Product References
Immunogenic Chemotherapy Enhances Recruitment of CAR-T Cells to Lung Tumors and Improves Antitumor Efficacy when Combined with Checkpoint Blockade.
Cancer cell
Srivastava S,Furlan SN,Jaeger-Ruckstuhl CA,Sarvothama M,Berger C,Smythe KS,Garrison SM,Specht JM,Lee SM,Amezquita RA,Voillet V,Muhunthan V,Yechan-Gunja S,Pillai SPS,Rader C,Houghton AM,Pierce RH,Gottardo R,Maloney DG,Riddell SR
Mon Feb 08 00:00:00 EST 2021
SLAMF receptors negatively regulate B cell receptor signaling in chronic lymphocytic leukemia via recruitment of prohibitin-2.
Leukemia
von Wenserski L,Schultheiß C,Bolz S,Schliffke S,Simnica D,Willscher E,Gerull H,Wolters-Eisfeld G,Riecken K,Fehse B,Altfeld M,Nollau P,Binder M
Thu Apr 01 00:00:00 EDT 2021
A T cell redirection platform for co-targeting dual antigens on solid tumors.
mAbs
Enderle L,Shalaby KH,Gorelik M,Weiss A,Blazer LL,Paduch M,Cardarelli L,Kossiakoff A,Adams JJ,Sidhu SS
AF-200-15 was used in Cell Culture to engineer the Dual Antigen T cell Engager to enable T cell activity to specific solid cancer cell features.
Tue Dec 28 00:00:00 EST 2021
Epigenetic modulation of immune synaptic-cytoskeletal networks potentiates γδ T cell-mediated cytotoxicity in lung cancer.
Nature communications
Weng RR,Lu HH,Lin CT,Fan CC,Lin RS,Huang TC,Lin SY,Huang YJ,Juan YH,Wu YC,Hung ZC,Liu C,Lin XH,Hsieh WC,Chiu TY,Liao JC,Chiu YL,Chen SY,Yu CJ,Tsai HC
Mon Apr 12 00:00:00 EDT 2021
A CAR RNA FISH assay to study functional and spatial heterogeneity of chimeric antigen receptor T cells in tissue.
Scientific reports
Eichholz K,Li AZ,Diem K,Jensen MC,Zhu J,Corey L
Mon Jun 21 00:00:00 EDT 2021
CRISPR-Cas9 cytidine and adenosine base editing of splice-sites mediates highly-efficient disruption of proteins in primary and immortalized cells.
Nature communications
Kluesner MG,Lahr WS,Lonetree CL,Smeester BA,Qiu X,Slipek NJ,Claudio Vázquez PN,Pitzen SP,Pomeroy EJ,Vignes MJ,Lee SC,Bingea SP,Andrew AA,Webber BR,Moriarity BS
Fri Apr 23 00:00:00 EDT 2021
Oncolytic measles virus therapy enhances tumor antigen-specific T-cell responses in patients with multiple myeloma.
Leukemia
Packiriswamy N,Upreti D,Zhou Y,Khan R,Miller A,Diaz RM,Rooney CM,Dispenzieri A,Peng KW,Russell SJ
Tue Dec 01 00:00:00 EST 2020
TGF-β and IL-15 Synergize through MAPK Pathways to Drive the Conversion of Human NK Cells to an Innate Lymphoid Cell 1-like Phenotype.
Journal of immunology (Baltimore, Md. : 1950)
Hawke LG,Mitchell BZ,Ormiston ML
Mon Jun 15 00:00:00 EDT 2020
Assessment of long non-coding RNA expression reveals novel mediators of the lung tumour immune response.
Scientific reports
Sage AP,Ng KW,Marshall EA,Stewart GL,Minatel BC,Enfield KSS,Martin SD,Brown CJ,Abraham N,Lam WL
Fri Oct 09 00:00:00 EDT 2020
Distinctive phenotypes and functions of innate lymphoid cells in human decidua during early pregnancy.
Nature communications
Huhn O,Ivarsson MA,Gardner L,Hollinshead M,Stinchcombe JC,Chen P,Shreeve N,Chazara O,Farrell LE,Theorell J,Ghadially H,Parham P,Griffiths G,Horowitz A,Moffett A,Sharkey AM,Colucci F
Mon Jan 20 00:00:00 EST 2020
Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma.
