Product References
Contribution of Elevated Glucose and Oxidized LDL to Macrophage Inflammation: A Role for PRAS40/Akt-Dependent Shedding of Soluble CD14.
Antioxidants (Basel, Switzerland)
Sanjurjo L,Castelblanco E,Julve J,Villalmanzo N,Téllez É,Ramirez-Morros A,Alonso N,Mauricio D,Sarrias MR
200-10 was used in In vitro experiments to support an enhanced synergistic pro-inflammatory effect induced by HG and oxLDL in cultured human macrophages, possibly explained by increased sCD14 shedding.
Thu May 11 00:00:00 UTC 2023
Bow-tie architectures in biological and artificial neural networks: Implications for network evolution and assay design.
iScience
Hilliard S,Mosoyan K,Branciamore S,Gogoshin G,Zhang A,Simons DL,Rockne RC,Lee PP,Rodin AS
200-10 was used in In vitro experiments to propose that the ubiquitous information-theoretic principles underlying the development of artificial neural networks are similar to the principles guiding the macro-evolution of biological networks and that insights gained from one field can be applied to the other.
Fri Feb 17 00:00:00 UTC 2023
Breast tumors interfere with endothelial TRAIL at the premetastatic niche to promote cancer cell seeding.
Science advances
Riera-Domingo C,Leite-Gomes E,Charatsidou I,Zhao P,Carrá G,Cappellesso F,Mourao L,De Schepper M,Liu D,Serneels J,Alameh MG,Shuvaev VV,Geukens T,Isnaldi E,Prenen H,Weissman D,Muzykantov VR,Soenen S,Desmedt C,Scheele CLGJ,Sablina A,Di Matteo M,Martín-Pérez R,Mazzone M
200-10 was used in In vitro experiments to find that ECs at the PMN coexpress tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and its cognate death receptor 5 (DR5).
Wed Mar 22 00:00:00 UTC 2023
Interleukin-10 contributes to reservoir establishment and persistence in SIV-infected macaques treated with antiretroviral therapy.
The Journal of clinical investigation
Harper J,Ribeiro SP,Chan CN,Aid M,Deleage C,Micci L,Pino M,Cervasi B,Raghunathan G,Rimmer E,Ayanoglu G,Wu G,Shenvi N,Barnard RJ,Del Prete GQ,Busman-Sahay K,Silvestri G,Kulpa DA,Bosinger SE,Easley KA,Howell BJ,Gorman D,Hazuda DJ,Estes JD,Sekaly RP,Paiardini M
200-10 was used in In vitro experiments to investigate IL-10 expression during SIV infection and effects on T follicular helper cells.
Fri Apr 15 00:00:00 UTC 2022
P2RY8 variants in lupus patients uncover a role for the receptor in immunological tolerance.
The Journal of experimental medicine
He Y,Gallman AE,Xie C,Shen Q,Ma J,Wolfreys FD,Sandy M,Arsov T,Wu X,Qin Y,Zhang P,Jiang S,Stanley M,Wu P,Tan J,Ding H,Xue H,Chen W,Xu J,Criswell LA,Nititham J,Adamski M,Kitching AR,Cook MC,Cao L,Shen N,Cyster JG,Vinuesa CG
200-10 was used in Sample Preparation (FC/FACS) to identify germline novel or rare P2RY8 missense variants in lupus kindreds or the related antiphospholipid syndrome, including a de novo" variant in a child with severe nephritis to uncover a role of P2RY8 in immunological tolerance and lupus pathogenesis."
Mon Jan 03 00:00:00 UTC 2022
A positive feedback loop between gastric cancer cells and tumor-associated macrophage induces malignancy progression.
Journal of experimental & clinical cancer research : CR
Piao H,Fu L,Wang Y,Liu Y,Wang Y,Meng X,Yang D,Xiao X,Zhang J
200-10 was used in Enzyme-linked immunosorbent assay to investigate the interactions of tumor-associated macrophages and gastric cancer cells.
Sat May 14 00:00:00 UTC 2022
Human Mesenchymal Stem Cell Secretome Driven T Cell Immunomodulation Is IL-10 Dependent.
International journal of molecular sciences
Shephard MT,Merkhan MM,Forsyth NR
200-10 was used in In vitro experiments to investigate human mesenchymal stem cell secretions in treatment therapies.
Sun Nov 06 00:00:00 UTC 2022
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.
JCI insight
Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA
200-10 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.
Wed Jun 08 00:00:00 UTC 2022
Stress Granules Determine the Development of Obesity-Associated Pancreatic Cancer.
Cancer discovery
Fonteneau G,Redding A,Hoag-Lee H,Sim ES,Heinrich S,Gaida MM,Grabocka E
200-10 was used in In vitro experiments to show that stress adaptation via the phase-separation organelles stress granules (SGs) mediates pancreatic ductal adenocarcinoma (PDAC) development.
Fri Aug 05 00:00:00 UTC 2022
Polymersomes-Mediated Delivery of CSF1R Inhibitor to Tumor Associated Macrophages Promotes M2 to M1-Like Macrophage Repolarization.
Macromolecular bioscience
Rodriguez-Perdigon M,Jimaja S,Haeni L,Bruns N,Rothen-Rutishauser B,Rüegg C
200-10 was used in Cell Culture to develop a CSF1Ri-loaded polymersomes (PMs) based delivery platform to promote M2-like macrophage repolarization.
Mon Aug 01 00:00:00 UTC 2022
PGE2 promotes macrophage recruitment and neovascularization in murine wet-type AMD models.
Cell communication and signaling : CCS
Zhan P,Cui Y,Cao Y,Bao X,Wu M,Yang Q,Yang J,Zheng H,Zou J,Xie T,Cai J,Yao Y,Wang X
200-10 was used in Cell Culture to describe the effects of cyclooxygenase-2 (COX2)/prostaglandin E2 (PGE2) signalling on the macrophage activation and choroidal neovascularization formation of wet Age-related macular degeneration.
Thu Oct 13 00:00:00 UTC 2022
Density dependent regulation of inflammatory responses in macrophages.
Frontiers in immunology
Vaughan-Jackson A,Stodolak S,Ebrahimi KH,Johnson E,Reardon PK,Dupont M,Zhang S,McCullagh JSO,James WS
200-10 was used in In vitro experiments to highlight cell plating density as an important but frequently overlooked consideration of in vitro macrophage research relevant to a variety of fields ranging from basic macrophage cell biology to disease studies.
Tue Jan 03 00:00:00 UTC 2023
Selenium-GPX4 axis protects follicular helper T cells from ferroptosis.
Nature immunology
Yao Y,Chen Z,Zhang H,Chen C,Zeng M,Yunis J,Wei Y,Wan Y,Wang N,Zhou M,Qiu C,Zeng Q,Ong HS,Wang H,Makota FV,Yang Y,Yang Z,Wang N,Deng J,Shen C,Xia Y,Yuan L,Lian Z,Deng Y,Guo C,Huang A,Zhou P,Shi H,Zhang W,Yi H,Li D,Xia M,Fu J,Wu N,de Haan JB,Shen N,Zhang W,Liu Z,Yu D
Wed Sep 01 00:00:00 UTC 2021
Seasonal coronavirus-specific B cells with limited SARS-CoV-2 cross-reactivity dominate the IgG response in severe COVID-19.
The Journal of clinical investigation
Aguilar-Bretones M,Westerhuis BM,Raadsen MP,de Bruin E,Chandler FD,Okba NM,Haagmans BL,Langerak T,Endeman H,van den Akker JP,Gommers DA,van Gorp EC,GeurtsvanKessel CH,de Vries RD,Fouchier RA,Rockx BH,Koopmans MP,van Nierop GP
Mon Nov 01 00:00:00 UTC 2021
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.
Science translational medicine
Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N
Wed Jun 16 00:00:00 UTC 2021
The ORF8 protein of SARS-CoV-2 mediates immune evasion through down-regulating MHC-Ι.
