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          • Proteins & Peptides ›
          • IL-8 Proteins
          The PeproTech website has now moved to Thermofisher.com. All orders for PeproTech products must be placed on thermofisher.com or offline via phone, fax, email, or distributor partner. For any questions, please contact PeproTech.CustomerService@thermofisher.com

          Gibco

          Human IL-8 (CXCL8) (72 aa) Recombinant Protein, PeproTech®

          129 References
          View all (7) IL-8 proteins

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          Cite Human IL-8 (CXCL8) (72 aa) Recombinant Protein, PeproTech®

          • Testing Data (1)
          Human IL-8 (CXCL8) (72 aa) Protein in Functional Assay (Functional)
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          Human IL-8 (CXCL8) (72 aa) Protein in Functional Assay (Functional)
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          FIGURE: 1 / 1

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          Human IL-8 (CXCL8) (72 aa) Protein (200-08M-100UG) in Functional

          Bioassay analysis of Human IL-8 (CXCL8) (72 aa) Recombinant Protein, PeproTech® (Product # 200-08M-1MG). {{ $ctrl.currentElement.advancedVerification.fullName }} validation info. View more
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          Human IL-8 (CXCL8) (72 aa) Protein in Functional Assay (Functional)

          Product Details

          200-08M-100UG

          Applications
          Tested Dilution
          Publications

          Western Blot (WB)

          Assay-dependent
          -

          ELISA (ELISA)

          Assay-dependent
          View 10 publications 10 publications

          Functional Assay (Functional)

          Assay-dependent
          -

          Immunoelectrophoresis (IE)

          -
          View 1 publication 1 publication

          In vitro Assay (IV)

          -
          View 108 publications 108 publications

          Competition Assay (CA)

          -
          View 1 publication 1 publication

          Miscellaneous PubMed (Misc)

          -
          View 9 publications 9 publications
          Product Specifications

          Species

          Human

          Published species

          Bacteria, Dog, Fungi, Human, Mouse, Non-human primate, Rat

          Expression System

          E. coli

          Amino acid sequence

          SAKELRCQCI KTYSKPFHPK FIKELRVIES GPHCANTEII VKLSDGRELC LDPKENWVQR VVEKFLKRAE NS

          Molecular weight

          8.4 kDa

          Class

          Recombinant

          Type

          Protein

          Purity

          ≥ 98% by SDS-PAGE gel and HPLC analyses.

          Endotoxin concentration

          <1 EU/µg

          Activity

          Determined by its ability to chemoattract human peripheral blood neutrophils using a concentration range of 10.0-100.0 ng/ml.

          Conjugate

          Unconjugated Unconjugated Unconjugated

          Form

          Lyophilized

          Purification

          purified

          Contains

          no preservative

          Storage conditions

          -20°C

          Shipping conditions

          Ambient

          Product Specific Information

          Recombinant Human IL-8 (monocyte-derived) is an 8.4 kDa protein containing 72 amino acid residues.

          This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

          Target Information

          Interleukin 8 (IL-8, CXCL8) is a 72 amino acid pro-inflammatory factor which belongs to the CXC subfamily of chemokines, and are bound by the cell surface receptors IL-8RA and IL-8RB. IL-8 functions as a chemoattractant and potent angiogenic factor. The expression and secretion of IL-8 can be induced by diverse inflammatory stimuli in many cells, including macrophages and endothelial cells. In endothelial cells, IL-8 is present in storage vesicles called Weibel-Palade bodies. IL-8, first isolated from osteosarcoma cells, contains the ELR-motif (N-terminal Glu-Leu-Arg amino acid sequence) and signals through the CXCR1 and CXCR2 receptors. Previous nomenclature for IL-8 includes neutrophil activating protein 1 (NAP-1), granulocyte chemotactic protein 1 (GCP-1), monocyte-derived neutrophil-activating peptide (MONAP) and protein 3-10C. IL-8 and ten other members of the CXC chemokine gene family form a chemokine gene cluster in a region mapped to chromosome 4q. Cancer studies have demonstrated a role for IL-8 in the angiogenesis and growth of tumours, and IL-8 is believed to play a role in the pathogenesis of bronchiolitis, a common respiratory tract disease caused by viral infection.

          For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

          Bioinformatics

          Protein Aliases: alveolar macrophage chemotactic factor I; ANX7; beta endothelial cell-derived neutrophil activating peptide; beta-thromboglobulin-like protein; C-X-C motif chemokine 8; Chemokine (C-X-C motif) ligand 8; Emoctakin; GCP-1; Granulocyte chemotactic protein 1; IL-8; ILN; Interleukin; interleukin 8; Interleukin-8; Interleukin8; lung giant cell carcinoma-derived chemotactic protein; lymphocyte derived neutrophil activating peptide; MDNCF; MONAP; Monocyte-derived neutrophil chemotactic factor; Monocyte-derived neutrophil-activating peptide; NAP-1; neutrophil-activating peptide 1; Neutrophil-activating protein 1; Protein 3-10C; RP11-537A6.8; small inducible cytokine subfamily B, member 8; SNX; SYNEXIN; T-cell chemotactic factor; tumor necrosis factor-induced gene 1

          View more View less

          Gene Aliases: CXCL8; GCP-1; GCP1; IL8; LECT; LUCT; LYNAP; MDNCF; MONAP; NAF; NAP-1; NAP1

          View more View less

          UniProt ID: (Human) P10145

          View more View less

          Entrez Gene ID: (Human) 3576

          View more View less

          It has to be done as per old AB suggested Products section.
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