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Invitrogen
Human KPNA2 Synthetic Peptide
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Product Details
PEP-1148
Product Specifications
Species Reactivity
Human
Class
Synthetic
Type
Peptide
Conjugate
Form
Liquid
Concentration
200 µg/mL
Purification
purified
Storage buffer
PBS, pH 7.2, with 0.1% BSA
Contains
0.02% sodium azide
Storage conditions
-20°C
Product Specific Information
This peptide corresponds to 15 amino acids near the amino terminus of human KPNA2.
PEP-1148 can be used as a blocking peptide with polyclonal antibody PA5-21034.
Target Information
The import of proteins into the nucleus is a process that involves at least 2 steps. The first is an energy-independent docking of the protein to the nuclear envelope and the second is an energy-dependent translocation through the nuclear pore complex. Imported proteins require a nuclear localization sequence which generally consists of a short region of basic amino acids or 2 such regions spaced about 10 amino acids apart. Proteins involved in the first step of nuclear import have been identified in different systems. These include the Xenopus protein importin and its yeast homolog, SRP1, which bind to the NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T antigen and may be involved in the nuclear transport of proteins. KPNA2 also may play a role in VJ recombination.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: IMA2; importin alpha 2; Importin subunit alpha-1; importin subunit alpha-2; importin-alpha-P1; IPOA 1; IPOA1 QIP2; Karyopherin A2; karyopherin alpha 2 (RAG cohort 1, importin alpha 1); Karyopherin subunit alpha-2; pendulin; RAG cohort 1; RAG cohort protein 1; RCH 1; SRP 1; SRP1 alpha; SRP1-alpha
Gene Aliases: IPOA1; KPNA2; QIP2; RCH1; SRP1; SRP1-alpha; SRP1alpha
UniProt ID: (Human) P52292
Entrez Gene ID: (Human) 3838
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