Proceedings of the National Academy of Sciences of the United States of America
Zhang Y,Chen Y,Li Y,Huang F,Luo B,Yuan Y,Xia B,Ma X,Yang T,Yu F,Liu J,Liu B,Song Z,Chen J,Yan S,Wu L,Pan T,Zhang X,Li R,Huang W,He X,Xiao F,Zhang J,Zhang H
Tue Jun 08 00:00:00 UTC 2021
Bifidobacterium dentium-derived y-glutamylcysteine suppresses ER-mediated goblet cell stress and reduces TNBS-driven colonic inflammation.
Gut microbes
Engevik MA,Herrmann B,Ruan W,Engevik AC,Engevik KA,Ihekweazu F,Shi Z,Luck B,Chang-Graham AL,Esparza M,Venable S,Horvath TD,Haidacher SJ,Hoch KM,Haag AM,Schady DA,Hyser JM,Spinler JK,Versalovic J
200-10 was used in Cell Culture to demonstrate positive modulation of the UPR and MUC2 production by B. dentium-secreted compounds.
Thu Nov 18 00:00:00 UTC 2021
Mantle cell lymphoma polarizes tumor-associated macrophages into M2-like macrophages, which in turn promote tumorigenesis.
Blood advances
Le K,Sun J,Khawaja H,Shibata M,Maggirwar SB,Smith MR,Gupta M
Tue Jul 27 00:00:00 UTC 2021
IL-10 alleviates lipopolysaccharide-induced skin scarring via IL-10R/STAT3 axis regulating TLR4/NF-κB pathway in dermal fibroblasts.
Journal of cellular and molecular medicine
Shi J,Shi S,Xie W,Zhao M,Li Y,Zhang J,Li N,Bai X,Cai W,Hu X,Hu D,Han J,Guan H
Mon Feb 01 00:00:00 UTC 2021
IL-10 alleviates lipopolysaccharide-induced skin scarring via IL-10R/STAT3 axis regulating TLR4/NF-κB pathway in dermal fibroblasts.
Journal of cellular and molecular medicine
Shi J,Shi S,Xie W,Zhao M,Li Y,Zhang J,Li N,Bai X,Cai W,Hu X,Hu D,Han J,Guan H
Mon Feb 01 00:00:00 UTC 2021
Rapid generation of monocyte-derived antigen-presenting cells with dendritic cell-like properties.
Transfusion
Cunningham S,Hackstein H
Tue Jun 01 00:00:00 UTC 2021
Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy.
Nature communications
Bent EH,Millán-Barea LR,Zhuang I,Goulet DR,Fröse J,Hemann MT
Thu Oct 28 00:00:00 UTC 2021
Fractional response analysis reveals logarithmic cytokine responses in cellular populations.
Nature communications
Nienałtowski K,Rigby RE,Walczak J,Zakrzewska KE,Głów E,Rehwinkel J,Komorowski M
Wed Jul 07 00:00:00 UTC 2021
SLAMF1 signaling induces Mycobacterium tuberculosis uptake leading to endolysosomal maturation in human macrophages.
Journal of leukocyte biology
Barbero AM,Trotta A,Genoula M,Pino REHD,Estermann MA,Celano J,Fuentes F,García VE,Balboa L,Barrionuevo P,Pasquinelli V
200-10 was used in Cell Culture to provide evidence that SLAMF1 improves the uptake of M. tuberculosis by human monocyte-derived macrophages.
Fri Jan 01 00:00:00 UTC 2021
S-1-Propenylcysteine promotes IL-10-induced M2c macrophage polarization through prolonged activation of IL-10R/STAT3 signaling.
Scientific reports
Miki S,Suzuki JI,Takashima M,Ishida M,Kokubo H,Yoshizumi M
Wed Nov 17 00:00:00 UTC 2021
Dectin-1 Controls TSLP-Induced Th2 Response by Regulating STAT3, STAT6, and p50-RelB Activities in Dendritic Cells.
Frontiers in immunology
Gu C,Upchurch K,Horton J,Wiest M,Zurawski S,Millard M,Kane RR,Joo H,Miller LA,Oh S
200-10 was used in In vitro experiments to provide a molecular explanation of Dectin-1-mediated suppression of Th2-type inflammatory responses and suggests Dectin-1 as a target for controlling Th2-type inflammation.
Tue Oct 26 00:00:00 UTC 2021
Antibody Conjugation of Fluorescent Nanodiamonds for Targeted Innate Immune Cell Activation.
ACS applied nano materials
Suarez-Kelly LP,Sun SH,Ren C,Rampersaud IV,Albertson D,Duggan MC,Noel TC,Courtney N,Buteyn NJ,Moritz C,Yu L,Yildiz VO,Butchar JP,Tridandapani S,Rampersaud AA,Carson WE
200-10 was used in Cell Culture to study how antibody-conjugated fluorescent nanodiamonds (FNDs) may serve as immune drug delivery vehicles with track and trace capabilities" to promote directed antitumor activity and minimize systemic toxicities."
Fri Mar 26 00:00:00 UTC 2021
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.
Nature communications
Hu G,Su Y,Kang BH,Fan Z,Dong T,Brown DR,Cheah J,Wittrup KD,Chen J
Wed Feb 03 00:00:00 UTC 2021
Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity.
Cell reports
Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA,Hitosugi T,Bernlohr DA,Sun J,Zeng H
Tue Jan 05 00:00:00 UTC 2021
B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells.
bioRxiv : the preprint server for biology
Yu B,Qi Y,Li R,Shi Q,Satpathy A,Chang HY
Tue Jan 05 00:00:00 UTC 2021
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Cell
Bouhaddou M,Memon D,Meyer B,White KM,Rezelj VV,Correa Marrero M,Polacco BJ,Melnyk JE,Ulferts S,Kaake RM,Batra J,Richards AL,Stevenson E,Gordon DE,Rojc A,Obernier K,Fabius JM,Soucheray M,Miorin L,Moreno E,Koh C,Tran QD,Hardy A,Robinot R,Vallet T,Nilsson-Payant BE,Hernandez-Armenta C,Dunham A,Weigang S,Knerr J,Modak M,Quintero D,Zhou Y,Dugourd A,Valdeolivas A,Patil T,Li Q,Hüttenhain R,Cakir M,Muralidharan M,Kim M,Jang G,Tutuncuoglu B,Hiatt J,Guo JZ,Xu J,Bouhaddou S,Mathy CJP,Gaulton A,Manners EJ,Félix E,Shi Y,Goff M,Lim JK,McBride T,O'Neal MC,Cai Y,Chang JCJ,Broadhurst DJ,Klippsten S,De Wit E,Leach AR,Kortemme T,Shoichet B,Ott M,Saez-Rodriguez J,tenOever BR,Mullins RD,Fischer ER,Kochs G,Grosse R,García-Sastre A,Vignuzzi M,Johnson JR,Shokat KM,Swaney DL,Beltrao P,Krogan NJ
200-10 was used in Enzyme-linked immunosorbent assay to present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins.
Thu Aug 06 00:00:00 UTC 2020
The Global Phosphorylation Landscape of SARS-CoV-2 Infection.
Cell
Bouhaddou M,Memon D,Meyer B,White KM,Rezelj VV,Correa Marrero M,Polacco BJ,Melnyk JE,Ulferts S,Kaake RM,Batra J,Richards AL,Stevenson E,Gordon DE,Rojc A,Obernier K,Fabius JM,Soucheray M,Miorin L,Moreno E,Koh C,Tran QD,Hardy A,Robinot R,Vallet T,Nilsson-Payant BE,Hernandez-Armenta C,Dunham A,Weigang S,Knerr J,Modak M,Quintero D,Zhou Y,Dugourd A,Valdeolivas A,Patil T,Li Q,Hüttenhain R,Cakir M,Muralidharan M,Kim M,Jang G,Tutuncuoglu B,Hiatt J,Guo JZ,Xu J,Bouhaddou S,Mathy CJP,Gaulton A,Manners EJ,Félix E,Shi Y,Goff M,Lim JK,McBride T,O'Neal MC,Cai Y,Chang JCJ,Broadhurst DJ,Klippsten S,De Wit E,Leach AR,Kortemme T,Shoichet B,Ott M,Saez-Rodriguez J,tenOever BR,Mullins RD,Fischer ER,Kochs G,Grosse R,García-Sastre A,Vignuzzi M,Johnson JR,Shokat KM,Swaney DL,Beltrao P,Krogan NJ
200-10 was used in Enzyme-linked immunosorbent assay to present a quantitative mass spectrometry-based phosphoproteomics survey of SARS-CoV-2 infection in Vero E6 cells, revealing dramatic rewiring of phosphorylation on host and viral proteins.
