Product References
Astrocytes express aberrant immunoglobulins as putative gatekeeper of astrocytes to neuronal progenitor conversion.
Cell death & disease
Capuz A,Osien S,Karnoub MA,Aboulouard S,Laurent E,Coyaud E,Raffo-Romero A,Duhamel M,Bonnefond A,Derhourhi M,Trerotola M,El Yazidi-Belkoura I,Devos D,Zilkova M,Kobeissy F,Vanden Abeele F,Fournier I,Cizkova D,Rodet F,Salzet M
200-12 was used in In vitro experiments to demonstrate that these chains are synthesized individually and associated to recognize specific targets.
Tue Apr 04 00:00:00 UTC 2023
Targeting Aquaporin-3 Attenuates Skin Inflammation in Rosacea.
International journal of biological sciences
Chen M,Peng Q,Tan Z,Xu S,Wang Y,Wu A,Xiao W,Wang Q,Xie H,Li J,Shi W,Deng Z
200-12 was used in Cell Culture to reveal that AQP3-mediated activation of NF-κB in keratinocytes and activation of STAT3 in CD4+ T cells acted synergistically and contributed to the inflammation in rosacea.
Tue Nov 07 00:00:00 UTC 2023
A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways.
Cell communication and signaling : CCS
Chen CX,Zhang W,Qu S,Xia F,Zhu Y,Chen B
200-12 was used in In vitro experiments to suggest that QL-1200186 is a highly selective and potent inhibitor of tyrosine kinase 2 as a clinical drug candidate for the treatment of psoriasis and other autoimmune diseases.
Mon Oct 16 00:00:00 UTC 2023
Defective STAT5 Activation and Aberrant Expression of BCL6 in Naive CD4 T Cells Enhances Follicular Th Cell-like Differentiation in Patients with Granulomatosis with Polyangiitis.
Journal of immunology (Baltimore, Md. : 1950)
Kim S,Boehme L,Nel L,Casian A,Sangle S,Nova-Lamperti E,Seitan V,Spencer J,Lavender P,D'Cruz DP,John S
Tue Feb 15 00:00:00 UTC 2022
Identification of Keratinocyte Mitogens: Implications for Hyperproliferation in Psoriasis and Atopic Dermatitis.
JID innovations : skin science from molecules to population health
Niehues H,Rikken G,van Vlijmen-Willems IMJJ,Rodijk-Olthuis D,van Erp PEJ,Zeeuwen PLJM,Schalkwijk J,van den Bogaard EH
200-12 was used in In vitro experiments to investigate the mitogens involved in keratinocyte proliferation and stratification.
Sat Jan 01 00:00:00 UTC 2022
Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.
Cellular and molecular gastroenterology and hepatology
Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR
200-12 was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.
Mon Apr 04 00:00:00 UTC 2022
Selenium-GPX4 axis protects follicular helper T cells from ferroptosis.
Nature immunology
Yao Y,Chen Z,Zhang H,Chen C,Zeng M,Yunis J,Wei Y,Wan Y,Wang N,Zhou M,Qiu C,Zeng Q,Ong HS,Wang H,Makota FV,Yang Y,Yang Z,Wang N,Deng J,Shen C,Xia Y,Yuan L,Lian Z,Deng Y,Guo C,Huang A,Zhou P,Shi H,Zhang W,Yi H,Li D,Xia M,Fu J,Wu N,de Haan JB,Shen N,Zhang W,Liu Z,Yu D
Wed Sep 01 00:00:00 UTC 2021
Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues.
Nature immunology
Friedrich C,Taggenbrock RLRE,Doucet-Ladevèze R,Golda G,Moenius R,Arampatzi P,Kragten NAM,Kreymborg K,Gomez de Agüero M,Kastenmüller W,Saliba AE,Grün D,van Gisbergen KPJM,Gasteiger G
Fri Oct 01 00:00:00 UTC 2021
Suppressive Monocytes Impair MAIT Cells Response via IL-10 in Patients with Severe COVID-19.
Journal of immunology (Baltimore, Md. : 1950)
Yang Q,Wen Y,Qi F,Gao X,Chen W,Xu G,Wei C,Wang H,Tang X,Lin J,Zhao J,Zhang M,Zhang S,Zhang Z
Fri Oct 01 00:00:00 UTC 2021
ZEB1 promotes pathogenic Th1 and Th17 cell differentiation in multiple sclerosis.
Cell reports
Qian Y,Arellano G,Ifergan I,Lin J,Snowden C,Kim T,Thomas JJ,Law C,Guan T,Balabanov RD,Kaech SM,Miller SD,Choi J
Tue Aug 24 00:00:00 UTC 2021
The metabolic hormone leptin promotes the function of TFH cells and supports vaccine responses.
Nature communications
Deng J,Chen Q,Chen Z,Liang K,Gao X,Wang X,Makota FV,Ong HS,Wan Y,Luo K,Gong D,Yu X,Camuglia S,Zeng Q,Zhou T,Xue F,He J,Wei Y,Xiao F,Ma J,Hill DL,Pierson W,Nguyen THO,Zhou H,Wang Y,Shen W,Sun L,Li Z,Xia Q,Qian K,Ye L,Rockman S,Linterman MA,Kedzierska K,Shen N,Lu L,Yu D
Mon May 24 00:00:00 UTC 2021
Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy.
Nature communications
Bent EH,Millán-Barea LR,Zhuang I,Goulet DR,Fröse J,Hemann MT
Thu Oct 28 00:00:00 UTC 2021
MAIT cells regulate NK cell-mediated tumor immunity.
Nature communications
Petley EV,Koay HF,Henderson MA,Sek K,Todd KL,Keam SP,Lai J,House IG,Li J,Zethoven M,Chen AXY,Oliver AJ,Michie J,Freeman AJ,Giuffrida L,Chan JD,Pizzolla A,Mak JYW,McCulloch TR,Souza-Fonseca-Guimaraes F,Kearney CJ,Millen R,Ramsay RG,Huntington ND,McCluskey J,Oliaro J,Fairlie DP,Neeson PJ,Godfrey DI,Beavis PA,Darcy PK
Fri Aug 06 00:00:00 UTC 2021
STAT3 governs the HIF-1α response in IL-15 primed human NK cells.
Scientific reports
Coulibaly A,Velásquez SY,Kassner N,Schulte J,Barbarossa MV,Lindner HA
Mon Mar 29 00:00:00 UTC 2021
Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.
Cell reports
Zebley CC,Abdelsamed HA,Ghoneim HE,Alli S,Brown C,Haydar D,Mi T,Harris T,McGargill MA,Krenciute G,Youngblood B
Tue Oct 12 00:00:00 UTC 2021
KSHV infection drives poorly cytotoxic CD56-negative natural killer cell differentiation in vivo upon KSHV/EBV dual infection.
Cell reports
Caduff N,McHugh D,Rieble L,Forconi CS,Ong'echa JM,Oluoch PO,Raykova A,Murer A,Böni M,Zuppiger L,Schulz TF,Blackbourn DJ,Chijioke O,Moormann AM,Münz C
Tue May 04 00:00:00 UTC 2021
Tissue Determinants of Human NK Cell Development, Function, and Residence.
Cell
Dogra P,Rancan C,Ma W,Toth M,Senda T,Carpenter DJ,Kubota M,Matsumoto R,Thapa P,Szabo PA,Li Poon MM,Li J,Arakawa-Hoyt J,Shen Y,Fong L,Lanier LL,Farber DL
Thu Feb 20 00:00:00 UTC 2020
Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment.
Blood
Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR
Thu Dec 24 00:00:00 UTC 2020
GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.
The Journal of clinical investigation
Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y
Thu Oct 01 00:00:00 UTC 2020
GLS1-mediated glutaminolysis unbridled by MALT1 protease promotes psoriasis pathogenesis.
The Journal of clinical investigation
Xia X,Cao G,Sun G,Zhu L,Tian Y,Song Y,Guo C,Wang X,Zhong J,Zhou W,Li P,Zhang H,Hao J,Li Z,Deng L,Yin Z,Gao Y
Thu Oct 01 00:00:00 UTC 2020
Ebola virus glycoprotein stimulates IL-18-dependent natural killer cell responses.
