stress granules (SGs) mediates pancreatic ductal adenocarcinoma (PDAC) development.
Fri Aug 05 00:00:00 EDT 2022
OCT4-induced oligodendrocyte progenitor cells promote remyelination and ameliorate disease.
NPJ Regenerative medicine
Yun W,Choi KA,Hwang I,Zheng J,Park M,Hong W,Jang AY,Kim JH,Choi W,Kim DS,Kim IY,Kim YJ,Liu Y,Yoon BS,Park G,Song G,Hong S,You S
Thu Jan 13 00:00:00 EST 2022
Expression of Lineage Transcription Factors Identifies Differences in Transition States of Induced Human Oligodendrocyte Differentiation.
Cells
Raabe FJ,Stephan M,Waldeck JB,Huber V,Demetriou D,Kannaiyan N,Galinski S,Glaser LV,Wehr MC,Ziller MJ,Schmitt A,Falkai P,Rossner MJ
100-11 was used in In vitro experiments to highlight that TFs for generating iOPCs or iOLs should be chosen depending on the intended application or research question, and that SON might be beneficial to study more mature iOLs while S might be better suited to investigate iOPC biology.
Tue Jan 11 00:00:00 EST 2022
Artesunate inhibits proliferation and migration of RPE cells and TGF-β2 mediated epithelial mesenchymal transition by suppressing PI3K/AKT pathway.
International journal of ophthalmology
Wang ZY,Zhang Y,Wu LD,Chen J,Chen ML,Chen CM,Xu QH
100-11 was used in Cell Culture to indicate that PI3K/.
Wed Feb 23 00:00:00 EST 2022
Differentiation and CRISPR-Cas9-mediated genetic engineering of human intestinal organoids.
STAR protocols
Martinez-Silgado A,Yousef Yengej FA,Puschhof J,Geurts V,Boot C,Geurts MH,Rookmaaker MB,Verhaar MC,Beumer J,Clevers H
100-11 was used in In vitro experiments to investigate the effects of BMP agonists on differentiation of human small intestinal organoids.
Fri Sep 16 00:00:00 EDT 2022
Population-based high-throughput toxicity screen of human iPSC-derived cardiomyocytes and neurons.
Cell reports
Huang CY,Nicholson MW,Wang JY,Ting CY,Tsai MH,Cheng YC,Liu CL,Chan DZH,Lee YC,Hsu CC,Hsu YH,Yang CF,Chang CMC,Ruan SC,Lin PJ,Lin JH,Chen LL,Hsieh ML,Cheng YY,Hsu WT,Lin YL,Chen CH,Hsu YH,Wu YT,Hacker TA,Wu JC,Kamp TJ,Hsieh PCH
100-11 was used in Cell Culture to study a a population-based human induced pluripotent stem cell (hiPSC) drug screening platform for toxicity assessment.
Tue Apr 05 00:00:00 EDT 2022
CRISPR/Cas9-mediated deletion of Interleukin-30 suppresses IGF1 and CXCL5 and boosts SOCS3 reducing prostate cancer growth and mortality.
Journal of hematology & oncology
Sorrentino C,D'Antonio L,Ciummo SL,Fieni C,Landuzzi L,Ruzzi F,Vespa S,Lanuti P,Lotti LV,Lollini PL,Di Carlo E
100-11 was used in In vitro experiments to shed light on the relationship between IL30 and canonical prostate cancer driver genes and explore the anti-tumour potential of CRISPR/Cas9-mediated deletion of IL30.
Thu Oct 13 00:00:00 EDT 2022
Microarrayed human bone marrow organoids for modeling blood stem cell dynamics.
APL bioengineering
Giger S,Hofer M,Miljkovic-Licina M,Hoehnel S,Brandenberg N,Guiet R,Ehrbar M,Kleiner E,Gegenschatz-Schmid K,Matthes T,Lutolf MP
100-11 was used in Sample Preparation (FC/FACS) to propose an organoid system as a preclinical model for pharmacokinetic assays and toxicity studies of novel drugs in a bone marrow niche-mimicking 3D environment.
Thu Sep 01 00:00:00 EDT 2022
RAB31 marks and controls an ESCRT-independent exosome pathway.
Cell research
Wei D,Zhan W,Gao Y,Huang L,Gong R,Wang W,Zhang R,Wu Y,Gao S,Kang T
Mon Feb 01 00:00:00 EST 2021
H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model.
Cancer cell
Haag D,Mack N,Benites Goncalves da Silva P,Statz B,Clark J,Tanabe K,Sharma T,Jäger N,Jones DTW,Kawauchi D,Wernig M,Pfister SM
Mon Mar 08 00:00:00 EST 2021
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape.
Cell metabolism
Salvadori G,Zanardi F,Iannelli F,Lobefaro R,Vernieri C,Longo VD
100-11 was used in Cell Culture to investigate fast-mimicking diet in tripe-negative breast cancer treatment.
Tue Nov 02 00:00:00 EDT 2021
Fasting-mimicking diet blocks triple-negative breast cancer and cancer stem cell escape.
Cell metabolism
Salvadori G,Zanardi F,Iannelli F,Lobefaro R,Vernieri C,Longo VD
100-11 was used in Cell Culture to investigate fast-mimicking diet in tripe-negative breast cancer treatment.
Tue Nov 02 00:00:00 EDT 2021
SARS-CoV-2 infection induces beta cell transdifferentiation.
Cell metabolism
Tang X,Uhl S,Zhang T,Xue D,Li B,Vandana JJ,Acklin JA,Bonnycastle LL,Narisu N,Erdos MR,Bram Y,Chandar V,Chong ACN,Lacko LA,Min Z,Lim JK,Borczuk AC,Xiang J,Naji A,Collins FS,Evans T,Liu C,tenOever BR,Schwartz RE,Chen S
Tue Aug 03 00:00:00 EDT 2021
Human Stem Cell-Derived Neurons Repair Circuits and Restore Neural Function.
Cell stem cell
Xiong M,Tao Y,Gao Q,Feng B,Yan W,Zhou Y,Kotsonis TA,Yuan T,You Z,Wu Z,Xi J,Haberman A,Graham J,Block J,Zhou W,Chen Y,Zhang SC
Thu Jan 07 00:00:00 EST 2021
Principles of signaling pathway modulation for enhancing human naive pluripotency induction.
Cell stem cell
Bayerl J,Ayyash M,Shani T,Manor YS,Gafni O,Massarwa R,Kalma Y,Aguilera-Castrejon A,Zerbib M,Amir H,Sheban D,Geula S,Mor N,Weinberger L,Naveh Tassa S,Krupalnik V,Oldak B,Livnat N,Tarazi S,Tawil S,Wildschutz E,Ashouokhi S,Lasman L,Rotter V,Hanna S,Ben-Yosef D,Novershtern N,Viukov S,Hanna JH
Thu Sep 02 00:00:00 EDT 2021
Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival.
Developmental cell
Gagliardi PA,Dobrzyński M,Jacques MA,Dessauges C,Ender P,Blum Y,Hughes RM,Cohen AR,Pertz O
Mon Jun 21 00:00:00 EDT 2021
Long-term effects of human induced pluripotent stem cell-derived retinal cell transplantation in Pde6b knockout rats.
Experimental & molecular medicine
Yang JM,Chung S,Yun K,Kim B,So S,Kang S,Kang E,Lee JY
Thu Apr 01 00:00:00 EDT 2021
Convergent genomic and pharmacological evidence of PI3K/GSK3 signaling alterations in neurons from schizophrenia patients.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
Stertz L,Di Re J,Pei G,Fries GR,Mendez E,Li S,Smith-Callahan L,Raventos H,Tipo J,Cherukuru R,Zhao Z,Liu Y,Jia P,Laezza F,Walss-Bass C
Mon Feb 01 00:00:00 EST 2021
Ex vivo conditioning of peripheral blood mononuclear cells of diabetic patients promotes vasculogenic wound healing.
Stem cells translational medicine
Tanaka R,Ito-Hirano R,Fujimura S,Arita K,Hagiwara H,Mita T,Itoh M,Kawaji H,Ogawa T,Watada H,Masuda H,Asahara T,Mizuno H
Tue Jun 01 00:00:00 EDT 2021
Berberine Suppresses EMT in Liver and Gastric Carcinoma Cells through Combination with TGFβR Regulating TGF-β/Smad Pathway.
Oxidative medicine and cellular longevity
Du H,Gu J,Peng Q,Wang X,Liu L,Shu X,He Q,Tan Y
Mon Feb 07 00:00:00 EST 2022
Three-dimensional migration of human amniotic fluid stem cells involves mesenchymal and amoeboid modes and is regulated by mTORC1.
Stem cells (Dayton, Ohio)
Rosner M,Hengstschläger M
Wed Dec 01 00:00:00 EST 2021
IGF-I and NGFβ enhance in vitro progressive motility and vitality of human spermatozoa.
Reproductive medicine and biology
Asimakopoulos B,Tiptiri-Kourpeti A,Metallinou C
Thu Jul 01 00:00:00 EDT 2021
Role of PI3K/AKT Signaling Pathway in Nucleus Pulposus Cells.
BioMed research international
Xiao Q,Teng Y,Xu C,Pan W,Yang H,Zhao J,Zhou Q
Wed Sep 22 00:00:00 EDT 2021
Electroacupuncture Promotes the Survival of the Grafted Human MGE Neural Progenitors in Rats with Cerebral Ischemia by Promoting Angiogenesis and Inhibiting Inflammation.
Neural plasticity
Li J,Chen L,Li D,Lu M,Huang X,Han X,Chen H
Wed Mar 02 00:00:00 EST 2022
Sarcomere function activates a p53-dependent DNA damage response that promotes polyploidization and limits in vivo cell engraftment.
Cell reports
Pettinato AM,Yoo D,VanOudenhove J,Chen YS,Cohn R,Ladha FA,Yang X,Thakar K,Romano R,Legere N,Meredith E,Robson P,Regnier M,Cotney JL,Murry CE,Hinson JT
Tue May 04 00:00:00 EDT 2021
Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.
Nature communications
Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H
Fri May 21 00:00:00 EDT 2021
Chemically defined and xeno-free culture condition for human extended pluripotent stem cells.
Nature communications
Liu B,Chen S,Xu Y,Lyu Y,Wang J,Du Y,Sun Y,Liu H,Zhou H,Lai W,Xue A,Yin M,Li C,Bai Y,Xu J,Deng H
Fri May 21 00:00:00 EDT 2021
Histone H4 lysine 16 acetylation controls central carbon metabolism and diet-induced obesity in mice.
Nature communications
Pessoa Rodrigues C,Chatterjee A,Wiese M,Stehle T,Szymanski W,Shvedunova M,Akhtar A
Wed Oct 27 00:00:00 EDT 2021
Transcriptional networks identify synaptotagmin-like 3 as a regulator of cortical neuronal migration during early neurodevelopment.
Cell reports
Dong X,Yang L,Liu K,Ji X,Tang C,Li W,Ma L,Mei Y,Peng T,Feng B,Wu Z,Tang Q,Gao Y,Yan K,Zhou W,Xiong M
Tue Mar 02 00:00:00 EST 2021
One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2.
Stem cell reports
Chanoumidou K,Hernández-Rodríguez B,Windener F,Thomas C,Stehling M,Mozafari S,Albrecht S,Ottoboni L,Antel J,Kim KP,Velychko S,Cui QL,Xu YKT,Martino G,Winkler J,Schöler HR,Baron-Van Evercooren A,Boespflug-Tanguy O,Vaquerizas JM,Ehrlich M,Kuhlmann T
Tue Apr 13 00:00:00 EDT 2021
Bioengineered model of the human motor unit with physiologically functional neuromuscular junctions.
Scientific reports
Rimington RP,Fleming JW,Capel AJ,Wheeler PC,Lewis MP
Thu Jun 03 00:00:00 EDT 2021
Optimization of Neurite Tracing and Further Characterization of Human Monocyte-Derived-Neuronal-like Cells.
Brain sciences
Bellon A,Hasoglu T,Peterson M,Gao K,Chen M,Blandin E,Cortez-Resendiz A,Clawson GA,Hong LE
100-11 was used in Cell Culture to transdifferentiate monocytes to neuronal-like cells with a rapid new protocol.
Wed Oct 20 00:00:00 EDT 2021
Protocol for establishing organoids from human ovarian cancer biopsies.
STAR protocols
Maenhoudt N,Vankelecom H
100-11 was used in Cell Culture to provide a detailed protocol for establishing organoid cultures from patient OC biopsies.