Thu Aug 06 00:00:00 UTC 2020
Nanoparticle Vaccines Based on the Receptor Binding Domain (RBD) and Heptad Repeat (HR) of SARS-CoV-2 Elicit Robust Protective Immune Responses.
Immunity
Ma X,Zou F,Yu F,Li R,Yuan Y,Zhang Y,Zhang X,Deng J,Chen T,Song Z,Qiao Y,Zhan Y,Liu J,Zhang J,Zhang X,Peng Z,Li Y,Lin Y,Liang L,Wang G,Chen Y,Chen Q,Pan T,He X,Zhang H
200-10 was used in Flow cytometry/Cell sorting to develop nanoparticle vaccines by covalently conjugating the self-assembled 24-mer ferritin to the receptor binding domain (RBD) and/or heptad repeat (HR) subunits of the Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) spike (S) protein.
Tue Dec 15 00:00:00 UTC 2020
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
200-10 was used in In vitro experiments to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.
Mon Jul 13 00:00:00 UTC 2020
Loss of ZBTB24 impairs nonhomologous end-joining and class-switch recombination in patients with ICF syndrome.
The Journal of experimental medicine
Helfricht A,Thijssen PE,Rother MB,Shah RG,Du L,Takada S,Rogier M,Moritz J,IJspeert H,Stoepker C,van Ostaijen-Ten Dam MM,Heyer V,Luijsterburg MS,de Groot A,Jak R,Grootaers G,Wang J,Rao P,Vertegaal ACO,van Tol MJD,Pan-Hammarström Q,Reina-San-Martin B,Shah GM,van der Burg M,van der Maarel SM,van Attikum H
Mon Nov 02 00:00:00 UTC 2020
IL-35 is critical in suppressing superantigenic Staphylococcus aureus-driven inflammatory Th17 responses in human nasopharynx-associated lymphoid tissue.
Mucosal immunology
Xu R,Shears RK,Sharma R,Krishna M,Webb C,Ali R,Wei X,Kadioglu A,Zhang Q
Fri May 01 00:00:00 UTC 2020
The Interaction of Sodium and Zinc in the Priming of T Cell Subpopulations Regarding Th17 and Treg Cells.
Molecular nutrition & food research
Dünkelberg S,Maywald M,Schmitt AK,Schwerdtle T,Meyer S,Rink L
Wed Jan 01 00:00:00 UTC 2020
The Metalloproteinase ADAMTS5 Is Expressed by Interstitial Inflammatory Cells in IgA Nephropathy and Is Proteolytically Active on the Kidney Matrix.
Journal of immunology (Baltimore, Md. : 1950)
Taylor S,Whitfield M,Barratt J,Didangelos A
Thu Oct 15 00:00:00 UTC 2020
Triggering of the cGAS-STING Pathway in Human Plasmacytoid Dendritic Cells Inhibits TLR9-Mediated IFN Production.
Journal of immunology (Baltimore, Md. : 1950)
Deb P,Dai J,Singh S,Kalyoussef E,Fitzgerald-Bocarsly P
Wed Jul 01 00:00:00 UTC 2020
TNF-α and IL-10 Control CXCL13 Expression in Human Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Bellamri N,Viel R,Morzadec C,Lecureur V,Joannes A,de Latour B,Llamas-Gutierrez F,Wollin L,Jouneau S,Vernhet L
Fri May 01 00:00:00 UTC 2020
Specific Effects of Trabectedin and Lurbinectedin on Human Macrophage Function and Fate-Novel Insights.
Cancers
Povo-Retana A,Mojena M,Stremtan AB,Fernández-García VB,Gómez-Sáez A,Nuevo-Tapioles C,Molina-Guijarro JM,Avendaño-Ortiz J,Cuezva JM,López-Collazo E,Martínez-Leal JF,Boscá L
200-10 was used in In vitro experiments to study the effect of trabectedin and lurbinectedin on human macrophage cell viability and function.
Tue Oct 20 00:00:00 UTC 2020
Dual Role of WISP1 in maintaining glioma stem cells and tumor-supportive macrophages in glioblastoma.
Nature communications
Tao W,Chu C,Zhou W,Huang Z,Zhai K,Fang X,Huang Q,Zhang A,Wang X,Yu X,Huang H,Wu Q,Sloan AE,Yu JS,Li X,Stark GR,Rich JN,Bao S
Mon Jun 15 00:00:00 UTC 2020
Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration.
Cell death & disease
Luo B,Zhan Y,Luo M,Dong H,Liu J,Lin Y,Zhang J,Wang G,Verhoeyen E,Zhang Y,Zhang H
Thu Nov 12 00:00:00 UTC 2020
Human recombinant IL-10 reduces xenogenic cytotoxicity via macrophage M2 polarization.
Biochemistry and biophysics reports
Kim YK,Kim SE,Chang Park H,Hwang JH,Lee HT
200-10 was used in In vitro experiments to show that hIL-10 transgenic pig can be used as a model to overcome acute immune rejection in pig-to-human xenotransplantation.
Tue Dec 01 00:00:00 UTC 2020
Triggering Receptor Expressed on Myeloid Cell 2 R47H Exacerbates Immune Response in Alzheimer's Disease Brain.
Frontiers in immunology
Korvatska O,Kiianitsa K,Ratushny A,Matsushita M,Beeman N,Chien WM,Satoh JI,Dorschner MO,Keene CD,Bammler TK,Bird TD,Raskind WH
200-10 was used in Cell Culture to point to a role of the TREM2 receptor in the control of the interferon type I response in myeloid cells and provide insight regarding the contribution of R47H TREM2 to AD pathology.
Fri Apr 30 00:00:00 UTC 2021
Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages.
eLife
Dupont M,Souriant S,Balboa L,Vu Manh TP,Pingris K,Rousset S,Cougoule C,Rombouts Y,Poincloux R,Ben Neji M,Allers C,Kaushal D,Kuroda MJ,Benet S,Martinez-Picado J,Izquierdo-Useros N,Sasiain MDC,Maridonneau-Parini I,Neyrolles O,Vérollet C,Lugo-Villarino G
200-10 was used in Cell Culture to uncover a deleterious role for Siglec-1 in TB-HIV-1 co-infection and open new avenues to understand TNT biology.
Mon Mar 30 00:00:00 UTC 2020
3D Scaffold-Based Macrophage Fibroblast Coculture Model Reveals IL-10 Dependence of Wound Resolution Phase.
Advanced biosystems
Ullm F,Riedl P,Machado de Amorim A,Patzschke A,Weiß R,Hauschildt S,Franke K,Anderegg U,Pompe T
Wed Jan 01 00:00:00 UTC 2020
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.
Cell
Georgouli M,Herraiz C,Crosas-Molist E,Fanshawe B,Maiques O,Perdrix A,Pandya P,Rodriguez-Hernandez I,Ilieva KM,Cantelli G,Karagiannis P,Mele S,Lam H,Josephs DH,Matias-Guiu X,Marti RM,Nestle FO,Orgaz JL,Malanchi I,Fruhwirth GO,Karagiannis SN,Sanz-Moreno V
Thu Feb 07 00:00:00 UTC 2019
Regulatory roles of IL-10-producing human follicular T cells.