The Journal of clinical investigation
Wagstaffe HR,Clutterbuck EA,Bockstal V,Stoop JN,Luhn K,Douoguih M,Shukarev G,Snape MD,Pollard AJ,Riley EM,Goodier MR
Wed Jul 01 00:00:00 UTC 2020
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases.
The Journal of clinical investigation
Wang Z,Zhao M,Yin J,Liu L,Hu L,Huang Y,Liu A,Ouyang J,Min X,Rao S,Zhou W,Wu H,Yoshimura A,Lu Q
Wed Jul 01 00:00:00 UTC 2020
Ecto-NTPDase CD39 is a negative checkpoint that inhibits follicular helper cell generation.
The Journal of clinical investigation
Cao W,Fang F,Gould T,Li X,Kim C,Gustafson C,Lambert S,Weyand CM,Goronzy JJ
Wed Jul 01 00:00:00 UTC 2020
IL-7Rαlow CD8+ T Cells from Healthy Individuals Are Anergic with Defective Glycolysis.
Journal of immunology (Baltimore, Md. : 1950)
Sim JH,Kim JH,Park AK,Lee J,Kim KM,Shin HM,Kim M,Choi K,Choi EY,Kang I,Lee DS,Kim HR
Tue Dec 01 00:00:00 UTC 2020
Non-heat inactivated autologous serum increases accuracy of in vitro CFSE lymphocyte proliferation test (LPT) for nickel.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology
de Graaf NPJ,Bontkes HJ,Roffel S,Kleverlaan CJ,Rustemeyer T,Gibbs S,Feilzer AJ
Mon Jun 01 00:00:00 UTC 2020
CNTF Prevents Development of Outer Retinal Neovascularization Through Upregulation of CxCl10.
Investigative ophthalmology & visual science
Bucher F,Aguilar E,Marra KV,Rapp J,Arnold J,Diaz-Aguilar S,Lange C,Agostini H,Schlunck G,Stahl A,Friedlander M
200-12 was used in In vitro experiments to investigate the effects of of ciliary neurotrophic factor on outer retinal and choroidal angiogenesis and the mechanisms underpinning any changes in outer retinal neovascularisation following this treatment.
Mon Aug 03 00:00:00 UTC 2020
Mucosal-associated invariant T-cells are severely reduced and exhausted in humans with chronic HBV infection.
Journal of viral hepatitis
Huang W,He W,Shi X,Ye Q,He X,Dou L,Gao Y
Sun Nov 01 00:00:00 UTC 2020
Chlorzoxazone, a small molecule drug, augments immunosuppressive capacity of mesenchymal stem cells via modulation of FOXO3 phosphorylation.
Cell death & disease
Deng L,Li H,Su X,Zhang Y,Xu H,Fan L,Fan J,Han Q,Bai X,Zhao RC
Mon Mar 02 00:00:00 UTC 2020
Human Thymic CD10+ PD-1+ Intraepithelial Lymphocyte Precursors Acquire Interleukin-15 Responsiveness at the CD1a- CD95+ CD28- CCR7- Developmental Stage.
International journal of molecular sciences
Billiet L,Goetgeluk G,Bonte S,De Munter S,De Cock L,Pille M,Ingels J,Jansen H,Weening K,Van Nieuwerburgh F,Kerre T,Taghon T,Leclercq G,Vandekerckhove B
200-12 was used in Sample Preparation (FC/FACS) to study the phenotypical and transcriptional differentiation of the thymic intraepithelial lymphocytes precursor lineage upon in vitro exposure to cytokines prominent in the peripheral tissues such as interleukin-15 and the inflammatory cytokines interleukin-12 and interleukin-18.
Fri Nov 20 00:00:00 UTC 2020
iPSC-Based Modeling of RAG2 Severe Combined Immunodeficiency Reveals Multiple T Cell Developmental Arrests.
Stem cell reports
Themeli M,Chhatta A,Boersma H,Prins HJ,Cordes M,de Wilt E,Farahani AS,Vandekerckhove B,van der Burg M,Hoeben RC,Staal FJT,Mikkers HMM
Tue Feb 11 00:00:00 UTC 2020
Anti-ORAI1 antibody DS-2741a, a specific CRAC channel blocker, shows ideal therapeutic profiles for allergic disease via suppression of aberrant T-cell and mast cell activation.
FASEB bioAdvances
Aki A,Tanaka K,Nagaoka N,Kimura T,Baba D,Onodera Y,Wada T,Maeda H,Nakanishi T,Agatsuma T,Komai T
Sat Aug 01 00:00:00 UTC 2020
Endogenous antisense RNA curbs CD39 expression in Crohn's disease.
Nature communications
Harshe RP,Xie A,Vuerich M,Frank LA,Gromova B,Zhang H,Robles RJ,Mukherjee S,Csizmadia E,Kokkotou E,Cheifetz AS,Moss AC,Kota SK,Robson SC,Longhi MS
Wed Nov 18 00:00:00 UTC 2020
Inherited salt-losing tubulopathies are associated with immunodeficiency due to impaired IL-17 responses.
Nature communications
Evans RDR,Antonelou M,Sathiananthamoorthy S,Rega M,Henderson S,Ceron-Gutierrez L,Barcenas-Morales G,Müller CA,Doffinger R,Walsh SB,Salama AD
200-12 was used in In vitro experiments to investigate immunity in patients with inherited salt-losing tubulopathies (SLT).
Mon Aug 31 00:00:00 UTC 2020
IL23 Promotes Antimicrobial Pathways in Human Macrophages, Which Are Reduced With the IBD-Protective IL23R R381Q Variant.
Cellular and molecular gastroenterology and hepatology
Sun R,Abraham C
200-12 was used in In vitro experiments to identify that autocrine/paracrine IL23 is required for optimal PRR-enhanced macrophage bacterial uptake and intracellular bacterial clearance, define mechanisms regulating IL23R-induced bacterial clearance, and determine how the IBD-protective IL23R-R381Q variant modulates these processes.
Mon Nov 22 00:00:00 UTC 2021
Protocol for Isolation, Stimulation and Functional Profiling of Primary and iPSC-derived Human NK Cells.
Bio-protocol
Melsen JE,Themeli M,van Ostaijen-Ten Dam MM,van Beelen E,Lugthart G,Hoeben RC,Schilham MW,Mikkers HM
200-12 was used in In vitro experiments to investigate NK cells classification.
Sat Dec 05 00:00:00 UTC 2020
CD161 contributes to prenatal immune suppression of IFNγ-producing PLZF+ T cells.
The Journal of clinical investigation
Halkias J,Rackaityte E,Hillman SL,Aran D,Mendoza VF,Marshall LR,MacKenzie TC,Burt TD
Thu May 30 00:00:00 UTC 2019
Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.
The Journal of experimental medicine
Zhang Z,Gothe F,Pennamen P,James JR,McDonald D,Mata CP,Modis Y,Alazami AM,Acres M,Haller W,Bowen C,Döffinger R,Sinclair J,Brothers S,Zhang Y,Matthews HF,Naudion S,Pelluard F,Alajlan H,Yamazaki Y,Notarangelo LD,Thaventhiran JE,Engelhardt KR,Al-Mousa H,Hambleton S,Rooryck C,Smith KGC,Lenardo MJ
Mon Jun 03 00:00:00 UTC 2019
Transcription factor networks in aged naïve CD4 T cells bias lineage differentiation.
Aging cell
Hu B,Li G,Ye Z,Gustafson CE,Tian L,Weyand CM,Goronzy JJ
Thu Aug 01 00:00:00 UTC 2019
Soluble factors derived from neuroblastoma cell lines suppress dendritic cell differentiation and activation.
Cancer science
Harada K,Ihara F,Takami M,Kamata T,Mise N,Yoshizawa H,Hishiki T,Saito T,Terui K,Nakata M,Komatsu S,Ikeuchi T,Nakayama T,Yoshida H,Motohashi S
Fri Mar 01 00:00:00 UTC 2019
Lymphocyte innateness defined by transcriptional states reflects a balance between proliferation and effector functions.