Fri Jun 18 00:00:00 EDT 2021
Cilium induction triggers differentiation of glioma stem cells.
Cell reports
Goranci-Buzhala G,Mariappan A,Ricci-Vitiani L,Josipovic N,Pacioni S,Gottardo M,Ptok J,Schaal H,Callaini G,Rajalingam K,Dynlacht B,Hadian K,Papantonis A,Pallini R,Gopalakrishnan J
Tue Sep 07 00:00:00 EDT 2021
AKT3 Expression in Mesenchymal Colorectal Cancer Cells Drives Growth and Is Associated with Epithelial-Mesenchymal Transition.
Cancers
Buikhuisen JY,Gomez Barila PM,Torang A,Dekker D,de Jong JH,Cameron K,Vitale S,Stassi G,van Hooff SR,Castro MAA,Vermeulen L,Medema JP
100-11 was used in In vitro experiments to investigate the role of CMS4 signalling on colorectal cancer phenotypes.
Sun Feb 14 00:00:00 EST 2021
Autologous transplantation of thecal stem cells restores ovarian function in nonhuman primates.
Cell discovery
Chen H,Xia K,Huang W,Li H,Wang C,Ma Y,Chen J,Luo P,Zheng S,Wang J,Wang Y,Dong L,Tan Z,Lai X,Mao FF,Li W,Liang X,Wang T,Xiang AP,Ke Q
Tue Aug 31 00:00:00 EDT 2021
Upregulation of LINC01426 promotes the progression and stemness in lung adenocarcinoma by enhancing the level of SHH protein to activate the hedgehog pathway.
Cell death & disease
Liu X,Yin Z,Xu L,Liu H,Jiang L,Liu S,Sun X
Wed Feb 10 00:00:00 EST 2021
IFITM proteins promote SARS-CoV-2 infection and are targets for virus inhibition in vitro.
Nature communications
Prelli Bozzo C,Nchioua R,Volcic M,Koepke L,Krüger J,Schütz D,Heller S,Stürzel CM,Kmiec D,Conzelmann C,Müller J,Zech F,Braun E,Groß R,Wettstein L,Weil T,Weiß J,Diofano F,Rodríguez Alfonso AA,Wiese S,Sauter D,Münch J,Goffinet C,Catanese A,Schön M,Boeckers TM,Stenger S,Sato K,Just S,Kleger A,Sparrer KMJ,Kirchhoff F
Wed Jul 28 00:00:00 EDT 2021
Deep learning-based predictive identification of neural stem cell differentiation.
Nature communications
Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R
100-11 was used in Cell Culture to showcase effectiveness of deep learning-based platform in precisely, accurately and robustly detecting NSC differentiation.
Mon May 10 00:00:00 EDT 2021
Deep learning-based predictive identification of neural stem cell differentiation.
Nature communications
Zhu Y,Huang R,Wu Z,Song S,Cheng L,Zhu R
100-11 was used in Cell Culture to showcase effectiveness of deep learning-based platform in precisely, accurately and robustly detecting NSC differentiation.
Mon May 10 00:00:00 EDT 2021
Directed Differentiation of Human Pluripotent Stem Cells toward Skeletal Myogenic Progenitors and Their Purification Using Surface Markers.
Cells
Xu N,Wu J,Ortiz-Vitali JL,Li Y,Darabi R
100-11 was used in In vitro experiments to develop an improved directed differentiation method for the derivation of skeletal myogenic progenitors from Human Pluripotent Stem Cells.
Thu Oct 14 00:00:00 EDT 2021
Brain endothelial PTEN/AKT/NEDD4-2/MFSD2A axis regulates blood-brain barrier permeability.
Cell reports
Cui Y,Wang Y,Song X,Ning H,Zhang Y,Teng Y,Wang J,Yang X
Tue Jul 06 00:00:00 EDT 2021
GOLPH3/CKAP4 promotes metastasis and tumorigenicity by enhancing the secretion of exosomal WNT3A in non-small-cell lung cancer.
Cell death & disease
Song JW,Zhu J,Wu XX,Tu T,Huang JQ,Chen GZ,Liang LY,Zhou CH,Xu X,Gong LY
Thu Oct 21 00:00:00 EDT 2021
Molecular and cellular basis of hyperassembly and protein aggregation driven by a rare pathogenic mutation in DDX3X.
iScience
de Castro Fonseca M,de Oliveira JF,Araujo BHS,Canateli C,do Prado PFV,Amorim Neto DP,Bosque BP,Rodrigues PV,de Godoy JVP,Tostes K,Filho HVR,Nascimento AFZ,Saito A,Tonoli CCC,Batista FAH,de Oliveira PSL,Figueira AC,Souza da Costa S,Krepischi ACV,Rosenberg C,Westfahl H,da Silva AJR,Franchini KG
Fri Aug 20 00:00:00 EDT 2021
CODEX, a neural network approach to explore signaling dynamics landscapes.
Molecular systems biology
Jacques MA,Dobrzyński M,Gagliardi PA,Sznitman R,Pertz O
Thu Apr 01 00:00:00 EDT 2021
EWSR1-WT1 Target Genes and Therapeutic Options Identified in a Novel DSRCT In Vitro Model.
Cancers
Bleijs M,Pleijte C,Engels S,Ringnalda F,Meyer-Wentrup F,van de Wetering M,Clevers H
100-11 was used in Cell Culture to investigate potential treatment for desmoplastic small round cell tumour.
Thu Dec 02 00:00:00 EST 2021
Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices.
Cells
Walz M,Höflich C,Walz C,Ohde D,Brenmoehl J,Sawitzky M,Vernunft A,Zettl UK,Holtze S,Hildebrandt TB,Wolf E,Hoeflich A
100-11 was used in In vitro experiments to develop a bioassay for assessing the IGF-related activation of the AKT/mTOR pathway.
Wed Feb 24 00:00:00 EST 2021
Development of a Sensitive Bioassay for the Analysis of IGF-Related Activation of AKT/mTOR Signaling in Biological Matrices.
Cells
Walz M,Höflich C,Walz C,Ohde D,Brenmoehl J,Sawitzky M,Vernunft A,Zettl UK,Holtze S,Hildebrandt TB,Wolf E,Hoeflich A
100-11 was used in In vitro experiments to develop a bioassay for assessing the IGF-related activation of the AKT/mTOR pathway.
Wed Feb 24 00:00:00 EST 2021
Novel culture media enhances mononuclear cells from patients with chronic limb-threatening ischemia to increase vasculogenesis and anti-inflammatory effect.
Stem cell research & therapy
Chruewkamlow N,Pruekprasert K,Phutthakunphithak P,Acharayothin O,Prapassaro T,Hongku K,Hahtapornsawan S,Puangpunngam N,Chinsakchai K,Wongwanit C,Ruangsetakit C,Sermsathanasawadi N
100-11 was used in In vitro experiments to evaluate the use of Quality and Quantity culture media to culture mononuclear cells from chronic limb-threatening ischemia patients.
Tue Sep 28 00:00:00 EDT 2021
Patient-derived iPSC-cerebral organoid modeling of the 17q11.2 microdeletion syndrome establishes CRLF3 as a critical regulator of neurogenesis.
Cell reports
Wegscheid ML,Anastasaki C,Hartigan KA,Cobb OM,Papke JB,Traber JN,Morris SM,Gutmann DH
Tue Jul 06 00:00:00 EDT 2021
BMSC-derived extracellular vesicles intervened the pathogenic changes of scleroderma in mice through miRNAs.
Stem cell research & therapy
Jin J,Ou Q,Wang Z,Tian H,Xu JY,Gao F,Hu S,Chen J,Wang J,Zhang J,Lu L,Jin C,Xu GT,Zhao J
100-11 was used in Cell Culture to investigate development of skin cells and bone-marrow mesenchymal stem cells in systemic sclerosis.
Sat Jun 05 00:00:00 EDT 2021
Adaptable haemodynamic endothelial cells for organogenesis and tumorigenesis.
Nature
Palikuqi B,Nguyen DT,Li G,Schreiner R,Pellegata AF,Liu Y,Redmond D,Geng F,Lin Y,Gómez-Salinero JM,Yokoyama M,Zumbo P,Zhang T,Kunar B,Witherspoon M,Han T,Tedeschi AM,Scottoni F,Lipkin SM,Dow L,Elemento O,Xiang JZ,Shido K,Spence JR,Zhou QJ,Schwartz RE,De Coppi P,Rabbany SY,Rafii S
Tue Sep 01 00:00:00 EDT 2020
Astrocytic trans-Differentiation Completes a Multicellular Paracrine Feedback Loop Required for Medulloblastoma Tumor Growth.
Cell
Yao M,Ventura PB,Jiang Y,Rodriguez FJ,Wang L,Perry JSA,Yang Y,Wahl K,Crittenden RB,Bennett ML,Qi L,Gong CC,Li XN,Barres BA,Bender TP,Ravichandran KS,Janes KA,Eberhart CG,Zong H
Thu Feb 06 00:00:00 EST 2020
An Important Role for DNMT3A-Mediated DNA Methylation in Cardiomyocyte Metabolism and Contractility.
Circulation
Madsen A,Höppner G,Krause J,Hirt MN,Laufer SD,Schweizer M,Tan WLW,Mosqueira D,Anene-Nzelu CG,Lim I,Foo RSY,Hansen A,Eschenhagen T,Stenzig J
100-11 was used in In vitro experiments to investigate the role of DNA methylation in the normal homeostasis of cardiomyocytes and during cardiac stress.
Tue Oct 20 00:00:00 EDT 2020
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer.
Signal transduction and targeted therapy
Zheng Y,Wu C,Yang J,Zhao Y,Jia H,Xue M,Xu D,Yang F,Fu D,Wang C,Hu B,Zhang Z,Li T,Yan S,Wang X,Nelson PJ,Bruns C,Qin L,Dong Q
Wed May 13 00:00:00 EDT 2020
Naive Pluripotent Stem Cells Exhibit Phenotypic Variability that Is Driven by Genetic Variation.
Cell stem cell
Ortmann D,Brown S,Czechanski A,Aydin S,Muraro D,Huang Y,Tomaz RA,Osnato A,Canu G,Wesley BT,Skelly DA,Stegle O,Choi T,Churchill GA,Baker CL,Rugg-Gunn PJ,Munger SC,Reinholdt LG,Vallier L
100-11 was used in Cell Culture to investigate the variability in experimental reproducibility of pluripotent stem cell lines in mice.
Thu Sep 03 00:00:00 EDT 2020
Cystatin B is essential for proliferation and interneuron migration in individuals with EPM1 epilepsy.
EMBO molecular medicine
Di Matteo F,Pipicelli F,Kyrousi C,Tovecci I,Penna E,Crispino M,Chambery A,Russo R,Ayo-Martin AC,Giordano M,Hoffmann A,Ciusani E,Canafoglia L,Götz M,Di Giaimo R,Cappello S
Mon Jun 08 00:00:00 EDT 2020
Metabolic Regulation of Inflammasome Activity Controls Embryonic Hematopoietic Stem and Progenitor Cell Production.
Developmental cell
Frame JM,Kubaczka C,Long TL,Esain V,Soto RA,Hachimi M,Jing R,Shwartz A,Goessling W,Daley GQ,North TE
100-11 was used in In vitro experiments to establish the inflammasome as a conserved metabolic sensor that expands HSPC production in vivo and in vitro.
Mon Oct 26 00:00:00 EDT 2020
Hyaluronate supports hESC-cardiomyocyte cell therapy for cardiac regeneration after acute myocardial infarction.
Cell proliferation
Tan Y,Wang L,Chen G,Liu W,Li Z,Wang Y,Wang L,Li W,Wu J,Hao J
Tue Dec 01 00:00:00 EST 2020
Aspirin sensitizes osimertinib-resistant NSCLC cells in vitro and in vivo via Bim-dependent apoptosis induction.
Molecular oncology
Han R,Hao S,Lu C,Zhang C,Lin C,Li L,Wang Y,Hu C,He Y
Mon Jun 01 00:00:00 EDT 2020
USP15 promotes the apoptosis of degenerative nucleus pulposus cells by suppressing the PI3K/AKT signalling pathway.
Journal of cellular and molecular medicine
Yu B,Shen B,Ba Z,Liu Z,Yuan J,Zhao W,Wu D
Tue Dec 01 00:00:00 EST 2020
Odontogenesis and neuronal differentiation characteristics of periodontal ligament stem cells from beagle dog.
