Product References
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
200-15 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 EDT 2023
Epitope editing enables targeted immunotherapy of acute myeloid leukaemia.
Nature
Casirati G,Cosentino A,Mucci A,Salah Mahmoud M,Ugarte Zabala I,Zeng J,Ficarro SB,Klatt D,Brendel C,Rambaldi A,Ritz J,Marto JA,Pellin D,Bauer DE,Armstrong SA,Genovese P
200-15 was used in Cell Culture to show that multiplex epitope engineering of haematopoietic stem/progenitor cells is feasible and enables more effective immunotherapies against multiple targets without incurring overlapping off-tumour toxicities.
Fri Sep 01 00:00:00 EDT 2023
EGFR as a potent CAR T target in triple negative breast cancer brain metastases.
Breast cancer research and treatment
Subham S,Jeppson JD,Worcester C,Schatmeyer B,Zhao J,Madan R,Lakis NS,Kimler BF,McGuirk JP,Chen RC,Stecklein SR,Akhavan D
200-15 was used in Cell Culture to demonstrate anti-tumor activity of EGFR806 CAR T cells against TNBC cells in vitro and in vivo.
Sun Jan 01 00:00:00 EST 2023
Engineered virus-like particles for efficient in vivo delivery of therapeutic proteins.
Cell
Banskota S,Raguram A,Suh S,Du SW,Davis JR,Choi EH,Wang X,Nielsen SC,Newby GA,Randolph PB,Osborn MJ,Musunuru K,Palczewski K,Liu DR
Thu Jan 20 00:00:00 EST 2022
Rapid, efficient and activation-neutral gene editing of polyclonal primary human resting CD4+ T cells allows complex functional analyses.
Nature methods
Albanese M,Ruhle A,Mittermaier J,Mejías-Pérez E,Gapp M,Linder A,Schmacke NA,Hofmann K,Hennrich AA,Levy DN,Humpe A,Conzelmann KK,Hornung V,Fackler OT,Keppler OT
Sat Jan 01 00:00:00 EST 2022
Disease-associated mutations in topoisomerase IIβ result in defective NK cells.
The Journal of allergy and clinical immunology
Broderick L,Clay GM,Blum RH,Liu Y,McVicar R,Papes F,Booshehri LM,Cowell IG,Austin CA,Putnam CD,Kaufman DS
200-15 was used in Cell Culture to support that Hoffman syndrome-associated mutations in TOP2B impact NK-cell development and function in murine and human models.
Wed Jun 01 00:00:00 EDT 2022
Epigenetic state determines inflammatory sensing in neuroblastoma.
Proceedings of the National Academy of Sciences of the United States of America
Wolpaw AJ,Grossmann LD,Dessau JL,Dong MM,Aaron BJ,Brafford PA,Volgina D,Pascual-Pasto G,Rodriguez-Garcia A,Uzun Y,Arsenian-Henriksson M,Powell DJ,Bosse KR,Kossenkov A,Tan K,Hogarty MD,Maris JM,Dang CV
200-15 was used in In vitro experiments to investigate inflammatory signaling pathways in neuroblastoma which was found to rely on epigentic state of the tumor.
Tue Feb 08 00:00:00 EST 2022
Pyruvate metabolism guides definitive lineage specification during hematopoietic emergence.
EMBO reports
Oburoglu L,Mansell E,Canals I,Sigurdsson V,Guibentif C,Soneji S,Woods NB
200-15 was used in Cell Culture to reveal that during endothelial-to-hematopoietic transition (EHT), metabolism is a major regulator of primitive versus definitive hematopoietic differentiation.
Thu Feb 03 00:00:00 EST 2022
LINC00152 expression in normal and Chronic Lymphocytic Leukemia B cells.
Hematological oncology
Matis S,Rossi M,Brondolo L,Cardillo M,Reverberi D,Massara R,Colombo M,Ibatici A,Angelucci E,Vaisitti T,Bruno S,Fabris S,Neri A,Gentile M,Morabito F,Cutrona G,Briata P,Gherzi R,Fais F
Tue Feb 01 00:00:00 EST 2022
JAK inhibitor blocks COVID-19 cytokine-induced JAK/STAT/APOL1 signaling in glomerular cells and podocytopathy in human kidney organoids.
JCI insight
Nystrom SE,Li G,Datta S,Soldano KL,Silas D,Weins A,Hall G,Thomas DB,Olabisi OA
200-15 was used in Cell Culture to investigate mechanisms of COVID-19 associated nephropathy.
Wed Jun 08 00:00:00 EDT 2022
Orthotopic T-cell receptor replacement in primary human T cells using CRISPR-Cas9-mediated homology-directed repair.
STAR protocols
Moosmann C,Müller TR,Busch DH,Schober K
Fri Mar 18 00:00:00 EDT 2022
IL-6-induced FOXO1 activity determines the dynamics of metabolism in CD8 T cells cross-primed by liver sinusoidal endothelial cells.
Cell reports
Dudek M,Lohr K,Donakonda S,Baumann T,Lüdemann M,Hegenbarth S,Dübbel L,Eberhagen C,Michailidou S,Yassin A,Prinz M,Popper B,Rose-John S,Zischka H,Knolle PA
200-15 was used in In vitro experiments to report that high-level mitochondrial respiration and constitutive low-level glycolysis support LSEC scavenger and sentinel functions.
Tue Feb 15 00:00:00 EST 2022
CAR T cells redirected to cell surface GRP78 display robust anti-acute myeloid leukemia activity and do not target hematopoietic progenitor cells.
Nature communications
Hebbar N,Epperly R,Vaidya A,Thanekar U,Moore SE,Umeda M,Ma J,Patil SL,Langfitt D,Huang S,Cheng C,Klco JM,Gottschalk S,Velasquez MP
Mon Jan 31 00:00:00 EST 2022
Phospho-proteomics reveals that RSK signaling is required for proliferation of natural killer cells stimulated with IL-2 or IL-15.
Cytokine
MacMullan MA,Wang P,Graham NA
200-15 was used in In vitro experiments to compare the early signalling dynamics induced by the cytokines interleukin (IL)-2 and IL-15 using liquid chromatography-mass spectrometry-based phospho-proteomics in NK-92 cells.
Thu Sep 01 00:00:00 EDT 2022
Functional HPV-specific PD-1+ stem-like CD8 T cells in head and neck cancer.
Nature
Eberhardt CS,Kissick HT,Patel MR,Cardenas MA,Prokhnevska N,Obeng RC,Nasti TH,Griffith CC,Im SJ,Wang X,Shin DM,Carrington M,Chen ZG,Sidney J,Sette A,Saba NF,Wieland A,Ahmed R
Wed Sep 01 00:00:00 EDT 2021
Untimely TGFβ responses in COVID-19 limit antiviral functions of NK cells.
Nature
Witkowski M,Tizian C,Ferreira-Gomes M,Niemeyer D,Jones TC,Heinrich F,Frischbutter S,Angermair S,Hohnstein T,Mattiola I,Nawrath P,McEwen S,Zocche S,Viviano E,Heinz GA,Maurer M,Kölsch U,Chua RL,Aschman T,Meisel C,Radke J,Sawitzki B,Roehmel J,Allers K,Moos V,Schneider T,Hanitsch L,Mall MA,Conrad C,Radbruch H,Duerr CU,Trapani JA,Marcenaro E,Kallinich T,Corman VM,Kurth F,Sander LE,Drosten C,Treskatsch S,Durek P,Kruglov A,Radbruch A,Mashreghi MF,Diefenbach A
200-15 was used in Cell Culture to investigate if a decline in viral load in COVID-19 correlates with Natural killer (NK) cell status and if NK cells can control SARS-CoV-2 replication by recognizing infected target cells.
Wed Dec 01 00:00:00 EST 2021
Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH.
Nature
Dudek M,Pfister D,Donakonda S,Filpe P,Schneider A,Laschinger M,Hartmann D,Hüser N,Meiser P,Bayerl F,Inverso D,Wigger J,Sebode M,Öllinger R,Rad R,Hegenbarth S,Anton M,Guillot A,Bowman A,Heide D,Müller F,Ramadori P,Leone V,Garcia-Caceres C,Gruber T,Seifert G,Kabat AM,Mallm JP,Reider S,Effenberger M,Roth S,Billeter AT,Müller-Stich B,Pearce EJ,Koch-Nolte F,Käser R,Tilg H,Thimme R,Boettler T,Tacke F,Dufour JF,Haller D,Murray PJ,Heeren R,Zehn D,Böttcher JP,Heikenwälder M,Knolle PA
200-15 was used in In vitro experiments to show that this killing by auto-aggressive CD8 T cells fundamentally differed from that by antigen-specific cells, which mechanistically distinguishes auto-aggressive and protective T cell immunity.
Thu Apr 01 00:00:00 EDT 2021
Transcriptional programs of neoantigen-specific TIL in anti-PD-1-treated lung cancers.
Nature
Caushi JX,Zhang J,Ji Z,Vaghasia A,Zhang B,Hsiue EH,Mog BJ,Hou W,Justesen S,Blosser R,Tam A,Anagnostou V,Cottrell TR,Guo H,Chan HY,Singh D,Thapa S,Dykema AG,Burman P,Choudhury B,Aparicio L,Cheung LS,Lanis M,Belcaid Z,El Asmar M,Illei PB,Wang R,Meyers J,Schuebel K,Gupta A,Skaist A,Wheelan S,Naidoo J,Marrone KA,Brock M,Ha J,Bush EL,Park BJ,Bott M,Jones DR,Reuss JE,Velculescu VE,Chaft JE,Kinzler KW,Zhou S,Vogelstein B,Taube JM,Hellmann MD,Brahmer JR,Merghoub T,Forde PM,Yegnasubramanian S,Ji H,Pardoll DM,Smith KN
Sun Aug 01 00:00:00 EDT 2021
Enhanced prime editing systems by manipulating cellular determinants of editing outcomes.
Cell
Chen PJ,Hussmann JA,Yan J,Knipping F,Ravisankar P,Chen PF,Chen C,Nelson JW,Newby GA,Sahin M,Osborn MJ,Weissman JS,Adamson B,Liu DR
Thu Oct 28 00:00:00 EDT 2021
Vaccination reshapes the virus-specific T cell repertoire in unexposed adults.
Immunity
Pan YG,Aiamkitsumrit B,Bartolo L,Wang Y,Lavery C,Marc A,Holec PV,Rappazzo CG,Eilola T,Gimotty PA,Hensley SE,Antia R,Zarnitsyna VI,Birnbaum ME,Su LF
200-15 was used in In vitro experiments to examine how baseline CD4+ T cell repertoire and precursor states impact responses to pathogen infection in humans using primary immunization with yellow fever virus vaccine.
Tue Jun 08 00:00:00 EDT 2021
Atypical acute myeloid leukemia-specific transcripts generate shared and immunogenic MHC class-I-associated epitopes.
Immunity
Ehx G,Larouche JD,Durette C,Laverdure JP,Hesnard L,Vincent K,Hardy MP,Thériault C,Rulleau C,Lanoix J,Bonneil E,Feghaly A,Apavaloaei A,Noronha N,Laumont CM,Delisle JS,Vago L,Hébert J,Sauvageau G,Lemieux S,Thibault P,Perreault C
Tue Apr 13 00:00:00 EDT 2021
Personalized neoantigen pulsed dendritic cell vaccine for advanced lung cancer.
Signal transduction and targeted therapy
Ding Z,Li Q,Zhang R,Xie L,Shu Y,Gao S,Wang P,Su X,Qin Y,Wang Y,Fang J,Zhu Z,Xia X,Wei G,Wang H,Qian H,Guo X,Gao Z,Wang Y,Wei Y,Xu Q,Xu H,Yang L
Wed Jan 20 00:00:00 EST 2021
Interaction between HLA-G and NK cell receptor KIR2DL4 orchestrates HER2-positive breast cancer resistance to trastuzumab.
Signal transduction and targeted therapy
Zheng G,Guo Z,Li W,Xi W,Zuo B,Zhang R,Wen W,Yang AG,Jia L
200-15 was used in In vitro experiments to investigate if the nonclassical histocompatibility antigen HLA-G desensitizes breast cancer cells to trastuzumab by binding to the natural killer (NK) cell receptor KIR2DL4.
Wed Jun 23 00:00:00 EDT 2021
Effector differentiation downstream of lineage commitment in ILC1s is driven by Hobit across tissues.
Nature immunology
Friedrich C,Taggenbrock RLRE,Doucet-Ladevèze R,Golda G,Moenius R,Arampatzi P,Kragten NAM,Kreymborg K,Gomez de Agüero M,Kastenmüller W,Saliba AE,Grün D,van Gisbergen KPJM,Gasteiger G
Fri Oct 01 00:00:00 EDT 2021
Regnase-1 suppresses TCF-1+ precursor exhausted T-cell formation to limit CAR-T-cell responses against ALL.
Blood
Zheng W,Wei J,Zebley CC,Jones LL,Dhungana Y,Wang YD,Mavuluri J,Long L,Fan Y,Youngblood B,Chi H,Geiger TL
Thu Jul 15 00:00:00 EDT 2021
Human skin is colonized by T cells that recognize CD1a independently of lipid.
The Journal of clinical investigation
Cotton RN,Cheng TY,Wegrecki M,Le Nours J,Orgill DP,Pomahac B,Talbot SG,Willis RA,Altman JD,de Jong A,Ogg G,Van Rhijn I,Rossjohn J,Clark RA,Moody DB
Mon Jan 04 00:00:00 EST 2021
A therapeutic cancer vaccine delivers antigens and adjuvants to lymphoid tissues using genetically modified T cells.
The Journal of clinical investigation
Veatch JR,Singhi N,Srivastava S,Szeto JL,Jesernig B,Stull SM,Fitzgibbon M,Sarvothama M,Yechan-Gunja S,James SE,Riddell SR
Mon Aug 16 00:00:00 EDT 2021
CD1a selectively captures endogenous cellular lipids that broadly block T cell response.
The Journal of experimental medicine
Cotton RN,Wegrecki M,Cheng TY,Chen YL,Veerapen N,Le Nours J,Orgill DP,Pomahac B,Talbot SG,Willis R,Altman JD,de Jong A,Van Rhijn I,Clark RA,Besra GS,Ogg G,Rossjohn J,Moody DB
Mon Jul 05 00:00:00 EDT 2021
αβγδ T cells play a vital role in fetal human skin development and immunity.
The Journal of experimental medicine
Reitermaier R,Krausgruber T,Fortelny N,Ayub T,Vieyra-Garcia PA,Kienzl P,Wolf P,Scharrer A,Fiala C,Kölz M,Hiess M,Vierhapper M,Schuster C,Spittler A,Worda C,Weninger W,Bock C,Eppel W,Elbe-Bürger A
Mon Apr 05 00:00:00 EDT 2021
STING agonist promotes CAR T cell trafficking and persistence in breast cancer.
The Journal of experimental medicine
Xu N,Palmer DC,Robeson AC,Shou P,Bommiasamy H,Laurie SJ,Willis C,Dotti G,Vincent BG,Restifo NP,Serody JS
Mon Feb 01 00:00:00 EST 2021
The SIRPα-CD47 immune checkpoint in NK cells.
The Journal of experimental medicine
Deuse T,Hu X,Agbor-Enoh S,Jang MK,Alawi M,Saygi C,Gravina A,Tediashvili G,Nguyen VQ,Liu Y,Valantine H,Lanier LL,Schrepfer S
Mon Mar 01 00:00:00 EST 2021
Modeling, optimization, and comparable efficacy of T cell and hematopoietic stem cell gene editing for treating hyper-IgM syndrome.
EMBO molecular medicine
Vavassori V,Mercuri E,Marcovecchio GE,Castiello MC,Schiroli G,Albano L,Margulies C,Buquicchio F,Fontana E,Beretta S,Merelli I,Cappelleri A,Rancoita PM,Lougaris V,Plebani A,Kanariou M,Lankester A,Ferrua F,Scanziani E,Cotta-Ramusino C,Villa A,Naldini L,Genovese P
Fri Mar 05 00:00:00 EST 2021
CD8 coreceptor-mediated focusing can reorder the agonist hierarchy of peptide ligands recognized via the T cell receptor.
Proceedings of the National Academy of Sciences of the United States of America
Clement M,Knezevic L,Dockree T,McLaren JE,Ladell K,Miners KL,Llewellyn-Lacey S,Rubina A,Francis O,Cole DK,Sewell AK,Bridgeman JS,Price DA,van den Berg HA,Wooldridge L
Tue Jul 20 00:00:00 EDT 2021
Long-term in vitro expansion ensures increased yield of central memory T cells as perspective for manufacturing challenges.
International journal of cancer
Herda S,Heimann A,Obermayer B,Ciraolo E,Althoff S,Ruß J,Grunert C,Busse A,Bullinger L,Pezzutto A,Blankenstein T,Beule D,Na IK
Tue Jun 15 00:00:00 EDT 2021
Cutting Edge: mTORC1 Inhibition in Metastatic Breast Cancer Patients Negatively Affects Peripheral NK Cell Maturation and Number.
Journal of immunology (Baltimore, Md. : 1950)
Besson L,Mery B,Morelle M,Rocca Y,Heudel PE,You B,Bachelot T,Ray-Coquard I,Villard M,Charrier E,Parant F,Viel S,Garin G,Mayet R,Perol D,Walzer T,Tredan O,Marçais A
Sat May 15 00:00:00 EDT 2021
Methylation-Sensitive Restriction Enzyme Quantitative Polymerase Chain Reaction Enables Rapid, Accurate, and Precise Detection of Methylation Status of the Regulatory T Cell (Treg)-Specific Demethylation Region in Primary Human Tregs.
