Product References
Adaptation of Human iPSC-Derived Macrophages Toward an Alveolar Macrophage-Like Phenotype Post-Intra-Pulmonary Transfer into Murine Models.
Methods in molecular biology (Clifton, N.J.)
Hetzel M,Gensch I,Ackermann M,Lachmann N
300-25 was used in In vitro experiments to introduce the use of human-induced pluripotent stem cell (iPSC)-derived primitive macrophages, which can be further matured towards an AM-like phenotype upon intra-pulmonary transfer into mice.
Tue Aug 29 00:00:00 EDT 2023
Germline Neurofibromin 1 mutation enhances the anti-tumour immune response and decreases juvenile myelomonocytic leukaemia tumourigenicity.
British journal of haematology
Wang W,Li X,Qin X,Miao Y,Zhang Y,Li S,Yao R,Yang Y,Yu L,Zhu H,Song L,Mao S,Wang X,Chen J,Feng H,Li Y
300-25 was used in In vitro experiments to demonstrate that germline NF1 mutations alone cannot directly drive JMML development and suggest a potential cell immunotherapy for JMML patients.
Sat Jul 01 00:00:00 EDT 2023
FALCON systematically interrogates free fatty acid biology and identifies a novel mediator of lipotoxicity.
Cell metabolism
Wieder N,Fried JC,Kim C,Sidhom EH,Brown MR,Marshall JL,Arevalo C,Dvela-Levitt M,Kost-Alimova M,Sieber J,Gabriel KR,Pacheco J,Clish C,Abbasi HS,Singh S,Rutter JC,Therrien M,Yoon H,Lai ZW,Baublis A,Subramanian R,Devkota R,Small J,Sreekanth V,Han M,Lim D,Carpenter AE,Flannick J,Finucane H,Haigis MC,Claussnitzer M,Sheu E,Stevens B,Wagner BK,Choudhary A,Shaw JL,Pablo JL,Greka A
300-25 was used in Cell Culture to find that c-MAF-inducing protein (CMIP) protects cells from FFA exposure by modulating Akt signaling.
Tue May 02 00:00:00 EDT 2023
Peroxisomal ROS control cytosolic Mycobacterium tuberculosis replication in human macrophages.
The Journal of cell biology
Pellegrino E,Aylan B,Bussi C,Fearns A,Bernard EM,Athanasiadi N,Santucci P,Botella L,Gutierrez MG
300-25 was used in In vitro experiments to find peroxisomes increased ROS levels during Mtb WT infection.
Mon Dec 04 00:00:00 EST 2023
Colchicine exerts anti-atherosclerotic and -plaque-stabilizing effects targeting foam cell formation.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Schwarz N,Fernando S,Chen YC,Salagaras T,Rao SR,Liyanage S,Williamson AE,Toledo-Flores D,Dimasi C,Sargeant TJ,Manavis J,Eddy E,Kanellakis P,Thompson PL,Tan JTM,Snel MF,Bursill CA,Nicholls SJ,Peter K,Psaltis PJ
300-25 was used in Cell Culture to show that colchicine exerts anti-atherosclerotic and plaque-stabilizing effects at low dose by inhibiting foam cell formation and cholesterol crystal-induced inflammation.
Sat Apr 01 00:00:00 EDT 2023
METTL16 drives leukemogenesis and leukemia stem cell self-renewal by reprogramming BCAA metabolism.
Cell stem cell
Han L,Dong L,Leung K,Zhao Z,Li Y,Gao L,Chen Z,Xue J,Qing Y,Li W,Pokharel SP,Gao M,Chen M,Shen C,Tan B,Small A,Wang K,Zhang Z,Qin X,Yang L,Wunderlich M,Zhang B,Mulloy JC,Marcucci G,Chen CW,Wei M,Su R,Chen J,Deng X
300-25 was used in Cell Culture to show that METTL16 is a highly essential gene for the survival of acute myeloid leukemia (AML) cells via CRISPR-Cas9 screening and experimental validation.