Journal of cellular and molecular medicine
Li X,Liao D,Sun G,Chu H
Fri May 01 00:00:00 EDT 2020
Hybrid cardiovascular sourced extracellular matrix scaffolds as possible platforms for vascular tissue engineering.
Journal of biomedical materials research. Part B, Applied biomaterials
Reid JA,Callanan A
Wed Apr 01 00:00:00 EDT 2020
Calpain system is altered in survival motor neuron-reduced cells from in vitro and in vivo spinal muscular atrophy models.
Cell death & disease
de la Fuente S,Sansa A,Hidalgo I,Vivancos N,Romero-Guevara R,Garcera A,Soler RM
Thu Jun 25 00:00:00 EDT 2020
LncRNA TMPO-AS1 promotes hepatocellular carcinoma cell proliferation, migration and invasion through sponging miR-329-3p to stimulate FOXK1-mediated AKT/mTOR signaling pathway.
Cancer medicine
Guo X,Wang Y
Wed Jul 01 00:00:00 EDT 2020
Growth factors-based beneficial effects of platelet lysate on umbilical cord-derived stem cells and their synergistic use in osteoarthritis treatment.
Cell death & disease
Yan L,Zhou L,Yan B,Zhang L,Du W,Liu F,Yuan Q,Tong P,Shan L,Efferth T
Wed Oct 14 00:00:00 EDT 2020
Synergistic effect of fasting-mimicking diet and vitamin C against KRAS mutated cancers.
Nature communications
Di Tano M,Raucci F,Vernieri C,Caffa I,Buono R,Fanti M,Brandhorst S,Curigliano G,Nencioni A,de Braud F,Longo VD
Mon May 11 00:00:00 EDT 2020
Dysregulation of BRD4 Function Underlies the Functional Abnormalities of MeCP2 Mutant Neurons.
Molecular cell
Xiang Y,Tanaka Y,Patterson B,Hwang SM,Hysolli E,Cakir B,Kim KY,Wang W,Kang YJ,Clement EM,Zhong M,Lee SH,Cho YS,Patra P,Sullivan GJ,Weissman SM,Park IH
100-11 was used in In vitro experiments to study the function of methyl-CpG binding protein 2 (MeCP2) using 2D and 3D human brain cultures.
Thu Jul 02 00:00:00 EDT 2020
Oncogenic mutant RAS signaling activity is rescaled by the ERK/MAPK pathway.
Molecular systems biology
Gillies TE,Pargett M,Silva JM,Teragawa CK,McCormick F,Albeck JG
Thu Oct 01 00:00:00 EDT 2020
Nuclear interacting SET domain protein 1 inactivation impairs GATA1-regulated erythroid differentiation and causes erythroleukemia.
Nature communications
Leonards K,Almosailleakh M,Tauchmann S,Bagger FO,Thirant C,Juge S,Bock T,Méreau H,Bezerra MF,Tzankov A,Ivanek R,Losson R,Peters AHFM,Mercher T,Schwaller J
Fri Jun 12 00:00:00 EDT 2020
Vav2 catalysis-dependent pathways contribute to skeletal muscle growth and metabolic homeostasis.
Nature communications
Rodríguez-Fdez S,Lorenzo-Martín LF,Fernández-Pisonero I,Porteiro B,Veyrat-Durebex C,Beiroa D,Al-Massadi O,Abad A,Diéguez C,Coppari R,Nogueiras R,Bustelo XR
Mon Nov 16 00:00:00 EST 2020
IGF-1 Signalling Regulates Mitochondria Dynamics and Turnover through a Conserved GSK-3β-Nrf2-BNIP3 Pathway.
Cells
Riis S,Murray JB,O'Connor R
100-11 was used in Cell Culture to investigate the mechanisms involved in IGF-1 leading to BNIP3 induction.
Wed Jan 08 00:00:00 EST 2020
Glutamate-glutamine homeostasis is perturbed in neurons and astrocytes derived from patient iPSC models of frontotemporal dementia.
Molecular brain
Aldana BI,Zhang Y,Jensen P,Chandrasekaran A,Christensen SK,Nielsen TT,Nielsen JE,Hyttel P,Larsen MR,Waagepetersen HS,Freude KK
100-11 was used in Cell Culture to study changes in metabolism at a cellular level which are implicated in frontotemporal dementia (FTD) and in neurodegeneration.
Mon Sep 14 00:00:00 EDT 2020
Modulating electrospun polycaprolactone scaffold morphology and composition to alter endothelial cell proliferation and angiogenic gene response.
PloS one
Reid JA,McDonald A,Callanan A
Tue Dec 08 00:00:00 EST 2020
Sirt6 promotes tumorigenesis and drug resistance of diffuse large B-cell lymphoma by mediating PI3K/Akt signaling.
Journal of experimental & clinical cancer research : CR
Yang J,Li Y,Zhang Y,Fang X,Chen N,Zhou X,Wang X
100-11 was used in Cell Culture to study the expression and functions of Sirt6 in diffuse large B-cell lymphoma (DLBCL) and in response to the regulatory role of the OSS_128167 small molecular inhibitor targeting Sirt6.
Sat Jul 25 00:00:00 EDT 2020
Efficient Neural Differentiation using Single-Cell Culture of Human Embryonic Stem Cells.
Journal of visualized experiments : JoVE
Jeon K,Park K,Jetten AM
100-11 was used in In vitro experiments to study inefficient and time-cosuming standard approaches for human embryonic stem cell (hESC) culture using colony type culture to maintain undifferentiated hESCs and embryoid body (EB) and rosette formation for differentiation into different germ layers to instead present a single-cell culture method using hESCs instead of a colony-type culture.
Sat Jan 18 00:00:00 EST 2020
PKM2 Determines Myofiber Hypertrophy In Vitro and Increases in Response to Resistance Exercise in Human Skeletal Muscle.
International journal of molecular sciences
Verbrugge SAJ,Gehlert S,Stadhouders LEM,Jacko D,Aussieker T,M J de Wit G,Vogel ISP,Offringa C,Schönfelder M,Jaspers RT,Wackerhage H
100-11 was used in Cell Culture to conclude that PKM2 contributes to hypertrophy in C2C12 myotubes and indicates a changed metabolic environment within hypertrophying human skeletal muscle fibers.
Fri Sep 25 00:00:00 EDT 2020
Genetic aberrations in iPSCs are introduced by a transient G1/S cell cycle checkpoint deficiency.
Nature communications
Araki R,Hoki Y,Suga T,Obara C,Sunayama M,Imadome K,Fujita M,Kamimura S,Nakamura M,Wakayama S,Nagy A,Wakayama T,Abe M
Fri Jan 10 00:00:00 EST 2020
Gab1 mediates PDGF signaling and is essential to oligodendrocyte differentiation and CNS myelination.
eLife
Zhou L,Shao CY,Xie YJ,Wang N,Xu SM,Luo BY,Wu ZY,Ke YH,Qiu M,Shen Y
100-11 was used in Sample Preparation (Western Blotting) to investigate platelet-derived growth factor signaling in oligodendrocyte precursor cells.
Thu Jan 16 00:00:00 EST 2020
A 13-plex of tetra- and penta-STRs to identify zebrafish.
Scientific reports
Venta PJ,Nguyen AK,Senut MC,Poulos WG,Prukudom S,Cibelli JB
Mon Mar 02 00:00:00 EST 2020
Methylation Status of the Nanog Promoter Determines the Switch between Cancer Cells and Cancer Stem Cells.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Liu S,Cheng K,Zhang H,Kong R,Wang S,Mao C,Liu S
Sun Mar 01 00:00:00 EST 2020
Umbilical cord tissue is a robust source for mesenchymal stem cells with enhanced myogenic differentiation potential compared to cord blood.
Scientific reports
Mishra S,Sevak JK,Das A,Arimbasseri GA,Bhatnagar S,Gopinath SD
Wed Nov 04 00:00:00 EST 2020
Sequentially induced motor neurons from human fibroblasts facilitate locomotor recovery in a rodent spinal cord injury model.
eLife
Lee H,Lee HY,Lee BE,Gerovska D,Park SY,Zaehres H,Araúzo-Bravo MJ,Kim JI,Ha Y,Schöler HR,Kim JB
100-11 was used in Cell Culture to investigate the use of induced motor neurons to treat spinal cord injury.
Tue Jun 23 00:00:00 EDT 2020
FUS-mediated regulation of acetylcholine receptor transcription at neuromuscular junctions is compromised in amyotrophic lateral sclerosis.
Nature neuroscience
Picchiarelli G,Demestre M,Zuko A,Been M,Higelin J,Dieterlé S,Goy MA,Mallik M,Sellier C,Scekic-Zahirovic J,Zhang L,Rosenbohm A,Sijlmans C,Aly A,Mersmann S,Sanjuan-Ruiz I,Hübers A,Messaddeq N,Wagner M,van Bakel N,Boutillier AL,Ludolph A,Lagier-Tourenne C,Boeckers TM,Dupuis L,Storkebaum E
100-11 was used in Cell Culture to conclude that FUS regulates acetylcholine receptor gene expression in subsynaptic myonuclei, and muscle-intrinsic toxicity of ALS mutant FUS may contribute to dying-back motor neuronopathy.
Fri Nov 01 00:00:00 EDT 2019
Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation.
Cell stem cell
Nobuta H,Yang N,Ng YH,Marro SG,Sabeur K,Chavali M,Stockley JH,Killilea DW,Walter PB,Zhao C,Huie P,Goldman SA,Kriegstein AR,Franklin RJM,Rowitch DH,Wernig M
100-11 was used in Cell Culture to demonstrate that patient-derived oligodendrocytes can develop to the pre-myelinating stage, but subsequently undergo cell death using induced pluripotent stem cell (iPSC) and gene-correction.
Thu Oct 03 00:00:00 EDT 2019
PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease.
The Journal of clinical investigation
Li Y,Hu Q,Li C,Liang K,Xiang Y,Hsiao H,Nguyen TK,Park PK,Egranov SD,Ambati CR,Putluri N,Hawke DH,Han L,Hung MC,Danesh FR,Yang L,Lin C
Fri Mar 01 00:00:00 EST 2019
Loss of Adaptive Myelination Contributes to Methotrexate Chemotherapy-Related Cognitive Impairment.
Neuron
Geraghty AC,Gibson EM,Ghanem RA,Greene JJ,Ocampo A,Goldstein AK,Ni L,Yang T,Marton RM,Paşca SP,Greenberg ME,Longo FM,Monje M
Wed Jul 17 00:00:00 EDT 2019
Elevating Growth Factor Responsiveness and Axon Regeneration by Modulating Presynaptic Inputs.
Neuron
Zhang Y,Williams PR,Jacobi A,Wang C,Goel A,Hirano AA,Brecha NC,Kerschensteiner D,He Z
Wed Jul 03 00:00:00 EDT 2019
Familial t(1;11) translocation is associated with disruption of white matter structural integrity and oligodendrocyte-myelin dysfunction.
Molecular psychiatry
Vasistha NA,Johnstone M,Barton SK,Mayerl SE,Thangaraj Selvaraj B,Thomson PA,Dando O,Grünewald E,Alloza C,Bastin ME,Livesey MR,Economides K,Magnani D,Makedonopolou P,Burr K,Story DJ,Blackwood DHR,Wyllie DJA,McIntosh AM,Millar JK,Ffrench-Constant C,Hardingham GE,Lawrie SM,Chandran S
Fri Nov 01 00:00:00 EDT 2019
Parity predisposes breasts to the oncogenic action of PAPP-A and activation of the collagen receptor DDR2.
Breast cancer research : BCR
Slocum E,Craig A,Villanueva A,Germain D
100-11 was used in Cell Culture to support the notion that information about pregnancy may be critical in the prognosis of breast cancer as passage through a single pregnancy predisposes to the oncogenic action of PAPP-A.
Thu May 02 00:00:00 EDT 2019
Role of a Contactin multi-molecular complex secreted by oligodendrocytes in nodal protein clustering in the CNS.
Glia
Dubessy AL,Mazuir E,Rappeneau Q,Ou S,Abi Ghanem C,Piquand K,Aigrot MS,Thétiot M,Desmazières A,Chan E,Fitzgibbon M,Fleming M,Krauss R,Zalc B,Ranscht B,Lubetzki C,Sol-Foulon N
Sun Dec 01 00:00:00 EST 2019
Quantitative proteomics identifies proteins that resist translational repression and become dysregulated in ALS-FUS.