Nature communications
Tseng HC,Xiong W,Badeti S,Yang Y,Ma M,Liu T,Ramos CA,Dotti G,Fritzky L,Jiang JG,Yi Q,Guarrera J,Zong WX,Liu C,Liu D
Wed Sep 23 00:00:00 EDT 2020
TCR-induced alteration of primary MHC peptide anchor residue.
European journal of immunology
Madura F,Rizkallah PJ,Legut M,Holland CJ,Fuller A,Bulek A,Schauenburg AJ,Trimby A,Hopkins JR,Wells SA,Godkin A,Miles JJ,Sami M,Li Y,Liddy N,Jakobsen BK,Loveridge EJ,Cole DK,Sewell AK
Mon Jul 01 00:00:00 EDT 2019
Gene correction for SCID-X1 in long-term hematopoietic stem cells.
Nature communications
Pavel-Dinu M,Wiebking V,Dejene BT,Srifa W,Mantri S,Nicolas CE,Lee C,Bao G,Kildebeck EJ,Punjya N,Sindhu C,Inlay MA,Saxena N,DeRavin SS,Malech H,Roncarolo MG,Weinberg KI,Porteus MH
Tue Apr 09 00:00:00 EDT 2019
NK cells are activated and primed for skin-homing during acute dengue virus infection in humans.
Nature communications
Zimmer CL,Cornillet M,Solà-Riera C,Cheung KW,Ivarsson MA,Lim MQ,Marquardt N,Leo YS,Lye DC,Klingström J,MacAry PA,Ljunggren HG,Rivino L,Björkström NK
Thu Aug 29 00:00:00 EDT 2019
Missing self triggers NK cell-mediated chronic vascular rejection of solid organ transplants.
Nature communications
Koenig A,Chen CC,Marçais A,Barba T,Mathias V,Sicard A,Rabeyrin M,Racapé M,Duong-Van-Huyen JP,Bruneval P,Loupy A,Dussurgey S,Ducreux S,Meas-Yedid V,Olivo-Marin JC,Paidassi H,Guillemain R,Taupin JL,Callemeyn J,Morelon E,Nicoletti A,Charreau B,Dubois V,Naesens M,Walzer T,Defrance T,Thaunat O
Mon Nov 25 00:00:00 EST 2019
Human leucocyte antigen class I-redirected anti-tumour CD4+ T cells require a higher T cell receptor binding affinity for optimal activity than CD8+ T cells.
Clinical and experimental immunology
Tan MP,Dolton GM,Gerry AB,Brewer JE,Bennett AD,Pumphrey NJ,Jakobsen BK,Sewell AK
Sun Jan 01 00:00:00 EST 2017
In vitro Homeostatic Proliferation of Human CD8 T Cells.
Bio-protocol
Abdelsamed HA,Zebley CC,Youngblood B
AF-200-15 was used in Cell Culture to provide a protocol for the assessment of epigenetic programs in divided and undivided human naïve and memory CD8 T cells following 7 days in culture with IL-7 and IL-15 to illustrate how this approach can shed light on the mechanism(s) that governs the preservation of effector functions during homeostasis of long-lived memory CD8 T cells.
Mon Nov 20 00:00:00 EST 2017
Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia.
Blood
Waldmann TA,Conlon KC,Stewart DM,Worthy TA,Janik JE,Fleisher TA,Albert PS,Figg WD,Spencer SD,Raffeld M,Decker JR,Goldman CK,Bryant BR,Petrus MN,Creekmore SP,Morris JC
Thu Jan 17 00:00:00 EST 2013
Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia.
Blood
Waldmann TA,Conlon KC,Stewart DM,Worthy TA,Janik JE,Fleisher TA,Albert PS,Figg WD,Spencer SD,Raffeld M,Decker JR,Goldman CK,Bryant BR,Petrus MN,Creekmore SP,Morris JC
Thu Jan 17 00:00:00 EST 2013
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.
Blood
Cieri N,Camisa B,Cocchiarella F,Forcato M,Oliveira G,Provasi E,Bondanza A,Bordignon C,Peccatori J,Ciceri F,Lupo-Stanghellini MT,Mavilio F,Mondino A,Bicciato S,Recchia A,Bonini C
Thu Jan 24 00:00:00 EST 2013
Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Fu B,Li X,Sun R,Tong X,Ling B,Tian Z,Wei H
Tue Jan 15 00:00:00 EST 2013
High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.