The Journal of experimental medicine
Cañete PF,Sweet RA,Gonzalez-Figueroa P,Papa I,Ohkura N,Bolton H,Roco JA,Cuenca M,Bassett KJ,Sayin I,Barry E,Lopez A,Canaday DH,Meyer-Hermann M,Doglioni C,Fazekas de St Groth B,Sakaguchi S,Cook MC,Vinuesa CG
Mon Aug 05 00:00:00 UTC 2019
Apolipoprotein E is a concentration-dependent pulmonary danger signal that activates the NLRP3 inflammasome and IL-1β secretion by bronchoalveolar fluid macrophages from asthmatic subjects.
The Journal of allergy and clinical immunology
Gordon EM,Yao X,Xu H,Karkowsky W,Kaler M,Kalchiem-Dekel O,Barochia AV,Gao M,Keeran KJ,Jeffries KR,Levine SJ
200-10 was used in In vitro experiments to investigate APOE regulation of IL-1β secretion.
Thu Aug 01 00:00:00 UTC 2019
EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation.
Leukemia
Herviou L,Jourdan M,Martinez AM,Cavalli G,Moreaux J
Thu Aug 01 00:00:00 UTC 2019
STAT3 and STAT5 Signaling Thresholds Determine Distinct Regulation for Innate Receptor-Induced Inflammatory Cytokines, and STAT3/STAT5 Disease Variants Modulate These Outcomes.
Journal of immunology (Baltimore, Md. : 1950)
Hedl M,Sun R,Huang C,Abraham C
Sun Dec 15 00:00:00 UTC 2019
Pericytes Contribute to Dysfunction in a Human 3D Model of Placental Microvasculature through VEGF-Ang-Tie2 Signaling.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Haase K,Gillrie MR,Hajal C,Kamm RD
Sun Dec 01 00:00:00 UTC 2019
Cytokine Selection of MSC Clones with Different Functionality.
Stem cell reports
Selich A,Ha TC,Morgan M,Falk CS,von Kaisenberg C,Schambach A,Rothe M
Tue Aug 13 00:00:00 UTC 2019
In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay.
Scientific reports
Schulz D,Severin Y,Zanotelli VRT,Bodenmiller B
Wed Feb 13 00:00:00 UTC 2019
Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β.
Scientific reports
Bonne-Année S,Bush MC,Nutman TB
Fri Oct 04 00:00:00 UTC 2019
LACC1 Required for NOD2-Induced, ER Stress-Mediated Innate Immune Outcomes in Human Macrophages and LACC1 Risk Variants Modulate These Outcomes.
Cell reports
Huang C,Hedl M,Ranjan K,Abraham C
200-10 was used in Cell Culture to investigate that, if, upon stimulation of the pattern-recognition receptor (PRR) NOD2, LACC1 localizes to the endoplasmic reticulum (ER) and forms a complex with ER-stress sensors.
Tue Dec 24 00:00:00 UTC 2019
Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion.
Science advances
Johnston JM,Angyal A,Bauer RC,Hamby S,Suvarna SK,Baidžajevas K,Hegedus Z,Dear TN,Turner M,Wilson HL,Goodall AH,Rader DJ,Shoulders CC,Francis SE,Kiss-Toth E
200-10 was used in Cell Culture to suggest that a conserved, TRIB1-mediated mechanism drives foam cell formation in atherosclerotic plaque and that inhibiting mTRIB1 could be used therapeutically to reduce CHD.
Tue Oct 01 00:00:00 UTC 2019
ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12.
Cell death & disease
Kloss L,Dollt C,Schledzewski K,Krewer A,Melchers S,Manta C,Sticht C,Torre C,Utikal J,Umansky V,Schmieder A
Mon Oct 07 00:00:00 UTC 2019
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 UTC 2018
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 UTC 2018
Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution.
Immunity
Proto JD,Doran AC,Gusarova G,Yurdagul A,Sozen E,Subramanian M,Islam MN,Rymond CC,Du J,Hook J,Kuriakose G,Bhattacharya J,Tabas I
Tue Oct 16 00:00:00 UTC 2018
ATG16L1 orchestrates interleukin-22 signaling in the intestinal epithelium via cGAS-STING.
The Journal of experimental medicine
Aden K,Tran F,Ito G,Sheibani-Tezerji R,Lipinski S,Kuiper JW,Tschurtschenthaler M,Saveljeva S,Bhattacharyya J,Häsler R,Bartsch K,Luzius A,Jentzsch M,Falk-Paulsen M,Stengel ST,Welz L,Schwarzer R,Rabe B,Barchet W,Krautwald S,Hartmann G,Pasparakis M,Blumberg RS,Schreiber S,Kaser A,Rosenstiel P
Mon Nov 05 00:00:00 UTC 2018
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.
Frontiers in immunology
Ohradanova-Repic A,Machacek C,Charvet C,Lager F,Le Roux D,Platzer R,Leksa V,Mitulovic G,Burkard TR,Zlabinger GJ,Fischer MB,Feuillet V,Renault G,Blüml S,Benko M,Suchanek M,Huppa JB,Matsuyama T,Cavaco-Paulo A,Bismuth G,Stockinger H
Fri Jun 14 00:00:00 UTC 2019
BAFF augments IgA2 and IL-10 production by TLR7/8 stimulated total peripheral blood B cells.
European journal of immunology
den Hartog G,van Osch TLJ,Vos M,Meijer B,Savelkoul HFJ,van Neerven RJJ,Brugman S
200-10 was used in Sample Preparation (FC/FACS) to study whether T-cell-independent factors- promoting cell survival, class switching and immunoglobulin secretion- BAFF, APRIL, IL-10 and retinoic acid can boost IgA production in the context of viral or bacterial infection.
Thu Feb 01 00:00:00 UTC 2018
IL-10 Paradoxically Promotes Autoimmune Neuropathy through S1PR1-Dependent CD4+ T Cell Migration.
Journal of immunology (Baltimore, Md. : 1950)
Smith CJ,Allard DE,Wang Y,Howard JF,Montgomery SA,Su MA
Thu Mar 01 00:00:00 UTC 2018
Toxoplasma gondii Inactivates Human Plasmacytoid Dendritic Cells by Functional Mimicry of IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Pierog PL,Zhao Y,Singh S,Dai J,Yap GS,Fitzgerald-Bocarsly P
Mon Jan 01 00:00:00 UTC 2018
IgG Immunocomplexes Sensitize Human Monocytes for Inflammatory Hyperactivity via Transcriptomic and Epigenetic Reprogramming in Rheumatoid Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Zhong Q,Gong FY,Gong Z,Hua SH,Zeng KQ,Gao XM
Fri Jun 15 00:00:00 UTC 2018
STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas.
Nature communications
Pan YR,Chen CC,Chan YT,Wang HJ,Chien FT,Chen YL,Liu JL,Yang MH
Wed Sep 12 00:00:00 UTC 2018
Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.
Scientific reports
Silvola JMU,Li XG,Virta J,Marjamäki P,Liljenbäck H,Hytönen JP,Tarkia M,Saunavaara V,Hurme S,Palani S,Hakovirta H,Ylä-Herttuala S,Saukko P,Chen Q,Low PS,Knuuti J,Saraste A,Roivainen A
Tue Jun 26 00:00:00 UTC 2018
Compound heterozygous TYK2 mutations underlie primary immunodeficiency with T-cell lymphopenia.
Scientific reports
Nemoto M,Hattori H,Maeda N,Akita N,Muramatsu H,Moritani S,Kawasaki T,Maejima M,Ode H,Hachiya A,Sugiura W,Yokomaku Y,Horibe K,Iwatani Y
Thu May 03 00:00:00 UTC 2018
An Immune Atlas of Clear Cell Renal Cell Carcinoma.
Cell
Chevrier S,Levine JH,Zanotelli VRT,Silina K,Schulz D,Bacac M,Ries CH,Ailles L,Jewett MAS,Moch H,van den Broek M,Beisel C,Stadler MB,Gedye C,Reis B,Pe'er D,Bodenmiller B
Thu May 04 00:00:00 UTC 2017
Human Secretory IgM Emerges from Plasma Cells Clonally Related to Gut Memory B Cells and Targets Highly Diverse Commensals.