Nature communications
Gutierrez-Arcelus M,Teslovich N,Mola AR,Polidoro RB,Nathan A,Kim H,Hannes S,Slowikowski K,Watts GFM,Korsunsky I,Brenner MB,Raychaudhuri S,Brennan PJ
Fri Feb 08 00:00:00 UTC 2019
Significantly increased anti-tumor activity of carcinoembryonic antigen-specific chimeric antigen receptor T cells in combination with recombinant human IL-12.
Cancer medicine
Chi X,Yang P,Zhang E,Gu J,Xu H,Li M,Gao X,Li X,Zhang Y,Xu H,Hu J
Thu Aug 01 00:00:00 UTC 2019
RAB11FIP5 Expression and Altered Natural Killer Cell Function Are Associated with Induction of HIV Broadly Neutralizing Antibody Responses.
Cell
Bradley T,Peppa D,Pedroza-Pacheco I,Li D,Cain DW,Henao R,Venkat V,Hora B,Chen Y,Vandergrift NA,Overman RG,Edwards RW,Woods CW,Tomaras GD,Ferrari G,Ginsburg GS,Connors M,Cohen MS,Moody MA,Borrow P,Haynes BF
Thu Oct 04 00:00:00 UTC 2018
Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12.
Immunity
Garris CS,Arlauckas SP,Kohler RH,Trefny MP,Garren S,Piot C,Engblom C,Pfirschke C,Siwicki M,Gungabeesoon J,Freeman GJ,Warren SE,Ong S,Browning E,Twitty CG,Pierce RH,Le MH,Algazi AP,Daud AI,Pai SI,Zippelius A,Weissleder R,Pittet MJ
Tue Dec 18 00:00:00 UTC 2018
Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity.
Immunity
Cuadrado E,van den Biggelaar M,de Kivit S,Chen YY,Slot M,Doubal I,Meijer A,van Lier RAW,Borst J,Amsen D
Tue May 15 00:00:00 UTC 2018
The Transcription Factor Ets1 Suppresses T Follicular Helper Type 2 Cell Differentiation to Halt the Onset of Systemic Lupus Erythematosus.
Immunity
Kim CJ,Lee CG,Jung JY,Ghosh A,Hasan SN,Hwang SM,Kang H,Lee C,Kim GC,Rudra D,Suh CH,Im SH
Tue Dec 18 00:00:00 UTC 2018
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
Fri Jun 01 00:00:00 UTC 2018
MicroRNA-210 overexpression promotes psoriasis-like inflammation by inducing Th1 and Th17 cell differentiation.
The Journal of clinical investigation
Wu R,Zeng J,Yuan J,Deng X,Huang Y,Chen L,Zhang P,Feng H,Liu Z,Wang Z,Gao X,Wu H,Wang H,Su Y,Zhao M,Lu Q
Fri Jun 01 00:00:00 UTC 2018
ARID5B regulates metabolic programming in human adaptive NK cells.
The Journal of experimental medicine
Cichocki F,Wu CY,Zhang B,Felices M,Tesi B,Tuininga K,Dougherty P,Taras E,Hinderlie P,Blazar BR,Bryceson YT,Miller JS
Mon Sep 03 00:00:00 UTC 2018
Metal-isotope-tagged monoclonal antibodies for high-dimensional mass cytometry.
Nature protocols
Han G,Spitzer MH,Bendall SC,Fantl WJ,Nolan GP
200-12 was used in Cell Culture to provide three optimized protocols for conjugating monoclonal IgG antibodies with 48 high-purity heavy-metal isotopes for immunoassays.
Mon Oct 01 00:00:00 UTC 2018
The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool.
Proceedings of the National Academy of Sciences of the United States of America
Dias J,Boulouis C,Gorin JB,van den Biggelaar RHGA,Lal KG,Gibbs A,Loh L,Gulam MY,Sia WR,Bari S,Hwang WYK,Nixon DF,Nguyen S,Betts MR,Buggert M,Eller MA,Broliden K,Tjernlund A,Sandberg JK,Leeansyah E
Tue Dec 04 00:00:00 UTC 2018
LFA-1 Ligation by High-Density ICAM-1 Is Sufficient To Activate IFN-γ Release by Innate T Lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Sharma A,Lawry SM,Klein BS,Wang X,Sherer NM,Zumwalde NA,Gumperz JE
Mon Oct 15 00:00:00 UTC 2018
IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production.
Journal of immunology (Baltimore, Md. : 1950)
Wagstaffe HR,Nielsen CM,Riley EM,Goodier MR
Sun Apr 15 00:00:00 UTC 2018
Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Imbrechts M,Avau A,Vandenhaute J,Malengier-Devlies B,Put K,Mitera T,Berghmans N,Burton O,Junius S,Liston A,de Somer L,Wouters C,Matthys P
Thu Nov 01 00:00:00 UTC 2018
Insufficient IL-10 Production as a Mechanism Underlying the Pathogenesis of Systemic Juvenile Idiopathic Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Imbrechts M,Avau A,Vandenhaute J,Malengier-Devlies B,Put K,Mitera T,Berghmans N,Burton O,Junius S,Liston A,de Somer L,Wouters C,Matthys P
Thu Nov 01 00:00:00 UTC 2018
Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-γ Production.
Journal of immunology (Baltimore, Md. : 1950)
Zygmunt BM,Węgrzyn A,Gajska W,Yevsa T,Chodaczek G,Guzmán CA
Sat Sep 01 00:00:00 UTC 2018
Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j.
Journal of immunology (Baltimore, Md. : 1950)
Nuñez SY,Ziblat A,Secchiari F,Torres NI,Sierra JM,Raffo Iraolagoitia XL,Araya RE,Domaica CI,Fuertes MB,Zwirner NW
Thu Feb 01 00:00:00 UTC 2018
STAT3-coordinated migration facilitates the dissemination of diffuse large B-cell lymphomas.
Nature communications
Pan YR,Chen CC,Chan YT,Wang HJ,Chien FT,Chen YL,Liu JL,Yang MH
Wed Sep 12 00:00:00 UTC 2018
Enumeration, functional responses and cytotoxic capacity of MAIT cells in newly diagnosed and relapsed multiple myeloma.
Scientific reports
Gherardin NA,Loh L,Admojo L,Davenport AJ,Richardson K,Rogers A,Darcy PK,Jenkins MR,Prince HM,Harrison SJ,Quach H,Fairlie DP,Kedzierska K,McCluskey J,Uldrich AP,Neeson PJ,Ritchie DS,Godfrey DI
Wed Mar 07 00:00:00 UTC 2018
Antioxidant metabolism regulates CD8+ T memory stem cell formation and antitumor immunity.
JCI insight
Pilipow K,Scamardella E,Puccio S,Gautam S,De Paoli F,Mazza EM,De Simone G,Polletti S,Buccilli M,Zanon V,Di Lucia P,Iannacone M,Gattinoni L,Lugli E
200-12 was used in In vitro experiments to study the molecular signals at the basis of Tscm cell generation and find that less differentiated human circulating CD8+ T cells display substantial antioxidant capacity ex vivo compared with more differentiated central and effector memory T cells.
Thu Sep 20 00:00:00 UTC 2018
Human Sox4 facilitates the development of CXCL13-producing helper T cells in inflammatory environments.
Nature communications
Yoshitomi H,Kobayashi S,Miyagawa-Hayashino A,Okahata A,Doi K,Nishitani K,Murata K,Ito H,Tsuruyama T,Haga H,Matsuda S,Toguchida J
Wed Sep 19 00:00:00 UTC 2018
Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration.
Frontiers in immunology
Parodi M,Raggi F,Cangelosi D,Manzini C,Balsamo M,Blengio F,Eva A,Varesio L,Pietra G,Moretta L,Mingari MC,Vitale M,Bosco MC
200-12 was used in In vitro experiments to study the mechanisms by which hypoxia acts on natural killer cells.