Human molecular genetics
Baron DM,Matheny T,Lin YC,Leszyk JD,Kenna K,Gall KV,Santos DP,Tischbein M,Funes S,Hayward LJ,Kiskinis E,Landers JE,Parker R,Shaffer SA,Bosco DA
100-11 was used in Cell Culture to suggest that Golgi to ER retrograde transport may be important under conditions of stress and is perturbed upon the expression of disease-linked proteins such as FUS.
Mon Jul 01 00:00:00 EDT 2019
Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in the Subretinal Space of the Cat Eye.
Stem cells and development
Singh RK,Occelli LM,Binette F,Petersen-Jones SM,Nasonkin IO
Sun Sep 01 00:00:00 EDT 2019
Organoid-derived C-Kit+/SSEA4- human retinal progenitor cells promote a protective retinal microenvironment during transplantation in rodents.
Nature communications
Zou T,Gao L,Zeng Y,Li Q,Li Y,Chen S,Hu X,Chen X,Fu C,Xu H,Yin ZQ
Thu Mar 14 00:00:00 EDT 2019
iPSC-Derived Brain Endothelium Exhibits Stable, Long-Term Barrier Function in Perfused Hydrogel Scaffolds.
Stem cell reports
Faley SL,Neal EH,Wang JX,Bosworth AM,Weber CM,Balotin KM,Lippmann ES,Bellan LM
Tue Mar 05 00:00:00 EST 2019
Metabolism as an early predictor of DPSCs aging.
Scientific reports
Macrin D,Alghadeer A,Zhao YT,Miklas JW,Hussein AM,Detraux D,Robitaille AM,Madan A,Moon RT,Wang Y,Devi A,Mathieu J,Ruohola-Baker H
Mon Feb 18 00:00:00 EST 2019
Suppression of glioblastoma by a drug cocktail reprogramming tumor cells into neuronal like cells.
Scientific reports
Gao L,Huang S,Zhang H,Hua W,Xin S,Cheng L,Guan W,Yu Y,Mao Y,Pei G
Tue Mar 05 00:00:00 EST 2019
Chemical suppression of specific C-C chemokine signaling pathways enhances cardiac reprogramming.
The Journal of biological chemistry
Guo Y,Lei I,Tian S,Gao W,Hacer K,Li Y,Wang S,Liu L,Wang Z
Fri Jun 07 00:00:00 EDT 2019
Patterned human microvascular grafts enable rapid vascularization and increase perfusion in infarcted rat hearts.
Nature communications
Redd MA,Zeinstra N,Qin W,Wei W,Martinson A,Wang Y,Wang RK,Murry CE,Zheng Y
Mon Feb 04 00:00:00 EST 2019
Structural basis of the activation of type 1 insulin-like growth factor receptor.
Nature communications
Li J,Choi E,Yu H,Bai XC
Tue Oct 08 00:00:00 EDT 2019
Dystrophin deficiency leads to dysfunctional glutamate clearance in iPSC derived astrocytes.
Translational psychiatry
Patel AM,Wierda K,Thorrez L,van Putten M,De Smedt J,Ribeiro L,Tricot T,Gajjar M,Duelen R,Van Damme P,De Waele L,Goemans N,Tanganyika-de Winter C,Costamagna D,Aartsma-Rus A,van Duyvenvoorde H,Sampaolesi M,Buyse GM,Verfaillie CM
Wed Aug 21 00:00:00 EDT 2019
Insulin-like growth factor-1 attenuates oxidative stress-induced hepatocyte premature senescence in liver fibrogenesis via regulating nuclear p53-progerin interaction.
Cell death & disease
Luo X,Jiang X,Li J,Bai Y,Li Z,Wei P,Sun S,Liang Y,Han S,Li X,Zhang B
Thu Jun 06 00:00:00 EDT 2019
A novel epitope-presenting thermostable scaffold for the development of highly specific insulin-like growth factor-1/2 antibodies.
The Journal of biological chemistry
Peeß C,Scholz C,Casagolda D,Düfel H,Gerg M,Kowalewsky F,Bocola M,von Proff L,Goller S,Klöppel-Swarlik H,Hoppe A,Schräml M
Fri Sep 06 00:00:00 EDT 2019
A novel epitope-presenting thermostable scaffold for the development of highly specific insulin-like growth factor-1/2 antibodies.
The Journal of biological chemistry
Peeß C,Scholz C,Casagolda D,Düfel H,Gerg M,Kowalewsky F,Bocola M,von Proff L,Goller S,Klöppel-Swarlik H,Hoppe A,Schräml M
Fri Sep 06 00:00:00 EDT 2019
Maintaining multipotent trunk neural crest stem cells as self-renewing crestospheres.
Developmental biology
Mohlin S,Kunttas E,Persson CU,Abdel-Haq R,Castillo A,Murko C,Bronner ME,Kerosuo L
100-11 was used in Cell Culture to optimize culture conditions for maintenance of avian trunk crestospheres, comprised of both neural crest stem and progenitor cells.
Fri Mar 15 00:00:00 EDT 2019
Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency.
Nature communications
Mathieu J,Detraux D,Kuppers D,Wang Y,Cavanaugh C,Sidhu S,Levy S,Robitaille AM,Ferreccio A,Bottorff T,McAlister A,Somasundaram L,Artoni F,Battle S,Hawkins RD,Moon RT,Ware CB,Paddison PJ,Ruohola-Baker H
Thu Feb 07 00:00:00 EST 2019
IGF-1 facilitates thrombopoiesis primarily through Akt activation.
Blood
Chen S,Hu M,Shen M,Wang S,Wang C,Chen F,Tang Y,Wang X,Zeng H,Chen M,Gao J,Wang F,Su Y,Xu Y,Wang J
Thu Jul 12 00:00:00 EDT 2018
The COPII cargo adapter SEC24C is essential for neuronal homeostasis.
The Journal of clinical investigation
Wang B,Joo JH,Mount R,Teubner BJW,Krenzer A,Ward AL,Ichhaporia VP,Adams EJ,Khoriaty R,Peters ST,Pruett-Miller SM,Zakharenko SS,Ginsburg D,Kundu M
Wed Aug 01 00:00:00 EDT 2018
Therapeutically targeting tumor microenvironment-mediated drug resistance in estrogen receptor-positive breast cancer.
The Journal of experimental medicine
Shee K,Yang W,Hinds JW,Hampsch RA,Varn FS,Traphagen NA,Patel K,Cheng C,Jenkins NP,Kettenbach AN,Demidenko E,Owens P,Faber AC,Golub TR,Straussman R,Miller TW
Mon Mar 05 00:00:00 EST 2018
Myeloid p38α signaling promotes intestinal IGF-1 production and inflammation-associated tumorigenesis.
EMBO molecular medicine
Youssif C,Cubillos-Rojas M,Comalada M,Llonch E,Perna C,Djouder N,Nebreda AR
100-11 was used in In vivo experiments to determine the role of myeloid insulin-like growth factor-1 downstream of p38α in colitis-associated tumourigenesis.
Sun Jul 01 00:00:00 EDT 2018
The mitochondrial citrate carrier, SLC25A1, drives stemness and therapy resistance in non-small cell lung cancer.
Cell death and differentiation
Fernandez HR,Gadre SM,Tan M,Graham GT,Mosaoa R,Ongkeko MS,Kim KA,Riggins RB,Parasido E,Petrini I,Pacini S,Cheema A,Varghese R,Ressom HW,Zhang Y,Albanese C,Üren A,Paige M,Giaccone G,Avantaggiati ML
Sun Jul 01 00:00:00 EDT 2018
Repurposing the Cord Blood Bank for Haplobanking of HLA-Homozygous iPSCs and Their Usefulness to Multiple Populations.
Stem cells (Dayton, Ohio)
Lee S,Huh JY,Turner DM,Lee S,Robinson J,Stein JE,Shim SH,Hong CP,Kang MS,Nakagawa M,Kaneko S,Nakanishi M,Rao MS,Kurtz A,Stacey GN,Marsh SGE,Turner ML,Song J
Mon Oct 01 00:00:00 EDT 2018
Striking a new path in reducing cartilage breakdown: combination of antioxidative therapy and chondroanabolic stimulation after blunt cartilage trauma.
Journal of cellular and molecular medicine
Riegger J,Joos H,Palm HG,Friemert B,Reichel H,Ignatius A,Brenner RE
Mon Jan 01 00:00:00 EST 2018
Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.
Translational psychiatry
Srikanth P,Lagomarsino VN,Pearse RV,Liao M,Ghosh S,Nehme R,Seyfried N,Eggan K,Young-Pearse TL
Thu Nov 08 00:00:00 EST 2018
NOTCH signaling specifies arterial-type definitive hemogenic endothelium from human pluripotent stem cells.
Nature communications
Uenishi GI,Jung HS,Kumar A,Park MA,Hadland BK,McLeod E,Raymond M,Moskvin O,Zimmerman CE,Theisen DJ,Swanson S,J Tamplin O,Zon LI,Thomson JA,Bernstein ID,Slukvin II
Tue May 08 00:00:00 EDT 2018
A Myogenic Double-Reporter Human Pluripotent Stem Cell Line Allows Prospective Isolation of Skeletal Muscle Progenitors.
Cell reports
Wu J,Matthias N,Lo J,Ortiz-Vitali JL,Shieh AW,Wang SH,Darabi R
100-11 was used in Sample Preparation (FC/FACS) to study myogenic differentiation of human pluripotent stem cells using double-reporter cell resource and defined an improved myogenic differentiation and purification strategy.
Tue Nov 13 00:00:00 EST 2018
Single cell RNA sequencing of stem cell-derived retinal ganglion cells.
Scientific data
Daniszewski M,Senabouth A,Nguyen QH,Crombie DE,Lukowski SW,Kulkarni T,Sluch VM,Jabbari JS,Chamling X,Zack DJ,Pébay A,Powell JE,Hewitt AW
Tue Feb 13 00:00:00 EST 2018
Generation and selection of pluripotent stem cells for robust differentiation to insulin-secreting cells capable of reversing diabetes in rodents.
PloS one
Southard SM,Kotipatruni RP,Rust WL
100-11 was used in In vitro experiments to show that SR1423 is a candidate cell line for the production of insulin-producing cells useful for the treatment of diabetes.
Thu Feb 21 00:00:00 EST 2019
Loss of GCNT2/I-branched glycans enhances melanoma growth and survival.
Nature communications
Sweeney JG,Liang J,Antonopoulos A,Giovannone N,Kang S,Mondala TS,Head SR,King SL,Tani Y,Brackett D,Dell A,Murphy GF,Haslam SM,Widlund HR,Dimitroff CJ
100-11 was used inIn vitro experiments to study the functional contributions of glycans to cancer initiation and progression using expression-based analyses across cancer lineages and showing that melanomas exhibit significant transcriptional changes in glycosylation-related genes.
Wed Aug 22 00:00:00 EDT 2018
Early Human Hemogenic Endothelium Generates Primitive and Definitive Hematopoiesis In Vitro.
Stem cell reports
Garcia-Alegria E,Menegatti S,Fadlullah MZH,Menendez P,Lacaud G,Kouskoff V
Tue Nov 13 00:00:00 EST 2018
Downregulation of Endothelin Receptor B Contributes to Defective B Cell Lymphopoiesis in Trisomy 21 Pluripotent Stem Cells.
Scientific reports
MacLean GA,McEldoon J,Huang J,Allred J,Canver MC,Orkin SH
Tue May 22 00:00:00 EDT 2018
ALS-related human cortical and motor neurons survival is differentially affected by Sema3A.
Cell death & disease
Birger A,Ottolenghi M,Perez L,Reubinoff B,Behar O
Thu Feb 15 00:00:00 EST 2018
Self-assembled Collagen-Fibrin Hydrogel Reinforces Tissue Engineered Adventitia Vessels Seeded with Human Fibroblasts.
Scientific reports
Patel B,Xu Z,Pinnock CB,Kabbani LS,Lam MT
Mon Feb 19 00:00:00 EST 2018
ALCAM+ stromal cells: role in giant cell tumor of bone progression.
Cell death & disease
Zhou Z,Li Y,Wang X,Hu J,Kuang M,Wang Z,Li S,Xu W,Xiao J
Tue Feb 20 00:00:00 EST 2018
High-efficiency RNA-based reprogramming of human primary fibroblasts.
Nature communications
Kogut I,McCarthy SM,Pavlova M,Astling DP,Chen X,Jakimenko A,Jones KL,Getahun A,Cambier JC,Pasmooij AMG,Jonkman MF,Roop DR,Bilousova G
Wed Feb 21 00:00:00 EST 2018
Rapid Mast Cell Generation from Gata2 Reporter Pluripotent Stem Cells.