Immunity
Magri G,Comerma L,Pybus M,Sintes J,Lligé D,Segura-Garzón D,Bascones S,Yeste A,Grasset EK,Gutzeit C,Uzzan M,Ramanujam M,van Zelm MC,Albero-González R,Vazquez I,Iglesias M,Serrano S,Márquez L,Mercade E,Mehandru S,Cerutti A
Tue Jul 18 00:00:00 UTC 2017
Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.
Cell systems
Martins AJ,Narayanan M,Prüstel T,Fixsen B,Park K,Gottschalk RA,Lu Y,Andrews-Pfannkoch C,Lau WW,Wendelsdorf KV,Tsang JS
200-10 was used in In vitro experiments to explore context-dependent noise propagation among genes in human macrophages.
Wed Apr 26 00:00:00 UTC 2017
Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.
The Journal of clinical investigation
Cantaert T,Schickel JN,Bannock JM,Ng YS,Massad C,Delmotte FR,Yamakawa N,Glauzy S,Chamberlain N,Kinnunen T,Menard L,Lavoie A,Walter JE,Notarangelo LD,Bruneau J,Al-Herz W,Kilic SS,Ochs HD,Cunningham-Rundles C,van der Burg M,Kuijpers TW,Kracker S,Kaneko H,Sekinaka Y,Nonoyama S,Durandy A,Meffre E
Tue Nov 01 00:00:00 UTC 2016
The soluble pattern recognition receptor PTX3 links humoral innate and adaptive immune responses by helping marginal zone B cells.
The Journal of experimental medicine
Chorny A,Casas-Recasens S,Sintes J,Shan M,Polentarutti N,García-Escudero R,Walland AC,Yeiser JR,Cassis L,Carrillo J,Puga I,Cunha C,Bastos H,Rodrigues F,Lacerda JF,Morais A,Dieguez-Gonzalez R,Heeger PS,Salvatori G,Carvalho A,Garcia-Sastre A,Blander JM,Mantovani A,Garlanda C,Cerutti A
Mon Sep 19 00:00:00 UTC 2016
Large-scale sequence and structural comparisons of human naive and antigen-experienced antibody repertoires.
Proceedings of the National Academy of Sciences of the United States of America
DeKosky BJ,Lungu OI,Park D,Johnson EL,Charab W,Chrysostomou C,Kuroda D,Ellington AD,Ippolito GC,Gray JJ,Georgiou G
Tue May 10 00:00:00 UTC 2016
Immunomodulatory Factors Control the Fate of Melanoma Tumor Initiating Cells.
Stem cells (Dayton, Ohio)
Tuccitto A,Tazzari M,Beretta V,Rini F,Miranda C,Greco A,Santinami M,Patuzzo R,Vergani B,Villa A,Manenti G,Cleris L,Giardiello D,Alison M,Rivoltini L,Castelli C,Perego M
Sat Oct 01 00:00:00 UTC 2016
Dual Function of Ccr5 during Langat Virus Encephalitis: Reduction in Neutrophil-Mediated Central Nervous System Inflammation and Increase in T Cell-Mediated Viral Clearance.
Journal of immunology (Baltimore, Md. : 1950)
Michlmayr D,Bardina SV,Rodriguez CA,Pletnev AG,Lim JK
Wed Jun 01 00:00:00 UTC 2016
Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.
Scientific reports
Huynh L,Kusnadi A,Park SH,Murata K,Park-Min KH,Ivashkiv LB
Thu Aug 25 00:00:00 UTC 2016
IL10 inhibits starvation-induced autophagy in hypertrophic scar fibroblasts via cross talk between the IL10-IL10R-STAT3 and IL10-AKT-mTOR pathways.
Cell death & disease
Shi J,Wang H,Guan H,Shi S,Li Y,Wu X,Li N,Yang C,Bai X,Cai W,Yang F,Wang X,Su L,Zheng Z,Hu D
Thu Mar 10 00:00:00 UTC 2016
M2b Monocytes Provoke Bacterial Pneumonia and Gut Bacteria-Associated Sepsis in Alcoholics.
Journal of immunology (Baltimore, Md. : 1950)
Tsuchimoto Y,Asai A,Tsuda Y,Ito I,Nishiguchi T,Garcia MC,Suzuki S,Kobayashi M,Higuchi K,Suzuki F
Tue Dec 01 00:00:00 UTC 2015
Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer's disease pathology.
Nature communications
Baruch K,Rosenzweig N,Kertser A,Deczkowska A,Sharif AM,Spinrad A,Tsitsou-Kampeli A,Sarel A,Cahalon L,Schwartz M
Tue Aug 18 00:00:00 UTC 2015
Treatment of dextran sodium sulfate-induced experimental colitis by adoptive transfer of peritoneal cells.
Scientific reports
Liu T,Ren J,Wang W,Wei XW,Shen GB,Liu YT,Luo M,Xu GC,Shao B,Deng SY,He ZY,Liang X,Liu Y,Wen YZ,Xiang R,Yang L,Deng HX,Wei YQ
Fri Nov 13 00:00:00 UTC 2015
IL-10 induces the development of immunosuppressive CD14(+)HLA-DR(low/-) monocytes in B-cell non-Hodgkin lymphoma.
Blood cancer journal
Xiu B,Lin Y,Grote DM,Ziesmer SC,Gustafson MP,Maas ML,Zhang Z,Dietz AB,Porrata LF,Novak AJ,Liang AB,Yang ZZ,Ansell SM
Fri Jul 31 00:00:00 UTC 2015
miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program.
Nature communications
Su S,Zhao Q,He C,Huang D,Liu J,Chen F,Chen J,Liao JY,Cui X,Zeng Y,Yao H,Su F,Liu Q,Jiang S,Song E
Mon Oct 05 00:00:00 UTC 2015
PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy.
Cell death & disease
Wang SC,Li YH,Piao HL,Hong XW,Zhang D,Xu YY,Tao Y,Wang Y,Yuan MM,Li DJ,Du MR
Thu May 07 00:00:00 UTC 2015
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
Immunity
Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR
Thu Sep 18 00:00:00 UTC 2014
Lenalidomide inhibits the proliferation of CLL cells via a cereblon/p21(WAF1/Cip1)-dependent mechanism independent of functional p53.
Blood
Fecteau JF,Corral LG,Ghia EM,Gaidarova S,Futalan D,Bharati IS,Cathers B,Schwaederlé M,Cui B,Lopez-Girona A,Messmer D,Kipps TJ
Thu Sep 04 00:00:00 UTC 2014
Transcription of the activating receptor NKG2D in natural killer cells is regulated by STAT3 tyrosine phosphorylation.
Blood
Zhu S,Phatarpekar PV,Denman CJ,Senyukov VV,Somanchi SS,Nguyen-Jackson HT,Mace EM,Freeman AF,Watowich SS,Orange JS,Holland SM,Lee DA
Thu Jul 17 00:00:00 UTC 2014
Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry.
The Journal of experimental medicine
Williams GR,Fierens K,Preston SG,Lunn D,Rysnik O,De Prijck S,Kool M,Buckley HC,Lambrecht BN,O'Hare D,Austyn JM
Mon Jun 02 00:00:00 UTC 2014
A CD8 T cell/indoleamine 2,3-dioxygenase axis is required for mesenchymal stem cell suppression of human systemic lupus erythematosus.
Arthritis & rheumatology (Hoboken, N.J.)
Wang D,Feng X,Lu L,Konkel JE,Zhang H,Chen Z,Li X,Gao X,Lu L,Shi S,Chen W,Sun L
Fri Aug 01 00:00:00 UTC 2014
ABCG1-mediated generation of extracellular cholesterol microdomains.
Journal of lipid research
Freeman SR,Jin X,Anzinger JJ,Xu Q,Purushothaman S,Fessler MB,Addadi L,Kruth HS
Wed Jan 01 00:00:00 UTC 2014
Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells.
