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          • Proteins & Peptides ›
          • IL-10 Proteins
          The PeproTech website has now moved to Thermofisher.com. All orders for PeproTech products must be placed on thermofisher.com or offline via phone, fax, email, or distributor partner. For any questions, please contact PeproTech.CustomerService@thermofisher.com

          Gibco

          Human IL-10 Recombinant Protein, PeproTech®

          170 References
          View all (15) IL-10 proteins
          Datasheet
          Tech Support
          Datasheet
          Tech Support

          Cite Human IL-10 Recombinant Protein, PeproTech®

          • Testing Data (2)
          Human IL-10 Protein in Functional Assay (Functional)
          Group 53 Created with Sketch.
          Human IL-10 Protein in Functional Assay (Functional)
          Group 53 Created with Sketch.

          FIGURE: 1 / 2

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          Human IL-10 Protein (200-10-1MG) in Functional

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          Human IL-10 Protein in Functional Assay (Functional)
          Human IL-10 Protein in Functional Assay (Functional)

          Product Details

          200-10-1MG

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          Flow Cytometry (Flow)

          -
          View 1 publication 1 publication

          ELISA (ELISA)

          Assay-dependent
          View 6 publications 6 publications

          Functional Assay (Functional)

          Assay-dependent
          -

          In vitro Assay (IV)

          -
          View 149 publications 149 publications

          Miscellaneous PubMed (Misc)

          -
          View 14 publications 14 publications
          Product Specifications

          Species

          Human

          Published species

          Human, Mouse, Non-human primate, Pig, Virus

          Expression System

          E. coli

          Amino acid sequence

          MSPGQGTQSE NSCTHFPGNL PNMLRDLRDA FSRVKTFFQM KDQLDNLLLK ESLLEDFKGY LGCQALSEMI QFYLEEVMPQ AENQDPDIKA HVNSLGENLK TLRLRLRRCH RFLPCENKSK AVEQVKNAFN KLQEKGIYKA MSEFDIFINY IEAYMTMKIR N

          Molecular weight

          18.6 kDa

          Class

          Recombinant

          Type

          Protein

          Purity

          ≥ 98% by SDS-PAGE gel and HPLC analyses.

          Endotoxin concentration

          <1 EU/µg

          Activity

          Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 10^5 units/mg.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Purification

          purified

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient

          Product Specific Information

          Recombinant Human IL-10 is an 18.6 kDa protein of 161 amino acid residues.

          This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

          Target Information

          IL-10 encodes a protein that acts as a cytokine and is primarily produced by monocytes, with some production by lymphocytes. This cytokine has various effects on immunoregulation and inflammation, including down-regulating the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. Additionally, IL-10 can block NF-kappa B activity and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice have suggested that this cytokine is an essential immunoregulator in the intestinal tract. Mutations in this gene have been associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. Diseases associated with IL10 include Graft-Versus-Host Disease and Human Immunodeficiency Virus Type 1.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: CSIF; Cytokine synthesis inhibitory factor; H-IL-10; il 10; IL-10; ILN; Interleukin; Interleukin-10; Interleukin10; MGC126450; MGC126451; RP11-262N9.1; T-cell growth inhibitory factor

          View more View less

          Gene Aliases: CSIF; GVHDS; IL-10; IL10; IL10A; TGIF

          View more View less

          UniProt ID: (Human) P22301

          View more View less

          Entrez Gene ID: (Human) 3586

          View more View less

          It has to be done as per old AB suggested Products section.
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