Thu Jan 05 00:00:00 EST 2023
The adiponectin receptor agonist AdipoAI attenuates periodontitis in diabetic rats by inhibiting gingival fibroblast-induced macrophage migration.
British journal of pharmacology
Qiu W,Wang Z,Chen Z,Sun Q,Wu H,Chen Z,Luan K,Liu Z,Ding D,Tu Q,Chen J,Wu B,Fang F
300-25 was used in Cell Culture to examine chemokine expression levels in hGFs and hGF-induced monocyte/macrophage migration upon siRNA knockdown of Adiponectin receptor expression.
Fri Sep 01 00:00:00 EDT 2023
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein.
Molecular psychiatry
Albornoz EA,Amarilla AA,Modhiran N,Parker S,Li XX,Wijesundara DK,Aguado J,Zamora AP,McMillan CLD,Liang B,Peng NYG,Sng JDJ,Saima FT,Fung JN,Lee JD,Paramitha D,Parry R,Avumegah MS,Isaacs A,Lo MW,Miranda-Chacon Z,Bradshaw D,Salinas-Rebolledo C,Rajapakse NW,Wolvetang EJ,Munro TP,Rojas-Fernandez A,Young PR,Stacey KJ,Khromykh AA,Chappell KJ,Watterson D,Woodruff TM
300-25 was used in Cell Culture to support a possible mechanism of microglial innate immune activation by SARS-CoV-2, which could explain the increased vulnerability to developing neurological symptoms akin to Parkinson's disease in COVID-19 infected individuals, and a potential therapeutic avenue for intervention.
Sat Jul 01 00:00:00 EDT 2023
Targeting RAF Isoforms and Tumor Microenvironments in RAS or BRAF Mutant Colorectal Cancers with SJ-C1044 for Anti-Tumor Activity.
Current issues in molecular biology
Hong S,Jeon M,Kwon J,Park H,Lee G,Kim K,Ahn S
300-25 was used in In vitro experiments to evaluate the potential of a novel pan-RAF inhibitor, SJ-C1044, for targeting mutant KRAS-mediated signaling and inhibiting CRC cell proliferation.
Thu Jul 13 00:00:00 EDT 2023
Self-organized yolk sac-like organoids allow for scalable generation of multipotent hematopoietic progenitor cells from induced pluripotent stem cells.
Cell reports methods
Tamaoki N,Siebert S,Maeda T,Ha NH,Good ML,Huang Y,Vodnala SK,Haro-Mora JJ,Uchida N,Tisdale JF,Sweeney CL,Choi U,Brault J,Koontz S,Malech HL,Yamazaki Y,Isonaka R,Goldstein DS,Kimura M,Takebe T,Zou J,Stroncek DF,Robey PG,Kruhlak MJ,Restifo NP,Vizcardo R
300-25 was used in Cell Culture to demonstrate that organoid-induced HPCs can be differentiated into erythroid cells, macrophages, and T lymphocytes with current maturation protocols.
Mon Apr 24 00:00:00 EDT 2023
Stereochemistry and functions of the new cysteinyl-resolvin, 4S,5R-RCTR1, in efferocytosis and erythrophagocytosis of human senescent erythrocytes.
American journal of hematology
Nshimiyimana R,Libreros S,Simard M,Chiang N,Rodriguez AR,Spur BW,Haeggström JZ,Serhan CN
300-25 was used in Cell Culture to establish the complete stereochemistry of 4S,5R-RCTR1 as 5R-glutathionyl-4S,17S-dihydroxy-6E,8E,10Z,13Z,15E,19Z-docosahexaenoic acid and give evidence of its novel bioactivities in human phagocyte responses.
Sat Jul 01 00:00:00 EDT 2023
Three-dimensional human neural culture on a chip recapitulating neuroinflammation and neurodegeneration.