Immunology and cell biology
Ghamlouch H,Ouled-Haddou H,Guyart A,Regnier A,Trudel S,Claisse JF,Fuentes V,Royer B,Marolleau JP,Gubler B
Fri Aug 01 00:00:00 UTC 2014
Eosinophils regulate peripheral B cell numbers in both mice and humans.
Journal of immunology (Baltimore, Md. : 1950)
Wong TW,Doyle AD,Lee JJ,Jelinek DF
Tue Apr 15 00:00:00 UTC 2014
Noncanonical NF-κB activation mediates STAT3-stimulated IDO upregulation in myeloid-derived suppressor cells in breast cancer.
Journal of immunology (Baltimore, Md. : 1950)
Yu J,Wang Y,Yan F,Zhang P,Li H,Zhao H,Yan C,Yan F,Ren X
Mon Sep 01 00:00:00 UTC 2014
Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950)
Herter S,Birk MC,Klein C,Gerdes C,Umana P,Bacac M
Sat Mar 01 00:00:00 UTC 2014
Chronic exposure to glucocorticoids shapes gene expression and modulates innate and adaptive activation pathways in macrophages with distinct changes in leukocyte attraction.
Journal of immunology (Baltimore, Md. : 1950)
van de Garde MD,Martinez FO,Melgert BN,Hylkema MN,Jonkers RE,Hamann J
Sat Feb 01 00:00:00 UTC 2014
Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
Journal of immunology (Baltimore, Md. : 1950)
Wehrli M,Cortinas-Elizondo F,Hlushchuk R,Daudel F,Villiger PM,Miescher S,Zuercher AW,Djonov V,Simon HU,von Gunten S
Mon Dec 01 00:00:00 UTC 2014
Binding of HLA-G to ITIM-bearing Ig-like transcript 2 receptor suppresses B cell responses.
Journal of immunology (Baltimore, Md. : 1950)
Naji A,Menier C,Morandi F,Agaugué S,Maki G,Ferretti E,Bruel S,Pistoia V,Carosella ED,Rouas-Freiss N
Sat Feb 15 00:00:00 UTC 2014
IL-21 signalling via STAT3 primes human naive B cells to respond to IL-2 to enhance their differentiation into plasmablasts.
Blood
Berglund LJ,Avery DT,Ma CS,Moens L,Deenick EK,Bustamante J,Boisson-Dupuis S,Wong M,Adelstein S,Arkwright PD,Bacchetta R,Bezrodnik L,Dadi H,Roifman CM,Fulcher DA,Ziegler JB,Smart JM,Kobayashi M,Picard C,Durandy A,Cook MC,Casanova JL,Uzel G,Tangye SG
Thu Dec 05 00:00:00 UTC 2013
Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.
The Journal of clinical investigation
Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN
Thu Aug 01 00:00:00 UTC 2013
Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models.
Molecular cancer therapeutics
Herter S,Herting F,Mundigl O,Waldhauer I,Weinzierl T,Fauti T,Muth G,Ziegler-Landesberger D,Van Puijenbroek E,Lang S,Duong MN,Reslan L,Gerdes CA,Friess T,Baer U,Burtscher H,Weidner M,Dumontet C,Umana P,Niederfellner G,Bacac M,Klein C
200-10 was used in Sample Preparation (FC/FACS) to show that the glyoengineered type II CD20 antibody GA101 is differentiated from the two approved type I CD20 antibodies rituximab and ofatumumab by its overall preclinical activity, further supporting its clinical investigation.
Tue Oct 01 00:00:00 UTC 2013
STAT-3 activation by differential cytokines is critical for human in vivo-generated plasma cell survival and Ig secretion.
Journal of immunology (Baltimore, Md. : 1950)
Rodríguez-Bayona B,Ramos-Amaya A,López-Blanco R,Campos-Caro A,Brieva JA
Fri Nov 15 00:00:00 UTC 2013
Two rare disease-associated Tyk2 variants are catalytically impaired but signaling competent.
Journal of immunology (Baltimore, Md. : 1950)
Li Z,Gakovic M,Ragimbeau J,Eloranta ML,Rönnblom L,Michel F,Pellegrini S
Fri Mar 01 00:00:00 UTC 2013
Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.
Journal of immunology (Baltimore, Md. : 1950)
Seow V,Lim J,Iyer A,Suen JY,Ariffin JK,Hohenhaus DM,Sweet MJ,Fairlie DP
Tue Oct 15 00:00:00 UTC 2013
IL-21 enhances the activity of the TLR-MyD88-STAT3 pathway but not the classical TLR-MyD88-NF-κB pathway in human B cells to boost antibody production.
Journal of immunology (Baltimore, Md. : 1950)
Liu BS,Stoop JN,Huizinga TW,Toes RE
Tue Oct 15 00:00:00 UTC 2013
IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.
Journal of immunology (Baltimore, Md. : 1950)
Zizzo G,Cohen PL
Wed May 15 00:00:00 UTC 2013
Cytokine response is determined by duration of receptor and signal transducers and activators of transcription 3 (STAT3) activation.
The Journal of biological chemistry
Braun DA,Fribourg M,Sealfon SC
Fri Feb 01 00:00:00 UTC 2013
IL-10 reduces levels of apoptosis in Toxoplasma gondii-infected trophoblasts.
PloS one
Zhao M,Zhang R,Xu X,Liu Y,Zhang H,Zhai X,Hu X
Tue Aug 27 00:00:00 UTC 2013
IL-10 reduces levels of apoptosis in Toxoplasma gondii-infected trophoblasts.
PloS one
Zhao M,Zhang R,Xu X,Liu Y,Zhang H,Zhai X,Hu X
Tue Aug 27 00:00:00 UTC 2013
Expression of Myc, but not pSTAT3, is an adverse prognostic factor for diffuse large B-cell lymphoma treated with epratuzumab/R-CHOP.
Blood
Gupta M,Maurer MJ,Wellik LE,Law ME,Han JJ,Ozsan N,Micallef IN,Dogan A,Witzig TE
Thu Nov 22 00:00:00 UTC 2012
Serum from patients with SLE instructs monocytes to promote IgG and IgA plasmablast differentiation.
The Journal of experimental medicine
Joo H,Coquery C,Xue Y,Gayet I,Dillon SR,Punaro M,Zurawski G,Banchereau J,Pascual V,Oh S
Mon Jul 02 00:00:00 UTC 2012
IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model.
Journal of molecular medicine (Berlin, Germany)
Schilling B,Harasymczuk M,Schuler P,Egan JE,Whiteside TL
Wed Feb 01 00:00:00 UTC 2012
Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Agbanoma G,Li C,Ennis D,Palfreeman AC,Williams LM,Brennan FM
Wed Feb 01 00:00:00 UTC 2012
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Journal of immunology (Baltimore, Md. : 1950)
Zizzo G,Hilliard BA,Monestier M,Cohen PL
Mon Oct 01 00:00:00 UTC 2012
Cellular and cytokine correlates of severe dengue infection.
PloS one
Malavige GN,Huang LC,Salimi M,Gomes L,Jayaratne SD,Ogg GS
Mon Jun 24 00:00:00 UTC 2013
Differential expression of HIV-1 interfering factors in monocyte-derived macrophages stimulated with polarizing cytokines or interferons.
Scientific reports
Cobos Jiménez V,Booiman T,de Taeye SW,van Dort KA,Rits MA,Hamann J,Kootstra NA
Thu Mar 21 00:00:00 UTC 2013
Cloning and characterization of CD300d, a novel member of the human CD300 family of immune receptors.
The Journal of biological chemistry
Comas-Casellas E,Martínez-Barriocanal Á,Miró F,Ejarque-Ortiz A,Schwartz S,Martín M,Sayós J
Fri Mar 23 00:00:00 UTC 2012
Influenza virus A infection of human monocyte and macrophage subpopulations reveals increased susceptibility associated with cell differentiation.