Wed Oct 02 00:00:00 UTC 2019
Respiratory Syncytial Virus Infects Regulatory B Cells in Human Neonates via Chemokine Receptor CX3CR1 and Promotes Lung Disease Severity.
Immunity
Zhivaki D,Lemoine S,Lim A,Morva A,Vidalain PO,Schandene L,Casartelli N,Rameix-Welti MA,Hervé PL,Dériaud E,Beitz B,Ripaux-Lefevre M,Miatello J,Lemercier B,Lorin V,Descamps D,Fix J,Eléouët JF,Riffault S,Schwartz O,Porcheray F,Mascart F,Mouquet H,Zhang X,Tissières P,Lo-Man R
Tue Feb 21 00:00:00 UTC 2017
Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs.
Blood
Corat MA,Schlums H,Wu C,Theorell J,Espinoza DA,Sellers SE,Townsley DM,Young NS,Bryceson YT,Dunbar CE,Winkler T
Thu Apr 06 00:00:00 UTC 2017
Acquired somatic mutations in PNH reveal long-term maintenance of adaptive NK cells independent of HSPCs.
Blood
Corat MA,Schlums H,Wu C,Theorell J,Espinoza DA,Sellers SE,Townsley DM,Young NS,Bryceson YT,Dunbar CE,Winkler T
Thu Apr 06 00:00:00 UTC 2017
Phenotypic and Functional Characterization of Circulatory, Splenic, and Hepatic NK Cells in Simian Immunodeficiency Virus-Controlling Macaques.
Journal of immunology (Baltimore, Md. : 1950)
Vargas-Inchaustegui DA,Helmold Hait S,Chung HK,Narola J,Hoang T,Robert-Guroff M
Wed Nov 01 00:00:00 UTC 2017
NKG2D Signaling between Human NK Cells Enhances TACE-Mediated TNF-α Release.
Journal of immunology (Baltimore, Md. : 1950)
Sharma N,Trinidad CV,Trembath AP,Markiewicz MA
Sun Oct 15 00:00:00 UTC 2017
Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Bellora F,Dondero A,Corrias MV,Casu B,Regis S,Caliendo F,Moretta A,Cazzola M,Elena C,Vinti L,Locatelli F,Bottino C,Castriconi R
Tue Aug 15 00:00:00 UTC 2017
Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells.
Scientific reports
Vahedi F,Nham T,Poznanski SM,Chew MV,Shenouda MM,Lee D,Ashkar AA
Thu Sep 21 00:00:00 UTC 2017
Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production.
Oncoimmunology
Capuano C,Pighi C,Molfetta R,Paolini R,Battella S,Palmieri G,Giannini G,Belardinilli F,Santoni A,Galandrini R
200-12 was used in In vitro experiments to highlight a relationship between CD16 aggregation conditions and the ability to promote a degradative pathway of CD16-coupled signaling elements associated to the shift of NK functional program.
Tue Jan 12 00:00:00 UTC 2021
Butyrate and propionate inhibit antigen-specific CD8+ T cell activation by suppressing IL-12 production by antigen-presenting cells.
Scientific reports
Nastasi C,Fredholm S,Willerslev-Olsen A,Hansen M,Bonefeld CM,Geisler C,Andersen MH,Ødum N,Woetmann A
Mon Nov 06 00:00:00 UTC 2017
Activated Tissue-Resident Mesenchymal Stromal Cells Regulate Natural Killer Cell Immune and Tissue-Regenerative Function.
Stem cell reports
Petri RM,Hackel A,Hahnel K,Dumitru CA,Bruderek K,Flohe SB,Paschen A,Lang S,Brandau S
Tue Sep 12 00:00:00 UTC 2017
Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.
The Journal of clinical investigation
Cantaert T,Schickel JN,Bannock JM,Ng YS,Massad C,Delmotte FR,Yamakawa N,Glauzy S,Chamberlain N,Kinnunen T,Menard L,Lavoie A,Walter JE,Notarangelo LD,Bruneau J,Al-Herz W,Kilic SS,Ochs HD,Cunningham-Rundles C,van der Burg M,Kuijpers TW,Kracker S,Kaneko H,Sekinaka Y,Nonoyama S,Durandy A,Meffre E
Tue Nov 01 00:00:00 UTC 2016
Engagement of SLAMF3 enhances CD4+ T-cell sensitivity to IL-2 and favors regulatory T-cell polarization in systemic lupus erythematosus.
Proceedings of the National Academy of Sciences of the United States of America
Comte D,Karampetsou MP,Kis-Toth K,Yoshida N,Bradley SJ,Mizui M,Kono M,Solomon JR,Kyttaris VC,Tsokos GC
Tue Aug 16 00:00:00 UTC 2016
Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.
Journal of immunology (Baltimore, Md. : 1950)
Cuff AO,Robertson FP,Stegmann KA,Pallett LJ,Maini MK,Davidson BR,Male V
Thu Dec 01 00:00:00 UTC 2016
IL-21-Induced MHC Class II+ NK Cells Promote the Expansion of Human Uncommitted CD4+ Central Memory T Cells in a Macrophage Migration Inhibitory Factor-Dependent Manner.
Journal of immunology (Baltimore, Md. : 1950)
Loyon R,Picard E,Mauvais O,Queiroz L,Mougey V,Pallandre JR,Galaine J,Mercier-Letondal P,Kellerman G,Chaput N,Wijdenes J,Adotévi O,Ferrand C,Romero P,Godet Y,Borg C
Fri Jul 01 00:00:00 UTC 2016
Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Goodier MR,Rodriguez-Galan A,Lusa C,Nielsen CM,Darboe A,Moldoveanu AL,White MJ,Behrens R,Riley EM
Fri Jul 01 00:00:00 UTC 2016
Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens.
Journal of immunology (Baltimore, Md. : 1950)
Zannetti C,Roblot G,Charrier E,Ainouze M,Tout I,Briat F,Isorce N,Faure-Dupuy S,Michelet M,Marotel M,Kati S,Schulz TF,Rivoire M,Traverse-Glehen A,Luangsay S,Alatiff O,Henry T,Walzer T,Durantel D,Hasan U
Fri Jul 01 00:00:00 UTC 2016
Hepatitis C Virus-Induced Myeloid-Derived Suppressor Cells Suppress NK Cell IFN-γ Production by Altering Cellular Metabolism via Arginase-1.
Journal of immunology (Baltimore, Md. : 1950)
Goh CC,Roggerson KM,Lee HC,Golden-Mason L,Rosen HR,Hahn YS
Tue Mar 01 00:00:00 UTC 2016
Human Lymphoid Tissues Harbor a Distinct CD69+CXCR6+ NK Cell Population.
Journal of immunology (Baltimore, Md. : 1950)
Lugthart G,Melsen JE,Vervat C,van Ostaijen-Ten Dam MM,Corver WE,Roelen DL,van Bergen J,van Tol MJ,Lankester AC,Schilham MW
Fri Jul 01 00:00:00 UTC 2016
NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Blom K,Braun M,Pakalniene J,Lunemann S,Enqvist M,Dailidyte L,Schaffer M,Lindquist L,Mickiene A,Michaëlsson J,Ljunggren HG,Gredmark-Russ S
Sat Oct 01 00:00:00 UTC 2016
Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells.
The Journal of biological chemistry
Zanetti SR,Ziblat A,Torres NI,Zwirner NW,Bouzat C
Fri Aug 05 00:00:00 UTC 2016
IL-12 protects from psoriasiform skin inflammation.
Nature communications
Kulig P,Musiol S,Freiberger SN,Schreiner B,Gyülveszi G,Russo G,Pantelyushin S,Kishihara K,Alessandrini F,Kündig T,Sallusto F,Hofbauer GF,Haak S,Becher B
Mon Nov 28 00:00:00 UTC 2016
IL-12 protects from psoriasiform skin inflammation.