Stem cell reports
Kauts ML,De Leo B,Rodríguez-Seoane C,Ronn R,Glykofrydis F,Maglitto A,Kaimakis P,Basi M,Taylor H,Forrester L,Wilkinson AC,Göttgens B,Saunders P,Dzierzak E
Tue Oct 09 00:00:00 EDT 2018
hPSC-Derived Striatal Cells Generated Using a Scalable 3D Hydrogel Promote Recovery in a Huntington Disease Mouse Model.
Stem cell reports
Adil MM,Gaj T,Rao AT,Kulkarni RU,Fuentes CM,Ramadoss GN,Ekman FK,Miller EW,Schaffer DV
Tue May 08 00:00:00 EDT 2018
ACK1/TNK2 Regulates Histone H4 Tyr88-phosphorylation and AR Gene Expression in Castration-Resistant Prostate Cancer.
Cancer cell
Mahajan K,Malla P,Lawrence HR,Chen Z,Kumar-Sinha C,Malik R,Shukla S,Kim J,Coppola D,Lawrence NJ,Mahajan NP
Mon Jun 12 00:00:00 EDT 2017
A Sensitized IGF1 Treatment Restores Corticospinal Axon-Dependent Functions.
Neuron
Liu Y,Wang X,Li W,Zhang Q,Li Y,Zhang Z,Zhu J,Chen B,Williams PR,Zhang Y,Yu B,Gu X,He Z
Wed Aug 16 00:00:00 EDT 2017
Oncostatin M promotes cancer cell plasticity through cooperative STAT3-SMAD3 signaling.
Oncogene
Junk DJ,Bryson BL,Smigiel JM,Parameswaran N,Bartel CA,Jackson MW
Thu Jul 13 00:00:00 EDT 2017
WRN conditioned media is sufficient for in vitro propagation of intestinal organoids from large farm and small companion animals.
Biology open
Powell RH,Behnke MS
100-11 was used in Sample Preparation to investigate organoid development of intestinal crypts.
Mon May 15 00:00:00 EDT 2017
Critical role for arginase 2 in obesity-associated pancreatic cancer.
Nature communications
Zaytouni T,Tsai PY,Hitchcock DS,DuBois CD,Freinkman E,Lin L,Morales-Oyarvide V,Lenehan PJ,Wolpin BM,Mino-Kenudson M,Torres EM,Stylopoulos N,Clish CB,Kalaany NY
Mon Aug 14 00:00:00 EDT 2017
Transplanted human p75-positive stem Leydig cells replace disrupted Leydig cells for testosterone production.
Cell death & disease
Zhang M,Wang J,Deng C,Jiang MH,Feng X,Xia K,Li W,Lai X,Xiao H,Ge RS,Gao Y,Xiang AP
Thu Oct 12 00:00:00 EDT 2017
Defined, serum/feeder-free conditions for expansion and drug screening of primary B-acute lymphoblastic leukemia.
Oncotarget
Jiang Z,Wu D,Ye W,Weng J,Lai P,Shi P,Guo X,Huang G,Deng Q,Tang Y,Zhao H,Cui S,Lin S,Wang S,Li B,Wu Q,Li Y,Liu P,Pei D,Du X,Yao Y,Li P
100-11 was used in Cell Culture to develop a defined condition for the ex vivo expansion of primary B-ALL cells that is suitable for high-throughput screening of novel compounds.
Tue Dec 05 00:00:00 EST 2017
In Vivo Maturation of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes in Neonatal and Adult Rat Hearts.
Stem cell reports
Kadota S,Pabon L,Reinecke H,Murry CE
Tue Feb 14 00:00:00 EST 2017
Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.
Stem cell reports
Muratore CR,Zhou C,Liao M,Fernandez MA,Taylor WM,Lagomarsino VN,Pearse RV,Rice HC,Negri JM,He A,Srikanth P,Callahan DG,Shin T,Zhou M,Bennett DA,Noggle S,Love JC,Selkoe DJ,Young-Pearse TL
Tue Dec 12 00:00:00 EST 2017
Growth factors regulate phospholipid biosynthesis in human fibroblast-like synoviocytes obtained from osteoarthritic knees.
Scientific reports
Sluzalska KD,Liebisch G,Wilhelm J,Ishaque B,Hackstein H,Schmitz G,Rickert M,Steinmeyer J
Wed Oct 18 00:00:00 EDT 2017
Therapeutic potential of human minor salivary gland epithelial progenitor cells in liver regeneration.
Scientific reports
Zhang C,Li Y,Zhang XY,Liu L,Tong HZ,Han TL,Li WD,Jin XL,Yin NB,Song T,Li HD,Zhi J,Zhao ZM,Lu L
Thu Oct 05 00:00:00 EDT 2017
Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.
Nature communications
Rosner M,Pham HTT,Moriggl R,Hengstschläger M
Tue Sep 19 00:00:00 EDT 2017
Human stem cells alter the invasive properties of somatic cells via paracrine activation of mTORC1.
Nature communications
Rosner M,Pham HTT,Moriggl R,Hengstschläger M
Tue Sep 19 00:00:00 EDT 2017
Differentiation of Human Induced Pluripotent Stem Cells (iPS Cells) and Embryonic Stem Cells (ES Cells) into Dendritic Cell (DC) Subsets.
Bio-protocol
Sontag S,Förster M,Seré K,Zenke M
100-11 was used in Sample Preparation to study subset specification and function of human dendritic cells (DCs) using a protocol which generates classical cDC1, classical cDC2 and plasmacytoid pDC in vitro from human induced pluripotent stem cells (iPS) cells or ES cells.
Sat Aug 05 00:00:00 EDT 2017
Central IGF1 improves glucose tolerance and insulin sensitivity in mice.
Nutrition & diabetes
Hong H,Cui ZZ,Zhu L,Fu SP,Rossi M,Cui YH,Zhu BM
Tue Dec 19 00:00:00 EST 2017
Central IGF1 improves glucose tolerance and insulin sensitivity in mice.
Nutrition & diabetes
Hong H,Cui ZZ,Zhu L,Fu SP,Rossi M,Cui YH,Zhu BM
Tue Dec 19 00:00:00 EST 2017
In vivo transplantation of 3D encapsulated ovarian constructs in rats corrects abnormalities of ovarian failure.
Nature communications
Sittadjody S,Saul JM,McQuilling JP,Joo S,Register TC,Yoo JJ,Atala A,Opara EC
Tue Dec 05 00:00:00 EST 2017
Compartmentalization of Two Cell Types in Multilayered Alginate Microcapsules.
Methods in molecular biology (Clifton, N.J.)
Sittadjody S,Saul JM,Opara EC
100-11 was used in Cell Culture to provide the protocol to compartmentalize two cell types in the same multilayer microcapsules.
Mon Dec 25 00:00:00 EST 2017
Identification of 4-phenylquinolin-2(1H)-one as a specific allosteric inhibitor of Akt.
Scientific reports
Huang BX,Newcomer K,Kevala K,Barnaeva E,Zheng W,Hu X,Patnaik S,Southall N,Marugan J,Ferrer M,Kim HY
Fri Sep 15 00:00:00 EDT 2017
Defined and Scalable Differentiation of Human Oligodendrocyte Precursors from Pluripotent Stem Cells in a 3D Culture System.
Stem cell reports
Rodrigues GMC,Gaj T,Adil MM,Wahba J,Rao AT,Lorbeer FK,Kulkarni RU,Diogo MM,Cabral JMS,Miller EW,Hockemeyer D,Schaffer DV
Tue Jun 06 00:00:00 EDT 2017
Differential Maturation of the Two Regulated Secretory Pathways in Human iPSC-Derived Neurons.
Stem cell reports
Emperador Melero J,Nadadhur AG,Schut D,Weering JV,Heine VM,Toonen RF,Verhage M
Tue Mar 14 00:00:00 EDT 2017
Wnt/β-catenin signaling promotes self-renewal and inhibits the primed state transition in naïve human embryonic stem cells.
Proceedings of the National Academy of Sciences of the United States of America
Xu Z,Robitaille AM,Berndt JD,Davidson KC,Fischer KA,Mathieu J,Potter JC,Ruohola-Baker H,Moon RT
Tue Oct 18 00:00:00 EDT 2016
Enforced Expression of HOXB4 in Human Embryonic Stem Cells Enhances the Production of Hematopoietic Progenitors but Has No Effect on the Maturation of Red Blood Cells.
Stem cells translational medicine
Jackson M,Ma R,Taylor AH,Axton RA,Easterbrook J,Kydonaki M,Olivier E,Marenah L,Stanley EG,Elefanty AG,Mountford JC,Forrester LM
100-11 was used in Cell Culture to investigate whether activation of exogenous HOXB4 promotes the production of more mature, definitive red blood cells.
Mon Aug 01 00:00:00 EDT 2016
High-Throughput Phenotypic Screening of Human Astrocytes to Identify Compounds That Protect Against Oxidative Stress.
Stem cells translational medicine
Thorne N,Malik N,Shah S,Zhao J,Class B,Aguisanda F,Southall N,Xia M,McKew JC,Rao M,Zheng W
100-11 was used in Cell Culture to develop as assay to identify compounds that protect against oxidative stress, a condition associated with many neurodegenerative diseases using astrocytes differentiated from human embryonic stem cells.
Sun May 01 00:00:00 EDT 2016
Maturation and electrophysiological properties of human pluripotent stem cell-derived oligodendrocytes.
Stem cells (Dayton, Ohio)
Livesey MR,Magnani D,Cleary EM,Vasistha NA,James OT,Selvaraj BT,Burr K,Story D,Shaw CE,Kind PC,Hardingham GE,Wyllie DJ,Chandran S
Fri Apr 01 00:00:00 EDT 2016
RIG-I inhibits pancreatic β cell proliferation through competitive binding of activated Src.
Scientific reports
Pan Y,Li G,Zhong H,Chen M,Chen T,Gao L,Wu H,Guo J
Tue Jun 28 00:00:00 EDT 2016
Enhanced Generation of Integration-free iPSCs from Human Adult Peripheral Blood Mononuclear Cells with an Optimal Combination of Episomal Vectors.
Stem cell reports
Wen W,Zhang JP,Xu J,Su RJ,Neises A,Ji GZ,Yuan W,Cheng T,Zhang XB
Tue Jun 14 00:00:00 EDT 2016
5-HT2 receptors mediate functional modulation of GABAa receptors and inhibitory synaptic transmissions in human iPS-derived neurons.
Scientific reports
Wang H,Hu L,Liu C,Su Z,Wang L,Pan G,Guo Y,He J
Wed Feb 03 00:00:00 EST 2016
Fyn Kinase regulates GluN2B subunit-dominant NMDA receptors in human induced pluripotent stem cell-derived neurons.
Scientific reports
Zhang WB,Ross PJ,Tu Y,Wang Y,Beggs S,Sengar AS,Ellis J,Salter MW
Mon Apr 04 00:00:00 EDT 2016
ROR1 sustains caveolae and survival signalling as a scaffold of cavin-1 and caveolin-1.
Nature communications
Yamaguchi T,Lu C,Ida L,Yanagisawa K,Usukura J,Cheng J,Hotta N,Shimada Y,Isomura H,Suzuki M,Fujimoto T,Takahashi T
Mon Jan 04 00:00:00 EST 2016
Enriched retinal ganglion cells derived from human embryonic stem cells.
Scientific reports
Gill KP,Hung SS,Sharov A,Lo CY,Needham K,Lidgerwood GE,Jackson S,Crombie DE,Nayagam BA,Cook AL,Hewitt AW,Pébay A,Wong RC
Wed Aug 10 00:00:00 EDT 2016
Multi-Organ toxicity demonstration in a functional human in vitro system composed of four organs.
Scientific reports
Oleaga C,Bernabini C,Smith AS,Srinivasan B,Jackson M,McLamb W,Platt V,Bridges R,Cai Y,Santhanam N,Berry B,Najjar S,Akanda N,Guo X,Martin C,Ekman G,Esch MB,Langer J,Ouedraogo G,Cotovio J,Breton L,Shuler ML,Hickman JJ
Wed Feb 03 00:00:00 EST 2016
The adipokine lipocalin-2 in the context of the osteoarthritic osteochondral junction.
Scientific reports
Villalvilla A,García-Martín A,Largo R,Gualillo O,Herrero-Beaumont G,Gómez R
Thu Jul 07 00:00:00 EDT 2016
IGF-1/IGF-1R/hsa-let-7c axis regulates the committed differentiation of stem cells from apical papilla.