Journal of immunology (Baltimore, Md. : 1950)
Perry N,Wasko K,Cheng J,Tabbaa D,Marco E,Giannoukos G,Albright CF,Borges CM
Fri Jan 15 00:00:00 EST 2021
CD29 Enriches for Cytotoxic Human CD4+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Nicolet BP,Guislain A,Wolkers MC
Wed Dec 15 00:00:00 EST 2021
GD2-specific chimeric antigen receptor-modified T cells targeting retinoblastoma - assessing tumor and T cell interaction.
Translational oncology
Sujjitjoon J,Sayour E,Tsao ST,Uiprasertkul M,Sanpakit K,Buaboonnam J,Yenchitsomanus PT,Atchaneeyasakul LO,Chang LJ
Mon Feb 01 00:00:00 EST 2021
Peripheral leukemia burden at time of apheresis negatively affects the clinical efficacy of CART19 in refractory or relapsed B-ALL.
Molecular therapy. Methods & clinical development
Deng B,Pan J,Liu Z,Liu S,Chen Y,Qu X,Zhang Y,Lin Y,Zhang Y,Yu X,Zhang Z,Niu X,Luan R,Ma M,Li X,Liu T,Wu X,Niu H,Chang AH,Tong C
Fri Dec 10 00:00:00 EST 2021
CRISPR/Cas9 mediated deletion of the adenosine A2A receptor enhances CAR T cell efficacy.
Nature communications
Giuffrida L,Sek K,Henderson MA,Lai J,Chen AXY,Meyran D,Todd KL,Petley EV,Mardiana S,Mølck C,Stewart GD,Solomon BJ,Parish IA,Neeson PJ,Harrison SJ,Kats LM,House IG,Darcy PK,Beavis PA
Fri May 28 00:00:00 EDT 2021
Expanded human NK cells armed with CAR uncouple potent anti-tumor activity from off-tumor toxicity against solid tumors.
iScience
Portillo AL,Hogg R,Poznanski SM,Rojas EA,Cashell NJ,Hammill JA,Chew MV,Shenouda MM,Ritchie TM,Cao QT,Hirota JA,Dhesy-Thind S,Bramson JL,Ashkar AA
Fri Jun 25 00:00:00 EDT 2021
IL-15 enhances CCR5-mediated migration of memory CD8+ T cells by upregulating CCR5 expression in the absence of TCR stimulation.
Cell reports
Seo IH,Eun HS,Kim JK,Lee H,Jeong S,Choi SJ,Lee J,Lee BS,Kim SH,Rou WS,Lee DH,Kim W,Park SH,Shin EC
Tue Jul 27 00:00:00 EDT 2021
SIRT3 overexpression and epigenetic silencing of catalase regulate ROS accumulation in CLL cells activating AXL signaling axis.
Blood cancer journal
Maiti GP,Sinha S,Mahmud H,Boysen J,Mendez MT,Vesely SK,Holter-Chakrabarty J,Kay NE,Ghosh AK
Mon May 17 00:00:00 EDT 2021
Characteristics of Immune Memory and Effector Activity to Cancer-Expressed MHC Class I Phosphopeptides Differ in Healthy Donors and Ovarian Cancer Patients.
Cancer immunology research
Lulu AM,Cummings KL,Jeffery ED,Myers PT,Underwood D,Lacy RM,Chianese-Bullock KA,Slingluff CL,Modesitt SC,Engelhard VH
200-15 was used in In vitro experiments to suggest that the immunogens generating most phosphopeptide-specific immune memory are rare infectious agents or incipient cancer cells with distinct phosphoproteome dysregulations, and that repetitive immunogenic exposures occur in individual donors.
Mon Nov 01 00:00:00 EDT 2021
Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling.
Frontiers in immunology
Wurzer H,Filali L,Hoffmann C,Krecke M,Biolato AM,Mastio J,De Wilde S,François JH,Largeot A,Berchem G,Paggetti J,Moussay E,Thomas C
200-15 was used in Cell Culture to study the role of the chronic lymphocytic leukemia (CLL) cell actin cytoskeleton during natural killer (NK) cell attack to show CLL cells can undergo fast actin cytoskeleton remodeling which is characterized by a NK cell contact-induced accumulation of actin filaments at the immunological synapse (IS).
Mon Jun 28 00:00:00 EDT 2021
Inflammatory Cell Death, PANoptosis, Mediated by Cytokines in Diverse Cancer Lineages Inhibits Tumor Growth.
ImmunoHorizons
Malireddi RKS,Karki R,Sundaram B,Kancharana B,Lee S,Samir P,Kanneganti TD
200-15 was used in Cell Culture to investigate correlations between cytokine expression and mortality.
Wed Jul 21 00:00:00 EDT 2021
HLA-A∗02:01 restricted T cell receptors against the highly conserved SARS-CoV-2 polymerase cross-react with human coronaviruses.
Cell reports
Nesterenko PA,McLaughlin J,Tsai BL,Burton Sojo G,Cheng D,Zhao D,Mao Z,Bangayan NJ,Obusan MB,Su Y,Ng RH,Chour W,Xie J,Li YR,Lee D,Noguchi M,Carmona C,Phillips JW,Kim JT,Yang L,Heath JR,Boutros PC,Witte ON
Tue Dec 28 00:00:00 EST 2021
Directly reprogrammed natural killer cells for cancer immunotherapy.
Nature biomedical engineering
Kim HS,Kim JY,Seol B,Song CL,Jeong JE,Cho YS
Mon Nov 01 00:00:00 EDT 2021
The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells.
Communications biology
Ito T,Kawai Y,Yasui Y,Iriguchi S,Minagawa A,Ishii T,Miyoshi H,Taketo MM,Kawada K,Obama K,Sakai Y,Kaneko S
Mon Jun 07 00:00:00 EDT 2021
A single-chain antibody generation system yielding CAR-T cells with superior antitumor function.
Communications biology
Ochi T,Maruta M,Tanimoto K,Kondo F,Yamamoto T,Kurata M,Fujiwara H,Masumoto J,Takenaka K,Yasukawa M
Tue Mar 02 00:00:00 EST 2021
Microenvironmental IL-6 inhibits anti-cancer immune responses generated by cytotoxic chemotherapy.
Nature communications
Bent EH,Millán-Barea LR,Zhuang I,Goulet DR,Fröse J,Hemann MT
Thu Oct 28 00:00:00 EDT 2021
Virus Induced Lymphocytes (VIL) as a novel viral antigen-specific T cell therapy for COVID-19 and potential future pandemics.
Scientific reports
Sivapalan R,Liu J,Chakraborty K,Arthofer E,Choudhry M,Barie PS,Barouch DH,Henley T
Tue Jul 27 00:00:00 EDT 2021
Immune inactivation of anti-simian immunodeficiency virus chimeric antigen receptor T cells in rhesus macaques.
Molecular therapy. Methods & clinical development
Haeseleer F,Fukazawa Y,Park H,Varco-Merth B,Rust BJ,Smedley JV,Eichholz K,Peterson CW,Mason R,Kiem HP,Roederer M,Picker LJ,Okoye AA,Corey L
Fri Sep 10 00:00:00 EDT 2021
Optimized Liquid and Gas Phase Fractionation Increases HLA-Peptidome Coverage for Primary Cell and Tissue Samples.
Molecular & cellular proteomics : MCP
Klaeger S,Apffel A,Clauser KR,Sarkizova S,Oliveira G,Rachimi S,Le PM,Tarren A,Chea V,Abelin JG,Braun DA,Ott PA,Keshishian H,Hacohen N,Keskin DB,Wu CJ,Carr SA
Thu Mar 24 00:00:00 EDT 2022
STAT3 governs the HIF-1α response in IL-15 primed human NK cells.
Scientific reports
Coulibaly A,Velásquez SY,Kassner N,Schulte J,Barbarossa MV,Lindner HA
Mon Mar 29 00:00:00 EDT 2021
Proinflammatory cytokines promote TET2-mediated DNA demethylation during CD8 T cell effector differentiation.
Cell reports
Zebley CC,Abdelsamed HA,Ghoneim HE,Alli S,Brown C,Haydar D,Mi T,Harris T,McGargill MA,Krenciute G,Youngblood B
Tue Oct 12 00:00:00 EDT 2021
NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions.
Cell reports
Cazzetta V,Bruni E,Terzoli S,Carenza C,Franzese S,Piazza R,Marzano P,Donadon M,Torzilli G,Cimino M,Simonelli M,Bello L,Villa A,Tan L,Ravens S,Prinz I,Supino D,Colombo FS,Lugli E,Marcenaro E,Vivier E,Della Bella S,Mikulak J,Mavilio D
Tue Oct 19 00:00:00 EDT 2021
Activated Lymphocytes and Increased Risk of Dermatologic Adverse Events during Sorafenib Therapy for Hepatocellular Carcinoma.
Cancers
Corominas J,Sapena V,Sanduzzi-Zamparelli M,Millán C,Samper E,Llarch N,Iserte G,Torres F,Da Fonseca LG,Muñoz-Martínez S,Forner A,Bruix J,Boix L,Reig M
200-15 was used in In vitro experiments to investigate immune implication accompanying better prognosis and dermatological adverse effects of sorafenib treatment of advanced hepatocellular carcinoma.
Sat Jan 23 00:00:00 EST 2021
SARS-CoV-2-specific T cell memory is sustained in COVID-19 convalescent patients for 10 months with successful development of stem cell-like memory T cells.
Nature communications
Jung JH,Rha MS,Sa M,Choi HK,Jeon JH,Seok H,Park DW,Park SH,Jeong HW,Choi WS,Shin EC
Wed Jun 30 00:00:00 EDT 2021
Genetic re-direction of canine primary T cells for clinical trial use in pet dogs with spontaneous cancer.
STAR protocols
Rotolo A,Atherton MJ,Kasper BT,Haran KP,Mason NJ
200-15 was used in In vitro experiments to optimize a retrovirus-based protocol to efficiently CAR transduce primary T cells from healthy and tumor-bearing dogs.
Fri Dec 17 00:00:00 EST 2021
Targeted T cell receptor gene editing provides predictable T cell product function for immunotherapy.
Cell reports. Medicine
Müller TR,Jarosch S,Hammel M,Leube J,Grassmann S,Bernard B,Effenberger M,Andrä I,Chaudhry MZ,Käuferle T,Malo A,Cicin-Sain L,Steinberger P,Feuchtinger T,Protzer U,Schumann K,Neuenhahn M,Schober K,Busch DH
Tue Aug 17 00:00:00 EDT 2021
Targeting human Acyl-CoA:cholesterol acyltransferase as a dual viral and T cell metabolic checkpoint.
Nature communications
Schmidt NM,Wing PAC,Diniz MO,Pallett LJ,Swadling L,Harris JM,Burton AR,Jeffery-Smith A,Zakeri N,Amin OE,Kucykowicz S,Heemskerk MH,Davidson B,Meyer T,Grove J,Stauss HJ,Pineda-Torra I,Jolly C,Jury EC,McKeating JA,Maini MK
Fri May 14 00:00:00 EDT 2021
Development of allogeneic HSC-engineered iNKT cells for off-the-shelf cancer immunotherapy.
Cell reports. Medicine
Li YR,Zhou Y,Kim YJ,Zhu Y,Ma F,Yu J,Wang YC,Chen X,Li Z,Zeng S,Wang X,Lee D,Ku J,Tsao T,Hardoy C,Huang J,Cheng D,Montel-Hagen A,Seet CS,Crooks GM,Larson SM,Sasine JP,Wang X,Pellegrini M,Ribas A,Kohn DB,Witte O,Wang P,Yang L
200-15 was used in In vitro experiments to investigate cancer treatment by cell-based immunotherapy.
Tue Nov 16 00:00:00 EST 2021
EZH2 Inhibition Compromises α4-1BB-Mediated Antitumor Efficacy by Reducing the Survival and Effector Programming of CD8+ T Cells.
Frontiers in immunology
Stairiker CJ,Pfister SX,Hendrickson E,Yang W,Xie T,Lee C,Zhang H,Dillon C,Thomas GD,Salek-Ardakani S
200-15 was used in In vitro experiments to support the requirement of EZH2 function in 4-1BB-mediated CD8+ T cell expansion and effector programming and emphasize the consideration that must be given when combining such antitumoral therapies.
Mon Feb 14 00:00:00 EST 2022
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Nature biomedical engineering
Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S
Mon Nov 01 00:00:00 EDT 2021
T cells armed with C-X-C chemokine receptor type 6 enhance adoptive cell therapy for pancreatic tumours.
Nature biomedical engineering
Lesch S,Blumenberg V,Stoiber S,Gottschlich A,Ogonek J,Cadilha BL,Dantes Z,Rataj F,Dorman K,Lutz J,Karches CH,Heise C,Kurzay M,Larimer BM,Grassmann S,Rapp M,Nottebrock A,Kruger S,Tokarew N,Metzger P,Hoerth C,Benmebarek MR,Dhoqina D,Grünmeier R,Seifert M,Oener A,Umut Ö,Joaquina S,Vimeux L,Tran T,Hank T,Baba T,Huynh D,Megens RTA,Janssen KP,Jastroch M,Lamp D,Ruehland S,Di Pilato M,Pruessmann JN,Thomas M,Marr C,Ormanns S,Reischer A,Hristov M,Tartour E,Donnadieu E,Rothenfusser S,Duewell P,König LM,Schnurr M,Subklewe M,Liss AS,Halama N,Reichert M,Mempel TR,Endres S,Kobold S
Mon Nov 01 00:00:00 EDT 2021
Stearoyl-CoA Desaturase-Mediated Monounsaturated Fatty Acid Availability Supports Humoral Immunity.
Cell reports
Zhou X,Zhu X,Li C,Li Y,Ye Z,Shapiro VS,Copland JA,Hitosugi T,Bernlohr DA,Sun J,Zeng H
Tue Jan 05 00:00:00 EST 2021
Dual Targeting CAR-T Cells with Optimal Costimulation and Metabolic Fitness enhance Antitumor Activity and Prevent Escape in Solid Tumors.
Nature cancer
Hirabayashi K,Du H,Xu Y,Shou P,Zhou X,Fucá G,Landoni E,Sun C,Chen Y,Savoldo B,Dotti G
Wed Sep 01 00:00:00 EDT 2021
Formatting and gene-based delivery of a human PD-L1 single domain antibody for immune checkpoint blockade.
Molecular therapy. Methods & clinical development
Awad RM,Lecocq Q,Zeven K,Ertveldt T,De Beck L,Ceuppens H,Broos K,De Vlaeminck Y,Goyvaerts C,Verdonck M,Raes G,Van Parys A,Cauwels A,Keyaerts M,Devoogdt N,Breckpot K
Fri Sep 10 00:00:00 EDT 2021
B cell-specific XIST complex enforces X-inactivation and restrains atypical B cells.
bioRxiv : the preprint server for biology
Yu B,Qi Y,Li R,Shi Q,Satpathy A,Chang HY
Tue Jan 05 00:00:00 EST 2021
Tissue Determinants of Human NK Cell Development, Function, and Residence.
Cell
Dogra P,Rancan C,Ma W,Toth M,Senda T,Carpenter DJ,Kubota M,Matsumoto R,Thapa P,Szabo PA,Li Poon MM,Li J,Arakawa-Hoyt J,Shen Y,Fong L,Lanier LL,Farber DL
Thu Feb 20 00:00:00 EST 2020
Senescence-Induced Vascular Remodeling Creates Therapeutic Vulnerabilities in Pancreas Cancer.
Cell
Ruscetti M,Morris JP,Mezzadra R,Russell J,Leibold J,Romesser PB,Simon J,Kulick A,Ho YJ,Fennell M,Li J,Norgard RJ,Wilkinson JE,Alonso-Curbelo D,Sridharan R,Heller DA,de Stanchina E,Stanger BZ,Sherr CJ,Lowe SW
200-15 was used in Cell Culture to show that a combination of MEK and CDK4/6 inhibitors that target KRAS-directed oncogenic signaling can suppress PDAC proliferation through induction of retinoblastoma (RB) protein-mediated senescence.
Thu Apr 16 00:00:00 EDT 2020
Single-Cell RNA-Seq Mapping of Human Thymopoiesis Reveals Lineage Specification Trajectories and a Commitment Spectrum in T Cell Development.
Immunity
Le J,Park JE,Ha VL,Luong A,Branciamore S,Rodin AS,Gogoshin G,Li F,Loh YE,Camacho V,Patel SB,Welner RS,Parekh C
Tue Jun 16 00:00:00 EDT 2020
THEMIS-SHP1 Recruitment by 4-1BB Tunes LCK-Mediated Priming of Chimeric Antigen Receptor-Redirected T Cells.
Cancer cell
Sun C,Shou P,Du H,Hirabayashi K,Chen Y,Herring LE,Ahn S,Xu Y,Suzuki K,Li G,Tsahouridis O,Su L,Savoldo B,Dotti G
Mon Feb 10 00:00:00 EST 2020
Robust expansion of HIV CAR T cells following antigen boosting in ART-suppressed nonhuman primates.
Blood
Rust BJ,Kean LS,Colonna L,Brandenstein KE,Poole NH,Obenza W,Enstrom MR,Maldini CR,Ellis GI,Fennessey CM,Huang ML,Keele BF,Jerome KR,Riley JL,Kiem HP,Peterson CW
Thu Oct 08 00:00:00 EDT 2020
Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment.
Blood
Kobayashi T,Lam PY,Jiang H,Bednarska K,Gloury R,Murigneux V,Tay J,Jacquelot N,Li R,Tuong ZK,Leggatt GR,Gandhi MK,Hill MM,Belz GT,Ngo S,Kallies A,Mattarollo SR
Thu Dec 24 00:00:00 EST 2020
JAK/STAT pathway inhibition sensitizes CD8 T cells to dexamethasone-induced apoptosis in hyperinflammation.