Nature protocols
Kang YJ,Diep YN,Tran M,Tran VTA,Ambrin G,Ngo H,Cho H
300-25 was used in In vitro experiments to show that our human BoCs serve as reliable and valuable platforms to investigate pathological mechanisms involving neuroinflammation and to assess therapeutic strategies modulating neuroinflammation in neurological disorders.
Fri Sep 01 00:00:00 EDT 2023
C-Myc-induced hypersialylation of small cell lung cancer facilitates pro-tumoral phenotypes of macrophages.
iScience
Tian L,Li H,Zhao P,Liu Y,Lu Y,Zhong R,Jin Y,Tan T,Cheng Y
300-25 was used in Cell Culture to provide a comprehensive overview of the cancer-specific immune signature of monocytes and macrophages and reveals tumor-associated biomarkers as potential therapeutic targets for SCLC.
Fri Oct 20 00:00:00 EDT 2023
Directed Differentiation of Human iPSCs into Microglia-Like Cells Using Defined Transcription Factors.
Methods in molecular biology (Clifton, N.J.)
Chen SW,Wong YH
300-25 was used in Cell Culture to provide a stepwise protocol for the simple, robust, and efficient differentiation of hiPSCs into microglia-like cells (iMGs) by overexpression of SPI1 and CEBPA.
Mon Jun 12 00:00:00 EDT 2023
A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states.
Nature neuroscience
Dräger NM,Sattler SM,Huang CT,Teter OM,Leng K,Hashemi SH,Hong J,Aviles G,Clelland CD,Zhan L,Udeochu JC,Kodama L,Singleton AB,Nalls MA,Ichida J,Ward ME,Faghri F,Gan L,Kampmann M
300-25 was used in In vitro experiments to present a screening platform to systematically elucidate functional consequences of genetic perturbations in human induced pluripotent stem cell-derived microglia.
Thu Sep 01 00:00:00 EDT 2022
CD127 imprints functional heterogeneity to diversify monocyte responses in inflammatory diseases.
The Journal of experimental medicine
Zhang B,Zhang Y,Xiong L,Li Y,Zhang Y,Zhao J,Jiang H,Li C,Liu Y,Liu X,Liu H,Ping YF,Zhang QC,Zhang Z,Bian XW,Zhao Y,Hu X
Mon Feb 07 00:00:00 EST 2022
Continuous human iPSC-macrophage mass production by suspension culture in stirred tank bioreactors.
Nature protocols
Ackermann M,Rafiei Hashtchin A,Manstein F,Carvalho Oliveira M,Kempf H,Zweigerdt R,Lachmann N
Tue Feb 01 00:00:00 EST 2022
Carfilzomib modulates tumor microenvironment to potentiate immune checkpoint therapy for cancer.
EMBO molecular medicine
Zhou Q,Liang J,Yang T,Liu J,Li B,Li Y,Fan Z,Wang W,Chen W,Yuan S,Xu M,Xu Q,Luan Z,Xia Z,Zhou P,Huang Y,Chen L
300-25 was used in Cell Culture to conduct high-throughput screening to show that Carfilzomib potently drives M2 macrophages to express M1 cytokines, phagocytose tumor cells, and present antigens to T cells to suggest a potentially immediate application of combinational treatment with Carfilzomib and PD-1 inhibitors for patients with solid tumors.
Tue Jan 11 00:00:00 EST 2022
Heterozygous expression of the Alzheimer's disease-protective PLCγ2 P522R variant enhances Aβ clearance while preserving synapses.
Cellular and molecular life sciences : CMLS
Solomon S,Sampathkumar NK,Carre I,Mondal M,Chennell G,Vernon AC,Ruepp MD,Mitchell JC
300-25 was used in Sample Preparation to investigate P522R in Alzheimer’s disease.
Wed Jul 27 00:00:00 EDT 2022
Staphylococcus aureus controls eicosanoid and specialized pro-resolving mediator production via lipoteichoic acid.