Scientific reports
Ma S,Liu G,Jin L,Pang X,Wang Y,Wang Z,Yu Y,Yu J
Fri Nov 11 00:00:00 EST 2016
Empirical inference of circuitry and plasticity in a kinase signaling network.
Proceedings of the National Academy of Sciences of the United States of America
Wilkes EH,Terfve C,Gribben JG,Saez-Rodriguez J,Cutillas PR
Tue Jun 23 00:00:00 EDT 2015
A facile method to establish human induced pluripotent stem cells from adult blood cells under feeder-free and xeno-free culture conditions: a clinically compliant approach.
Stem cells translational medicine
Chou BK,Gu H,Gao Y,Dowey SN,Wang Y,Shi J,Li Y,Ye Z,Cheng T,Cheng L
100-11 was used in In vitro experiments to derive human induced pluripotent stem cells from blood mononuclear cells under clinically compliant culture conditions.
Wed Apr 01 00:00:00 EDT 2015
Notch signaling regulates motor neuron differentiation of human embryonic stem cells.
Stem cells (Dayton, Ohio)
Ben-Shushan E,Feldman E,Reubinoff BE
Sun Feb 01 00:00:00 EST 2015
Multipotent caudal neural progenitors derived from human pluripotent stem cells that give rise to lineages of the central and peripheral nervous system.
Stem cells (Dayton, Ohio)
Denham M,Hasegawa K,Menheniott T,Rollo B,Zhang D,Hough S,Alshawaf A,Febbraro F,Ighaniyan S,Leung J,Elliott DA,Newgreen DF,Pera MF,Dottori M
Mon Jun 01 00:00:00 EDT 2015
Survival of human circulating antigen-induced plasma cells is supported by plasma cell-niche cytokines and T follicular helper lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Ramos-Amaya A,Rodríguez-Bayona B,López-Blanco R,Andújar E,Pérez-Alegre M,Campos-Caro A,Brieva JA
Sun Feb 01 00:00:00 EST 2015
Targeting lung cancer stem-like cells with TRAIL gene armed oncolytic adenovirus.
Journal of cellular and molecular medicine
Yang Y,Xu H,Huang W,Ding M,Xiao J,Yang D,Li H,Liu XY,Chu L
Fri May 01 00:00:00 EDT 2015
Insulin-Like Growth Factor-Independent Effects of Growth Hormone on Growth Plate Chondrogenesis and Longitudinal Bone Growth.
Endocrinology
Wu S,Yang W,De Luca F
100-11 was used in In vivo experiments to study whether GH has IGF-independent growth-promoting effects using (TamCart)Igf1r(flox/flox) mice models to demonstrate that GH can promote growth plate chondrogenesis and longitudinal bone growth directly at the growth plate, even when the local effects of IGF-1 and IGF-2 are prevented.
Wed Jul 01 00:00:00 EDT 2015
Role of sox9 in growth factor regulation of articular chondrocytes.
Journal of cellular biochemistry
Shi S,Wang C,Acton AJ,Eckert GJ,Trippel SB
Wed Jul 01 00:00:00 EDT 2015
RGD-modifided oncolytic adenovirus exhibited potent cytotoxic effect on CAR-negative bladder cancer-initiating cells.
Cell death & disease
Yang Y,Xu H,Shen J,Yang Y,Wu S,Xiao J,Xu Y,Liu XY,Chu L
Thu May 14 00:00:00 EDT 2015
Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.
Scientific reports
Wang S,Wang B,Pan N,Fu L,Wang C,Song G,An J,Liu Z,Zhu W,Guan Y,Xu ZQ,Chan P,Chen Z,Zhang YA
Wed Mar 18 00:00:00 EDT 2015
Differentiation of human induced pluripotent stem cells to mature functional Purkinje neurons.
Scientific reports
Wang S,Wang B,Pan N,Fu L,Wang C,Song G,An J,Liu Z,Zhu W,Guan Y,Xu ZQ,Chan P,Chen Z,Zhang YA
Wed Mar 18 00:00:00 EDT 2015
A novel small molecular STAT3 inhibitor, LY5, inhibits cell viability, cell migration, and angiogenesis in medulloblastoma cells.
The Journal of biological chemistry
Xiao H,Bid HK,Jou D,Wu X,Yu W,Li C,Houghton PJ,Lin J
Fri Feb 06 00:00:00 EST 2015
Optimizing culture medium composition to improve oligodendrocyte progenitor cell yields in vitro from subventricular zone-derived neural progenitor cell neurospheres.
PloS one
Franco PG,Pasquini JM,Silvestroff L
100-11 was used in Cell Culture to study cell proliferation and OPC yield using Subventricular Zone-derived NSC/NPC primary cultures from newborn mice and studying the effects of different growth factor combinations on the. The Platelet Derived Growth Factor-AA and BB homodimers had a positive and significant impact on OPC generation. The OPC generated by this protocol were able to mature into Myelin Basic Protein-expressing cells, thus proposing an optimized in vitro method for increasing OPC.
Thu Mar 31 00:00:00 EDT 2016
SC06, a novel small molecule compound, displays preclinical activity against multiple myeloma by disrupting the mTOR signaling pathway.
Scientific reports
Han K,Xu X,Xu Z,Chen G,Zeng Y,Zhang Z,Cao B,Kong Y,Tang X,Mao X
Wed Sep 02 00:00:00 EDT 2015
Spinal muscular atrophy phenotype is ameliorated in human motor neurons by SMN increase via different novel RNA therapeutic approaches.
Scientific reports
Nizzardo M,Simone C,Dametti S,Salani S,Ulzi G,Pagliarani S,Rizzo F,Frattini E,Pagani F,Bresolin N,Comi G,Corti S
Tue Jun 30 00:00:00 EDT 2015
The Specification and Maturation of Nociceptive Neurons from Human Embryonic Stem Cells.
Scientific reports
Boisvert EM,Engle SJ,Hallowell SE,Liu P,Wang ZW,Li XJ
Thu Nov 19 00:00:00 EST 2015
Multiple receptor tyrosine kinase activation attenuates therapeutic efficacy of the fibroblast growth factor receptor 2 inhibitor AZD4547 in FGFR2 amplified gastric cancer.
Oncotarget
Chang J,Wang S,Zhang Z,Liu X,Wu Z,Geng R,Ge X,Dai C,Liu R,Zhang Q,Li W,Li J
Tue Feb 10 00:00:00 EST 2015
Foxp1-mediated programming of limb-innervating motor neurons from mouse and human embryonic stem cells.
Nature communications
Adams KL,Rousso DL,Umbach JA,Novitch BG
Tue Apr 14 00:00:00 EDT 2015
Transdifferentiation of periodontal ligament-derived stem cells into retinal ganglion-like cells and its microRNA signature.
Scientific reports
Ng TK,Yung JS,Choy KW,Cao D,Leung CK,Cheung HS,Pang CP
Mon Nov 09 00:00:00 EST 2015
Insulin-like growth factor 1 (IGF-1) stabilizes nascent blood vessels.
The Journal of biological chemistry
Jacobo SM,Kazlauskas A
Fri Mar 06 00:00:00 EST 2015
Phenotypic and functional characterization of long-term cryopreserved human adipose-derived stem cells.
Scientific reports
Yong KW,Pingguan-Murphy B,Xu F,Abas WA,Choi JR,Omar SZ,Azmi MA,Chua KH,Wan Safwani WK
Wed Apr 15 00:00:00 EDT 2015
Human embryonic-stem-cell-derived cardiomyocytes regenerate non-human primate hearts.
Nature
Chong JJ,Yang X,Don CW,Minami E,Liu YW,Weyers JJ,Mahoney WM,Van Biber B,Cook SM,Palpant NJ,Gantz JA,Fugate JA,Muskheli V,Gough GM,Vogel KW,Astley CA,Hotchkiss CE,Baldessari A,Pabon L,Reinecke H,Gill EA,Nelson V,Kiem HP,Laflamme MA,Murry CE
Thu Jun 12 00:00:00 EDT 2014
Chemically defined generation of human cardiomyocytes.
Nature methods
Burridge PW,Matsa E,Shukla P,Lin ZC,Churko JM,Ebert AD,Lan F,Diecke S,Huber B,Mordwinkin NM,Plews JR,Abilez OJ,Cui B,Gold JD,Wu JC
Fri Aug 01 00:00:00 EDT 2014
Characterization of Nestin-positive stem Leydig cells as a potential source for the treatment of testicular Leydig cell dysfunction.
Cell research
Jiang MH,Cai B,Tuo Y,Wang J,Zang ZJ,Tu X,Gao Y,Su Z,Li W,Li G,Zhang M,Jiao J,Wan Z,Deng C,Lahn BT,Xiang AP
Mon Dec 01 00:00:00 EST 2014
Leukemia propagating cells rebuild an evolving niche in response to therapy.
Cancer cell
Duan CW,Shi J,Chen J,Wang B,Yu YH,Qin X,Zhou XC,Cai YJ,Li ZQ,Zhang F,Yin MZ,Tao Y,Mi JQ,Li LH,Enver T,Chen GQ,Hong DL
Mon Jun 16 00:00:00 EDT 2014
Human glial chimeric mice reveal astrocytic dependence of JC virus infection.
The Journal of clinical investigation
Kondo Y,Windrem MS,Zou L,Chandler-Militello D,Schanz SJ,Auvergne RM,Betstadt SJ,Harrington AR,Johnson M,Kazarov A,Gorelik L,Goldman SA
Mon Dec 01 00:00:00 EST 2014
Functional recovery with recombinant human IGF1 treatment in a mouse model of Rett Syndrome.
Proceedings of the National Academy of Sciences of the United States of America
Castro J,Garcia RI,Kwok S,Banerjee A,Petravicz J,Woodson J,Mellios N,Tropea D,Sur M
Tue Jul 08 00:00:00 EDT 2014
β2-Adrenergic receptor agonist ameliorates phenotypes and corrects microRNA-mediated IGF1 deficits in a mouse model of Rett syndrome.
Proceedings of the National Academy of Sciences of the United States of America
Mellios N,Woodson J,Garcia RI,Crawford B,Sharma J,Sheridan SD,Haggarty SJ,Sur M
Tue Jul 08 00:00:00 EDT 2014
Ampelopsin-induced autophagy protects breast cancer cells from apoptosis through Akt-mTOR pathway via endoplasmic reticulum stress.
Cancer science
Zhou Y,Liang X,Chang H,Shu F,Wu Y,Zhang T,Fu Y,Zhang Q,Zhu JD,Mi M
Wed Oct 01 00:00:00 EDT 2014
Maintenance and neuronal differentiation of chicken induced pluripotent stem-like cells.
Stem cells international
Dai R,Rossello R,Chen CC,Kessler J,Davison I,Hochgeschwender U,Jarvis ED
100-11 was used in Cell Culture to demonstrate an efficient method of maintaining chicken induced pluripotent stem (iPSC)-like cells and for differentiating them into action potential generating neurons.
Thu Jan 22 00:00:00 EST 2015
GSK3 protein positively regulates type I insulin-like growth factor receptor through forkhead transcription factors FOXO1/3/4.
The Journal of biological chemistry
Huo X,Liu S,Shao T,Hua H,Kong Q,Wang J,Luo T,Jiang Y
Fri Sep 05 00:00:00 EDT 2014
Derivation of novel human ground state naive pluripotent stem cells.
Nature
Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH
Thu Dec 12 00:00:00 EST 2013
Derivation of novel human ground state naive pluripotent stem cells.
Nature
Gafni O,Weinberger L,Mansour AA,Manor YS,Chomsky E,Ben-Yosef D,Kalma Y,Viukov S,Maza I,Zviran A,Rais Y,Shipony Z,Mukamel Z,Krupalnik V,Zerbib M,Geula S,Caspi I,Schneir D,Shwartz T,Gilad S,Amann-Zalcenstein D,Benjamin S,Amit I,Tanay A,Massarwa R,Novershtern N,Hanna JH
Thu Dec 12 00:00:00 EST 2013
Analysis of FOXO1 mutations in diffuse large B-cell lymphoma.
Blood
Trinh DL,Scott DW,Morin RD,Mendez-Lago M,An J,Jones SJ,Mungall AJ,Zhao Y,Schein J,Steidl C,Connors JM,Gascoyne RD,Marra MA
Thu May 02 00:00:00 EDT 2013
Ephrin-B2 controls PDGFRβ internalization and signaling.