Blood
Meyer LK,Verbist KC,Albeituni S,Scull BP,Bassett RC,Stroh AN,Tillman H,Allen CE,Hermiston ML,Nichols KE
Thu Aug 06 00:00:00 EDT 2020
Thioredoxin activity confers resistance against oxidative stress in tumor-infiltrating NK cells.
The Journal of clinical investigation
Yang Y,Neo SY,Chen Z,Cui W,Chen Y,Guo M,Wang Y,Xu H,Kurzay A,Alici E,Holmgren L,Haglund F,Wang K,Lundqvist A
Thu Oct 01 00:00:00 EDT 2020
CARD8 inflammasome activation triggers pyroptosis in human T cells.
The EMBO journal
Linder A,Bauernfried S,Cheng Y,Albanese M,Jung C,Keppler OT,Hornung V
Thu Oct 01 00:00:00 EDT 2020
CD29 identifies IFN-γ-producing human CD8+ T cells with an increased cytotoxic potential.
Proceedings of the National Academy of Sciences of the United States of America
Nicolet BP,Guislain A,van Alphen FPJ,Gomez-Eerland R,Schumacher TNM,van den Biggelaar M,Wolkers MC
Tue Mar 24 00:00:00 EDT 2020
Trans-endocytosis of intact IL-15Rα-IL-15 complex from presenting cells into NK cells favors signaling for proliferation.
Proceedings of the National Academy of Sciences of the United States of America
Anton OM,Peterson ME,Hollander MJ,Dorward DW,Arora G,Traba J,Rajagopalan S,Snapp EL,Garcia KC,Waldmann TA,Long EO
Tue Jan 07 00:00:00 EST 2020
Murine CD8 T-cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density.
European journal of immunology
Gilfillan CB,Wang C,Mohsen MO,Rufer N,Hebeisen M,Allard M,Verdeil G,Irvine DJ,Bachmann MF,Speiser DE
Wed Apr 01 00:00:00 EDT 2020
Human T cells employ conserved AU-rich elements to fine-tune IFN-γ production.
European journal of immunology
Freen-van Heeren JJ,Popović B,Guislain A,Wolkers MC
Wed Jul 01 00:00:00 EDT 2020
IL-7Rαlow CD8+ T Cells from Healthy Individuals Are Anergic with Defective Glycolysis.
Journal of immunology (Baltimore, Md. : 1950)
Sim JH,Kim JH,Park AK,Lee J,Kim KM,Shin HM,Kim M,Choi K,Choi EY,Kang I,Lee DS,Kim HR
Tue Dec 01 00:00:00 EST 2020
Protective Immune Responses Elicited by Deglycosylated Live-Attenuated Simian Immunodeficiency Virus Vaccine Are Associated with IL-15 Effector Functions.
Journal of immunology (Baltimore, Md. : 1950)
Watanabe S,Fujino M,Saito Y,Ahmed N,Sato H,Sugimoto C,Okamura T,Hanaki K,Nakayama EE,Shioda T,Matsushima K,Ansari AA,Villinger F,Mori K
Tue Sep 01 00:00:00 EDT 2020
Fumarate Upregulates Surface Expression of ULBP2/ULBP5 by Scavenging Glutathione Antioxidant Capacity.
Journal of immunology (Baltimore, Md. : 1950)
Høgh RI,Droujinine A,Møller SH,Jepsen SD,Mellergaard M,Andresen L,Skov S
Wed Apr 01 00:00:00 EDT 2020
Reconstitution of Circulating Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation: Its Association with the Riboflavin Synthetic Pathway of Gut Microbiota in Cord Blood Transplant Recipients.
Journal of immunology (Baltimore, Md. : 1950)
Konuma T,Kohara C,Watanabe E,Takahashi S,Ozawa G,Suzuki K,Mizukami M,Nagai E,Jimbo K,Kaito Y,Isobe M,Kato S,Takahashi S,Chiba A,Miyake S,Tojo A
Sun Mar 15 00:00:00 EDT 2020
Synovial fluid CD69+CD8+ T cells with tissue-resident phenotype mediate perforin-dependent citrullination in rheumatoid arthritis.
Clinical & translational immunology
Jung J,Lee JS,Kim YG,Lee CK,Yoo B,Shin EC,Hong S
Fri Apr 15 00:00:00 EDT 2022
Identifying the optimal donor for natural killer cell adoptive therapy to treat paediatric B- and T-cell acute lymphoblastic leukaemia.
Clinical & translational immunology
Foley B,Ta C,Barnes S,de Jong E,Nguyen M,Cheung LC,Buzzai A,Wagner T,Wylie B,Fernandez S,Cruickshank M,Endersby R,Kees U,Waithman J
Fri Apr 15 00:00:00 EDT 2022
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.
Nature communications
Kared H,Tan SW,Lau MC,Chevrier M,Tan C,How W,Wong G,Strickland M,Malleret B,Amoah A,Pilipow K,Zanon V,Govern NM,Lum J,Chen JM,Lee B,Florian MC,Geiger H,Ginhoux F,Ruiz-Mateos E,Fulop T,Rajasuriar R,Kamarulzaman A,Ng TP,Lugli E,Larbi A
Mon Feb 10 00:00:00 EST 2020
Immunological history governs human stem cell memory CD4 heterogeneity via the Wnt signaling pathway.
Nature communications
Kared H,Tan SW,Lau MC,Chevrier M,Tan C,How W,Wong G,Strickland M,Malleret B,Amoah A,Pilipow K,Zanon V,Govern NM,Lum J,Chen JM,Lee B,Florian MC,Geiger H,Ginhoux F,Ruiz-Mateos E,Fulop T,Rajasuriar R,Kamarulzaman A,Ng TP,Lugli E,Larbi A
Mon Feb 10 00:00:00 EST 2020
The Transcription Factor Promyelocytic Leukemia Zinc Finger Protein Is Associated With Expression of Liver-Homing Receptors on Human Blood CD56bright Natural Killer Cells.
Hepatology communications
Hess LU,Martrus G,Ziegler AE,Langeneckert AE,Salzberger W,Goebels H,Sagebiel AF,Hagen SH,Poch T,Ravichandran G,Koch M,Schramm C,Oldhafer KJ,Fischer L,Tiegs G,Richert L,Bunders MJ,Lunemann S,Altfeld M
Sun Mar 01 00:00:00 EST 2020
B7-H3 specific T cells with chimeric antigen receptor and decoy PD-1 receptors eradicate established solid human tumors in mouse models.
Oncoimmunology
Huang B,Luo L,Wang J,He B,Feng R,Xian N,Zhang Q,Chen L,Huang G
200-15 was used in In vitro experiments to indicate that B7-H3 specific CAR-T cells have the potential to treat multiple types of advanced solid tumors.
Wed Jul 28 00:00:00 EDT 2021
iPSC-Derived Platelets Depleted of HLA Class I Are Inert to Anti-HLA Class I and Natural Killer Cell Immunity.
Stem cell reports
Suzuki D,Flahou C,Yoshikawa N,Stirblyte I,Hayashi Y,Sawaguchi A,Akasaka M,Nakamura S,Higashi N,Xu H,Matsumoto T,Fujio K,Manz MG,Hotta A,Takizawa H,Eto K,Sugimoto N
Tue Jan 14 00:00:00 EST 2020
GD2-specific CAR T cells encapsulated in an injectable hydrogel control retinoblastoma and preserve vision.
Nature cancer
Wang K,Chen Y,Ahn S,Zheng M,Landoni E,Dotti G,Savoldo B,Han Z
Thu Oct 01 00:00:00 EDT 2020
Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration.
Cell death & disease
Luo B,Zhan Y,Luo M,Dong H,Liu J,Lin Y,Zhang J,Wang G,Verhoeyen E,Zhang Y,Zhang H
Thu Nov 12 00:00:00 EST 2020
Human CLEC9A antibodies deliver Wilms' tumor 1 (WT1) antigen to CD141+ dendritic cells to activate naïve and memory WT1-specific CD8+ T cells.
Clinical & translational immunology
Pearson FE,Tullett KM,Leal-Rojas IM,Haigh OL,Masterman KA,Walpole C,Bridgeman JS,McLaren JE,Ladell K,Miners K,Llewellyn-Lacey S,Price DA,Tunger A,Schmitz M,Miles JJ,Lahoud MH,Radford KJ
Fri Apr 15 00:00:00 EDT 2022
Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells.
Frontiers in immunology
Møller SH,Mellergaard M,Madsen M,Bermejo AV,Jepsen SD,Hansen MH,Høgh RI,Aldana BI,Desler C,Rasmussen LJ,Sustarsic EG,Gerhart-Hines Z,Daskalaki E,Wheelock CE,Hiron TK,Lin D,O'Callaghan CA,Wandall HH,Andresen L,Skov S
200-15 was used in In vitro experiments that cancer cell metabolism supports constitutive surface expression of the NKG2D ligand MHC class I chain-related proteins A (MICA).
Fri Apr 30 00:00:00 EDT 2021
The anti-B7-H4 checkpoint synergizes trastuzumab treatment to promote phagocytosis and eradicate breast cancer.
Neoplasia (New York, N.Y.)
Hu X,Liu Y,Zhang X,Kong D,Kong J,Zhao D,Guo Y,Sun L,Chu L,Liu S,Hou X,Ren F,Zhao Y,Lu C,Zhai D,Yuan X
200-15 was used in In vitro experiments to evaluate the role(s) of trastuzumab and other antibodies on macrophage activation and Ab-dependent cell-mediated phagocytosis (ADCP) of HER2+ breast cancer cells in vitro and in vivo.
Sun Nov 01 00:00:00 EDT 2020
Efficacy of anti-CD147 chimeric antigen receptors targeting hepatocellular carcinoma.
Nature communications
Tseng HC,Xiong W,Badeti S,Yang Y,Ma M,Liu T,Ramos CA,Dotti G,Fritzky L,Jiang JG,Yi Q,Guarrera J,Zong WX,Liu C,Liu D
Wed Sep 23 00:00:00 EDT 2020
convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting.
Communications biology
Landgraf KE,Williams SR,Steiger D,Gebhart D,Lok S,Martin DW,Roybal KT,Kim KC
200-15 was used in Sample Preparation (FC/FACS) to demonstrate that the exclusive ligand-receptor partnering enabled the targeted delivery of a mutant form of IL-2 to selectively promote the expansion of convertibleCAR-T cells in vitro and in vivo.
Tue Jun 09 00:00:00 EDT 2020
convertibleCARs: A chimeric antigen receptor system for flexible control of activity and antigen targeting.
Communications biology
Landgraf KE,Williams SR,Steiger D,Gebhart D,Lok S,Martin DW,Roybal KT,Kim KC
200-15 was used in Sample Preparation (FC/FACS) to demonstrate that the exclusive ligand-receptor partnering enabled the targeted delivery of a mutant form of IL-2 to selectively promote the expansion of convertibleCAR-T cells in vitro and in vivo.
Tue Jun 09 00:00:00 EDT 2020
Protocol for Isolation, Stimulation and Functional Profiling of Primary and iPSC-derived Human NK Cells.
Bio-protocol
Melsen JE,Themeli M,van Ostaijen-Ten Dam MM,van Beelen E,Lugthart G,Hoeben RC,Schilham MW,Mikkers HM
200-15 was used in In vitro experiments to investigate NK cells classification.
Sat Dec 05 00:00:00 EST 2020
PBRM1 and the glycosylphosphatidylinositol biosynthetic pathway promote tumor killing mediated by MHC-unrestricted cytotoxic lymphocytes.
Science advances
Menasche BL,Davis EM,Wang S,Ouyang Y,Li S,Yu H,Shen J
200-15 was used in Cell Culture to identify mechanisms utilised by major histocompatibility complex-unrestricted cytotoxic lymphocytes in tumour killing.
Sun Nov 01 00:00:00 EDT 2020
Streamlined selection of cancer antigens for vaccine development through integrative multi-omics and high-content cell imaging.
Scientific reports
Han KC,Park D,Ju S,Lee YE,Heo SH,Kim YA,Lee JE,Lee Y,Park KH,Park SH,Lee HJ,Lee C,Jang M
Fri Apr 03 00:00:00 EDT 2020
Toll-like receptor 7/8-matured RNA-transduced dendritic cells as post-remission therapy in acute myeloid leukaemia: results of a phase I trial.
Clinical & translational immunology
Lichtenegger FS,Schnorfeil FM,Rothe M,Deiser K,Altmann T,Bücklein VL,Köhnke T,Augsberger C,Konstandin NP,Spiekermann K,Moosmann A,Boehm S,Boxberg M,Heemskerk MH,Goerlich D,Wittmann G,Wagner B,Hiddemann W,Schendel DJ,Kvalheim G,Bigalke I,Subklewe M
Wed Apr 13 00:00:00 EDT 2022
Single-Cell RNA Sequencing Resolves Spatiotemporal Development of Pre-thymic Lymphoid Progenitors and Thymus Organogenesis in Human Embryos.
Immunity
Zeng Y,Liu C,Gong Y,Bai Z,Hou S,He J,Bian Z,Li Z,Ni Y,Yan J,Huang T,Shi H,Ma C,Chen X,Wang J,Bian L,Lan Y,Liu B,Hu H
Tue Nov 19 00:00:00 EST 2019
Antitumor Responses in the Absence of Toxicity in Solid Tumors by Targeting B7-H3 via Chimeric Antigen Receptor T Cells.
Cancer cell
Du H,Hirabayashi K,Ahn S,Kren NP,Montgomery SA,Wang X,Tiruthani K,Mirlekar B,Michaud D,Greene K,Herrera SG,Xu Y,Sun C,Chen Y,Ma X,Ferrone CR,Pylayeva-Gupta Y,Yeh JJ,Liu R,Savoldo B,Ferrone S,Dotti G
Mon Feb 11 00:00:00 EST 2019
Development of Hematopoietic Stem Cell-Engineered Invariant Natural Killer T Cell Therapy for Cancer.
Cell stem cell
Zhu Y,Smith DJ,Zhou Y,Li YR,Yu J,Lee D,Wang YC,Di Biase S,Wang X,Hardoy C,Ku J,Tsao T,Lin LJ,Pham AT,Moon H,McLaughlin J,Cheng D,Hollis RP,Campo-Fernandez B,Urbinati F,Wei L,Pang L,Rezek V,Berent-Maoz B,Macabali MH,Gjertson D,Wang X,Galic Z,Kitchen SG,An DS,Hu-Lieskovan S,Kaplan-Lefko PJ,De Oliveira SN,Seet CS,Larson SM,Forman SJ,Heath JR,Zack JA,Crooks GM,Radu CG,Ribas A,Kohn DB,Witte ON,Yang L
200-15 was used in Sample Preparation (FC/FACS) to develop a proof-of-concept for hematopoietic stem cell-engineered invariant natural killer T (iNKT) cell therapy with the potential to provide therapeutic levels of iNKT cells for a patient's lifetime.
Thu Oct 03 00:00:00 EDT 2019
Mucosal vaccine efficacy against intrarectal SHIV is independent of anti-Env antibody response.
The Journal of clinical investigation
Sui Y,Lewis GK,Wang Y,Berckmueller K,Frey B,Dzutsev A,Vargas-Inchaustegui D,Mohanram V,Musich T,Shen X,DeVico A,Fouts T,Venzon D,Kirk J,Waters RC,Talton J,Klinman D,Clements J,Tomaras GD,Franchini G,Robert-Guroff M,Trinchieri G,Gallo RC,Berzofsky JA
Fri Mar 01 00:00:00 EST 2019
A novel human IL2RB mutation results in T and NK cell-driven immune dysregulation.
The Journal of experimental medicine
Fernandez IZ,Baxter RM,Garcia-Perez JE,Vendrame E,Ranganath T,Kong DS,Lundquist K,Nguyen T,Ogolla S,Black J,Galambos C,Gumbart JC,Dawany N,Kelsen JR,de Zoeten EF,Quinones R,Eissa H,Verneris MR,Sullivan KE,Rochford R,Blish CA,Kedl RM,Dutmer CM,Hsieh EWY
200-15 was used in Enzyme-linked immunosorbent assay to investigate the clinical and immunological phenotypes of two siblings with the first described human IL-2Rβ defect.
Mon Jun 03 00:00:00 EDT 2019
Human interleukin-2 receptor β mutations associated with defects in immunity and peripheral tolerance.
The Journal of experimental medicine
Zhang Z,Gothe F,Pennamen P,James JR,McDonald D,Mata CP,Modis Y,Alazami AM,Acres M,Haller W,Bowen C,Döffinger R,Sinclair J,Brothers S,Zhang Y,Matthews HF,Naudion S,Pelluard F,Alajlan H,Yamazaki Y,Notarangelo LD,Thaventhiran JE,Engelhardt KR,Al-Mousa H,Hambleton S,Rooryck C,Smith KGC,Lenardo MJ
Mon Jun 03 00:00:00 EDT 2019
EZH2 is overexpressed in transitional preplasmablasts and is involved in human plasma cell differentiation.
Leukemia
Herviou L,Jourdan M,Martinez AM,Cavalli G,Moreaux J
Thu Aug 01 00:00:00 EDT 2019
MicroRNA-155 Expression Is Enhanced by T-cell Receptor Stimulation Strength and Correlates with Improved Tumor Control in Melanoma.
Cancer immunology research
Martinez-Usatorre A,Sempere LF,Carmona SJ,Carretero-Iglesia L,Monnot G,Speiser DE,Rufer N,Donda A,Zehn D,Jandus C,Romero P
200-15 was used in Cell Culture to explore the regulation of miR-155 expression in CD8+ cells.