PloS one
Hoeve MA,Nash AA,Jackson D,Randall RE,Dransfield I
Mon May 14 00:00:00 UTC 2012
Neuroimmunoendocrine regulation of the prion protein in neutrophils.
The Journal of biological chemistry
Mariante RM,Nóbrega A,Martins RAP,Areal RB,Bellio M,Linden R
Fri Oct 12 00:00:00 UTC 2012
CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.
Oncoimmunology
Mandapathil M,Szczepanski M,Harasymczuk M,Ren J,Cheng D,Jackson EK,Gorelik E,Johnson J,Lang S,Whiteside TL
Wed Aug 01 00:00:00 UTC 2012
HBsAg inhibits IFN-α production in plasmacytoid dendritic cells through TNF-α and IL-10 induction in monocytes.
PloS one
Shi B,Ren G,Hu Y,Wang S,Zhang Z,Yuan Z
Fri Feb 15 00:00:00 UTC 2013
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood
Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E
Thu Jan 06 00:00:00 UTC 2011
Defective IL-10 signaling in hyper-IgE syndrome results in impaired generation of tolerogenic dendritic cells and induced regulatory T cells.
The Journal of experimental medicine
Saito M,Nagasawa M,Takada H,Hara T,Tsuchiya S,Agematsu K,Yamada M,Kawamura N,Ariga T,Tsuge I,Nonoyama S,Karasuyama H,Minegishi Y
Mon Feb 14 00:00:00 UTC 2011
Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Svensson J,Jenmalm MC,Matussek A,Geffers R,Berg G,Ernerudh J
Sat Oct 01 00:00:00 UTC 2011
Characterization of a transitional preplasmablast population in the process of human B cell to plasma cell differentiation.
Journal of immunology (Baltimore, Md. : 1950)
Jourdan M,Caraux A,Caron G,Robert N,Fiol G,Rème T,Bolloré K,Vendrell JP,Le Gallou S,Mourcin F,De Vos J,Kassambara A,Duperray C,Hose D,Fest T,Tarte K,Klein B
Sat Oct 15 00:00:00 UTC 2011
Common lymphatic endothelial and vascular endothelial receptor-1 mediates the transmigration of regulatory T cells across human hepatic sinusoidal endothelium.
Journal of immunology (Baltimore, Md. : 1950)
Shetty S,Weston CJ,Oo YH,Westerlund N,Stamataki Z,Youster J,Hubscher SG,Salmi M,Jalkanen S,Lalor PF,Adams DH
Fri Apr 01 00:00:00 UTC 2011
Evaluation of transduction efficiency in macrophage colony-stimulating factor differentiated human macrophages using HIV-1 based lentiviral vectors.
BMC biotechnology
Leyva FJ,Anzinger JJ,McCoy JP,Kruth HS
Mon Jan 31 00:00:00 UTC 2011
Modulation of human immune responses by bovine interleukin-10.
PloS one
den Hartog G,Savelkoul HF,Schoemaker R,Tijhaar E,Westphal AH,de Ruiter T,van de Weg-Schrijver E,van Neerven RJ
Fri Mar 25 00:00:00 UTC 2011
Amplification of the angiogenic signal through the activation of the TSC/mTOR/HIF axis by the KSHV vGPCR in Kaposi's sarcoma.
PloS one
Jham BC,Ma T,Hu J,Chaisuparat R,Friedman ER,Pandolfi PP,Schneider A,Sodhi A,Montaner S
Fri Apr 29 00:00:00 UTC 2011
LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release.
PloS one
Lundequist A,Boyce JA
Mon Mar 28 00:00:00 UTC 2011
Granzyme B produced by human plasmacytoid dendritic cells suppresses T-cell expansion.
Blood
Jahrsdörfer B,Vollmer A,Blackwell SE,Maier J,Sontheimer K,Beyer T,Mandel B,Lunov O,Tron K,Nienhaus GU,Simmet T,Debatin KM,Weiner GJ,Fabricius D
Thu Feb 11 00:00:00 UTC 2010
IL-10 administration reduces PGE-2 levels and promotes CR3-mediated clearance of Escherichia coli K1 by phagocytes in meningitis.
The Journal of experimental medicine
Mittal R,Gonzalez-Gomez I,Panigrahy A,Goth K,Bonnet R,Prasadarao NV
Mon Jun 07 00:00:00 UTC 2010
Soluble HIV-1 Env trimers in adjuvant elicit potent and diverse functional B cell responses in primates.
The Journal of experimental medicine
Sundling C,Forsell MN,O'Dell S,Feng Y,Chakrabarti B,Rao SS,Loré K,Mascola JR,Wyatt RT,Douagi I,Karlsson Hedestam GB
Mon Aug 30 00:00:00 UTC 2010
IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter.
Proceedings of the National Academy of Sciences of the United States of America
Kis LL,Salamon D,Persson EK,Nagy N,Scheeren FA,Spits H,Klein G,Klein E
Tue Jan 12 00:00:00 UTC 2010
Early production of IL-22 but not IL-17 by peripheral blood mononuclear cells exposed to live Borrelia burgdorferi: the role of monocytes and interleukin-1.
PLoS pathogens
Bachmann M,Horn K,Rudloff I,Goren I,Holdener M,Christen U,Darsow N,Hunfeld KP,Koehl U,Kind P,Pfeilschifter J,Kraiczy P,Mühl H
Thu Oct 14 00:00:00 UTC 2010
The highly virulent variola and monkeypox viruses express secreted inhibitors of type I interferon.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Fernández de Marco Mdel M,Alejo A,Hudson P,Damon IK,Alcami A
Sat May 01 00:00:00 UTC 2010
M2b monocytes predominated in peripheral blood of severely burned patients.
Journal of immunology (Baltimore, Md. : 1950)
Kobayashi M,Jeschke MG,Shigematsu K,Asai A,Yoshida S,Herndon DN,Suzuki F
Wed Dec 15 00:00:00 UTC 2010
Regulation of lentivirus neurovirulence by lipopolysaccharide conditioning: suppression of CXCL10 in the brain by IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Maingat F,Viappiani S,Zhu Y,Vivithanaporn P,Ellestad KK,Holden J,Silva C,Power C
Mon Feb 01 00:00:00 UTC 2010
Prostaglandin E2 inhibits IFN-alpha secretion and Th1 costimulation by human plasmacytoid dendritic cells via E-prostanoid 2 and E-prostanoid 4 receptor engagement.
Journal of immunology (Baltimore, Md. : 1950)
Fabricius D,Neubauer M,Mandel B,Schütz C,Viardot A,Vollmer A,Jahrsdörfer B,Debatin KM
Fri Jan 15 00:00:00 UTC 2010
Selective induction of DNA repair pathways in human B cells activated by CD4+ T cells.
PloS one
Wu X,Tschumper RC,Gutierrez A,Mihalcik SA,Nowakowski GS,Jelinek DF
Thu Dec 16 00:00:00 UTC 2010
HIV-1 inhibits autophagy in bystander macrophage/monocytic cells through Src-Akt and STAT3.
PloS one
Van Grol J,Subauste C,Andrade RM,Fujinaga K,Nelson J,Subauste CS
Thu Jul 22 00:00:00 UTC 2010
Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B.
Journal of immune based therapies and vaccines
Drozdowski B,Zhou Y,Kline B,Spidel J,Chan YY,Albone E,Turchin H,Chao Q,Henry M,Balogach J,Routhier E,Bavari S,Nicolaides NC,Sass PM,Grasso L
Tue Dec 21 00:00:00 UTC 2010
A T cell-dependent mechanism for the induction of human mucosal homing immunoglobulin A-secreting plasmablasts.
Immunity
Dullaers M,Li D,Xue Y,Ni L,Gayet I,Morita R,Ueno H,Palucka KA,Banchereau J,Oh S
Fri Jan 16 00:00:00 UTC 2009
Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors.
Cancer cell
Lee H,Herrmann A,Deng JH,Kujawski M,Niu G,Li Z,Forman S,Jove R,Pardoll DM,Yu H
Tue Apr 07 00:00:00 UTC 2009
An in vitro model of differentiation of memory B cells into plasmablasts and plasma cells including detailed phenotypic and molecular characterization.