Genes & development
Nakayama A,Nakayama M,Turner CJ,Höing S,Lepore JJ,Adams RH
100-11 was used in Cell Culture to show that ephrin-B2 is an important regulator of PDGFRβ endocytosis, acting as a molecular switch controlling the downstream signaling activity of this receptor in mural cells.
Sun Dec 01 00:00:00 EST 2013
Heparin-binding domain of fibrin(ogen) binds growth factors and promotes tissue repair when incorporated within a synthetic matrix.
Proceedings of the National Academy of Sciences of the United States of America
Martino MM,Briquez PS,Ranga A,Lutolf MP,Hubbell JA
Tue Mar 19 00:00:00 EDT 2013
STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.
Journal of immunology (Baltimore, Md. : 1950)
Rodríguez-Bayona B,Ramos-Amaya A,López-Blanco R,Campos-Caro A,Brieva JA
Fri Nov 15 00:00:00 EST 2013
A crayfish insulin-like-binding protein: another piece in the androgenic gland insulin-like hormone puzzle is revealed.
The Journal of biological chemistry
Rosen O,Weil S,Manor R,Roth Z,Khalaila I,Sagi A
Fri Aug 02 00:00:00 EDT 2013
Insulin-like growth factor 1 and 2 (IGF1, IGF2) expression in human microglia: differential regulation by inflammatory mediators.
Journal of neuroinflammation
Suh HS,Zhao ML,Derico L,Choi N,Lee SC
100-11 was used in Cell Culture to suggest that chronic neuroinflammation and upregulation of proinflammatory cytokines could lead to neurodegeneration by suppressing the production of microglia-derived neuronal growth factors, such as IGF1.
Tue Mar 12 00:00:00 EDT 2013
Akt Regulates TNFα synthesis downstream of RIP1 kinase activation during necroptosis.
PloS one
McNamara CR,Ahuja R,Osafo-Addo AD,Barrows D,Kettenbach A,Skidan I,Teng X,Cuny GD,Gerber S,Degterev A
Tue Aug 27 00:00:00 EDT 2013
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts.
Nature
Shiba Y,Fernandes S,Zhu WZ,Filice D,Muskheli V,Kim J,Palpant NJ,Gantz J,Moyes KW,Reinecke H,Van Biber B,Dardas T,Mignone JL,Izawa A,Hanna R,Viswanathan M,Gold JD,Kotlikoff MI,Sarvazyan N,Kay MW,Murry CE,Laflamme MA
Thu Sep 13 00:00:00 EDT 2012
Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors.
Nature
Wilson TR,Fridlyand J,Yan Y,Penuel E,Burton L,Chan E,Peng J,Lin E,Wang Y,Sosman J,Ribas A,Li J,Moffat J,Sutherlin DP,Koeppen H,Merchant M,Neve R,Settleman J
Thu Jul 26 00:00:00 EDT 2012
Generation of integration-free human induced pluripotent stem cells from postnatal blood mononuclear cells by plasmid vector expression.
Nature protocols
Dowey SN,Huang X,Chou BK,Ye Z,Cheng L
100-11 was used in Cell Culture to describe a detailed, validated protocol for effective generation of integration-free human induced pluripotent stem cells from blood mononuclear cells by plasmid vectors.
Thu Nov 01 00:00:00 EDT 2012
2D protrusion but not motility predicts growth factor-induced cancer cell migration in 3D collagen.
The Journal of cell biology
Meyer AS,Hughes-Alford SK,Kay JE,Castillo A,Wells A,Gertler FB,Lauffenburger DA
Mon Jun 11 00:00:00 EDT 2012
Pharmacological modulation of human mesenchymal stem cell chondrogenesis by a chemically oversulfated polysaccharide of marine origin: potential application to cartilage regenerative medicine.
Stem cells (Dayton, Ohio)
Merceron C,Portron S,Vignes-Colombeix C,Rederstorff E,Masson M,Lesoeur J,Sourice S,Sinquin C,Colliec-Jouault S,Weiss P,Vinatier C,Guicheux J
Thu Mar 01 00:00:00 EST 2012
ROS constitute a convergence nexus in the development of IGF1 resistance and impaired wound healing in a rat model of type 2 diabetes.
Disease models & mechanisms
Bitar MS,Al-Mulla F
Tue May 01 00:00:00 EDT 2012
Growth factors released from gelatin hydrogel microspheres increase new neurons in the adult mouse brain.
Stem cells international
Nakaguchi K,Jinnou H,Kaneko N,Sawada M,Hikita T,Saitoh S,Tabata Y,Sawamoto K
Thu Oct 25 00:00:00 EDT 2012
Dental pulp stem cells differentiation reveals new insights in Oct4A dynamics.
PloS one
Ferro F,Spelat R,D'Aurizio F,Puppato E,Pandolfi M,Beltrami AP,Cesselli D,Falini G,Beltrami CA,Curcio F
Wed Nov 28 00:00:00 EST 2012
Insulin-like growth factor-I receptor (IGF-IR) translocates to nucleus and autoregulates IGF-IR gene expression in breast cancer cells.
The Journal of biological chemistry
Sarfstein R,Pasmanik-Chor M,Yeheskel A,Edry L,Shomron N,Warman N,Wertheimer E,Maor S,Shochat L,Werner H
Fri Jan 20 00:00:00 EST 2012
Cross-talk between insulin and Wnt signaling in preadipocytes: role of Wnt co-receptor low density lipoprotein receptor-related protein-5 (LRP5).
The Journal of biological chemistry
Palsgaard J,Emanuelli B,Winnay JN,Sumara G,Karsenty G,Kahn CR
Fri Apr 06 00:00:00 EDT 2012
Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors.
PloS one
Kawamura K,Chen Y,Shu Y,Cheng Y,Qiao J,Behr B,Pera RA,Hsueh AJ
Tue May 07 00:00:00 EDT 2013
In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells.
PloS one
Sakurai H,Sakaguchi Y,Shoji E,Nishino T,Maki I,Sakai H,Hanaoka K,Kakizuka A,Sehara-Fujisawa A
Tue Apr 23 00:00:00 EDT 2013
In vitro modeling of paraxial mesodermal progenitors derived from induced pluripotent stem cells.
PloS one
Sakurai H,Sakaguchi Y,Shoji E,Nishino T,Maki I,Sakai H,Hanaoka K,Kakizuka A,Sehara-Fujisawa A
Tue Apr 23 00:00:00 EDT 2013
Sphingosine kinase/sphingosine 1-phosphate axis: a new player for insulin-like growth factor-1-induced myoblast differentiation.
Skeletal muscle
Bernacchioni C,Cencetti F,Blescia S,Donati C,Bruni P
Thu Jul 12 00:00:00 EDT 2012
Phase contrast microscopy of living cells within the whole lens: spatial correlations and morphological dynamics.
Molecular vision
Kong Z,Zhu X,Zhang S,Wu J,Luo Y
Fri Dec 21 00:00:00 EST 2012
Differential regulation of bone marrow-derived endothelial progenitor cells and endothelial outgrowth cells by the Notch signaling pathway.
PloS one
Chen JY,Feng L,Zhang HL,Li JC,Yang XW,Cao XL,Liu L,Qin HY,Liang YM,Han H
Thu May 09 00:00:00 EDT 2013
Anti-proliferative effect of cytohesin inhibition in gefitinib-resistant lung cancer cells.
PloS one
Bill A,Schmitz A,König K,Heukamp LC,Hannam JS,Famulok M
Wed Jan 16 00:00:00 EST 2013
A Novel Role of IGF1 in Apo2L/TRAIL-Mediated Apoptosis of Ewing Tumor Cells.
Sarcoma
van Valen F,Harrer H,Hotfilder M,Dirksen U,Pap T,Gosheger G,Humpf HU,Jürgens H
Wed Oct 24 00:00:00 EDT 2012
The metabolic regulator ERRα, a downstream target of HER2/IGF-1R, as a therapeutic target in breast cancer.
Cancer cell
Chang CY,Kazmin D,Jasper JS,Kunder R,Zuercher WJ,McDonnell DP
Tue Oct 18 00:00:00 EDT 2011
A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.
Blood
Mao X,Cao B,Wood TE,Hurren R,Tong J,Wang X,Wang W,Li J,Jin Y,Sun W,Spagnuolo PA,MacLean N,Moran MF,Datti A,Wrana J,Batey RA,Schimmer AD
Thu Feb 10 00:00:00 EST 2011
A small-molecule inhibitor of D-cyclin transactivation displays preclinical efficacy in myeloma and leukemia via phosphoinositide 3-kinase pathway.
Blood
Mao X,Cao B,Wood TE,Hurren R,Tong J,Wang X,Wang W,Li J,Jin Y,Sun W,Spagnuolo PA,MacLean N,Moran MF,Datti A,Wrana J,Batey RA,Schimmer AD
Thu Feb 10 00:00:00 EST 2011
MEK-ERK pathway modulation ameliorates disease phenotypes in a mouse model of Noonan syndrome associated with the Raf1(L613V) mutation.
The Journal of clinical investigation
Wu X,Simpson J,Hong JH,Kim KH,Thavarajah NK,Backx PH,Neel BG,Araki T
Tue Mar 01 00:00:00 EST 2011
High-level IGF1R expression is required for leukemia-initiating cell activity in T-ALL and is supported by Notch signaling.
The Journal of experimental medicine
Medyouf H,Gusscott S,Wang H,Tseng JC,Wai C,Nemirovsky O,Trumpp A,Pflumio F,Carboni J,Gottardis M,Pollak M,Kung AL,Aster JC,Holzenberger M,Weng AP
Mon Aug 29 00:00:00 EDT 2011
Phosphatase and tensin homolog regulates the pluripotent state and lineage fate choice in human embryonic stem cells.
Stem cells (Dayton, Ohio)
Alva JA,Lee GE,Escobar EE,Pyle AD
Thu Dec 01 00:00:00 EST 2011
Isolation of MECP2-null Rett Syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation.
Human molecular genetics
Cheung AY,Horvath LM,Grafodatskaya D,Pasceri P,Weksberg R,Hotta A,Carrel L,Ellis J
Wed Jun 01 00:00:00 EDT 2011
Rac1 and Stathmin but Not EB1 Are Required for Invasion of Breast Cancer Cells in Response to IGF-I.
International journal of cell biology
Morimura S,Takahashi K
Thu Nov 10 00:00:00 EST 2011
Apigenin inhibits proliferation and induces apoptosis in human multiple myeloma cells through targeting the trinity of CK2, Cdc37 and Hsp90.
Molecular cancer
Zhao M,Ma J,Zhu HY,Zhang XH,Du ZY,Xu YJ,Yu XD
Mon Aug 29 00:00:00 EDT 2011
Directed differentiation of dopamine neurons from human pluripotent stem cells.
Methods in molecular biology (Clifton, N.J.)
Ma L,Liu Y,Zhang SC
100-11 was used in Cell Culture to describe a chemically defined protocol for mDA neuron differentiation.
Thu Nov 24 00:00:00 EST 2011
The mechanism of action of the histone deacetylase inhibitor vorinostat involves interaction with the insulin-like growth factor signaling pathway.
PloS one
Sarfstein R,Bruchim I,Fishman A,Werner H
Fri Jun 08 00:00:00 EDT 2012
The mTOR (mammalian target of rapamycin) kinase maintains integrity of mTOR complex 2.
The Journal of biological chemistry
Chen CH,Sarbassov dos D
Fri Nov 18 00:00:00 EST 2011
Rap1-GTP-interacting adaptor molecule (RIAM) protein controls invasion and growth of melanoma cells.
The Journal of biological chemistry
Hernández-Varas P,Coló GP,Bartolomé RA,Paterson A,Medraño-Fernández I,Arellano-Sánchez N,Cabañas C,Sánchez-Mateos P,Lafuente EM,Boussiotis VA,Strömblad S,Teixidó J
Fri May 27 00:00:00 EDT 2011
A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells.
Cell
Marchetto MC,Carromeu C,Acab A,Yu D,Yeo GW,Mu Y,Chen G,Gage FH,Muotri AR
Fri Nov 12 00:00:00 EST 2010
GCS-100, a novel galectin-3 antagonist, modulates MCL-1, NOXA, and cell cycle to induce myeloma cell death.
Blood
Streetly MJ,Maharaj L,Joel S,Schey SA,Gribben JG,Cotter FE
Thu May 13 00:00:00 EDT 2010
Retinoic acid enhances the generation of hematopoietic progenitors from human embryonic stem cell-derived hemato-vascular precursors.