Nature communications
Kulig P,Musiol S,Freiberger SN,Schreiner B,Gyülveszi G,Russo G,Pantelyushin S,Kishihara K,Alessandrini F,Kündig T,Sallusto F,Hofbauer GF,Haak S,Becher B
Mon Nov 28 00:00:00 UTC 2016
CD3(bright)CD56(+) T cells associate with pegylated interferon-alpha treatment nonresponse in chronic hepatitis B patients.
Scientific reports
Guo C,Shen X,Fu B,Liu Y,Chen Y,Ni F,Ye Y,Sun R,Li J,Tian Z,Wei H
Fri May 13 00:00:00 UTC 2016
Nicotinic Acid Adenine Dinucleotide Phosphate Plays a Critical Role in Naive and Effector Murine T Cells but Not Natural Regulatory T Cells.
The Journal of biological chemistry
Ali RA,Camick C,Wiles K,Walseth TF,Slama JT,Bhattacharya S,Giovannucci DR,Wall KA
Fri Feb 26 00:00:00 UTC 2016
Follicular helper T cell signature in type 1 diabetes.
The Journal of clinical investigation
Kenefeck R,Wang CJ,Kapadi T,Wardzinski L,Attridge K,Clough LE,Heuts F,Kogimtzis A,Patel S,Rosenthal M,Ono M,Sansom DM,Narendran P,Walker LS
Thu Jan 01 00:00:00 UTC 2015
Survivin-specific T cell receptor targets tumor but not T cells.
The Journal of clinical investigation
Arber C,Feng X,Abhyankar H,Romero E,Wu MF,Heslop HE,Barth P,Dotti G,Savoldo B
Thu Jan 01 00:00:00 UTC 2015
Plasmacytoid dendritic cells promote HIV-1-induced group 3 innate lymphoid cell depletion.
The Journal of clinical investigation
Zhang Z,Cheng L,Zhao J,Li G,Zhang L,Chen W,Nie W,Reszka-Blanco NJ,Wang FS,Su L
Tue Sep 01 00:00:00 UTC 2015
MTMR3 risk allele enhances innate receptor-induced signaling and cytokines by decreasing autophagy and increasing caspase-1 activation.
Proceedings of the National Academy of Sciences of the United States of America
Lahiri A,Hedl M,Abraham C
Tue Aug 18 00:00:00 UTC 2015
The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Tilburgs T,Evans JH,Crespo ÂC,Strominger JL
Tue Oct 27 00:00:00 UTC 2015
Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor.
Proceedings of the National Academy of Sciences of the United States of America
Gornalusse GG,Mummidi S,Gaitan AA,Jimenez F,Ramsuran V,Picton A,Rogers K,Manoharan MS,Avadhanam N,Murthy KK,Martinez H,Molano Murillo A,Chykarenko ZA,Hutt R,Daskalakis D,Shostakovich-Koretskaya L,Abdool Karim S,Martin JN,Deeks SG,Hecht F,Sinclair E,Clark RA,Okulicz J,Valentine FT,Martinson N,Tiemessen CT,Ndung'u T,Hunt PW,He W,Ahuja SK
Tue Aug 25 00:00:00 UTC 2015
Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.
Aging cell
van der Geest KS,Abdulahad WH,Teteloshvili N,Tete SM,Peters JH,Horst G,Lorencetti PG,Bos NA,Lambeck A,Roozendaal C,Kroesen BJ,Koenen HJ,Joosten I,Brouwer E,Boots AM
Thu Oct 01 00:00:00 UTC 2015
Bone marrow-derived mesenchymal stromal cells harness purinergenic signaling to tolerize human Th1 cells in vivo.
Stem cells (Dayton, Ohio)
Amarnath S,Foley JE,Farthing DE,Gress RE,Laurence A,Eckhaus MA,Métais JY,Rose JJ,Hakim FT,Felizardo TC,Cheng AV,Robey PG,Stroncek DE,Sabatino M,Battiwalla M,Ito S,Fowler DH,Barrett AJ
Wed Apr 01 00:00:00 UTC 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 UTC 2015
The RUNX1 +24 enhancer and P1 promoter identify a unique subpopulation of hematopoietic progenitor cells derived from human pluripotent stem cells.
Stem cells (Dayton, Ohio)
Ferrell PI,Xi J,Ma C,Adlakha M,Kaufman DS
Wed Apr 01 00:00:00 UTC 2015
Impaired NK Cell Responses to Pertussis and H1N1 Influenza Vaccine Antigens in Human Cytomegalovirus-Infected Individuals.
Journal of immunology (Baltimore, Md. : 1950)
Nielsen CM,White MJ,Bottomley C,Lusa C,Rodríguez-Galán A,Turner SE,Goodier MR,Riley EM
Fri May 15 00:00:00 UTC 2015
Deficiency of MALT1 paracaspase activity results in unbalanced regulatory and effector T and B cell responses leading to multiorgan inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Bornancin F,Renner F,Touil R,Sic H,Kolb Y,Touil-Allaoui I,Rush JS,Smith PA,Bigaud M,Junker-Walker U,Burkhart C,Dawson J,Niwa S,Katopodis A,Nuesslein-Hildesheim B,Weckbecker G,Zenke G,Kinzel B,Traggiai E,Brenner D,Brüstle A,St Paul M,Zamurovic N,McCoy KD,Rolink A,Régnier CH,Mak TW,Ohashi PS,Patel DD,Calzascia T
Wed Apr 15 00:00:00 UTC 2015
M2b Monocytes Provoke Bacterial Pneumonia and Gut Bacteria-Associated Sepsis in Alcoholics.
Journal of immunology (Baltimore, Md. : 1950)
Tsuchimoto Y,Asai A,Tsuda Y,Ito I,Nishiguchi T,Garcia MC,Suzuki S,Kobayashi M,Higuchi K,Suzuki F
Tue Dec 01 00:00:00 UTC 2015
Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.
Journal of immunology (Baltimore, Md. : 1950)
Mattiola I,Pesant M,Tentorio PF,Molgora M,Marcenaro E,Lugli E,Locati M,Mavilio D
Tue Sep 15 00:00:00 UTC 2015
The Human NK Cell Response to Yellow Fever Virus 17D Is Primarily Governed by NK Cell Differentiation Independently of NK Cell Education.
Journal of immunology (Baltimore, Md. : 1950)
Marquardt N,Ivarsson MA,Blom K,Gonzalez VD,Braun M,Falconer K,Gustafsson R,Fogdell-Hahn A,Sandberg JK,Michaëlsson J
Thu Oct 01 00:00:00 UTC 2015
Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
Journal of immunology (Baltimore, Md. : 1950)
Spallanzani RG,Torres NI,Avila DE,Ziblat A,Iraolagoitia XL,Rossi LE,Domaica CI,Fuertes MB,Rabinovich GA,Zwirner NW
Tue Sep 01 00:00:00 UTC 2015
Skin Metabolites Define a New Paradigm in the Localization of Skin Tropic Memory T Cells.
Journal of immunology (Baltimore, Md. : 1950)
McCully ML,Collins PJ,Hughes TR,Thomas CP,Billen J,O'Donnell VB,Moser B
Wed Jul 01 00:00:00 UTC 2015
TLR-Stimulated Neutrophils Instruct NK Cells To Trigger Dendritic Cell Maturation and Promote Adaptive T Cell Responses.
Journal of immunology (Baltimore, Md. : 1950)
Riise RE,Bernson E,Aurelius J,Martner A,Pesce S,Della Chiesa M,Marcenaro E,Bylund J,Hellstrand K,Moretta L,Moretta A,Thorén FB
Sat Aug 01 00:00:00 UTC 2015
Batf is important for IL-4 expression in T follicular helper cells.
Nature communications
Sahoo A,Alekseev A,Tanaka K,Obertas L,Lerman B,Haymaker C,Clise-Dwyer K,McMurray JS,Nurieva R
Mon Aug 17 00:00:00 UTC 2015
Ex vivo Human Natural Killer (NK) Cell Stimulation and Intracellular IFNγ and CD107a Cytokine Staining.
Bio-protocol
York VA,Milush JM
200-12 was used in In vitro experiments to describe a method to assess IFNγ and CD107a expression in NK cells following stimulation with target cells or cytokines.