Sat Jun 01 00:00:00 EDT 2019
Efficient CRISPR/Cas9 Disruption of Autoimmune-Associated Genes Reveals Key Signaling Programs in Primary Human T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Anderson W,Thorpe J,Long SA,Rawlings DJ
Sun Dec 15 00:00:00 EST 2019
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.
Nature communications
Fan J,Liang H,Ji X,Wang S,Xue J,Li D,Peng H,Qin C,Yee C,Shao Y
Tue May 21 00:00:00 EDT 2019
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.
Nature communications
Fan J,Liang H,Ji X,Wang S,Xue J,Li D,Peng H,Qin C,Yee C,Shao Y
Tue May 21 00:00:00 EDT 2019
Unique transcriptional and protein-expression signature in human lung tissue-resident NK cells.
Nature communications
Marquardt N,Kekäläinen E,Chen P,Lourda M,Wilson JN,Scharenberg M,Bergman P,Al-Ameri M,Hård J,Mold JE,Ljunggren HG,Michaëlsson J
Mon Aug 26 00:00:00 EDT 2019
Hexamethylene bisacetamide impairs NK cell-mediated clearance of acute T lymphoblastic leukemia cells and HIV-1-infected T cells that exit viral latency.
Scientific reports
Giuliani E,Desimio MG,Doria M
Wed Mar 13 00:00:00 EDT 2019
CD8+ T cells from patients with narcolepsy and healthy controls recognize hypocretin neuron-specific antigens.
Nature communications
Pedersen NW,Holm A,Kristensen NP,Bjerregaard AM,Bentzen AK,Marquard AM,Tamhane T,Burgdorf KS,Ullum H,Jennum P,Knudsen S,Hadrup SR,Kornum BR
Tue Feb 19 00:00:00 EST 2019
The R132H mutation in IDH1 promotes the recruitment of NK cells through CX3CL1/CX3CR1 chemotaxis and is correlated with a better prognosis in gliomas.
Immunology and cell biology
Ren F,Zhao Q,Huang L,Zheng Y,Li L,He Q,Zhang C,Li F,Maimela NR,Sun Z,Jia Q,Ping Y,Zhang Z,Chen X,Yue Y,Liu S,Cao L,Zhang Y
200-15 was used in Cell Culture to identify a novel mechanism in which R132H mutation of the IDH1 gene serves as a tumor suppressor by promoting the recruitment of NK cells through CX3CL1/CX3CR1 chemotaxis.
Wed May 01 00:00:00 EDT 2019
Human γδ T-cell receptor repertoire is shaped by influenza viruses, age and tissue compartmentalisation.
Clinical & translational immunology
Sant S,Jenkins MR,Dash P,Watson KA,Wang Z,Pizzolla A,Koutsakos M,Nguyen TH,Lappas M,Crowe J,Loudovaris T,Mannering SI,Westall GP,Kotsimbos TC,Cheng AC,Wakim L,Doherty PC,Thomas PG,Loh L,Kedzierska K
Sun Apr 10 00:00:00 EDT 2022
Humanized anti-CD123 antibody facilitates NK cell antibody-dependent cell-mediated cytotoxicity (ADCC) of Hodgkin lymphoma targets via ARF6/PLD-1.
Blood cancer journal
Ernst D,Williams BA,Wang XH,Yoon N,Kim KP,Chiu J,Luo ZJ,Hermans KG,Krueger J,Keating A
Tue Jan 15 00:00:00 EST 2019
T cell recognition of novel shared breast cancer antigens is frequently observed in peripheral blood of breast cancer patients.
Oncoimmunology
Viborg N,Ramskov S,Andersen RS,Sturm T,Fugmann T,Bentzen AK,Rafa VM,Straten PT,Svane IM,Met Ö,Hadrup SR
200-15 was used in Cell Culture to identify T cell targets in breast cancer for future treatment options.
Tue Jan 12 00:00:00 EST 2021
Decidual stromal cells promote the differentiation of CD56bright CD16- NK cells by secreting IL-24 in early pregnancy.
American journal of reproductive immunology (New York, N.Y. : 1989)
Yang HL,Zhou WJ,Lu H,Lei ST,Ha SY,Lai ZZ,Zheng ZM,Ruan LY,He YY,Li DJ,Li MQ,Shao J
200-15 was used in Cell Culture to suggest that DSCs promote the differentiation of CD56bright CD16- NK with high levels of inhibitory receptors, immunotolerant, and angiogenic cytokines by secreting IL-24 during decidualization in early pregnancy.
Sat Jun 01 00:00:00 EDT 2019
Low immunogenic endothelial cells endothelialize the Left Ventricular Assist Device.
Scientific reports
Figueiredo C,Eicke D,Yuzefovych Y,Avsar M,Hanke JS,Pflaum M,Schmitto JD,Blasczyk R,Haverich A,Wiegmann B
Mon Aug 05 00:00:00 EDT 2019
Characterization of Human Mucosal-associated Invariant T (MAIT) Cells.
Current protocols in immunology
Souter MNT,Loh L,Li S,Meehan BS,Gherardin NA,Godfrey DI,Rossjohn J,Fairlie DP,Kedzierska K,Pellicci DG,Chen Z,Kjer-Nielsen L,Corbett AJ,McCluskey J,Eckle SBG
200-15 was used in Cell Culture to describe protocols to characterize the phenotype of human MAIT cells in blood and tissues by flow cytometry using fluorescently labeled human MR1 tetramers alongside antibodies specific for MAIT cell markers.
Sun Dec 01 00:00:00 EST 2019
UM171 expands distinct types of myeloid and NK progenitors from human pluripotent stem cells.
Scientific reports
Mesquitta WT,Wandsnider M,Kang H,Thomson J,Moskvin O,Suknuntha K,Slukvin II
Mon Apr 29 00:00:00 EDT 2019
iRGD synergizes with PD-1 knockout immunotherapy by enhancing lymphocyte infiltration in gastric cancer.
Nature communications
Ding N,Zou Z,Sha H,Su S,Qian H,Meng F,Chen F,Du S,Zhou S,Chen H,Zhang L,Yang J,Wei J,Liu B
Fri Mar 22 00:00:00 EDT 2019
Differential Modulation of Human Innate Lymphoid Cell (ILC) Subsets by IL-10 and TGF-β.
Scientific reports
Bonne-Année S,Bush MC,Nutman TB
Fri Oct 04 00:00:00 EDT 2019
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 EST 2018
FBXO38 mediates PD-1 ubiquitination and regulates anti-tumour immunity of T cells.
Nature
Meng X,Liu X,Guo X,Jiang S,Chen T,Hu Z,Liu H,Bai Y,Xue M,Hu R,Sun SC,Liu X,Zhou P,Huang X,Wei L,Yang W,Xu C
Sat Dec 01 00:00:00 EST 2018
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Cell
Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E
200-15 was used in Cell Culture to report here an unexpected finding that macrophages after antibody-dependent cellular cytotoxicity inhibit NK cell-mediated antibody-dependent cellular cytotoxicity and T cell-mediated cytotoxicity in breast cancers and lymphomas.
Thu Oct 04 00:00:00 EDT 2018
Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages.
Cell
Su S,Zhao J,Xing Y,Zhang X,Liu J,Ouyang Q,Chen J,Su F,Liu Q,Song E
200-15 was used in Cell Culture to report here an unexpected finding that macrophages after antibody-dependent cellular cytotoxicity inhibit NK cell-mediated antibody-dependent cellular cytotoxicity and T cell-mediated cytotoxicity in breast cancers and lymphomas.
Thu Oct 04 00:00:00 EDT 2018
Natural Killer Cells Control Tumor Growth by Sensing a Growth Factor.
Cell
Barrow AD,Edeling MA,Trifonov V,Luo J,Goyal P,Bohl B,Bando JK,Kim AH,Walker J,Andahazy M,Bugatti M,Melocchi L,Vermi W,Fremont DH,Cox S,Cella M,Schmedt C,Colonna M
Thu Jan 25 00:00:00 EST 2018
Innate-like Cytotoxic Function of Bystander-Activated CD8+ T Cells Is Associated with Liver Injury in Acute Hepatitis A.
Immunity
Kim J,Chang DY,Lee HW,Lee H,Kim JH,Sung PS,Kim KH,Hong SH,Kang W,Lee J,Shin SY,Yu HT,You S,Choi YS,Oh I,Lee DH,Lee DH,Jung MK,Suh KS,Hwang S,Kim W,Park SH,Kim HJ,Shin EC
Tue Jan 16 00:00:00 EST 2018
Peptide mimic for influenza vaccination using nonnatural combinatorial chemistry.
The Journal of clinical investigation
Miles JJ,Tan MP,Dolton G,Edwards ES,Galloway SA,Laugel B,Clement M,Makinde J,Ladell K,Matthews KK,Watkins TS,Tungatt K,Wong Y,Lee HS,Clark RJ,Pentier JM,Attaf M,Lissina A,Ager A,Gallimore A,Rizkallah PJ,Gras S,Rossjohn J,Burrows SR,Cole DK,Price DA,Sewell AK
Mon Apr 02 00:00:00 EDT 2018
CD122 signaling in CD8+ memory T cells drives costimulation-independent rejection.
The Journal of clinical investigation
Mathews DV,Dong Y,Higginbotham LB,Kim SC,Breeden CP,Stobert EA,Jenkins J,Tso JY,Larsen CP,Adams AB
Mon Oct 01 00:00:00 EDT 2018
High-dimensional single cell analysis identifies stem-like cytotoxic CD8+ T cells infiltrating human tumors.
The Journal of experimental medicine
Brummelman J,Mazza EMC,Alvisi G,Colombo FS,Grilli A,Mikulak J,Mavilio D,Alloisio M,Ferrari F,Lopci E,Novellis P,Veronesi G,Lugli E
Mon Oct 01 00:00:00 EDT 2018
Drug-Induced Senescent Multiple Myeloma Cells Elicit NK Cell Proliferation by Direct or Exosome-Mediated IL15 Trans-Presentation.
Cancer immunology research
Borrelli C,Ricci B,Vulpis E,Fionda C,Ricciardi MR,Petrucci MT,Masuelli L,Peri A,Cippitelli M,Zingoni A,Santoni A,Soriani A
200-15 was used in In vitro experiments to demonstrate that low doses of chemotherapeutic drugs induce tumour cell senescence and a senescence-associated secretory phenotype thus promoting IL15 trans-presentation to NK cells leading to their activation and proliferation.
Sun Jul 01 00:00:00 EDT 2018
Targeting LAG-3 and PD-1 to Enhance T Cell Activation by Antigen-Presenting Cells.
Frontiers in immunology
Lichtenegger FS,Rothe M,Schnorfeil FM,Deiser K,Krupka C,Augsberger C,Schlüter M,Neitz J,Subklewe M
200-15 was used in Sample Preparation (FC/FACS) to compare the efficacy of dendritic cell receptor-ligand blockades at various immune checkpoints on T cell activation, an suggest targets for enhanced immunotherapy.
Mon Apr 08 00:00:00 EDT 2019
Elevated Hepatic CD1d Levels Coincide with Invariant NKT Cell Defects in Chronic Hepatitis B Virus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Tan X,Ding Y,Zhu P,Dou R,Liang Z,Yang D,Huang Z,Wang W,Wu X,Weng X
Tue May 15 00:00:00 EDT 2018
Activation of Th1 Immunity within the Tumor Microenvironment Is Associated with Clinical Response to Lenalidomide in Chronic Lymphocytic Leukemia.
Journal of immunology (Baltimore, Md. : 1950)
Aue G,Sun C,Liu D,Park JH,Pittaluga S,Tian X,Lee E,Soto S,Valdez J,Maric I,Stetler-Stevenson M,Yuan C,Nakamura Y,Muranski P,Wiestner A
Mon Oct 01 00:00:00 EDT 2018
Differentiation of Langerhans Cells from Monocytes and Their Specific Function in Inducing IL-22-Specific Th Cells.
Journal of immunology (Baltimore, Md. : 1950)
Otsuka Y,Watanabe E,Shinya E,Okura S,Saeki H,Geijtenbeek TBH,Takahashi H
Thu Nov 15 00:00:00 EST 2018
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
Journal of immunology (Baltimore, Md. : 1950)
Hecht I,Toporik A,Podojil JR,Vaknin I,Cojocaru G,Oren A,Aizman E,Liang SC,Leung L,Dicken Y,Novik A,Marbach-Bar N,Elmesmari A,Tange C,Gilmour A,McIntyre D,Kurowska-Stolarska M,McNamee K,Leitner J,Greenwald S,Dassa L,Levine Z,Steinberger P,Williams RO,Miller SD,McInnes IB,Neria E,Rotman G
Thu Mar 15 00:00:00 EDT 2018
IL-15 Promotes Polyfunctional NK Cell Responses to Influenza by Boosting IL-12 Production.
Journal of immunology (Baltimore, Md. : 1950)
Wagstaffe HR,Nielsen CM,Riley EM,Goodier MR
Sun Apr 15 00:00:00 EDT 2018
Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j.
Journal of immunology (Baltimore, Md. : 1950)
Nuñez SY,Ziblat A,Secchiari F,Torres NI,Sierra JM,Raffo Iraolagoitia XL,Araya RE,Domaica CI,Fuertes MB,Zwirner NW
Thu Feb 01 00:00:00 EST 2018
DOT1L inhibition attenuates graft-versus-host disease by allogeneic T cells in adoptive immunotherapy models.
Nature communications
Kagoya Y,Nakatsugawa M,Saso K,Guo T,Anczurowski M,Wang CH,Butler MO,Arrowsmith CH,Hirano N
Tue May 15 00:00:00 EDT 2018
Enhancing the Activation and Releasing the Brakes: A Double Hit Strategy to Improve NK Cell Cytotoxicity Against Multiple Myeloma.
Frontiers in immunology
Tognarelli S,Wirsching S,von Metzler I,Rais B,Jacobs B,Serve H,Bader P,Ullrich E
200-15 was used in Cell Culture to investigate the potential use of natural killer cell-specific check point inhibitors in multiple myeloma.
Mon Sep 30 00:00:00 EDT 2019
Inhibition of histone H3K27 demethylases selectively modulates inflammatory phenotypes of natural killer cells.
The Journal of biological chemistry
Cribbs A,Hookway ES,Wells G,Lindow M,Obad S,Oerum H,Prinjha RK,Athanasou N,Sowman A,Philpott M,Penn H,Soderstrom K,Feldmann M,Oppermann U
Fri Feb 16 00:00:00 EST 2018
Divergent roles for antigenic drive in the aetiology of primary versus dasatinib-associated CD8+ TCR-Vβ+ expansions.
Scientific reports
Lissina A,McLaren JE,Ilander M,Andersson EI,Lewis CS,Clement M,Herman A,Ladell K,Llewellyn-Lacey S,Miners KL,Gostick E,Melenhorst JJ,Barrett AJ,Price DA,Mustjoki S,Wooldridge L
Wed Feb 07 00:00:00 EST 2018
Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.
Scientific reports
Treise I,Huber EM,Klein-Rodewald T,Heinemeyer W,Grassmann SA,Basler M,Adler T,Rathkolb B,Helming L,Andres C,Klaften M,Landbrecht C,Wieland T,Strom TM,McCoy KD,Macpherson AJ,Wolf E,Groettrup M,Ollert M,Neff F,Gailus-Durner V,Fuchs H,Hrabě de Angelis M,Groll M,Busch DH
Fri Apr 13 00:00:00 EDT 2018
Defective immuno- and thymoproteasome assembly causes severe immunodeficiency.
Scientific reports
Treise I,Huber EM,Klein-Rodewald T,Heinemeyer W,Grassmann SA,Basler M,Adler T,Rathkolb B,Helming L,Andres C,Klaften M,Landbrecht C,Wieland T,Strom TM,McCoy KD,Macpherson AJ,Wolf E,Groettrup M,Ollert M,Neff F,Gailus-Durner V,Fuchs H,Hrabě de Angelis M,Groll M,Busch DH
Fri Apr 13 00:00:00 EDT 2018
Generation of TCR-Expressing Innate Lymphoid-like Helper Cells that Induce Cytotoxic T Cell-Mediated Anti-leukemic Cell Response.
Stem cell reports
Ueda N,Uemura Y,Zhang R,Kitayama S,Iriguchi S,Kawai Y,Yasui Y,Tatsumi M,Ueda T,Liu TY,Mizoro Y,Okada C,Watanabe A,Nakanishi M,Senju S,Nishimura Y,Kuzushima K,Kiyoi H,Naoe T,Kaneko S
Tue Jun 05 00:00:00 EDT 2018
Hypoxia Modifies the Transcriptome of Human NK Cells, Modulates Their Immunoregulatory Profile, and Influences NK Cell Subset Migration.
Frontiers in immunology
Parodi M,Raggi F,Cangelosi D,Manzini C,Balsamo M,Blengio F,Eva A,Varesio L,Pietra G,Moretta L,Mingari MC,Vitale M,Bosco MC
200-15 was used in In vitro experiments to study the mechanisms by which hypoxia acts on natural killer cells.
Wed Oct 02 00:00:00 EDT 2019
Origin and differentiation of human memory CD8 T cells after vaccination.
Nature
Akondy RS,Fitch M,Edupuganti S,Yang S,Kissick HT,Li KW,Youngblood BA,Abdelsamed HA,McGuire DJ,Cohen KW,Alexe G,Nagar S,McCausland MM,Gupta S,Tata P,Haining WN,McElrath MJ,Zhang D,Hu B,Greenleaf WJ,Goronzy JJ,Mulligan MJ,Hellerstein M,Ahmed R
Thu Dec 21 00:00:00 EST 2017
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.
Nature
Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A
Thu Nov 02 00:00:00 EDT 2017
Heterogeneous Tumor-Immune Microenvironments among Differentially Growing Metastases in an Ovarian Cancer Patient.