Immunology
Miek L,Jordan PM,Günther K,Pace S,Beyer T,Kowalak D,Hoerr V,Löffler B,Tuchscherr L,Serhan CN,Gerstmeier J,Werz O
Sun May 01 00:00:00 EDT 2022
Concurrent stimulation of monocytes with CSF1 and polarizing cytokines reveals phenotypic and functional differences with classical polarized macrophages.
Journal of leukocyte biology
An L,Michaeli J,Pallavi P,Breedijk A,Xu X,Dietrich N,Sigl M,Keese M,Nitschke K,Jarczyk J,Nuhn P,Krämer BK,Yard BA,Leipe J
Thu Sep 01 00:00:00 EDT 2022
Trastuzumab/pertuzumab combination therapy stimulates antitumor responses through complement-dependent cytotoxicity and phagocytosis.
JCI insight
Tsao LC,Crosby EJ,Trotter TN,Wei J,Wang T,Yang X,Summers AN,Lei G,Rabiola CA,Chodosh LA,Muller WJ,Lyerly HK,Hartman ZC
300-25 was used in Sample Preparation (FC/FACS) to identify classical complement activation as a significant antitumor MOA for T+P therapy that may be functionally enhanced to potentially augment clinical therapeutic efficacy.
Tue Mar 22 00:00:00 EDT 2022
Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4.
iScience
Colombo G,Travelli C,Porta C,Genazzani AA
300-25 was used in Cell Culture to demonstrate that eNAMPT promotes inflammation by favoring both the recruitment of myeloid cells and the induction of an inflammatory transcriptional program.
Fri Apr 15 00:00:00 EDT 2022
A multi-organ chip with matured tissue niches linked by vascular flow.
Nature biomedical engineering
Ronaldson-Bouchard K,Teles D,Yeager K,Tavakol DN,Zhao Y,Chramiec A,Tagore S,Summers M,Stylianos S,Tamargo M,Lee BM,Halligan SP,Abaci EH,Guo Z,Jacków J,Pappalardo A,Shih J,Soni RK,Sonar S,German C,Christiano AM,Califano A,Hirschi KK,Chen CS,Przekwas A,Vunjak-Novakovic G
300-25 was used in Cell Culture to report the development and applicability of a tissue-chip system in which matured human heart, liver, bone and skin tissue niches are linked by recirculating vascular flow to allow for the recapitulation of interdependent organ functions.
Fri Apr 01 00:00:00 EDT 2022
Macrophages activated by hepatitis B virus have distinct metabolic profiles and suppress the virus via IL-1β to downregulate PPARα and FOXO3.
Cell reports
Li Y,Zhu Y,Feng S,Ishida Y,Chiu TP,Saito T,Wang S,Ann DK,Ou JJ
300-25 was used in Cell Culture to report that M1-like macrophages stimulated by HBV exhibit a strong HBV-suppressive effect, which is diminished in M2-like macrophages.
Tue Jan 25 00:00:00 EST 2022
Subversion of infiltrating prostate macrophages to a mixed immunosuppressive tumor-associated macrophage phenotype.
Clinical and translational medicine
Boibessot C,Molina O,Lachance G,Tav C,Champagne A,Neveu B,Pelletier JF,Pouliot F,Fradet V,Bilodeau S,Fradet Y,Bergeron A,Toren P
300-25 was used in Cell Culture to study the origin, development, and function of tumor-associated macrophages (TAMs) within the prostate tumor microenvironment (TME) to identify the immunosuppressive TAM marker CD163 in adjacent normal epithelium as an independent predictor of metastases or prostate cancer (PCa) death.
Sat Jan 01 00:00:00 EST 2022
TREM2 regulates purinergic receptor-mediated calcium signaling and motility in human iPSC-derived microglia.
eLife
Jairaman A,McQuade A,Granzotto A,Kang YJ,Chadarevian JP,Gandhi S,Parker I,Smith I,Cho H,Sensi SL,Othy S,Blurton-Jones M,Cahalan MD
300-25 was used in In vitro experiments to show that loss of TREM2 confers a defect in microglial Ca2+ response to purinergic signals, suggesting a window of Ca2+ signaling for optimal microglial motility.
