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Invitrogen
Human JAK2, GST Tag Recombinant Protein
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Product Details
PV4288
Product Specifications
Species
Human
Expression System
Insect cells
Amino acid sequence
809-1153 +9
Tag
GST-tag
Molecular weight
66.6 kDa
Class
Recombinant
Type
Protein
Purity
95% by SDS-PAGE
Conjugate
Form
Liquid
Concentration
See Label
Amount
1 mg
Purification
purified
Storage buffer
50mM tris, pH 7.5, with 2mM DTT, 150mM NaCl, 0.5mM EDTA, 50% glycerol, 0.02% Triton X-100
Contains
no preservative
Storage conditions
-80°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Dry ice
Product Specific Information
For maximum recovery please spin prior to use. Unless noted below, aliquots of the 5 µg, 10 µg and 20 µg sizes of kinase are not recommended as materials can be used in original packaging until exhausted. For larger sizes, the number of freeze/thaws may be reduced by preparing aliquots, aliquots below 20 µL are not recommended. Please never store a kinase diluted. If properly stored at -80C, this product is guaranteed for 6 months from date of purchase.
Protein Form: Recombinant, Catalytic Domain, Cytoplasmic
Target Information
Janus kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways and is mutated in polycythemia vera. This kinase contains the catalytic domain (JH1) of JAK2. The activation of JAKs can lead to the phosphorylation of STAT (signal transducers and activatiors of transcription) proteins, which dimerize and translocate to the nucleus. Once translocated to the nucleus, the STAT proteins can modify transcription of numerous genes, including interferon-stimulated genes. JAK2 is required for the IFN gamma-receptor complex initiation and JAK1 functions as an amplifier. Some studies have suggested that the role of JAK2 might be performed by Tyk2 and JAK3, if they were positioned correctly within the IFN gamma-receptor complex. Mutations affecting JAK2 can cause Budd-Chiari syndrome, Polycythemia vera, Thrombocythemia 3, myelofibrosis, or Acute myelogenous leukemia.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: EC 2.7.10.2; JAK 2; JAK-2; Janus kinase 2; Janus kinase 2 (a protein tyrosine kinase); JTK 10; kinase Jak2; Tyrosine-protein kinase JAK2; unnamed protein product
Gene Aliases: JAK2; JTK10
UniProt ID: (Human) O60674
Entrez Gene ID: (Human) 3717
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