Cell
Jiménez-Sánchez A,Memon D,Pourpe S,Veeraraghavan H,Li Y,Vargas HA,Gill MB,Park KJ,Zivanovic O,Konner J,Ricca J,Zamarin D,Walther T,Aghajanian C,Wolchok JD,Sala E,Merghoub T,Snyder A,Miller ML
Thu Aug 24 00:00:00 EDT 2017
Mitochondrial Priming by CD28.
Cell
Klein Geltink RI,O'Sullivan D,Corrado M,Bremser A,Buck MD,Buescher JM,Firat E,Zhu X,Niedermann G,Caputa G,Kelly B,Warthorst U,Rensing-Ehl A,Kyle RL,Vandersarren L,Curtis JD,Patterson AE,Lawless S,Grzes K,Qiu J,Sanin DE,Kretz O,Huber TB,Janssens S,Lambrecht BN,Rambold AS,Pearce EJ,Pearce EL
Thu Oct 05 00:00:00 EDT 2017
Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies.
The Journal of experimental medicine
Nandin IS,Fong C,Deantonio C,Torreno-Pina JA,Pecetta S,Maldonado P,Gasparrini F,Ordovas-Montanes J,Kazer SW,Kjaer S,Borley DW,Nair U,Coleman JA,Lingwood D,Shalek AK,Meffre E,Poignard P,Burton DR,Batista FD
Mon Sep 04 00:00:00 EDT 2017
Curtailed T-cell activation curbs effector differentiation and generates CD8+ T cells with a naturally-occurring memory stem cell phenotype.
European journal of immunology
Zanon V,Pilipow K,Scamardella E,De Paoli F,De Simone G,Price DA,Martinez Usatorre A,Romero P,Mavilio D,Roberto A,Lugli E
Fri Sep 01 00:00:00 EDT 2017
CD8+ T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold.
Immunology and cell biology
Dockree T,Holland CJ,Clement M,Ladell K,McLaren JE,van den Berg HA,Gostick E,L Miners K,Llewellyn-Lacey S,Bridgeman JS,Man S,Bailey M,Burrows SR,Price DA,Wooldridge L
Sun Jan 01 00:00:00 EST 2017
Comprehensive Approach for Identifying the T Cell Subset Origin of CD3 and CD28 Antibody-Activated Chimeric Antigen Receptor-Modified T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Schmueck-Henneresse M,Omer B,Shum T,Tashiro H,Mamonkin M,Lapteva N,Sharma S,Rollins L,Dotti G,Reinke P,Volk HD,Rooney CM
Sat Jul 01 00:00:00 EDT 2017
NKG2D Signaling between Human NK Cells Enhances TACE-Mediated TNF-α Release.
Journal of immunology (Baltimore, Md. : 1950)
Sharma N,Trinidad CV,Trembath AP,Markiewicz MA
Sun Oct 15 00:00:00 EDT 2017
Micromolar affinity CAR T cells to ICAM-1 achieves rapid tumor elimination while avoiding systemic toxicity.
Scientific reports
Park S,Shevlin E,Vedvyas Y,Zaman M,Park S,Hsu YS,Min IM,Jin MM
Mon Oct 30 00:00:00 EDT 2017
Ex Vivo Expanded Human NK Cells Survive and Proliferate in Humanized Mice with Autologous Human Immune Cells.
Scientific reports
Vahedi F,Nham T,Poznanski SM,Chew MV,Shenouda MM,Lee D,Ashkar AA
Thu Sep 21 00:00:00 EDT 2017
Structural Mechanism Underpinning Cross-reactivity of a CD8+ T-cell Clone That Recognizes a Peptide Derived from Human Telomerase Reverse Transcriptase.
The Journal of biological chemistry
Cole DK,van den Berg HA,Lloyd A,Crowther MD,Beck K,Ekeruche-Makinde J,Miles JJ,Bulek AM,Dolton G,Schauenburg AJ,Wall A,Fuller A,Clement M,Laugel B,Rizkallah PJ,Wooldridge L,Sewell AK
Fri Jan 20 00:00:00 EST 2017
Generation of "Off-the-Shelf" Natural Killer Cells from Peripheral Blood Cell-Derived Induced Pluripotent Stem Cells.
Stem cell reports
Zeng J,Tang SY,Toh LL,Wang S
Tue Dec 12 00:00:00 EST 2017
Loss of IFN-γ Pathway Genes in Tumor Cells as a Mechanism of Resistance to Anti-CTLA-4 Therapy.
Cell
Gao J,Shi LZ,Zhao H,Chen J,Xiong L,He Q,Chen T,Roszik J,Bernatchez C,Woodman SE,Chen PL,Hwu P,Allison JP,Futreal A,Wargo JA,Sharma P
Thu Oct 06 00:00:00 EDT 2016
Inheritable Silencing of Endogenous Genes by Hit-and-Run Targeted Epigenetic Editing.
Cell
Amabile A,Migliara A,Capasso P,Biffi M,Cittaro D,Naldini L,Lombardo A
Thu Sep 22 00:00:00 EDT 2016
The Helix-Loop-Helix Protein ID2 Governs NK Cell Fate by Tuning Their Sensitivity to Interleukin-15.
Immunity
Delconte RB,Shi W,Sathe P,Ushiki T,Seillet C,Minnich M,Kolesnik TB,Rankin LC,Mielke LA,Zhang JG,Busslinger M,Smyth MJ,Hutchinson DS,Nutt SL,Nicholson SE,Alexander WS,Corcoran LM,Vivier E,Belz GT,Carotta S,Huntington ND
Tue Jan 19 00:00:00 EST 2016
UV-inactivated HSV-1 potently activates NK cell killing of leukemic cells.
Blood
Samudio I,Rezvani K,Shaim H,Hofs E,Ngom M,Bu L,Liu G,Lee JT,Imren S,Lam V,Poon GF,Ghaedi M,Takei F,Humphries K,Jia W,Krystal G
Thu May 26 00:00:00 EDT 2016
BET bromodomain inhibition enhances T cell persistence and function in adoptive immunotherapy models.
The Journal of clinical investigation
Kagoya Y,Nakatsugawa M,Yamashita Y,Ochi T,Guo T,Anczurowski M,Saso K,Butler MO,Arrowsmith CH,Hirano N
Thu Sep 01 00:00:00 EDT 2016
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
The Journal of clinical investigation
Cole DK,Bulek AM,Dolton G,Schauenberg AJ,Szomolay B,Rittase W,Trimby A,Jothikumar P,Fuller A,Skowera A,Rossjohn J,Zhu C,Miles JJ,Peakman M,Wooldridge L,Rizkallah PJ,Sewell AK
Wed Jun 01 00:00:00 EDT 2016
Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.
The Journal of experimental medicine
Quek L,Otto GW,Garnett C,Lhermitte L,Karamitros D,Stoilova B,Lau IJ,Doondeea J,Usukhbayar B,Kennedy A,Metzner M,Goardon N,Ivey A,Allen C,Gale R,Davies B,Sternberg A,Killick S,Hunter H,Cahalin P,Price A,Carr A,Griffiths M,Virgo P,Mackinnon S,Grimwade D,Freeman S,Russell N,Craddock C,Mead A,Peniket A,Porcher C,Vyas P
Mon Jul 25 00:00:00 EDT 2016
A Traceless Selection: Counter-selection System That Allows Efficient Generation of Transposon and CRISPR-modified T-cell Products.
Molecular therapy. Nucleic acids
Mezzadra R,Hollenstein A,Gomez-Eerland R,Schumacher TN
Tue Mar 22 00:00:00 EDT 2016
Efficient Modification of the CCR5 Locus in Primary Human T Cells With megaTAL Nuclease Establishes HIV-1 Resistance.
Molecular therapy. Nucleic acids
Romano Ibarra GS,Paul B,Sather BD,Younan PM,Sommer K,Kowalski JP,Hale M,Stoddard B,Jarjour J,Astrakhan A,Kiem HP,Rawlings DJ
Tue Aug 23 00:00:00 EDT 2016
LLT1 and CD161 Expression in Human Germinal Centers Promotes B Cell Activation and CXCR4 Downregulation.
Journal of immunology (Baltimore, Md. : 1950)
Llibre A,López-Macías C,Marafioti T,Mehta H,Partridge A,Kanzig C,Rivellese F,Galson JD,Walker LJ,Milne P,Phillips RE,Kelly DF,Freeman GJ,El Shikh ME,Klenerman P,Willberg CB
Tue Mar 01 00:00:00 EST 2016
Eomeshi NK Cells in Human Liver Are Long-Lived and Do Not Recirculate but Can Be Replenished from the Circulation.
Journal of immunology (Baltimore, Md. : 1950)
Cuff AO,Robertson FP,Stegmann KA,Pallett LJ,Maini MK,Davidson BR,Male V
Thu Dec 01 00:00:00 EST 2016
Effector γδ T Cell Differentiation Relies on Master but Not Auxiliary Th Cell Transcription Factors.
Journal of immunology (Baltimore, Md. : 1950)
Barros-Martins J,Schmolka N,Fontinha D,Pires de Miranda M,Simas JP,Brok I,Ferreira C,Veldhoen M,Silva-Santos B,Serre K
Sun May 01 00:00:00 EDT 2016
Influenza Vaccination Generates Cytokine-Induced Memory-like NK Cells: Impact of Human Cytomegalovirus Infection.
Journal of immunology (Baltimore, Md. : 1950)
Goodier MR,Rodriguez-Galan A,Lusa C,Nielsen CM,Darboe A,Moldoveanu AL,White MJ,Behrens R,Riley EM
Fri Jul 01 00:00:00 EDT 2016
Engineering of Isogenic Cells Deficient for MR1 with a CRISPR/Cas9 Lentiviral System: Tools To Study Microbial Antigen Processing and Presentation to Human MR1-Restricted T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Laugel B,Lloyd A,Meermeier EW,Crowther MD,Connor TR,Dolton G,Miles JJ,Burrows SR,Gold MC,Lewinsohn DM,Sewell AK
Mon Aug 01 00:00:00 EDT 2016
Expression and Functional Role of α7 Nicotinic Receptor in Human Cytokine-stimulated Natural Killer (NK) Cells.
The Journal of biological chemistry
Zanetti SR,Ziblat A,Torres NI,Zwirner NW,Bouzat C
Fri Aug 05 00:00:00 EDT 2016
Targeted suppression of autoreactive CD8+ T-cell activation using blocking anti-CD8 antibodies.
Scientific reports
Clement M,Pearson JA,Gras S,van den Berg HA,Lissina A,Llewellyn-Lacey S,Willis MD,Dockree T,McLaren JE,Ekeruche-Makinde J,Gostick E,Robertson NP,Rossjohn J,Burrows SR,Price DA,Wong FS,Peakman M,Skowera A,Wooldridge L
Mon Oct 17 00:00:00 EDT 2016
Type 1 diabetes vaccine candidates promote human Foxp3(+)Treg induction in humanized mice.
Nature communications
Serr I,Fürst RW,Achenbach P,Scherm MG,Gökmen F,Haupt F,Sedlmeier EM,Knopff A,Shultz L,Willis RA,Ziegler AG,Daniel C
Tue Mar 15 00:00:00 EDT 2016
CD4(+) and CD8(+) TCRβ repertoires possess different potentials to generate extraordinarily high-avidity T cells.
Scientific reports
Nakatsugawa M,Rahman MA,Yamashita Y,Ochi T,Wnuk P,Tanaka S,Chamoto K,Kagoya Y,Saso K,Guo T,Anczurowski M,Butler MO,Hirano N
Thu Mar 31 00:00:00 EDT 2016
Soluble γc cytokine receptor suppresses IL-15 signaling and impairs iNKT cell development in the thymus.
Scientific reports
Park JY,Jo Y,Ko E,Luckey MA,Park YK,Park SH,Park JH,Hong C
Fri Nov 11 00:00:00 EST 2016
Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry.
Nature communications
Bassani-Sternberg M,Bräunlein E,Klar R,Engleitner T,Sinitcyn P,Audehm S,Straub M,Weber J,Slotta-Huspenina J,Specht K,Martignoni ME,Werner A,Hein R,H Busch D,Peschel C,Rad R,Cox J,Mann M,Krackhardt AM
Mon Nov 21 00:00:00 EST 2016
Short Term Hypoxia Synergizes with Interleukin 15 Priming in Driving Glycolytic Gene Transcription and Supports Human Natural Killer Cell Activities.
The Journal of biological chemistry
Velásquez SY,Killian D,Schulte J,Sticht C,Thiel M,Lindner HA
Fri Jun 17 00:00:00 EDT 2016
The MicroRNA miR-191 Supports T Cell Survival Following Common γ Chain Signaling.
The Journal of biological chemistry
Lykken EA,Li QJ
Fri Nov 04 00:00:00 EDT 2016
High-density preculture of PBMCs restores defective sensitivity of circulating CD8 T cells to virus- and tumor-derived antigens.
Blood
Wegner J,Hackenberg S,Scholz CJ,Chuvpilo S,Tyrsin D,Matskevich AA,Grigoleit GU,Stevanović S,Hünig T
Thu Jul 09 00:00:00 EDT 2015
Role of naive-derived T memory stem cells in T-cell reconstitution following allogeneic transplantation.
Blood
Roberto A,Castagna L,Zanon V,Bramanti S,Crocchiolo R,McLaren JE,Gandolfi S,Tentorio P,Sarina B,Timofeeva I,Santoro A,Carlo-Stella C,Bruno B,Carniti C,Corradini P,Gostick E,Ladell K,Price DA,Roederer M,Mavilio D,Lugli E
Thu Apr 30 00:00:00 EDT 2015
Inflammatory IL-15 is required for optimal memory T cell responses.
The Journal of clinical investigation
Richer MJ,Pewe LL,Hancox LS,Hartwig SM,Varga SM,Harty JT
Tue Sep 01 00:00:00 EDT 2015
Survivin-specific T cell receptor targets tumor but not T cells.
The Journal of clinical investigation
Arber C,Feng X,Abhyankar H,Romero E,Wu MF,Heslop HE,Barth P,Dotti G,Savoldo B
Thu Jan 01 00:00:00 EST 2015
Human HLA-G+ extravillous trophoblasts: Immune-activating cells that interact with decidual leukocytes.
Proceedings of the National Academy of Sciences of the United States of America
Tilburgs T,Crespo ÂC,van der Zwan A,Rybalov B,Raj T,Stranger B,Gardner L,Moffett A,Strominger JL
Tue Jun 09 00:00:00 EDT 2015
The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Tilburgs T,Evans JH,Crespo ÂC,Strominger JL
Tue Oct 27 00:00:00 EDT 2015
Ezh2 regulates differentiation and function of natural killer cells through histone methyltransferase activity.
Proceedings of the National Academy of Sciences of the United States of America
Yin J,Leavenworth JW,Li Y,Luo Q,Xie H,Liu X,Huang S,Yan H,Fu Z,Zhang LY,Zhang L,Hao J,Wu X,Deng X,Roberts CW,Orkin SH,Cantor H,Wang X
Tue Dec 29 00:00:00 EST 2015
Low-affinity TCR engagement drives IL-2-dependent post-thymic maintenance of naive CD4+ T cells in aged humans.
Aging cell
van der Geest KS,Abdulahad WH,Teteloshvili N,Tete SM,Peters JH,Horst G,Lorencetti PG,Bos NA,Lambeck A,Roozendaal C,Kroesen BJ,Koenen HJ,Joosten I,Brouwer E,Boots AM
Thu Oct 01 00:00:00 EDT 2015
T cell receptor binding affinity governs the functional profile of cancer-specific CD8+ T cells.
Clinical and experimental immunology
Tan MP,Gerry AB,Brewer JE,Melchiori L,Bridgeman JS,Bennett AD,Pumphrey NJ,Jakobsen BK,Price DA,Ladell K,Sewell AK
Fri May 01 00:00:00 EDT 2015
Synovial Regulatory T Cells Occupy a Discrete TCR Niche in Human Arthritis and Require Local Signals To Stabilize FOXP3 Protein Expression.
Journal of immunology (Baltimore, Md. : 1950)
Bending D,Giannakopoulou E,Lom H,Wedderburn LR
Tue Dec 15 00:00:00 EST 2015
CD58/CD2 Is the Primary Costimulatory Pathway in Human CD28-CD8+ T Cells.
Journal of immunology (Baltimore, Md. : 1950)
Leitner J,Herndler-Brandstetter D,Zlabinger GJ,Grubeck-Loebenstein B,Steinberger P
Wed Jul 15 00:00:00 EDT 2015
Tissue-Specific Education of Decidual NK Cells.
Journal of immunology (Baltimore, Md. : 1950)
Sharkey AM,Xiong S,Kennedy PR,Gardner L,Farrell LE,Chazara O,Ivarsson MA,Hiby SE,Colucci F,Moffett A
Thu Oct 01 00:00:00 EDT 2015
Priming of Human Resting NK Cells by Autologous M1 Macrophages via the Engagement of IL-1β, IFN-β, and IL-15 Pathways.
Journal of immunology (Baltimore, Md. : 1950)
Mattiola I,Pesant M,Tentorio PF,Molgora M,Marcenaro E,Lugli E,Locati M,Mavilio D
Tue Sep 15 00:00:00 EDT 2015
Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors.
Journal of immunology (Baltimore, Md. : 1950)
Spallanzani RG,Torres NI,Avila DE,Ziblat A,Iraolagoitia XL,Rossi LE,Domaica CI,Fuertes MB,Rabinovich GA,Zwirner NW
Tue Sep 01 00:00:00 EDT 2015
Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Marquardt N,Béziat V,Nyström S,Hengst J,Ivarsson MA,Kekäläinen E,Johansson H,Mjösberg J,Westgren M,Lankisch TO,Wedemeyer H,Ellis EC,Ljunggren HG,Michaëlsson J,Björkström NK
Sun Mar 15 00:00:00 EDT 2015
Antibody stabilization of peptide-MHC multimers reveals functional T cells bearing extremely low-affinity TCRs.
