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Invitrogen
Human LILRB2 (CD85d, ILT4) Fc Chimera Recombinant Protein
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Product Details
RP-88128
Applications
Tested Dilution
Publications
Product Specifications
Species
Human
Expression System
HEK293 cells
Amino acid sequence
Human LILRB2, amino acids Met1-Val461 (Accession # AAH36827.1) with a C-terminal human IgG1 Fc region
Tag
Fc-tag
Molecular weight
93 kDa
Class
Recombinant
Type
Protein
Purity
≥ 85% as determined by SDS-PAGE. ≥ 90% as determined by SEC-HPLC.
Endotoxin concentration
<1.0 EU/µg
Conjugate
Form
Lyophilized
Concentration
0.25 mg/mL
Amount
1 mg
Purification
purified
Storage buffer
PBS, pH 7.4, with 5% mannitol, 5% trehalose, 0.01% Tween 80
Contains
no preservative
Storage conditions
-20°C, Avoid Freeze/Thaw Cycles
Shipping conditions
Wet ice
Product Specific Information
It is recommended that the protein be aliquoted for optimal storage.
It is recommended that sterile water (1588 µL) be added to the vial to prepare a stock solution of 0.25 mg/mL.
Concentration is measured by UV.
Target Information
CD85d, also known as LILRB2 or ILT4, is a member of the immunoglobulin-like transcript (ILT), leukocyte Ig-like receptor (LIR), and monocyte Ig-like receptor (MIR) family. It is a 110 kDa single transmembrane receptor with three Ig-like domains and a long cytoplasmic domain containing immunoreceptor tyrosine-based inhibitory motifs (ITIMs). CD85d is expressed on monocytes, macrophages, and dendritic cells. The receptor binds to non-classical class I molecules such as HLA-G, -B, and G1. Upon ligand binding, the tyrosine phosphatase SHP-1 interacts with the ITIMs, transducing a negative signal that inhibits immune response stimulation. This interaction is thought to contribute to tolerance during fetal implantation and plays a role in controlling inflammatory responses and cytotoxicity, helping to focus the immune response and limit autoreactivity. CD85d is also involved in organ allograft rejection, with the levels of ILT3 and ILT4 on dendritic cells suggesting its role in this process. The LILRB2 gene, located in a gene cluster at chromosomal region 19q13.4, encodes multiple transcript variants with different isoforms, highlighting its complexity and importance in immune regulation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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Bioinformatics
Protein Aliases: CD85 antigen-like family member D; CD85d; CD85d antigen; Ig-like transcript 4; ILT-4; immunoglobulin superfamily; Immunoglobulin-like transcript 4; leucocyte Ig-like receptor B2; Leukocyte immunoglobulin-like receptor subfamily B member 2; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 2; LIR-2; LIR2CD85D; MIR-10; MIR10LILRA6; monocyte/macrophage Ig-related receptor; Monocyte/macrophage immunoglobulin-like receptor 10; myeloid inhibitory receptor 10; unnamed protein product
Gene Aliases: CD85D; ILT-4; ILT4; LILRB2; LIR-2; LIR2; MIR-10; MIR10
UniProt ID: (Human) Q8N423
Entrez Gene ID: (Human) 10288
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