Blood
Jourdan M,Caraux A,De Vos J,Fiol G,Larroque M,Cognot C,Bret C,Duperray C,Hose D,Klein B
Thu Dec 10 00:00:00 UTC 2009
Alternatively activated macrophages engage in homotypic and heterotypic interactions through IL-4 and polyamine-induced E-cadherin/catenin complexes.
Blood
Van den Bossche J,Bogaert P,van Hengel J,Guérin CJ,Berx G,Movahedi K,Van den Bergh R,Pereira-Fernandes A,Geuns JM,Pircher H,Dorny P,Grooten J,De Baetselier P,Van Ginderachter JA
Thu Nov 19 00:00:00 UTC 2009
Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions.
The Journal of clinical investigation
Buono C,Anzinger JJ,Amar M,Kruth HS
Fri May 01 00:00:00 UTC 2009
Characterization and regulation of bv8 in human blood cells.
Clinical cancer research : an official journal of the American Association for Cancer Research
Zhong C,Qu X,Tan M,Meng YG,Ferrara N
Wed Apr 15 00:00:00 UTC 2009
Different proliferative and survival capacity of CLL-cells in a newly established in vitro model for pseudofollicles.
Leukemia
Plander M,Seegers S,Ugocsai P,Diermeier-Daucher S,Iványi J,Schmitz G,Hofstädter F,Schwarz S,Orsó E,Knüchel R,Brockhoff G
Sun Nov 01 00:00:00 UTC 2009
Inhibitory effect of glycyrrhizin on the neutrophil-dependent increase of R5 HIV replication in cultures of macrophages.
Immunology and cell biology
Yoshida T,Kobayashi M,Li XD,Pollard RB,Suzuki F
Thu Oct 01 00:00:00 UTC 2009
Extracellular ATP acting at the P2X7 receptor inhibits secretion of soluble HLA-G from human monocytes.
Journal of immunology (Baltimore, Md. : 1950)
Rizzo R,Ferrari D,Melchiorri L,Stignani M,Gulinelli S,Baricordi OR,Di Virgilio F
Thu Oct 01 00:00:00 UTC 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 UTC 2009
Cysteinyl-leukotriene receptor type 1 expression and function is down-regulated during monocyte-derived dendritic cell maturation with zymosan: involvement of IL-10 and prostaglandins.
Journal of immunology (Baltimore, Md. : 1950)
Thivierge M,Stankova J,Rola-Pleszczynski M
Sun Nov 15 00:00:00 UTC 2009
Microdialysis of cytokines: methodological considerations, scanning electron microscopy, and determination of relative recovery.
Journal of neurotrauma
Helmy A,Carpenter KL,Skepper JN,Kirkpatrick PJ,Pickard JD,Hutchinson PJ
Wed Apr 01 00:00:00 UTC 2009
Mechanism and regulatory function of CpG signaling via scavenger receptor B1 in primary B cells.
The Journal of biological chemistry
Zhu P,Liu X,Treml LS,Cancro MP,Freedman BD
Fri Aug 21 00:00:00 UTC 2009
Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease.
Immunity
Zenewicz LA,Yancopoulos GD,Valenzuela DM,Murphy AJ,Stevens S,Flavell RA
Fri Dec 19 00:00:00 UTC 2008
Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.
Blood
Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA
Sat Nov 01 00:00:00 UTC 2008
IFN-gamma and STAT1 arrest monocyte migration and modulate RAC/CDC42 pathways.
Journal of immunology (Baltimore, Md. : 1950)
Hu Y,Hu X,Boumsell L,Ivashkiv LB
Sun Jun 15 00:00:00 UTC 2008
Inhibition of type I and type III interferons by a secreted glycoprotein from Yaba-like disease virus.
Proceedings of the National Academy of Sciences of the United States of America
Huang J,Smirnov SV,Lewis-Antes A,Balan M,Li W,Tang S,Silke GV,Pütz MM,Smith GL,Kotenko SV
Tue Jun 05 00:00:00 UTC 2007
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T
Sat Sep 15 00:00:00 UTC 2007
The inhibitory receptor IRp60 (CD300a) suppresses the effects of IL-5, GM-CSF, and eotaxin on human peripheral blood eosinophils.
Blood
Munitz A,Bachelet I,Eliashar R,Moretta A,Moretta L,Levi-Schaffer F
Wed Mar 01 00:00:00 UTC 2006
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.
Proceedings of the National Academy of Sciences of the United States of America
Bauer A,Villunger A,Labi V,Fischer SF,Strasser A,Wagner H,Schmid RM,Häcker G
Tue Jul 18 00:00:00 UTC 2006
Leukotriene B4, an activation product of mast cells, is a chemoattractant for their progenitors.
The Journal of experimental medicine
Weller CL,Collington SJ,Brown JK,Miller HR,Al-Kashi A,Clark P,Jose PJ,Hartnell A,Williams TJ
Mon Jun 20 00:00:00 UTC 2005
Human IL-19 regulates immunity through auto-induction of IL-19 and production of IL-10.
European journal of immunology
Jordan WJ,Eskdale J,Boniotto M,Lennon GP,Peat J,Campbell JD,Gallagher G
Sun May 01 00:00:00 UTC 2005
Decay-accelerating factor (CD55) is expressed by neurons in response to chronic but not acute autoimmune central nervous system inflammation associated with complement activation.
Journal of immunology (Baltimore, Md. : 1950)
van Beek J,van Meurs M,'t Hart BA,Brok HP,Neal JW,Chatagner A,Harris CL,Omidvar N,Morgan BP,Laman JD,Gasque P
Tue Feb 15 00:00:00 UTC 2005
Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.
The Journal of experimental medicine
Lin L,Gerth AJ,Peng SL
Mon Jul 05 00:00:00 UTC 2004
Monocyte derived dendritic cell responses in common variable immunodeficiency.
Clinical and experimental immunology
Scott-Taylor TH,Green MR,Eren E,Webster AD
200-10 was used in Enzyme-linked immunosorbent assay to study the function of monocyte derived dendritic cells (MdDC) in 25 patients with common variable immunodeficiency (CVID) to discern the failure of antibody production. DCs from the majority of CVID patients were normal, while 5 patients susceptible and with affected family members expressed abnormally low levels of DR. DCs from many CVID patients had high spontaneous production of IL-8 and lipopolysaccharide stimulation often caused by
Wed Dec 01 00:00:00 UTC 2004
Production of hemo- and immunoregulatory cytokines by erythroblast antigen+ and glycophorin A+ cells from human bone marrow.
BMC cell biology
Sennikov SV,Injelevskaya TV,Krysov SV,Silkov AN,Kovinev IB,Dyachkova NJ,Zenkov AN,Loseva MI,Kozlov VA
200-10 was used in In vitro experiments to show, that the unstimulated erythroblasts (Gl A+ or AG-EB+) produced a wide spectrum of immunoregulatory cytokines.
Mon Oct 18 00:00:00 UTC 2004
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 UTC 2003
Immune responses to Plasmodium falciparum-merozoite surface protein 1 (MSP1) antigen, II. Induction of parasite-specific immunoglobulin G in unsensitized human B cells after in vitro T-cell priming with MSP119.
Immunology
Garraud O,Diouf A,Holm I,Perraut R,Longacre S
Thu Jul 01 00:00:00 UTC 1999
Identification of functional domains on human interleukin 10.
Proceedings of the National Academy of Sciences of the United States of America
Gesser B,Leffers H,Jinquan T,Vestergaard C,Kirstein N,Sindet-Pedersen S,Jensen SL,Thestrup-Pedersen K,Larsen CG
200-10 was used in In vitro experiments to study two functional domains of IL-10 exerting different IL-10 like activities, suggesting that relatively small segments of these signal proteins are responsible for particular biological functions.
Tue Dec 23 00:00:00 UTC 1997