Journal of immunology (Baltimore, Md. : 1950)
Tungatt K,Bianchi V,Crowther MD,Powell WE,Schauenburg AJ,Trimby A,Donia M,Miles JJ,Holland CJ,Cole DK,Godkin AJ,Peakman M,Straten PT,Svane IM,Sewell AK,Dolton G
Thu Jan 01 00:00:00 EST 2015
Specific roles of each TCR hemichain in generating functional chain-centric TCR.
Journal of immunology (Baltimore, Md. : 1950)
Nakatsugawa M,Yamashita Y,Ochi T,Tanaka S,Chamoto K,Guo T,Butler MO,Hirano N
Wed Apr 01 00:00:00 EDT 2015
Knowledge, Behavioral, and Sociocultural Factors Related to Human Papillomavirus Infection and Cervical Cancer Screening Among Inner-City Women in Panama.
Journal of community health
Vamos CA,Calvo AE,Daley EM,Giuliano AR,López Castillo H
Tue Dec 01 00:00:00 EST 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
Delineation of Natural Killer Cell Differentiation from Myeloid Progenitors in Human.
Scientific reports
Chen Q,Ye W,Jian Tan W,Mei Yong KS,Liu M,Qi Tan S,Loh E,Te Chang K,Chye Tan T,Preiser PR,Chen J
Mon Oct 12 00:00:00 EDT 2015
Targeting the binding interface on a shared receptor subunit of a cytokine family enables the inhibition of multiple member cytokines with selectable target spectrum.
The Journal of biological chemistry
Nata T,Basheer A,Cocchi F,van Besien R,Massoud R,Jacobson S,Azimi N,Tagaya Y
Fri Sep 11 00:00:00 EDT 2015
Tyrosine Kinase 2-mediated Signal Transduction in T Lymphocytes Is Blocked by Pharmacological Stabilization of Its Pseudokinase Domain.
The Journal of biological chemistry
Tokarski JS,Zupa-Fernandez A,Tredup JA,Pike K,Chang C,Xie D,Cheng L,Pedicord D,Muckelbauer J,Johnson SR,Wu S,Edavettal SC,Hong Y,Witmer MR,Elkin LL,Blat Y,Pitts WJ,Weinstein DS,Burke JR
Fri Apr 24 00:00:00 EDT 2015
AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.
Cell death & disease
Six E,Lagresle-Peyrou C,Susini S,De Chappedelaine C,Sigrist N,Sadek H,Chouteau M,Cagnard N,Fontenay M,Hermine O,Chomienne C,Reynier P,Fischer A,André-Schmutz I,Gueguen N,Cavazzana M
Thu Aug 13 00:00:00 EDT 2015
TCR-dependent sensitization of human γδ T cells to non-myeloid IL-18 in cytomegalovirus and tumor stress surveillance.
Oncoimmunology
Guerville F,Daburon S,Marlin R,Lartigue L,Loizon S,Pitard V,Couzi L,Moreau JF,Déchanet-Merville J,Faustin B
200-15 was used in In vitro experiments to investigate the relationship between inflammasome secreted by tumor cells and γδ cell immusurveillance.
Fri May 01 00:00:00 EDT 2015
Targeted genome editing in human repopulating haematopoietic stem cells.
Nature
Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L
Thu Jun 12 00:00:00 EDT 2014
Targeted genome editing in human repopulating haematopoietic stem cells.
Nature
Genovese P,Schiroli G,Escobar G,Tomaso TD,Firrito C,Calabria A,Moi D,Mazzieri R,Bonini C,Holmes MC,Gregory PD,van der Burg M,Gentner B,Montini E,Lombardo A,Naldini L
Thu Jun 12 00:00:00 EDT 2014
Transforming growth factor β-mediated suppression of antitumor T cells requires FoxP1 transcription factor expression.
Immunity
Stephen TL,Rutkowski MR,Allegrezza MJ,Perales-Puchalt A,Tesone AJ,Svoronos N,Nguyen JM,Sarmin F,Borowsky ME,Tchou J,Conejo-Garcia JR
Thu Sep 18 00:00:00 EDT 2014
Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15.
Blood
Xu Y,Zhang M,Ramos CA,Durett A,Liu E,Dakhova O,Liu H,Creighton CJ,Gee AP,Heslop HE,Rooney CM,Savoldo B,Dotti G
Thu Jun 12 00:00:00 EDT 2014
Interleukin-15 enhances cellular proliferation and upregulates CNS homing molecules in pre-B acute lymphoblastic leukemia.
Blood
Williams MT,Yousafzai Y,Cox C,Blair A,Carmody R,Sai S,Chapman KE,McAndrew R,Thomas A,Spence A,Gibson B,Graham GJ,Halsey C
Thu May 15 00:00:00 EDT 2014
Vaccine-induced myeloid cell population dampens protective immunity to SIV.
The Journal of clinical investigation
Sui Y,Hogg A,Wang Y,Frey B,Yu H,Xia Z,Venzon D,McKinnon K,Smedley J,Gathuka M,Klinman D,Keele BF,Langermann S,Liu L,Franchini G,Berzofsky JA
Sun Jun 01 00:00:00 EDT 2014
Interactions between Siglec-7/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance.
The Journal of clinical investigation
Jandus C,Boligan KF,Chijioke O,Liu H,Dahlhaus M,Démoulins T,Schneider C,Wehrli M,Hunger RE,Baerlocher GM,Simon HU,Romero P,Münz C,von Gunten S
Tue Apr 01 00:00:00 EDT 2014
T-cell responses to oncogenic merkel cell polyomavirus proteins distinguish patients with merkel cell carcinoma from healthy donors.
Clinical cancer research : an official journal of the American Association for Cancer Research
Lyngaa R,Pedersen NW,Schrama D,Thrue CA,Ibrani D,Met O,Thor Straten P,Nghiem P,Becker JC,Hadrup SR
200-15 was used in In vitro experiments to investigate the association between Merkel cell carcinoma and the Merkel cell polyomavirus by detecting MCPyV-derived CD8 T-cell epitopes.
Tue Apr 01 00:00:00 EDT 2014
Alloreactive cytotoxic T cells provide means to decipher the immunopeptidome and reveal a plethora of tumor-associated self-epitopes.
Proceedings of the National Academy of Sciences of the United States of America
Kumari S,Wälchli S,Fallang LE,Yang W,Lund-Johansen F,Schumacher TN,Olweus J
Tue Jan 07 00:00:00 EST 2014
Diversity and clonal selection in the human T-cell repertoire.
Proceedings of the National Academy of Sciences of the United States of America
Qi Q,Liu Y,Cheng Y,Glanville J,Zhang D,Lee JY,Olshen RA,Weyand CM,Boyd SD,Goronzy JJ
Tue Sep 09 00:00:00 EDT 2014
IL-15.IL-15Rα complex shedding following trans-presentation is essential for the survival of IL-15 responding NK and T cells.
Proceedings of the National Academy of Sciences of the United States of America
Tamzalit F,Barbieux I,Plet A,Heim J,Nedellec S,Morisseau S,Jacques Y,Mortier E
Tue Jun 10 00:00:00 EDT 2014
5-Azacytidine treatment sensitizes tumor cells to T-cell mediated cytotoxicity and modulates NK cells in patients with myeloid malignancies.
Blood cancer journal
Gang AO,Frøsig TM,Brimnes MK,Lyngaa R,Treppendahl MB,Grønbæk K,Dufva IH,Straten PT,Hadrup SR
Fri Mar 28 00:00:00 EDT 2014
Activin A as a mediator of NK-dendritic cell functional interactions.
Journal of immunology (Baltimore, Md. : 1950)
Seeger P,Bosisio D,Parolini S,Badolato R,Gismondi A,Santoni A,Sozzani S
Sat Feb 01 00:00:00 EST 2014
Tissue-specific microvascular endothelial cells show distinct capacity to activate NK cells: implications for the pathophysiology of granulomatosis with polyangiitis.
Journal of immunology (Baltimore, Md. : 1950)
Tognarelli S,Gayet J,Lambert M,Dupuy S,Karras A,Cohen P,Guillevin L,de Menthon M,Caillat-Zucman S
Tue Apr 01 00:00:00 EDT 2014
Qualitatively different T cell phenotypic responses to IL-2 versus IL-15 are unified by identical dependences on receptor signal strength and duration.
Journal of immunology (Baltimore, Md. : 1950)
Arneja A,Johnson H,Gabrovsek L,Lauffenburger DA,White FM
Wed Jan 01 00:00:00 EST 2014
The NKG2D ligand ULBP2 is specifically regulated through an invariant chain-dependent endosomal pathway.
Journal of immunology (Baltimore, Md. : 1950)
Uhlenbrock F,Hagemann-Jensen M,Kehlet S,Andresen L,Pastorekova S,Skov S
Fri Aug 15 00:00:00 EDT 2014
Pan-Bcl-2 inhibitor, GX15-070 (obatoclax), decreases human T regulatory lymphocytes while preserving effector T lymphocytes: a rationale for its use in combination immunotherapy.
Journal of immunology (Baltimore, Md. : 1950)
Kim PS,Jochems C,Grenga I,Donahue RN,Tsang KY,Gulley JL,Schlom J,Farsaci B
Sat Mar 15 00:00:00 EDT 2014
Induction and activation of human Th17 by targeting antigens to dendritic cells via dectin-1.
Journal of immunology (Baltimore, Md. : 1950)
Duluc D,Joo H,Ni L,Yin W,Upchurch K,Li D,Xue Y,Klucar P,Zurawski S,Zurawski G,Oh S
Sun Jun 15 00:00:00 EDT 2014
Immunotherapy with TCR-redirected T cells: comparison of TCR-transduced and TCR-engineered hematopoietic stem cell-derived T cells.
Journal of immunology (Baltimore, Md. : 1950)
Stärck L,Popp K,Pircher H,Uckert W
Wed Jan 01 00:00:00 EST 2014
TL1A induces TCR independent IL-6 and TNF-α production and growth of PLZF⁺ leukocytes.
PloS one
Reichwald K,Jørgensen TZ,Tougaard P,Skov S
200-15 was used in In vitro experiments to investigate the role of the cytokine TL1A in autoimmune disease, showing that it induces the production of IL-6 and TNF-alpha, suggesting that it could be a possible target for the treatment of autoimmune disease
Mon Sep 08 00:00:00 EDT 2014
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.
Immunity
Fuchs A,Vermi W,Lee JS,Lonardi S,Gilfillan S,Newberry RD,Cella M,Colonna M
Thu Apr 18 00:00:00 EDT 2013
Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells.
Immunity
Fuchs A,Vermi W,Lee JS,Lonardi S,Gilfillan S,Newberry RD,Cella M,Colonna M
Thu Apr 18 00:00:00 EDT 2013
Src-kinase inhibitors sensitize human cells of myeloid origin to Toll-like-receptor-induced interleukin 12 synthesis.
Blood
Wölfl M,Schwinn S,Yoo YE,Reß ML,Braun M,Chopra M,Schreiber SC,Ayala VI,Ohlen C,Eyrich M,Beilhack A,Schlegel PG
Thu Aug 15 00:00:00 EDT 2013
Mutations in GATA2 cause human NK cell deficiency with specific loss of the CD56(bright) subset.
Blood
Mace EM,Hsu AP,Monaco-Shawver L,Makedonas G,Rosen JB,Dropulic L,Cohen JI,Frenkel EP,Bagwell JC,Sullivan JL,Biron CA,Spalding C,Zerbe CS,Uzel G,Holland SM,Orange JS
Thu Apr 04 00:00:00 EDT 2013
The adaptor molecule SAP plays essential roles during invariant NKT cell cytotoxicity and lytic synapse formation.
Blood
Das R,Bassiri H,Guan P,Wiener S,Banerjee PP,Zhong MC,Veillette A,Orange JS,Nichols KE
Thu Apr 25 00:00:00 EDT 2013
Development of a novel redirected T-cell-based adoptive immunotherapy targeting human telomerase reverse transcriptase for adult T-cell leukemia.
Blood
Miyazaki Y,Fujiwara H,Asai H,Ochi F,Ochi T,Azuma T,Ishida T,Okamoto S,Mineno J,Kuzushima K,Shiku H,Yasukawa M
Thu Jun 13 00:00:00 EDT 2013
CD44v6-targeted T cells mediate potent antitumor effects against acute myeloid leukemia and multiple myeloma.
Blood
Casucci M,Nicolis di Robilant B,Falcone L,Camisa B,Norelli M,Genovese P,Gentner B,Gullotta F,Ponzoni M,Bernardi M,Marcatti M,Saudemont A,Bordignon C,Savoldo B,Ciceri F,Naldini L,Dotti G,Bonini C,Bondanza A
Thu Nov 14 00:00:00 EST 2013
Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia.
Blood
Waldmann TA,Conlon KC,Stewart DM,Worthy TA,Janik JE,Fleisher TA,Albert PS,Figg WD,Spencer SD,Raffeld M,Decker JR,Goldman CK,Bryant BR,Petrus MN,Creekmore SP,Morris JC
Thu Jan 17 00:00:00 EST 2013
Phase 1 trial of IL-15 trans presentation blockade using humanized Mikβ1 mAb in patients with T-cell large granular lymphocytic leukemia.
Blood
Waldmann TA,Conlon KC,Stewart DM,Worthy TA,Janik JE,Fleisher TA,Albert PS,Figg WD,Spencer SD,Raffeld M,Decker JR,Goldman CK,Bryant BR,Petrus MN,Creekmore SP,Morris JC
Thu Jan 17 00:00:00 EST 2013
Toward eliminating HLA class I expression to generate universal cells from allogeneic donors.
Blood
Torikai H,Reik A,Soldner F,Warren EH,Yuen C,Zhou Y,Crossland DL,Huls H,Littman N,Zhang Z,Tykodi SS,Kebriaei P,Lee DA,Miller JC,Rebar EJ,Holmes MC,Jaenisch R,Champlin RE,Gregory PD,Cooper LJ
Thu Aug 22 00:00:00 EDT 2013
IL-7 and IL-15 instruct the generation of human memory stem T cells from naive precursors.
Blood
Cieri N,Camisa B,Cocchiarella F,Forcato M,Oliveira G,Provasi E,Bondanza A,Bordignon C,Peccatori J,Ciceri F,Lupo-Stanghellini MT,Mavilio F,Mondino A,Bicciato S,Recchia A,Bonini C
Thu Jan 24 00:00:00 EST 2013
Isocitrate ameliorates anemia by suppressing the erythroid iron restriction response.
The Journal of clinical investigation
Richardson CL,Delehanty LL,Bullock GC,Rival CM,Tung KS,Kimpel DL,Gardenghi S,Rivella S,Goldfarb AN
Thu Aug 01 00:00:00 EDT 2013
Natural killer cells promote immune tolerance by regulating inflammatory TH17 cells at the human maternal-fetal interface.
Proceedings of the National Academy of Sciences of the United States of America
Fu B,Li X,Sun R,Tong X,Ling B,Tian Z,Wei H
Tue Jan 15 00:00:00 EST 2013
MicroRNA-155 tunes both the threshold and extent of NK cell activation via targeting of multiple signaling pathways.
Journal of immunology (Baltimore, Md. : 1950)
Sullivan RP,Fogel LA,Leong JW,Schneider SE,Wong R,Romee R,Thai TH,Sexl V,Matkovich SJ,Dorn GW,French AR,Fehniger TA
Sun Dec 15 00:00:00 EST 2013
CX3CR1 regulates the maintenance of KLRG1+ NK cells into the bone marrow by promoting their entry into circulation.
Journal of immunology (Baltimore, Md. : 1950)
Ponzetta A,Sciumè G,Benigni G,Antonangeli F,Morrone S,Santoni A,Bernardini G
Sun Dec 01 00:00:00 EST 2013
Conversion of peripheral blood NK cells to a decidual NK-like phenotype by a cocktail of defined factors.
Journal of immunology (Baltimore, Md. : 1950)
Cerdeira AS,Rajakumar A,Royle CM,Lo A,Husain Z,Thadhani RI,Sukhatme VP,Karumanchi SA,Kopcow HD
Mon Apr 15 00:00:00 EDT 2013
Uterine NK cells regulate endometrial bleeding in women and are suppressed by the progesterone receptor modulator asoprisnil.
Journal of immunology (Baltimore, Md. : 1950)
Wilkens J,Male V,Ghazal P,Forster T,Gibson DA,Williams AR,Brito-Mutunayagam SL,Craigon M,Lourenco P,Cameron IT,Chwalisz K,Moffett A,Critchley HO
Sun Sep 01 00:00:00 EDT 2013
Age-associated changes in the differentiation potentials of human circulating hematopoietic progenitors to T- or NK-lineage cells.
Journal of immunology (Baltimore, Md. : 1950)
Kyoizumi S,Kubo Y,Kajimura J,Yoshida K,Imai K,Hayashi T,Nakachi K,Young LF,Moore MA,van den Brink MR,Kusunoki Y
Sat Jun 15 00:00:00 EDT 2013
IL-21 enhances phagocytosis in mononuclear phagocyte cells: identification of spleen tyrosine kinase as a novel molecular target of IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Vallières F,Girard D
Fri Mar 15 00:00:00 EDT 2013
Co-introduced functional CCR2 potentiates in vivo anti-lung cancer functionality mediated by T cells double gene-modified to express WT1-specific T-cell receptor.