Tue Feb 22 00:00:00 EST 2022
Exosomes derived from M2 macrophages induce angiogenesis to promote wound healing.
Frontiers in molecular biosciences
Lyu L,Cai Y,Zhang G,Jing Z,Liang J,Zhang R,Dang X,Zhang C
300-25 was used in Cell Culture to demonstrate that M2-EXO can be used as a promising nanomedicine strategy for therapeutic exploration of skin healing with the potential to be translated into clinical practice.
Sat Oct 29 00:00:00 EDT 2022
Protocol of Co-Culture of Human Osteoblasts and Osteoclasts to Test Biomaterials for Bone Tissue Engineering.
Methods and protocols
Borciani G,Montalbano G,Baldini N,Vitale-Brovarone C,Ciapetti G
Fri Jan 14 00:00:00 EST 2022
Bone erosion in inflammatory arthritis is attenuated by Trichinella spiralis through inhibiting M1 monocyte/macrophage polarization.
iScience
Cheng Y,Yu Y,Zhuang Q,Wang L,Zhan B,Du S,Liu Y,Huang J,Hao J,Zhu X
300-25 was used in Cell Culture to investigate helminths in rheumatoid arthritis treatment.
Fri Mar 18 00:00:00 EDT 2022
Visualizing Pyrazinamide Action by Live Single-Cell Imaging of Phagosome Acidification and Mycobacterium tuberculosis pH Homeostasis.
mBio
Santucci P,Aylan B,Botella L,Bernard EM,Bussi C,Pellegrino E,Athanasiadi N,Gutierrez MG
300-25 was used in Cell Culture to describe a dual live imaging approach to monitor mycobacterial pH homeostasis, host cell environment, and antibiotic action, and show that intracellular localization of M. tuberculosis affects the efficacy of pyrazinamide.
Tue Apr 26 00:00:00 EDT 2022
EC-18 prevents autoimmune arthritis by suppressing inflammatory cytokines and osteoclastogenesis.
Arthritis research & therapy
Park JS,Yang SC,Jeong HY,Lee SY,Ryu JG,Choi JW,Kang HY,Kim SM,Hwang SH,Cho ML,Park SH
300-25 was used in In vitro experiments to investigate the efficacy of EC-18 on the development of RA.
Thu Nov 17 00:00:00 EST 2022
Tofacitinib-Induced Modulation of Intestinal Adaptive and Innate Immunity and Factors Driving Cellular and Systemic Pharmacokinetics.
Cellular and molecular gastroenterology and hepatology
Texler B,Zollner A,Reinstadler V,Reider SJ,Macheiner S,Jelusic B,Pfister A,Watschinger C,Przysiecki N,Tilg H,Oberacher H,Moschen AR
300-25 was used in In vitro experiments to describe an unappreciated mechanism-namely induction of equilibrative nucleoside transporters-enhancing baseline cellular uptake that can be inhibited pharmaceutically.
Mon Apr 04 00:00:00 EDT 2022
Distinct SARS-CoV-2 RNA fragments activate Toll-like receptors 7 and 8 and induce cytokine release from human macrophages and microglia.
Frontiers in immunology
Wallach T,Raden M,Hinkelmann L,Brehm M,Rabsch D,Weidling H,Krüger C,Kettenmann H,Backofen R,Lehnardt S
300-25 was used in In vitro experiments to determine TLR7 and TLR8 as key sensors of SARS-CoV-2-derived ssRNAs and may deepen our understanding of the mechanisms how this virus triggers, but also modulates an inflammatory response through innate immune signaling.
Tue Jan 31 00:00:00 EST 2023
Itaconate and fumarate derivatives inhibit priming and activation of the canonical NLRP3 inflammasome in macrophages.