Blood
Zocchi MR,Catellani S,Canevali P,Tavella S,Garuti A,Villaggio B,Zunino A,Gobbi M,Fraternali-Orcioni G,Kunkl A,Ravetti JL,Boero S,Musso A,Poggi A
Thu Feb 09 00:00:00 EST 2012
Dasatinib enhances the expansion of CD56+CD3- NK cells from cord blood.
Blood
Tanaka J,Sugita J,Shiratori S,Shigematsu A,Imamura M
Thu Jun 21 00:00:00 EDT 2012
Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity.
Blood
Nagai K,Ochi T,Fujiwara H,An J,Shirakata T,Mineno J,Kuzushima K,Shiku H,Melenhorst JJ,Gostick E,Price DA,Ishii E,Yasukawa M
Thu Jan 12 00:00:00 EST 2012
Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa).
Blood
Couzi L,Pitard V,Sicard X,Garrigue I,Hawchar O,Merville P,Moreau JF,Déchanet-Merville J
Thu Feb 09 00:00:00 EST 2012
K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Singh K,Deshpande P,Li G,Yu M,Pryshchep S,Cavanagh M,Weyand CM,Goronzy JJ
Tue Jun 19 00:00:00 EDT 2012
TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence.
PLoS pathogens
Sun C,Fu B,Gao Y,Liao X,Sun R,Tian Z,Wei H
Mon Jul 09 00:00:00 EDT 2012
IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model.
Journal of molecular medicine (Berlin, Germany)
Schilling B,Harasymczuk M,Schuler P,Egan JE,Whiteside TL
Wed Feb 01 00:00:00 EST 2012
Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.
Journal of immunology (Baltimore, Md. : 1950)
Lissauer D,Piper K,Goodyear O,Kilby MD,Moss PA
Sun Jul 15 00:00:00 EDT 2012
IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950)
Imataki O,Ansén S,Tanaka M,Butler MO,Berezovskaya A,Milstein MI,Kuzushima K,Nadler LM,Hirano N
Wed Feb 15 00:00:00 EST 2012
CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.
Journal of immunology (Baltimore, Md. : 1950)
Hervas-Stubbs S,Mancheño U,Riezu-Boj JI,Larraga A,Ochoa MC,Alignani D,Alfaro C,Morales-Kastresana A,Gonzalez I,Larrea E,Pircher H,Le Bon A,Lopez-Picazo JM,Martín-Algarra S,Prieto J,Melero I
Mon Oct 01 00:00:00 EDT 2012
Identification of circulating human antigen-reactive CD4+ FOXP3+ natural regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Litjens NH,Boer K,Betjes MG
Wed Feb 01 00:00:00 EST 2012
Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Fuchs S,Rensing-Ehl A,Speckmann C,Bengsch B,Schmitt-Graeff A,Bondzio I,Maul-Pavicic A,Bass T,Vraetz T,Strahm B,Ankermann T,Benson M,Caliebe A,Fölster-Holst R,Kaiser P,Thimme R,Schamel WW,Schwarz K,Feske S,Ehl S
Wed Feb 01 00:00:00 EST 2012
IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950)
Paine A,Kirchner H,Immenschuh S,Oelke M,Blasczyk R,Eiz-Vesper B
Wed Feb 15 00:00:00 EST 2012
Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells.
PloS one
Jensen H,Folkersen L,Skov S
Tue Feb 19 00:00:00 EST 2013
Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure.
Oncoimmunology
Wilde S,Geiger C,Milosevic S,Mosetter B,Eichenlaub S,Schendel DJ
Thu Mar 01 00:00:00 EST 2012
MiRNA-mediated control of HLA-G expression and function.
PloS one
Manaster I,Goldman-Wohl D,Greenfield C,Nachmani D,Tsukerman P,Hamani Y,Yagel S,Mandelboim O
Mon Aug 13 00:00:00 EDT 2012
A pilot study of IL-2Rα blockade during lymphopenia depletes regulatory T-cells and correlates with enhanced immunity in patients with glioblastoma.