Blood
Yu C,Liu Y,Miao Z,Yin M,Lu W,Lv Y,Ding M,Deng H
Thu Dec 02 00:00:00 EST 2010
Anti-angiogenic effects of resveratrol mediated by decreased VEGF and increased TSP1 expression in melanoma-endothelial cell co-culture.
Angiogenesis
Trapp V,Parmakhtiar B,Papazian V,Willmott L,Fruehauf JP
Wed Dec 01 00:00:00 EST 2010
Mesenchymal cells appearing in pancreatic tissue culture are bone marrow-derived stem cells with the capacity to improve transplanted islet function.
Stem cells (Dayton, Ohio)
Sordi V,Melzi R,Mercalli A,Formicola R,Doglioni C,Tiboni F,Ferrari G,Nano R,Chwalek K,Lammert E,Bonifacio E,Borg D,Piemonti L
Fri Jan 01 00:00:00 EST 2010
Membrane-based cultures generate scaffold-free neocartilage in vitro: influence of growth factors.
Tissue engineering. Part A
Mayer-Wagner S,Schiergens TS,Sievers B,Docheva D,Schieker M,Betz OB,Jansson V,Müller PE
Mon Feb 01 00:00:00 EST 2010
Ribosomal 18 S RNA processing by the IGF-I-responsive WDR3 protein is integrated with p53 function in cancer cell proliferation.
The Journal of biological chemistry
McMahon M,Ayllón V,Panov KI,O'Connor R
Fri Jun 11 00:00:00 EDT 2010
Specification of region-specific neurons including forebrain glutamatergic neurons from human induced pluripotent stem cells.
PloS one
Zeng H,Guo M,Martins-Taylor K,Wang X,Zhang Z,Park JW,Zhan S,Kronenberg MS,Lichtler A,Liu HX,Chen FP,Yue L,Li XJ,Xu RH
Thu Jul 29 00:00:00 EDT 2010
Characterization of a human fetal spinal cord stem cell line, NSI-566RSC, and its induction to functional motoneurons.
Journal of tissue engineering and regenerative medicine
Guo X,Johe K,Molnar P,Davis H,Hickman J
100-11 was used in In vitro experiments to report the first successful differentiation of MNs from human spinal cord stem cells in vitro, providing a novel approach for obtaining functional MNs when designing the therapeutic strategy for spinal cord diseases or injuries.
Mon Mar 01 00:00:00 EST 2010
A serum factor induces insulin-independent translocation of GLUT4 to the cell surface which is maintained in insulin resistance.
PloS one
Berenguer M,Martinez L,Giorgetti-Peraldi S,Le Marchand-Brustel Y,Govers R
Mon Dec 20 00:00:00 EST 2010
Heme-binding protein HRG-1 is induced by insulin-like growth factor I and associates with the vacuolar H+-ATPase to control endosomal pH and receptor trafficking.
The Journal of biological chemistry
O'Callaghan KM,Ayllon V,O'Keeffe J,Wang Y,Cox OT,Loughran G,Forgac M,O'Connor R
Fri Jan 01 00:00:00 EST 2010
Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.
The Journal of biological chemistry
Leenders JJ,Wijnen WJ,Hiller M,van der Made I,Lentink V,van Leeuwen REW,Herias V,Pokharel S,Heymans S,de Windt LJ,Høydal MA,Pinto YM,Creemers EE
Fri Aug 27 00:00:00 EDT 2010
Selective disruption of insulin-like growth factor-1 (IGF-1) signaling via phosphoinositide-dependent kinase-1 prevents the protective effect of IGF-1 on human cancer cell death.
The Journal of biological chemistry
Alberobello AT,D'Esposito V,Marasco D,Doti N,Ruvo M,Bianco R,Tortora G,Esposito I,Fiory F,Miele C,Beguinot F,Formisano P
Fri Feb 26 00:00:00 EST 2010
Networks inferred from biochemical data reveal profound differences in toll-like receptor and inflammatory signaling between normal and transformed hepatocytes.
Molecular & cellular proteomics : MCP
Alexopoulos LG,Saez-Rodriguez J,Cosgrove BD,Lauffenburger DA,Sorger PK
Wed Sep 01 00:00:00 EDT 2010
The reciprocal regulation of gamma-synuclein and IGF-I receptor expression creates a circuit that modulates IGF-I signaling.
The Journal of biological chemistry
Li M,Yin Y,Hua H,Sun X,Luo T,Wang J,Jiang Y
Fri Oct 01 00:00:00 EDT 2010
Mitochondrial clearance is regulated by Atg7-dependent and -independent mechanisms during reticulocyte maturation.
Blood
Zhang J,Randall MS,Loyd MR,Dorsey FC,Kundu M,Cleveland JL,Ney PA
Thu Jul 02 00:00:00 EDT 2009
Differentiation of human oligodendrocytes from pluripotent stem cells.
Nature protocols
Hu BY,Du ZW,Zhang SC
Wed Jan 06 00:00:00 EST 2010
Physiological function and transplantation of scaffold-free and vascularized human cardiac muscle tissue.
Proceedings of the National Academy of Sciences of the United States of America
Stevens KR,Kreutziger KL,Dupras SK,Korte FS,Regnier M,Muskheli V,Nourse MB,Bendixen K,Reinecke H,Murry CE
Tue Sep 29 00:00:00 EDT 2009
Preclinical targeting of the type I insulin-like growth factor receptor in adrenocortical carcinoma.
The Journal of clinical endocrinology and metabolism
Barlaskar FM,Spalding AC,Heaton JH,Kuick R,Kim AC,Thomas DG,Giordano TJ,Ben-Josef E,Hammer GD
Thu Jan 01 00:00:00 EST 2009
Complement factor H, a marker of self protects against experimental autoimmune encephalomyelitis.
Journal of immunology (Baltimore, Md. : 1950)
Griffiths MR,Neal JW,Fontaine M,Das T,Gasque P
Wed Apr 01 00:00:00 EDT 2009
Insulin-like growth factor-I and slow, bi-directional perfusion enhance the formation of tissue-engineered cardiac grafts.
Tissue engineering. Part A
Cheng M,Moretti M,Engelmayr GC,Freed LE
Sun Mar 01 00:00:00 EST 2009
Evidence for in vivo growth potential and vascular remodeling of tissue-engineered artery.
Tissue engineering. Part A
Cho SW,Kim IK,Kang JM,Song KW,Kim HS,Park CH,Yoo KJ,Kim BS
Wed Apr 01 00:00:00 EDT 2009
Development of serum-free, chemically defined conditions for human embryonic stem cell-derived fibrochondrogenesis.
Tissue engineering. Part A
Koay EJ,Athanasiou KA
Sat Aug 01 00:00:00 EDT 2009
Streptococcus agalactiae CspA is a serine protease that inactivates chemokines.
Journal of bacteriology
Bryan JD,Shelver DW
Sun Mar 01 00:00:00 EST 2009
SGK1 phosphorylation of IkappaB Kinase alpha and p300 Up-regulates NF-kappaB activity and increases N-Methyl-D-aspartate receptor NR2A and NR2B expression.
The Journal of biological chemistry
Tai DJ,Su CC,Ma YL,Lee EH
Fri Feb 13 00:00:00 EST 2009
The transcription of FOXO genes is stimulated by FOXO3 and repressed by growth factors.
The Journal of biological chemistry
Essaghir A,Dif N,Marbehant CY,Coffer PJ,Demoulin JB
Fri Apr 17 00:00:00 EDT 2009
A conserved mechanism for control of human and mouse embryonic stem cell pluripotency and differentiation by shp2 tyrosine phosphatase.
PloS one
Wu D,Pang Y,Ke Y,Yu J,He Z,Tautz L,Mustelin T,Ding S,Huang Z,Feng GS
Thu May 28 00:00:00 EDT 2009
Evaluation of intracellular signalling pathways in response to insulin-like growth factor I in apoptotic-resistant activated human hepatic stellate cells.
Fibrogenesis & tissue repair
Gentilini A,Lottini B,Brogi M,Caligiuri A,Cosmi L,Marra F,Pinzani M
Fri Jan 30 00:00:00 EST 2009
Growth factor regulation of growth factors in articular chondrocytes.
The Journal of biological chemistry
Shi S,Mercer S,Eckert GJ,Trippel SB
Fri Mar 13 00:00:00 EDT 2009
Discrete logic modelling as a means to link protein signalling networks with functional analysis of mammalian signal transduction.
Molecular systems biology
Saez-Rodriguez J,Alexopoulos LG,Epperlein J,Samaga R,Lauffenburger DA,Klamt S,Sorger PK
Thu Apr 01 00:00:00 EDT 2010
Systems-level interactions between insulin-EGF networks amplify mitogenic signaling.
Molecular systems biology
Borisov N,Aksamitiene E,Kiyatkin A,Legewie S,Berkhout J,Maiwald T,Kaimachnikov NP,Timmer J,Hoek JB,Kholodenko BN
Fri Jun 26 00:00:00 EDT 2009
Epigenetic regulation of neural cell differentiation plasticity in the adult mammalian brain.
Proceedings of the National Academy of Sciences of the United States of America
Kohyama J,Kojima T,Takatsuka E,Yamashita T,Namiki J,Hsieh J,Gage FH,Namihira M,Okano H,Sawamoto K,Nakashima K
Tue Nov 18 00:00:00 EST 2008
Donor age and cell passage affects differentiation potential of murine bone marrow-derived stem cells.
BMC cell biology
Kretlow JD,Jin YQ,Liu W,Zhang WJ,Hong TH,Zhou G,Baggett LS,Mikos AG,Cao Y
Tue Oct 28 00:00:00 EDT 2008
Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.
The Journal of biological chemistry
Lindemann MJ,Hu Z,Benczik M,Liu KD,Gaffen SL
Fri May 16 00:00:00 EDT 2008
The in vitro migration capacity of human bone marrow mesenchymal stem cells: comparison of chemokine and growth factor chemotactic activities.
Stem cells (Dayton, Ohio)
Ponte AL,Marais E,Gallay N,Langonné A,Delorme B,Hérault O,Charbord P,Domenech J
Sun Jul 01 00:00:00 EDT 2007
A comparative analysis of cartilage engineered from different perinatal mesenchymal progenitor cells.
Tissue engineering
Kunisaki SM,Fuchs JR,Steigman SA,Fauza DO
Thu Nov 01 00:00:00 EDT 2007
Constitutive activation of MEK1 in chondrocytes causes Stat1-independent achondroplasia-like dwarfism and rescues the Fgfr3-deficient mouse phenotype.
Genes & development
Murakami S,Balmes G,McKinney S,Zhang Z,Givol D,de Crombrugghe B
Sun Feb 01 00:00:00 EST 2004
Identification of selective basophil chemoattractants in human nasal polyps as insulin-like growth factor-1 and insulin-like growth factor-2.
Journal of immunology (Baltimore, Md. : 1950)
Hartnell A,Heinemann A,Conroy DM,Wait R,Sturm GJ,Caversaccio M,Jose PJ,Williams TJ
Mon Nov 15 00:00:00 EST 2004
Growth factors regulate phototransduction in retinal rods by modulating cyclic nucleotide-gated channels through dephosphorylation of a specific tyrosine residue.
Proceedings of the National Academy of Sciences of the United States of America
Savchenko A,Kraft TW,Molokanova E,Kramer RH
Tue May 08 00:00:00 EDT 2001
Cyclic AMP elevation is sufficient to promote the survival of spinal motor neurons in vitro.
The Journal of neuroscience : the official journal of the Society for Neuroscience
Hanson MG,Shen S,Wiemelt AP,McMorris FA,Barres BA
Tue Sep 15 00:00:00 EDT 1998
Regulation of quantal secretion by neurotrophic factors at developing motoneurons in Xenopus cell cultures.
The Journal of physiology
Liou JC,Yang RS,Fu WM
Fri Aug 15 00:00:00 EDT 1997
Heparin binding and oligomerization of hepatocyte growth factor/scatter factor isoforms. Heparan sulfate glycosaminoglycan requirement for Met binding and signaling.
The Journal of biological chemistry
Sakata H,Stahl SJ,Taylor WG,Rosenberg JM,Sakaguchi K,Wingfield PT,Rubin JS
100-11 was used in Cell Culture to establish the importance of the N domain for heparin-ligand and ligand-ligand interactions, and demonstrate a crucial role for HSGAG in receptor binding and signal transduction.
Fri Apr 04 00:00:00 EST 1997