PloS one
Asai H,Fujiwara H,An J,Ochi T,Miyazaki Y,Nagai K,Okamoto S,Mineno J,Kuzushima K,Shiku H,Inoue H,Yasukawa M
Tue Aug 13 00:00:00 EDT 2013
IGF-1 promotes the development and cytotoxic activity of human NK cells.
Nature communications
Ni F,Sun R,Fu B,Wang F,Guo C,Tian Z,Wei H
Thu Jun 20 00:00:00 EDT 2013
High ERp5/ADAM10 expression in lymph node microenvironment and impaired NKG2D ligands recognition in Hodgkin lymphomas.
Blood
Zocchi MR,Catellani S,Canevali P,Tavella S,Garuti A,Villaggio B,Zunino A,Gobbi M,Fraternali-Orcioni G,Kunkl A,Ravetti JL,Boero S,Musso A,Poggi A
Thu Feb 09 00:00:00 EST 2012
Dasatinib enhances the expansion of CD56+CD3- NK cells from cord blood.
Blood
Tanaka J,Sugita J,Shiratori S,Shigematsu A,Imamura M
Thu Jun 21 00:00:00 EDT 2012
Aurora kinase A-specific T-cell receptor gene transfer redirects T lymphocytes to display effective antileukemia reactivity.
Blood
Nagai K,Ochi T,Fujiwara H,An J,Shirakata T,Mineno J,Kuzushima K,Shiku H,Melenhorst JJ,Gostick E,Price DA,Ishii E,Yasukawa M
Thu Jan 12 00:00:00 EST 2012
Antibody-dependent anti-cytomegalovirus activity of human γδ T cells expressing CD16 (FcγRIIIa).
Blood
Couzi L,Pitard V,Sicard X,Garrigue I,Hawchar O,Merville P,Moreau JF,Déchanet-Merville J
Thu Feb 09 00:00:00 EST 2012
IL-15 protects NKT cells from inhibition by tumor-associated macrophages and enhances antimetastatic activity.
The Journal of clinical investigation
Liu D,Song L,Wei J,Courtney AN,Gao X,Marinova E,Guo L,Heczey A,Asgharzadeh S,Kim E,Dotti G,Metelitsa LS
Fri Jun 01 00:00:00 EDT 2012
K-RAS GTPase- and B-RAF kinase-mediated T-cell tolerance defects in rheumatoid arthritis.
Proceedings of the National Academy of Sciences of the United States of America
Singh K,Deshpande P,Li G,Yu M,Pryshchep S,Cavanagh M,Weyand CM,Goronzy JJ
Tue Jun 19 00:00:00 EDT 2012
TGF-β1 down-regulation of NKG2D/DAP10 and 2B4/SAP expression on human NK cells contributes to HBV persistence.
PLoS pathogens
Sun C,Fu B,Gao Y,Liao X,Sun R,Tian Z,Wei H
Mon Jul 09 00:00:00 EDT 2012
IRX-2, a novel biologic, favors the expansion of T effector over T regulatory cells in a human tumor microenvironment model.
Journal of molecular medicine (Berlin, Germany)
Schilling B,Harasymczuk M,Schuler P,Egan JE,Whiteside TL
Wed Feb 01 00:00:00 EST 2012
Fetal-specific CD8+ cytotoxic T cell responses develop during normal human pregnancy and exhibit broad functional capacity.
Journal of immunology (Baltimore, Md. : 1950)
Lissauer D,Piper K,Goodyear O,Kilby MD,Moss PA
Sun Jul 15 00:00:00 EDT 2012
IL-21 can supplement suboptimal Lck-independent MAPK activation in a STAT-3-dependent manner in human CD8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950)
Imataki O,Ansén S,Tanaka M,Butler MO,Berezovskaya A,Milstein MI,Kuzushima K,Nadler LM,Hirano N
Wed Feb 15 00:00:00 EST 2012
CD8 T cell priming in the presence of IFN-α renders CTLs with improved responsiveness to homeostatic cytokines and recall antigens: important traits for adoptive T cell therapy.
Journal of immunology (Baltimore, Md. : 1950)
Hervas-Stubbs S,Mancheño U,Riezu-Boj JI,Larraga A,Ochoa MC,Alignani D,Alfaro C,Morales-Kastresana A,Gonzalez I,Larrea E,Pircher H,Le Bon A,Lopez-Picazo JM,Martín-Algarra S,Prieto J,Melero I
Mon Oct 01 00:00:00 EDT 2012
Identification of circulating human antigen-reactive CD4+ FOXP3+ natural regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Litjens NH,Boer K,Betjes MG
Wed Feb 01 00:00:00 EST 2012
Antiviral and regulatory T cell immunity in a patient with stromal interaction molecule 1 deficiency.
Journal of immunology (Baltimore, Md. : 1950)
Fuchs S,Rensing-Ehl A,Speckmann C,Bengsch B,Schmitt-Graeff A,Bondzio I,Maul-Pavicic A,Bass T,Vraetz T,Strahm B,Ankermann T,Benson M,Caliebe A,Fölster-Holst R,Kaiser P,Thimme R,Schamel WW,Schwarz K,Feske S,Ehl S
Wed Feb 01 00:00:00 EST 2012
IL-2 upregulates CD86 expression on human CD4(+) and CD8(+) T cells.
Journal of immunology (Baltimore, Md. : 1950)
Paine A,Kirchner H,Immenschuh S,Oelke M,Blasczyk R,Eiz-Vesper B
Wed Feb 15 00:00:00 EST 2012
Regulation and gene expression profiling of NKG2D positive human cytomegalovirus-primed CD4+ T-cells.
PloS one
Jensen H,Folkersen L,Skov S
Tue Feb 19 00:00:00 EST 2013
Generation of allo-restricted peptide-specific T cells using RNA-pulsed dendritic cells: A three phase experimental procedure.
Oncoimmunology
Wilde S,Geiger C,Milosevic S,Mosetter B,Eichenlaub S,Schendel DJ
Thu Mar 01 00:00:00 EST 2012
IL-15 augments TCR-induced CD4+ T cell expansion in vitro by inhibiting the suppressive function of CD25 High CD4+ T cells.
PloS one
Van Belle TL,Dooms H,Boonefaes T,Wei XQ,Leclercq G,Grooten J
Thu Feb 28 00:00:00 EST 2013
Phospho-specific flow cytometry identifies aberrant signaling in indolent B-cell lymphoma.
BMC cancer
Blix ES,Irish JM,Husebekk A,Delabie J,Forfang L,Tierens AM,Myklebust JH,Kolstad A
Tue Oct 16 00:00:00 EDT 2012
MiRNA-mediated control of HLA-G expression and function.
PloS one
Manaster I,Goldman-Wohl D,Greenfield C,Nachmani D,Tsukerman P,Hamani Y,Yagel S,Mandelboim O
Mon Aug 13 00:00:00 EDT 2012
Cytotoxicity of CD56(bright) NK cells towards autologous activated CD4+ T cells is mediated through NKG2D, LFA-1 and TRAIL and dampened via CD94/NKG2A.
PloS one
Nielsen N,Ødum N,Ursø B,Lanier LL,Spee P
Mon Aug 27 00:00:00 EDT 2012
T-cell receptor-optimized peptide skewing of the T-cell repertoire can enhance antigen targeting.
The Journal of biological chemistry
Ekeruche-Makinde J,Clement M,Cole DK,Edwards ES,Ladell K,Miles JJ,Matthews KK,Fuller A,Lloyd KA,Madura F,Dolton GM,Pentier J,Lissina A,Gostick E,Baxter TK,Baker BM,Rizkallah PJ,Price DA,Wooldridge L,Sewell AK
Fri Oct 26 00:00:00 EDT 2012
Autophagy creates a CTL epitope that mimics tumor-associated antigens.
PloS one
Demachi-Okamura A,Torikai H,Akatsuka Y,Miyoshi H,Yoshimori T,Kuzushima K
Wed May 01 00:00:00 EDT 2013
MHC class I-presented T cell epitopes identified by immunoproteomics analysis are targets for a cross reactive influenza-specific T cell response.
PloS one
Testa JS,Shetty V,Hafner J,Nickens Z,Kamal S,Sinnathamby G,Philip R
Wed Apr 24 00:00:00 EDT 2013
Human natural killer cell maturation defect supports in vivo CD56(bright) to CD56(dim) lineage development.
PloS one
Domaica CI,Fuertes MB,Uriarte I,Girart MV,Sardañons J,Comas DI,Di Giovanni D,Gaillard MI,Bezrodnik L,Zwirner NW
Thu May 30 00:00:00 EDT 2013
Signal transducer and activator of transcription 5b (Stat5b) serine 193 is a novel cytokine-induced phospho-regulatory site that is constitutively activated in primary hematopoietic malignancies.
The Journal of biological chemistry
Mitra A,Ross JA,Rodriguez G,Nagy ZS,Wilson HL,Kirken RA
Fri May 11 00:00:00 EDT 2012
Activation of STAT6 by STING is critical for antiviral innate immunity.
Cell
Chen H,Sun H,You F,Sun W,Zhou X,Chen L,Yang J,Wang Y,Tang H,Guan Y,Xia W,Gu J,Ishikawa H,Gutman D,Barber G,Qin Z,Jiang Z
Fri Oct 14 00:00:00 EDT 2011
A critical role for STAT3 transcription factor signaling in the development and maintenance of human T cell memory.
Immunity
Siegel AM,Heimall J,Freeman AF,Hsu AP,Brittain E,Brenchley JM,Douek DC,Fahle GH,Cohen JI,Holland SM,Milner JD
Wed Nov 23 00:00:00 EST 2011
Down-regulation of the RUNX1-target gene NR4A3 contributes to hematopoiesis deregulation in familial platelet disorder/acute myelogenous leukemia.
Blood
Bluteau D,Gilles L,Hilpert M,Antony-Debré I,James C,Debili N,Camara-Clayette V,Wagner-Ballon O,Cordette-Lagarde V,Robert T,Ripoche H,Gonin P,Swierczek S,Prchal J,Vainchenker W,Favier R,Raslova H
Thu Dec 08 00:00:00 EST 2011
IL-7 receptor expression identifies suicide gene-modified allospecific CD8+ T cells capable of self-renewal and differentiation into antileukemia effectors.
Blood
Bondanza A,Hambach L,Aghai Z,Nijmeijer B,Kaneko S,Mastaglio S,Radrizzani M,Fleischhauer K,Ciceri F,Bordignon C,Bonini C,Goulmy E
Thu Jun 16 00:00:00 EDT 2011
Novel adoptive T-cell immunotherapy using a WT1-specific TCR vector encoding silencers for endogenous TCRs shows marked antileukemia reactivity and safety.
Blood
Ochi T,Fujiwara H,Okamoto S,An J,Nagai K,Shirakata T,Mineno J,Kuzushima K,Shiku H,Yasukawa M
Thu Aug 11 00:00:00 EDT 2011
STAT6 signaling pathway activated by the cytokines IL-4 and IL-13 induces expression of the Epstein-Barr virus-encoded protein LMP-1 in absence of EBNA-2: implications for the type II EBV latent gene expression in Hodgkin lymphoma.
Blood
Kis LL,Gerasimcik N,Salamon D,Persson EK,Nagy N,Klein G,Severinson E,Klein E
Thu Jan 06 00:00:00 EST 2011
Severe impairment of IFN-γ and IFN-α responses in cells of a patient with a novel STAT1 splicing mutation.
Blood
Vairo D,Tassone L,Tabellini G,Tamassia N,Gasperini S,Bazzoni F,Plebani A,Porta F,Notarangelo LD,Parolini S,Giliani S,Badolato R
Thu Aug 18 00:00:00 EDT 2011
Complex regulation of human NKG2D-DAP10 cell surface expression: opposing roles of the γc cytokines and TGF-β1.
Blood
Park YP,Choi SC,Kiesler P,Gil-Krzewska A,Borrego F,Weck J,Krzewski K,Coligan JE
Thu Sep 15 00:00:00 EDT 2011
Development of an IL-15-autocrine CD8 T-cell leukemia in IL-15-transgenic mice requires the cis expression of IL-15Rα.
Blood
Sato N,Sabzevari H,Fu S,Ju W,Petrus MN,Bamford RN,Waldmann TA,Tagaya Y
Thu Apr 14 00:00:00 EDT 2011
CX3CR1 expression defines 2 KLRG1+ mouse NK-cell subsets with distinct functional properties and positioning in the bone marrow.
Blood
Sciumè G,De Angelis G,Benigni G,Ponzetta A,Morrone S,Santoni A,Bernardini G
Thu Apr 28 00:00:00 EDT 2011
Control of Plasmodium falciparum erythrocytic cycle: γδ T cells target the red blood cell-invasive merozoites.
Blood
Costa G,Loizon S,Guenot M,Mocan I,Halary F,de Saint-Basile G,Pitard V,Déchanet-Merville J,Moreau JF,Troye-Blomberg M,Mercereau-Puijalon O,Behr C
Thu Dec 22 00:00:00 EST 2011
A polymorphism in TIM1 is associated with susceptibility to severe hepatitis A virus infection in humans.
The Journal of clinical investigation
Kim HY,Eyheramonho MB,Pichavant M,Gonzalez Cambaceres C,Matangkasombut P,Cervio G,Kuperman S,Moreiro R,Konduru K,Manangeeswaran M,Freeman GJ,Kaplan GG,DeKruyff RH,Umetsu DT,Rosenzweig SD
Tue Mar 01 00:00:00 EST 2011
Revisiting human natural killer cell subset function revealed cytolytic CD56(dim)CD16+ NK cells as rapid producers of abundant IFN-gamma on activation.
Proceedings of the National Academy of Sciences of the United States of America
De Maria A,Bozzano F,Cantoni C,Moretta L
Tue Jan 11 00:00:00 EST 2011
ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis.
Proceedings of the National Academy of Sciences of the United States of America
Maul-Pavicic A,Chiang SC,Rensing-Ehl A,Jessen B,Fauriat C,Wood SM,Sjöqvist S,Hufnagel M,Schulze I,Bass T,Schamel WW,Fuchs S,Pircher H,McCarl CA,Mikoshiba K,Schwarz K,Feske S,Bryceson YT,Ehl S
Tue Feb 22 00:00:00 EST 2011
Chemotherapy-resistant osteosarcoma is highly susceptible to IL-15-activated allogeneic and autologous NK cells.
Cancer immunology, immunotherapy : CII
Buddingh EP,Schilham MW,Ruslan SE,Berghuis D,Szuhai K,Suurmond J,Taminiau AH,Gelderblom H,Egeler RM,Serra M,Hogendoorn PC,Lankester AC
Fri Apr 01 00:00:00 EDT 2011
Two modes of lytic granule fusion during degranulation by natural killer cells.
Immunology and cell biology
Liu D,Martina JA,Wu XS,Hammer JA,Long EO
Mon Aug 01 00:00:00 EDT 2011
Phagocytosis, a potential mechanism for myeloid-derived suppressor cell regulation of CD8+ T cell function mediated through programmed cell death-1 and programmed cell death-1 ligand interaction.
Journal of immunology (Baltimore, Md. : 1950)
Kim YJ,Park SJ,Broxmeyer HE
Thu Sep 01 00:00:00 EDT 2011
Transfer of regulatory properties from tolerogenic to proinflammatory dendritic cells via induced autoreactive regulatory T cells.
Journal of immunology (Baltimore, Md. : 1950)
Kleijwegt FS,Laban S,Duinkerken G,Joosten AM,Koeleman BP,Nikolic T,Roep BO
Thu Dec 15 00:00:00 EST 2011
Tumor cell programmed death ligand 1-mediated T cell suppression is overcome by coexpression of CD80.
Journal of immunology (Baltimore, Md. : 1950)
Haile ST,Bosch JJ,Agu NI,Zeender AM,Somasundaram P,Srivastava MK,Britting S,Wolf JB,Ksander BR,Ostrand-Rosenberg S
Wed Jun 15 00:00:00 EDT 2011
Activation of Wnt signaling arrests effector differentiation in human peripheral and cord blood-derived T lymphocytes.
Journal of immunology (Baltimore, Md. : 1950)
Muralidharan S,Hanley PJ,Liu E,Chakraborty R,Bollard C,Shpall E,Rooney C,Savoldo B,Rodgers J,Dotti G
Tue Nov 15 00:00:00 EST 2011
High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations.
PloS one
Hombrink P,Hadrup SR,Bakker A,Kester MG,Falkenburg JH,von dem Borne PA,Schumacher TN,Heemskerk MH
Thu Feb 02 00:00:00 EST 2012
Differentiation of chronic lymphocytic leukemia B cells into immunoglobulin secreting cells decreases LEF-1 expression.
PloS one
Gutierrez A,Arendt BK,Tschumper RC,Kay NE,Zent CS,Jelinek DF
Mon Feb 13 00:00:00 EST 2012
KIR and HLA-C interactions promote differential dendritic cell maturation and is a major determinant of graft failure following kidney transplantation.
PloS one
Hanvesakul R,Kubal C,Moore J,Neil D,Cook M,Ball S,Briggs D,Moss P,Cockwell P
Fri Dec 23 00:00:00 EST 2011
IL-7 promotes CD95-induced apoptosis in B cells via the IFN-γ/STAT1 pathway.
PloS one
Sammicheli S,Dang VP,Ruffin N,Pham HT,Lantto R,Vivar N,Chiodi F,Rethi B
Mon Aug 27 00:00:00 EDT 2012
Common gamma chain cytokines promote rapid in vitro expansion of allo-specific human CD8+ suppressor T cells.
PloS one
Yu Y,Zitzner JR,Houlihan J,Herrera N,Xu L,Miller J,Mathew JM,Tambur AR,Luo X
Mon Aug 27 00:00:00 EDT 2012
Identification of constitutively active interleukin 33 (IL-33) splice variant.