Sat Jun 20 00:00:00 UTC 2015
MicroRNA transcriptomes of distinct human NK cell populations identify miR-362-5p as an essential regulator of NK cell function.
Scientific reports
Ni F,Guo C,Sun R,Fu B,Yang Y,Wu L,Ren S,Tian Z,Wei H
Fri Apr 24 00:00:00 UTC 2015
Structural and Functional Characterization of the JH2 Pseudokinase Domain of JAK Family Tyrosine Kinase 2 (TYK2).
The Journal of biological chemistry
Min X,Ungureanu D,Maxwell S,Hammarén H,Thibault S,Hillert EK,Ayres M,Greenfield B,Eksterowicz J,Gabel C,Walker N,Silvennoinen O,Wang Z
Fri Nov 06 00:00:00 UTC 2015
Induced expression of FcγRIIIa (CD16a) on CD4+ T cells triggers generation of IFN-γhigh subset.
The Journal of biological chemistry
Chauhan AK,Chen C,Moore TL,DiPaolo RJ
Fri Feb 20 00:00:00 UTC 2015
Direct tumor recognition by a human CD4(+) T-cell subset potently mediates tumor growth inhibition and orchestrates anti-tumor immune responses.
Scientific reports
Matsuzaki J,Tsuji T,Luescher IF,Shiku H,Mineno J,Okamoto S,Old LJ,Shrikant P,Gnjatic S,Odunsi K
Thu Oct 08 00:00:00 UTC 2015
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
Immunity
Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR
Thu Sep 18 00:00:00 UTC 2014
Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.
The Journal of clinical investigation
Jandus C,Boligan KF,Chijioke O,Liu H,Dahlhaus M,Démoulins T,Schneider C,Wehrli M,Hunger RE,Baerlocher GM,Simon HU,Romero P,Münz C,von Gunten S
Tue Apr 01 00:00:00 UTC 2014
Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency.
The Journal of experimental medicine
Cichocki F,Schlums H,Li H,Stache V,Holmes T,Lenvik TR,Chiang SC,Miller JS,Meeths M,Anderson SK,Bryceson YT
Mon Jun 02 00:00:00 UTC 2014
Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells.
Immunology and cell biology
Ghamlouch H,Ouled-Haddou H,Guyart A,Regnier A,Trudel S,Claisse JF,Fuentes V,Royer B,Marolleau JP,Gubler B
Fri Aug 01 00:00:00 UTC 2014
Activin A as a mediator of NK-dendritic cell functional interactions.
Journal of immunology (Baltimore, Md. : 1950)
Seeger P,Bosisio D,Parolini S,Badolato R,Gismondi A,Santoni A,Sozzani S
Sat Feb 01 00:00:00 UTC 2014
Tissue-specific microvascular endothelial cells show distinct capacity to activate NK cells: implications for the pathophysiology of granulomatosis with polyangiitis.
Journal of immunology (Baltimore, Md. : 1950)
Tognarelli S,Gayet J,Lambert M,Dupuy S,Karras A,Cohen P,Guillevin L,de Menthon M,Caillat-Zucman S
Tue Apr 01 00:00:00 UTC 2014
Differentiation and functional regulation of human fetal NK cells.
The Journal of clinical investigation
Ivarsson MA,Loh L,Marquardt N,Kekäläinen E,Berglin L,Björkström NK,Westgren M,Nixon DF,Michaëlsson J
Sun Sep 01 00:00:00 UTC 2013
Lymphocyte-derived ACh regulates local innate but not adaptive immunity.
Proceedings of the National Academy of Sciences of the United States of America
Reardon C,Duncan GS,Brüstle A,Brenner D,Tusche MW,Olofsson PS,Rosas-Ballina M,Tracey KJ,Mak TW
Tue Jan 22 00:00:00 UTC 2013
MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.
Journal of immunology (Baltimore, Md. : 1950)
Sullivan RP,Fogel LA,Leong JW,Schneider SE,Wong R,Romee R,Thai TH,Sexl V,Matkovich SJ,Dorn GW,French AR,Fehniger TA
Sun Dec 15 00:00:00 UTC 2013
Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Hagberg N,Theorell J,Schlums H,Eloranta ML,Bryceson YT,Rönnblom L
Sun Sep 15 00:00:00 UTC 2013
Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.
Journal of immunology (Baltimore, Md. : 1950)
Pauls E,Jimenez E,Ruiz A,Permanyer M,Ballana E,Costa H,Nascimiento R,Parkhouse RM,Peña R,Riveiro-Muñoz E,Martinez MA,Clotet B,Esté JA,Bofill M
Wed May 01 00:00:00 UTC 2013
Cytokine activation induces human memory-like NK cells.
Blood
Romee R,Schneider SE,Leong JW,Chase JM,Keppel CR,Sullivan RP,Cooper MA,Fehniger TA
Thu Dec 06 00:00:00 UTC 2012
Tim-3 marks human natural killer cell maturation and suppresses cell-mediated cytotoxicity.
Blood
Ndhlovu LC,Lopez-Vergès S,Barbour JD,Jones RB,Jha AR,Long BR,Schoeffler EC,Fujita T,Nixon DF,Lanier LL
Thu Apr 19 00:00:00 UTC 2012
Epidermis instructs skin homing receptor expression in human T cells.
Blood
McCully ML,Ladell K,Hakobyan S,Mansel RE,Price DA,Moser B
Thu Nov 29 00:00:00 UTC 2012
Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa).
Blood
Couzi L,Pitard V,Sicard X,Garrigue I,Hawchar O,Merville P,Moreau JF,Déchanet-Merville J
Thu Feb 09 00:00:00 UTC 2012
Sustained effector function of IL-12/15/18-preactivated NK cells against established tumors.
The Journal of experimental medicine
Ni J,Miller M,Stojanovic A,Garbi N,Cerwenka A
Mon Dec 17 00:00:00 UTC 2012
Contact-dependent interference with invariant NKT cell activation by herpes simplex virus-infected cells.
Journal of immunology (Baltimore, Md. : 1950)
Bosnjak L,Sahlström P,Paquin-Proulx D,Leeansyah E,Moll M,Sandberg JK
Fri Jun 15 00:00:00 UTC 2012
Targeting Stat3 induces senescence in tumor cells and elicits prophylactic and therapeutic immune responses against breast cancer growth mediated by NK cells and CD4+ T cells.
Journal of immunology (Baltimore, Md. : 1950)
Tkach M,Coria L,Rosemblit C,Rivas MA,Proietti CJ,Díaz Flaqué MC,Beguelin W,Frahm I,Charreau EH,Cassataro J,Elizalde PV,Schillaci R
Wed Aug 01 00:00:00 UTC 2012
Th17 cells in multiple sclerosis express higher levels of JAK2, which increases their surface expression of IFN-γR2.
Journal of immunology (Baltimore, Md. : 1950)
Conti L,De Palma R,Rolla S,Boselli D,Rodolico G,Kaur S,Silvennoinen O,Niccolai E,Amedei A,Ivaldi F,Clerico M,Contessa G,Uccelli A,Durelli L,Novelli F
Wed Feb 01 00:00:00 UTC 2012
Natural killer cells are recruited during pulmonary tuberculosis and their ex vivo responses to mycobacteria vary between healthy human donors in association with KIR haplotype.
Cellular microbiology
Portevin D,Via LE,Eum S,Young D
Thu Nov 01 00:00:00 UTC 2012
The acute environment, rather than T cell subset pre-commitment, regulates expression of the human T cell cytokine amphiregulin.
PloS one
Qi Y,Operario DJ,Georas SN,Mosmann TR
Thu Dec 13 00:00:00 UTC 2012
Networked T cell death following macrophage infection by Mycobacterium tuberculosis.
PloS one
Macdonald SH,Woodward E,Coleman MM,Dorris ER,Nadarajan P,Chew WM,McLaughlin AM,Keane J
Thu Oct 11 00:00:00 UTC 2012
Preformed CD40L is stored in Th1, Th2, Th17, and T follicular helper cells as well as CD4+ 8- thymocytes and invariant NKT cells but not in Treg cells.