PloS one
Sampson JH,Schmittling RJ,Archer GE,Congdon KL,Nair SK,Reap EA,Desjardins A,Friedman AH,Friedman HS,Herndon JE,Coan A,McLendon RE,Reardon DA,Vredenburgh JJ,Bigner DD,Mitchell DA
AF-200-15 was used in In vitro experiments to examine the combination of daclizumab and EGFRvIII targeted peptide vaccination for depleting regulatory T cells in glioblastoma treated with lymphodepleting temozolomide.
Mon Aug 27 00:00:00 EDT 2012
Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.
PloS one
Nielsen N,Ødum N,Ursø B,Lanier LL,Spee P
Mon Aug 27 00:00:00 EDT 2012
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.
The Journal of biological chemistry
Ekeruche-Makinde J,Clement M,Cole DK,Edwards ES,Ladell K,Miles JJ,Matthews KK,Fuller A,Lloyd KA,Madura F,Dolton GM,Pentier J,Lissina A,Gostick E,Baxter TK,Baker BM,Rizkallah PJ,Price DA,Wooldridge L,Sewell AK
Fri Oct 26 00:00:00 EDT 2012
MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.
PloS one
Testa JS,Shetty V,Hafner J,Nickens Z,Kamal S,Sinnathamby G,Philip R
Wed Apr 24 00:00:00 EDT 2013
Human natural killer cell maturation defect supports in vivo CD56(bright) to CD56(dim) lineage development.
PloS one
Domaica CI,Fuertes MB,Uriarte I,Girart MV,Sardañons J,Comas DI,Di Giovanni D,Gaillard MI,Bezrodnik L,Zwirner NW
Thu May 30 00:00:00 EDT 2013
Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.
The Journal of biological chemistry
Mitra A,Ross JA,Rodriguez G,Nagy ZS,Wilson HL,Kirken RA
Fri May 11 00:00:00 EDT 2012
Activation of STAT6 by STING is critical for antiviral innate immunity.
Cell
Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z
Fri Oct 14 00:00:00 EDT 2011
Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety.
Blood
Ochi T,Fujiwara H,Okamoto S,An J,Nagai K,Shirakata T,Mineno J,Kuzushima K,Shiku H,Yasukawa M
Thu Aug 11 00:00:00 EDT 2011
Severe impairment of IFN-γ and IFN-α responses in cells of a patient with a novel STAT1 splicing mutation.
Blood
Vairo D,Tassone L,Tabellini G,Tamassia N,Gasperini S,Bazzoni F,Plebani A,Porta F,Notarangelo LD,Parolini S,Giliani S,Badolato R
Thu Aug 18 00:00:00 EDT 2011
Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.
Blood
Park YP,Choi SC,Kiesler P,Gil-Krzewska A,Borrego F,Weck J,Krzewski K,Coligan JE
Thu Sep 15 00:00:00 EDT 2011
Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell-invasive merozoites.
Blood
Costa G,Loizon S,Guenot M,Mocan I,Halary F,de Saint-Basile G,Pitard V,Déchanet-Merville J,Moreau JF,Troye-Blomberg M,Mercereau-Puijalon O,Behr C
Thu Dec 22 00:00:00 EST 2011
Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Muralidharan S,Hanley PJ,Liu E,Chakraborty R,Bollard C,Shpall E,Rooney C,Savoldo B,Rodgers J,Dotti G
Tue Nov 15 00:00:00 EST 2011
Differentiation of chronic lymphocytic leukemia B cells into immunoglobulin secreting cells decreases LEF-1 expression.
PloS one
Gutierrez A,Arendt BK,Tschumper RC,Kay NE,Zent CS,Jelinek DF
Mon Feb 13 00:00:00 EST 2012
KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation.
PloS one
Hanvesakul R,Kubal C,Moore J,Neil D,Cook M,Ball S,Briggs D,Moss P,Cockwell P
Fri Dec 23 00:00:00 EST 2011
IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.
PloS one
Sammicheli S,Dang VP,Ruffin N,Pham HT,Lantto R,Vivar N,Chiodi F,Rethi B
Mon Aug 27 00:00:00 EDT 2012
Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
PloS one
Yu Y,Zitzner JR,Houlihan J,Herrera N,Xu L,Miller J,Mathew JM,Tambur AR,Luo X
Mon Aug 27 00:00:00 EDT 2012