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This peptide corresponds to 15 amino acids near the extracellular domain of human IL-21 Receptor.
PEP-0106 can be used as a blocking peptide with polyclonal antibody PA5-19982.
The protein encoded by this gene is a cytokine receptor for interleukin 21 (IL21). It belongs to the type I cytokine receptors, and has been shown to form a heterodimeric receptor complex with the common gamma-chain, a receptor subunit also shared by the receptors for interleukin 2 (IL2) and interleukin 5 (IL5). This receptor transduces the growth promoting signal of IL21, and is important for the proliferation and differentiation of T cells, B cells, and natural killer (NK) cells. The ligand binding of this receptor leads to the activation of multiple downstream signaling molecules, including JAK1, JAK3, STAT1, and STAT3. Knockout studies of a similar gene in mouse suggest a role for this gene in regulating immunoglobulin production. Three alternatively spliced transcript variants encoding the same protein have been described.
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Protein Aliases: CD360; IL-21 receptor; Interleukin-21 receptor; MGC10967; Novel interleukin receptor
Gene Aliases: CD360; IL21R; NILR; UNQ3121/PRO10273
UniProt ID: (Human) Q9HBE5
Entrez Gene ID: (Human) 50615
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