PloS one
Koguchi Y,Buenafe AC,Thauland TJ,Gardell JL,Bivins-Smith ER,Jacoby DB,Slifka MK,Parker DC
Fri Jun 29 00:00:00 UTC 2012
Increased IL-21 secretion by aged CD4+T cells is associated with prolonged STAT-4 activation and CMV seropositivity.
Aging
Agrawal A,Su H,Chen J,Osann K,Agrawal S,Gupta S
Sat Sep 01 00:00:00 UTC 2012
Autophagy creates a CTL epitope that mimics tumor-associated antigens.
PloS one
Demachi-Okamura A,Torikai H,Akatsuka Y,Miyoshi H,Yoshimori T,Kuzushima K
Wed May 01 00:00:00 UTC 2013
Characterization of T-cell responses against IκBα in cancer patients.
Oncoimmunology
Munir S,Frøsig TM,Hansen M,Svane IM,Andersen MH
Thu Nov 01 00:00:00 UTC 2012
Human natural killer cell maturation defect supports in vivo CD56(bright) to CD56(dim) lineage development.
PloS one
Domaica CI,Fuertes MB,Uriarte I,Girart MV,Sardañons J,Comas DI,Di Giovanni D,Gaillard MI,Bezrodnik L,Zwirner NW
Thu May 30 00:00:00 UTC 2013
CD26 expression and adenosine deaminase activity in regulatory T cells (Treg) and CD4(+) T effector cells in patients with head and neck squamous cell carcinoma.
Oncoimmunology
Mandapathil M,Szczepanski M,Harasymczuk M,Ren J,Cheng D,Jackson EK,Gorelik E,Johnson J,Lang S,Whiteside TL
Wed Aug 01 00:00:00 UTC 2012
Allogeneic effector/memory Th-1 cells impair FoxP3+ regulatory T lymphocytes and synergize with chaperone-rich cell lysate vaccine to treat leukemia.
Blood
Janikashvili N,LaCasse CJ,Larmonier C,Trad M,Herrell A,Bustamante S,Bonnotte B,Har-Noy M,Larmonier N,Katsanis E
Thu Feb 03 00:00:00 UTC 2011
Acquired STAT4 deficiency as a consequence of cancer chemotherapy.
Blood
Lupov IP,Voiles L,Han L,Schwartz A,De La Rosa M,Oza K,Pelloso D,Sahu RP,Travers JB,Robertson MJ,Chang HC
Thu Dec 01 00:00:00 UTC 2011
Indoleamine 2,3-dioxygenase specific, cytotoxic T cells as immune regulators.
Blood
Sørensen RB,Hadrup SR,Svane IM,Hjortsø MC,Thor Straten P,Andersen MH
Thu Feb 17 00:00:00 UTC 2011
Severe impairment of IFN-γ and IFN-α responses in cells of a patient with a novel STAT1 splicing mutation.
Blood
Vairo D,Tassone L,Tabellini G,Tamassia N,Gasperini S,Bazzoni F,Plebani A,Porta F,Notarangelo LD,Parolini S,Giliani S,Badolato R
Thu Aug 18 00:00:00 UTC 2011
MicroRNA regulation of STAT4 protein expression: rapid and sensitive modulation of IL-12 signaling in human natural killer cells.
Blood
Huang Y,Lei Y,Zhang H,Hou L,Zhang M,Dayton AI
Thu Dec 22 00:00:00 UTC 2011
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis.
Proceedings of the National Academy of Sciences of the United States of America
Maul-Pavicic A,Chiang SC,Rensing-Ehl A,Jessen B,Fauriat C,Wood SM,Sjöqvist S,Hufnagel M,Schulze I,Bass T,Schamel WW,Fuchs S,Pircher H,McCarl CA,Mikoshiba K,Schwarz K,Feske S,Bryceson YT,Ehl S
Tue Feb 22 00:00:00 UTC 2011
Reconstitution of huPBL-NSG mice with donor-matched dendritic cells enables antigen-specific T-cell activation.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Harui A,Kiertscher SM,Roth MD
Tue Mar 01 00:00:00 UTC 2011
Reconstitution of huPBL-NSG mice with donor-matched dendritic cells enables antigen-specific T-cell activation.
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology
Harui A,Kiertscher SM,Roth MD
Tue Mar 01 00:00:00 UTC 2011
Identification of a cyclin B1-derived CTL epitope eliciting spontaneous responses in both cancer patients and healthy donors.
Cancer immunology, immunotherapy : CII
Andersen RS,Sørensen RB,Ritter C,Svane IM,Becker JC,thor Straten P,Andersen MH
Tue Feb 01 00:00:00 UTC 2011
IFN-α production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1β and LFA-1.
Journal of immunology (Baltimore, Md. : 1950)
Hagberg N,Berggren O,Leonard D,Weber G,Bryceson YT,Alm GV,Eloranta ML,Rönnblom L
Sun May 01 00:00:00 UTC 2011
Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model.
Journal of immunology (Baltimore, Md. : 1950)
Lisiero DN,Soto H,Liau LM,Prins RM
Sun May 01 00:00:00 UTC 2011
Limited response of NK92 cells to Plasmodium falciparum-infected erythrocytes.
Malaria journal
de Carvalho EG,Böttger E,Hoang VT,Kremsner PG,Kun JF
Fri Oct 21 00:00:00 UTC 2011
Plasmodium falciparum-infected erythrocytes and IL-12/IL-18 induce diverse transcriptomes in human NK cells: IFN-α/β pathway versus TREM signaling.
PloS one
Grangeiro de Carvalho E,Bonin M,Kremsner PG,Kun JF
Fri Feb 03 00:00:00 UTC 2012
Regulation of human NK-cell cytokine and chemokine production by target cell recognition.
Blood
Fauriat C,Long EO,Ljunggren HG,Bryceson YT
Thu Mar 18 00:00:00 UTC 2010
CD57 defines a functionally distinct population of mature NK cells in the human CD56dimCD16+ NK-cell subset.
Blood
Lopez-Vergès S,Milush JM,Pandey S,York VA,Arakawa-Hoyt J,Pircher H,Norris PJ,Nixon DF,Lanier LL
Thu Nov 11 00:00:00 UTC 2010
Rapamycin generates anti-apoptotic human Th1/Tc1 cells via autophagy for induction of xenogeneic GVHD.
Autophagy
Amarnath S,Flomerfelt FA,Costanzo CM,Foley JE,Mariotti J,Konecki DM,Gangopadhyay A,Eckhaus M,Wong S,Levine BL,June CH,Fowler DH
200-12 was used in Cell Culture to study the nature and mechanism by which rapamycin maintains the ability of Tregs to differentiate.
Sat May 01 00:00:00 UTC 2010
Thymic stromal lymphopoietin-mediated STAT5 phosphorylation via kinases JAK1 and JAK2 reveals a key difference from IL-7-induced signaling.
Proceedings of the National Academy of Sciences of the United States of America
Rochman Y,Kashyap M,Robinson GW,Sakamoto K,Gomez-Rodriguez J,Wagner KU,Leonard WJ
Tue Nov 09 00:00:00 UTC 2010
Regulatory T cells and human myeloid dendritic cells promote tolerance via programmed death ligand-1.
PLoS biology
Amarnath S,Costanzo CM,Mariotti J,Ullman JL,Telford WG,Kapoor V,Riley JL,Levine BL,June CH,Fong T,Warner NL,Fowler DH
Tue Feb 02 00:00:00 UTC 2010
TL1A selectively enhances IL-12/IL-18-induced NK cell cytotoxicity against NK-resistant tumor targets.
Journal of clinical immunology
Heidemann SC,Chavez V,Landers CJ,Kucharzik T,Prehn JL,Targan SR
Thu Jul 01 00:00:00 UTC 2010
M2b monocytes predominated in peripheral blood of severely burned patients.