The Journal of biological chemistry
Hong J,Bae S,Jhun H,Lee S,Choi J,Kang T,Kwak A,Hong K,Kim E,Jo S,Kim S
Fri Jun 03 00:00:00 EDT 2011
Transient and persistent effects of IL-15 on lymphocyte homeostasis in nonhuman primates.
Blood
Lugli E,Goldman CK,Perera LP,Smedley J,Pung R,Yovandich JL,Creekmore SP,Waldmann TA,Roederer M
Thu Oct 28 00:00:00 EDT 2010
LEF-1 is a prosurvival factor in chronic lymphocytic leukemia and is expressed in the preleukemic state of monoclonal B-cell lymphocytosis.
Blood
Gutierrez A,Tschumper RC,Wu X,Shanafelt TD,Eckel-Passow J,Huddleston PM,Slager SL,Kay NE,Jelinek DF
Thu Oct 21 00:00:00 EDT 2010
Regulation of human NK-cell cytokine and chemokine production by target cell recognition.
Blood
Fauriat C,Long EO,Ljunggren HG,Bryceson YT
Thu Mar 18 00:00:00 EDT 2010
IL-21 imposes a type II EBV gene expression on type III and type I B cells by the repression of C- and activation of LMP-1-promoter.
Proceedings of the National Academy of Sciences of the United States of America
Kis LL,Salamon D,Persson EK,Nagy N,Scheeren FA,Spits H,Klein G,Klein E
Tue Jan 12 00:00:00 EST 2010
Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques.
Proceedings of the National Academy of Sciences of the United States of America
Sui Y,Zhu Q,Gagnon S,Dzutsev A,Terabe M,Vaccari M,Venzon D,Klinman D,Strober W,Kelsall B,Franchini G,Belyakov IM,Berzofsky JA
Tue May 25 00:00:00 EDT 2010
Contribution of astrocyte-derived IL-15 to CD8 T cell effector functions in multiple sclerosis.
Journal of immunology (Baltimore, Md. : 1950)
Saikali P,Antel JP,Pittet CL,Newcombe J,Arbour N
Mon Nov 15 00:00:00 EST 2010
MHC class I molecules with Superenhanced CD8 binding properties bypass the requirement for cognate TCR recognition and nonspecifically activate CTLs.
Journal of immunology (Baltimore, Md. : 1950)
Wooldridge L,Clement M,Lissina A,Edwards ES,Ladell K,Ekeruche J,Hewitt RE,Laugel B,Gostick E,Cole DK,Debets R,Berrevoets C,Miles JJ,Burrows SR,Price DA,Sewell AK
Thu Apr 01 00:00:00 EDT 2010
A single TCR alpha-chain with dominant peptide recognition in the allorestricted HER2/neu-specific T cell repertoire.
Journal of immunology (Baltimore, Md. : 1950)
Liang X,Weigand LU,Schuster IG,Eppinger E,van der Griendt JC,Schub A,Leisegang M,Sommermeyer D,Anderl F,Han Y,Ellwart J,Moosmann A,Busch DH,Uckert W,Peschel C,Krackhardt AM
Mon Feb 01 00:00:00 EST 2010
Suppressor of cytokine signaling 2 regulates IL-15-primed human NK cell function via control of phosphorylated Pyk2.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Piao ZH,Jeong M,Kim DO,Jung H,Lee J,Kim MJ,Kim MS,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Thu Jul 15 00:00:00 EDT 2010
An IL-2 paradox: blocking CD25 on T cells induces IL-2-driven activation of CD56(bright) NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Martin JF,Perry JS,Jakhete NR,Wang X,Bielekova B
Thu Jul 15 00:00:00 EDT 2010
Resistance of CD45RA- T cells to apoptosis and functional impairment, and activation of tumor-antigen specific T cells during radiation therapy of prostate cancer.
Journal of immunology (Baltimore, Md. : 1950)
Tabi Z,Spary LK,Coleman S,Clayton A,Mason MD,Staffurth J
Thu Jul 15 00:00:00 EDT 2010
The rapid induction of HLA-E is essential for the survival of antigen-activated naive CD4 T cells from attack by NK cells.
Journal of immunology (Baltimore, Md. : 1950)
Takao S,Ishikawa T,Yamashita K,Uchiyama T
Mon Nov 15 00:00:00 EST 2010
CD8 controls T cell cross-reactivity.
Journal of immunology (Baltimore, Md. : 1950)
Wooldridge L,Laugel B,Ekeruche J,Clement M,van den Berg HA,Price DA,Sewell AK
Fri Oct 15 00:00:00 EDT 2010
Immature NK cells, capable of producing IL-22, are present in human uterine mucosa.
Journal of immunology (Baltimore, Md. : 1950)
Male V,Hughes T,McClory S,Colucci F,Caligiuri MA,Moffett A
Fri Oct 01 00:00:00 EDT 2010
Impact of γ-chain cytokines on EBV-specific T cell cultures.
Journal of translational medicine
Merlo A,Turrini R,Trento C,Zanovello P,Dolcetti R,Rosato A
Mon Nov 22 00:00:00 EST 2010
Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers.
Nature methods
Hadrup SR,Bakker AH,Shu CJ,Andersen RS,van Veluw J,Hombrink P,Castermans E,Thor Straten P,Blank C,Haanen JB,Heemskerk MH,Schumacher TN
Wed Jul 01 00:00:00 EDT 2009
T-cell responses associated with neonatal alloimmune thrombocytopenia: isolation of HPA-1a-specific, HLA-DRB3*0101-restricted CD4+ T cells.
Blood
Ahlen MT,Husebekk A,Killie MK,Skogen B,Stuge TB
Thu Apr 16 00:00:00 EDT 2009
Human embryonic stem cells differentiate into a homogeneous population of natural killer cells with potent in vivo antitumor activity.
Blood
Woll PS,Grzywacz B,Tian X,Marcus RK,Knorr DA,Verneris MR,Kaufman DS
Thu Jun 11 00:00:00 EDT 2009
Heat shock protein 70 (HSP70) induces cytotoxicity of T-helper cells.
Blood
Figueiredo C,Wittmann M,Wang D,Dressel R,Seltsam A,Blasczyk R,Eiz-Vesper B
Thu Mar 26 00:00:00 EDT 2009
Ex vivo characterization of polyclonal memory CD8+ T-cell responses to PRAME-specific peptides in patients with acute lymphoblastic leukemia and acute and chronic myeloid leukemia.
Blood
Rezvani K,Yong AS,Tawab A,Jafarpour B,Eniafe R,Mielke S,Savani BN,Keyvanfar K,Li Y,Kurlander R,Barrett AJ
Thu Mar 05 00:00:00 EST 2009
IL-7 and IL-15 allow the generation of suicide gene-modified alloreactive self-renewing central memory human T lymphocytes.
Blood
Kaneko S,Mastaglio S,Bondanza A,Ponzoni M,Sanvito F,Aldrighetti L,Radrizzani M,La Seta-Catamancio S,Provasi E,Mondino A,Nagasawa T,Fleischhauer K,Russo V,Traversari C,Ciceri F,Bordignon C,Bonini C
Thu Jan 29 00:00:00 EST 2009
Reciprocal role of GATA-1 and vitamin D receptor in human myeloid dendritic cell differentiation.
Blood
Göbel F,Taschner S,Jurkin J,Konradi S,Vaculik C,Richter S,Kneidinger D,Mühlbacher C,Bieglmayer C,Elbe-Bürger A,Strobl H
Thu Oct 29 00:00:00 EDT 2009
Valpha24-invariant NKT cells mediate antitumor activity via killing of tumor-associated macrophages.
The Journal of clinical investigation
Song L,Asgharzadeh S,Salo J,Engell K,Wu HW,Sposto R,Ara T,Silverman AM,DeClerck YA,Seeger RC,Metelitsa LS
Mon Jun 01 00:00:00 EDT 2009
Characterization of the class I-restricted gp100 melanoma peptide-stimulated primary immune response in tumor-free vaccine-draining lymph nodes and peripheral blood.
Clinical cancer research : an official journal of the American Association for Cancer Research
Walker EB,Miller W,Haley D,Floyd K,Curti B,Urba WJ
Wed Apr 01 00:00:00 EDT 2009
Impaired STAT phosphorylation in T cells from melanoma patients in response to IL-2: association with clinical stage.
Clinical cancer research : an official journal of the American Association for Cancer Research
Mortarini R,Vegetti C,Molla A,Arienti F,Ravagnani F,Maurichi A,Patuzzo R,Santinami M,Anichini A
Mon Jun 15 00:00:00 EDT 2009
Antibody-mediated blockade of IL-15 reverses the autoimmune intestinal damage in transgenic mice that overexpress IL-15 in enterocytes.
Proceedings of the National Academy of Sciences of the United States of America
Yokoyama S,Watanabe N,Sato N,Perera PY,Filkoski L,Tanaka T,Miyasaka M,Waldmann TA,Hiroi T,Perera LP
Tue Sep 15 00:00:00 EDT 2009
Successful immunotherapy with IL-2/anti-CD40 induces the chemokine-mediated mitigation of an immunosuppressive tumor microenvironment.
Proceedings of the National Academy of Sciences of the United States of America
Weiss JM,Back TC,Scarzello AJ,Subleski JJ,Hall VL,Stauffer JK,Chen X,Micic D,Alderson K,Murphy WJ,Wiltrout RH
Tue Nov 17 00:00:00 EST 2009
Cross-presenting human gammadelta T cells induce robust CD8+ alphabeta T cell responses.
Proceedings of the National Academy of Sciences of the United States of America
Brandes M,Willimann K,Bioley G,Lévy N,Eberl M,Luo M,Tampé R,Lévy F,Romero P,Moser B
Tue Feb 17 00:00:00 EST 2009
IRX-2, a novel immunotherapeutic, protects human T cells from tumor-induced cell death.
Cell death and differentiation
Czystowska M,Han J,Szczepanski MJ,Szajnik M,Quadrini K,Brandwein H,Hadden JW,Signorelli K,Whiteside TL
Fri May 01 00:00:00 EDT 2009
High expression of CD244 and SAP regulated CD8 T cell responses of patients with HTLV-I associated neurologic disease.
PLoS pathogens
Enose-Akahata Y,Matsuura E,Oh U,Jacobson S
Tue Dec 01 00:00:00 EST 2009
Functionally mature CD4 and CD8 TCRalphabeta cells are generated in OP9-DL1 cultures from human CD34+ hematopoietic cells.
Journal of immunology (Baltimore, Md. : 1950)
Van Coppernolle S,Verstichel G,Timmermans F,Velghe I,Vermijlen D,De Smedt M,Leclercq G,Plum J,Taghon T,Vandekerckhove B,Kerre T
Thu Oct 15 00:00:00 EDT 2009
IL-12-dependent inducible expression of the CD94/NKG2A inhibitory receptor regulates CD94/NKG2C+ NK cell function.
Journal of immunology (Baltimore, Md. : 1950)
Sáez-Borderías A,Romo N,Magri G,Gumá M,Angulo A,López-Botet M
Thu Jan 15 00:00:00 EST 2009
Identification and characterization of a transmembrane isoform of CD160 (CD160-TM), a unique activating receptor selectively expressed upon human NK cell activation.
Journal of immunology (Baltimore, Md. : 1950)
Giustiniani J,Bensussan A,Marie-Cardine A
Thu Jan 01 00:00:00 EST 2009
Expansion of functionally skewed CD56-negative NK cells in chronic hepatitis C virus infection: correlation with outcome of pegylated IFN-alpha and ribavirin treatment.
Journal of immunology (Baltimore, Md. : 1950)
Gonzalez VD,Falconer K,Björkström NK,Blom KG,Weiland O,Ljunggren HG,Alaeus A,Sandberg JK
Sun Nov 15 00:00:00 EST 2009
Induction of alloantigen-specific human T regulatory cells by vasoactive intestinal peptide.
Journal of immunology (Baltimore, Md. : 1950)
Pozo D,Anderson P,Gonzalez-Rey E
Thu Oct 01 00:00:00 EDT 2009
NK cells recognize and kill human glioblastoma cells with stem cell-like properties.
Journal of immunology (Baltimore, Md. : 1950)
Castriconi R,Daga A,Dondero A,Zona G,Poliani PL,Melotti A,Griffero F,Marubbi D,Spaziante R,Bellora F,Moretta L,Moretta A,Corte G,Bottino C
Sun Mar 15 00:00:00 EDT 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 EDT 2009
RasGRP1 is required for human NK cell function.
Journal of immunology (Baltimore, Md. : 1950)
Lee SH,Yun S,Lee J,Kim MJ,Piao ZH,Jeong M,Chung JW,Kim TD,Yoon SR,Greenberg PD,Choi I
Tue Dec 15 00:00:00 EST 2009
Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.
Blood
Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA
Sat Nov 01 00:00:00 EDT 2008
The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentation.
Blood
Wu Z,Xue HH,Bernard J,Zeng R,Issakov D,Bollenbacher-Reilley J,Belyakov IM,Oh S,Berzofsky JA,Leonard WJ
Mon Dec 01 00:00:00 EST 2008
CTLs are targeted to kill beta cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope.
The Journal of clinical investigation
Skowera A,Ellis RJ,Varela-Calviño R,Arif S,Huang GC,Van-Krinks C,Zaremba A,Rackham C,Allen JS,Tree TI,Zhao M,Dayan CM,Sewell AK,Unger WW,Drijfhout JW,Ossendorp F,Roep BO,Peakman M
Wed Oct 01 00:00:00 EDT 2008
Dissociation of its opposing immunologic effects is critical for the optimization of antitumor CD8+ T-cell responses induced by interleukin 21.
Clinical cancer research : an official journal of the American Association for Cancer Research
Ansén S,Butler MO,Berezovskaya A,Murray AP,Stevenson K,Nadler LM,Hirano N
Wed Oct 01 00:00:00 EDT 2008
Surgery followed by persistence of high-grade squamous intraepithelial lesions is associated with the induction of a dysfunctional HPV16-specific T-cell response.
Clinical cancer research : an official journal of the American Association for Cancer Research
de Vos van Steenwijk PJ,Piersma SJ,Welters MJ,van der Hulst JM,Fleuren G,Hellebrekers BW,Kenter GG,van der Burg SH
Sat Nov 15 00:00:00 EST 2008
Endoplasmic reticulum stress regulator XBP-1 contributes to effector CD8+ T cell differentiation during acute infection.
Journal of immunology (Baltimore, Md. : 1950)
Kamimura D,Bevan MJ
Wed Oct 15 00:00:00 EDT 2008
Umbilical cord blood T cells express multiple natural cytotoxicity receptors after IL-15 stimulation, but only NKp30 is functional.
Journal of immunology (Baltimore, Md. : 1950)
Tang Q,Grzywacz B,Wang H,Kataria N,Cao Q,Wagner JE,Blazar BR,Miller JS,Verneris MR
Wed Oct 01 00:00:00 EDT 2008
Differential regulation of the IL-17 receptor by gammac cytokines: inhibitory signaling by the phosphatidylinositol 3-kinase pathway.
The Journal of biological chemistry
Lindemann MJ,Hu Z,Benczik M,Liu KD,Gaffen SL
Fri May 16 00:00:00 EDT 2008
Natural killer cells trigger differentiation of monocytes into dendritic cells.
Blood
Zhang AL,Colmenero P,Purath U,Teixeira de Matos C,Hueber W,Klareskog L,Tarner IH,Engleman EG,Söderström K
Mon Oct 01 00:00:00 EDT 2007
Invariant NKT cells biased for IL-5 production act as crucial regulators of inflammation.
Journal of immunology (Baltimore, Md. : 1950)
Sakuishi K,Oki S,Araki M,Porcelli SA,Miyake S,Yamamura T
Sat Sep 15 00:00:00 EDT 2007
The NF-kappaB regulator Bcl-3 and the BH3-only proteins Bim and Puma control the death of activated T cells.
Proceedings of the National Academy of Sciences of the United States of America
Bauer A,Villunger A,Labi V,Fischer SF,Strasser A,Wagner H,Schmid RM,Häcker G
Tue Jul 18 00:00:00 EDT 2006
Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Chiu WK,Fann M,Weng NP
Fri Dec 01 00:00:00 EST 2006
Generation and growth of CD28nullCD8+ memory T cells mediated by IL-15 and its induced cytokines.
Journal of immunology (Baltimore, Md. : 1950)
Chiu WK,Fann M,Weng NP
Fri Dec 01 00:00:00 EST 2006
Active inhibition of plasma cell development in resting B cells by microphthalmia-associated transcription factor.
The Journal of experimental medicine
Lin L,Gerth AJ,Peng SL
Mon Jul 05 00:00:00 EDT 2004
Modulation of coxsackie-adenovirus receptor expression for increased adenoviral transgene expression.
Cancer research
Hemminki A,Kanerva A,Liu B,Wang M,Alvarez RD,Siegal GP,Curiel DT
Sat Feb 15 00:00:00 EST 2003
Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice.
Blood
Shimoda K,Tsutsui H,Aoki K,Kato K,Matsuda T,Numata A,Takase K,Yamamoto T,Nukina H,Hoshino T,Asano Y,Gondo H,Okamura T,Okamura S,Nakayama K,Nakanishi K,Niho Y,Harada M
Fri Mar 15 00:00:00 EST 2002
Interleukin-15 is an autocrine/paracrine viability factor for cutaneous T-cell lymphoma cells.
Blood
Döbbeling U,Dummer R,Laine E,Potoczna N,Qin JZ,Burg G
Wed Jul 01 00:00:00 EDT 1998
Interleukin-15 is an autocrine/paracrine viability factor for cutaneous T-cell lymphoma cells.
Blood
Döbbeling U,Dummer R,Laine E,Potoczna N,Qin JZ,Burg G
Wed Jul 01 00:00:00 EDT 1998