Journal of immunology (Baltimore, Md. : 1950)
Kobayashi M,Jeschke MG,Shigematsu K,Asai A,Yoshida S,Herndon DN,Suzuki F
Wed Dec 15 00:00:00 UTC 2010
Meningeal mast cells affect early T cell central nervous system infiltration and blood-brain barrier integrity through TNF: a role for neutrophil recruitment?
Journal of immunology (Baltimore, Md. : 1950)
Sayed BA,Christy AL,Walker ME,Brown MA
Tue Jun 15 00:00:00 UTC 2010
Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Thu Jul 15 00:00:00 UTC 2010
Cross-talk between T cells and NK cells generates rapid effector responses to Plasmodium falciparum-infected erythrocytes.
Journal of immunology (Baltimore, Md. : 1950)
Horowitz A,Newman KC,Evans JH,Korbel DS,Davis DM,Riley EM
Tue Jun 01 00:00:00 UTC 2010
PRDM1/Blimp-1 controls effector cytokine production in human NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Smith MA,Maurin M,Cho HI,Becknell B,Freud AG,Yu J,Wei S,Djeu J,Celis E,Caligiuri MA,Wright KL
Mon Nov 15 00:00:00 UTC 2010
Polyfunctional T-cell responses are disrupted by the ovarian cancer ascites environment and only partially restored by clinically relevant cytokines.
PloS one
Tran E,Nielsen JS,Wick DA,Ng AV,Johnson LD,Nesslinger NJ,McMurtrie E,Webb JR,Nelson BH
Wed Dec 22 00:00:00 UTC 2010
Impaired development of human Th1 cells in patients with deficient expression of STAT4.
Blood
Chang HC,Han L,Goswami R,Nguyen ET,Pelloso D,Robertson MJ,Kaplan MH
Thu Jun 04 00:00:00 UTC 2009
Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells.
Blood
Figueiredo C,Wittmann M,Wang D,Dressel R,Seltsam A,Blasczyk R,Eiz-Vesper B
Thu Mar 26 00:00:00 UTC 2009
Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia.
Blood
Rezvani K,Yong AS,Tawab A,Jafarpour B,Eniafe R,Mielke S,Savani BN,Keyvanfar K,Li Y,Kurlander R,Barrett AJ
Thu Mar 05 00:00:00 UTC 2009
Functionally distinct subsets of human NK cells and monocyte/DC-like cells identified by coexpression of CD56, CD7, and CD4.
Blood
Milush JM,Long BR,Snyder-Cappione JE,Cappione AJ,York VA,Ndhlovu LC,Lanier LL,Michaëlsson J,Nixon DF
Thu Nov 26 00:00:00 UTC 2009
IL-12-dependent inducible expression of the CD94/NKG2A inhibitory receptor regulates CD94/NKG2C+ NK cell function.
Journal of immunology (Baltimore, Md. : 1950)
Sáez-Borderías A,Romo N,Magri G,Gumá M,Angulo A,López-Botet M
Thu Jan 15 00:00:00 UTC 2009
Expansion of functionally skewed CD56-negative NK cells in chronic hepatitis C virus infection: correlation with outcome of pegylated IFN-alpha and ribavirin treatment.
Journal of immunology (Baltimore, Md. : 1950)
Gonzalez VD,Falconer K,Björkström NK,Blom KG,Weiland O,Ljunggren HG,Alaeus A,Sandberg JK
Sun Nov 15 00:00:00 UTC 2009
Cutting edge: in vitro generated Th17 cells maintain their cytokine expression program in normal but not lymphopenic hosts.
Journal of immunology (Baltimore, Md. : 1950)
Nurieva R,Yang XO,Chung Y,Dong C
Sun Mar 01 00:00:00 UTC 2009
MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression.
Journal of immunology (Baltimore, Md. : 1950)
Enzler T,Chang X,Facchinetti V,Melino G,Karin M,Su B,Gallagher E
Tue Sep 15 00:00:00 UTC 2009
Killer Ig-like receptor (KIR) genotype predicts the capacity of human KIR-positive CD56dim NK cells to respond to pathogen-associated signals.
Journal of immunology (Baltimore, Md. : 1950)
Korbel DS,Norman PJ,Newman KC,Horowitz A,Gendzekhadze K,Parham P,Riley EM
Fri May 15 00:00:00 UTC 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 UTC 2009
RasGRP1 is required for human NK cell function.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Lee J,Kim MJ,Piao ZH,Jeong M,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Tue Dec 15 00:00:00 UTC 2009
A modified epitope identified for generation and monitoring of PSA-specific T cells in patients on early phases of PSA-based immunotherapeutic protocols.
Vaccine
Lundberg K,Roos AK,Pavlenko M,Leder C,Wehrum D,Guevara-Patiño J,Andersen RS,Pisa P
Wed Mar 04 00:00:00 UTC 2009
The immune system strikes back: cellular immune responses against indoleamine 2,3-dioxygenase.
PloS one
Sørensen RB,Berge-Hansen L,Junker N,Hansen CA,Hadrup SR,Schumacher TN,Svane IM,Becker JC,thor Straten P,Andersen MH
Mon Sep 07 00:00:00 UTC 2009
Generation and regulation of human CD4+ IL-17-producing T cells in ovarian cancer.
Proceedings of the National Academy of Sciences of the United States of America
Miyahara Y,Odunsi K,Chen W,Peng G,Matsuzaki J,Wang RF
Tue Oct 07 00:00:00 UTC 2008
B cell chemoattractant CXCL13 is preferentially expressed by human Th17 cell clones.
Journal of immunology (Baltimore, Md. : 1950)
Takagi R,Higashi T,Hashimoto K,Nakano K,Mizuno Y,Okazaki Y,Matsushita S
Tue Jul 01 00:00:00 UTC 2008
The FERM and PDZ domain-containing protein tyrosine phosphatases, PTPN4 and PTPN3, are both dispensable for T cell receptor signal transduction.
PloS one
Bauler TJ,Hendriks WJ,King PD
Thu Feb 19 00:00:00 UTC 2009
Effect of lipopolysaccharide (LPS) and peptidoglycan (PGN) on human mast cell numbers, cytokine production, and protease composition.
BMC immunology
Kirshenbaum AS,Swindle E,Kulka M,Wu Y,Metcalfe DD
Thu Aug 07 00:00:00 UTC 2008
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T
Sat Sep 15 00:00:00 UTC 2007
Soluble TNF-like cytokine (TL1A) production by immune complexes stimulated monocytes in rheumatoid arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Cassatella MA,Pereira-da-Silva G,Tinazzi I,Facchetti F,Scapini P,Calzetti F,Tamassia N,Wei P,Nardelli B,Roschke V,Vecchi A,Mantovani A,Bambara LM,Edwards SW,Carletto A
Fri Jun 01 00:00:00 UTC 2007
Multidirectional interactions are bridging human NK cells with plasmacytoid and monocyte-derived dendritic cells during innate immune responses.
Blood
Della Chiesa M,Romagnani C,Thiel A,Moretta L,Moretta A
Fri Dec 01 00:00:00 UTC 2006
CCR4 ligands are up-regulated in the airways of atopic asthmatics after segmental allergen challenge.
The European respiratory journal
Pilette C,Francis JN,Till SJ,Durham SR
Tue Jun 01 00:00:00 UTC 2004
Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.
The Journal of experimental medicine
Lin L,Gerth AJ,Peng SL
Mon Jul 05 00:00:00 UTC 2004
Bystander suppression of allergic airway inflammation by lung resident memory CD8+ T cells.
Proceedings of the National Academy of Sciences of the United States of America
Marsland BJ,Harris NL,Camberis M,Kopf M,Hook SM,Le Gros G
Tue Apr 20 00:00:00 UTC 2004
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 UTC 2003
Immune responses to Plasmodium falciparum-merozoite surface protein 1 (MSP1) antigen, II. Induction of parasite-specific immunoglobulin G in unsensitized human B cells after in vitro T-cell priming with MSP119.
Immunology
Garraud O,Diouf A,Holm I,Perraut R,Longacre S
Thu Jul 01 00:00:00 UTC 1999