Immunology
Hoyle C,Green JP,Allan SM,Brough D,Lemarchand E
300-25 was used in Cell Culture to highlight itaconate and fumarate derivatives as potential therapeutic options in NLRP3- and IL-1α-driven diseases, including in the brain.
Fri Apr 01 00:00:00 EDT 2022
Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy.
International journal of biological sciences
Gao L,Xu QH,Ma LN,Luo J,Muyayalo KP,Wang LL,Huang DH,Xiao XJ,Cheng SB,Mor G,Liao AH
300-25 was used in Sample Preparation (FC/FACS) to investigate the role of lactic acid metabolism on maternal-fetal interface during early pregnancy.
Mon Mar 21 00:00:00 EDT 2022
Targeting Immunosuppressive Tumor-Associated Macrophages Using Innate T Cells for Enhanced Antitumor Reactivity.
Cancers
Li YR,Brown J,Yu Y,Lee D,Zhou K,Dunn ZS,Hon R,Wilson M,Kramer A,Zhu Y,Fang Y,Yang L
300-25 was used in Sample Preparation (FC/FACS) to evaluate the targeting efficacy CAR-engineered T cells on MAIT, iNKT, and γδT cells.
Wed Jun 01 00:00:00 EDT 2022
Inter-cellular CRISPR screens reveal regulators of cancer cell phagocytosis.
Nature
Kamber RA,Nishiga Y,Morton B,Banuelos AM,Barkal AA,Vences-Catalán F,Gu M,Fernandez D,Seoane JA,Yao D,Liu K,Lin S,Spees K,Curtis C,Jerby-Arnon L,Weissman IL,Sage J,Bassik MC
Wed Sep 01 00:00:00 EDT 2021
Salt Transiently Inhibits Mitochondrial Energetics in Mononuclear Phagocytes.
Circulation
Geisberger S,Bartolomaeus H,Neubert P,Willebrand R,Zasada C,Bartolomaeus T,McParland V,Swinnen D,Geuzens A,Maifeld A,Krampert L,Vogl M,Mähler A,Wilck N,Markó L,Tilic E,Forslund SK,Binger KJ,Stegbauer J,Dechend R,Kleinewietfeld M,Jantsch J,Kempa S,Müller DN
300-25 was used in Cell Culture to investigate effects of sodium changes on human and murine phagocytes.
Tue Jul 13 00:00:00 EDT 2021
Interactions between cancer cells and immune cells drive transitions to mesenchymal-like states in glioblastoma.
Cancer cell
Hara T,Chanoch-Myers R,Mathewson ND,Myskiw C,Atta L,Bussema L,Eichhorn SW,Greenwald AC,Kinker GS,Rodman C,Gonzalez Castro LN,Wakimoto H,Rozenblatt-Rosen O,Zhuang X,Fan J,Hunter T,Verma IM,Wucherpfennig KW,Regev A,Suvà ML,Tirosh I
Mon Jun 14 00:00:00 EDT 2021
M2 macrophages, but not M1 macrophages, support megakaryopoiesis by upregulating PI3K-AKT pathway activity.
Signal transduction and targeted therapy
Zhao HY,Zhang YY,Xing T,Tang SQ,Wen Q,Lyu ZS,Lv M,Wang Y,Xu LP,Zhang XH,Kong Y,Huang XJ
Fri Jun 18 00:00:00 EDT 2021
Macrophage IRX3 promotes diet-induced obesity and metabolic inflammation.
Nature immunology
Yao J,Wu D,Zhang C,Yan T,Zhao Y,Shen H,Xue K,Huang X,Wang Z,Qiu Y
Fri Oct 01 00:00:00 EDT 2021
Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro.
Science translational medicine
Reyes M,Filbin MR,Bhattacharyya RP,Sonny A,Mehta A,Billman K,Kays KR,Pinilla-Vera M,Benson ME,Cosimi LA,Hung DT,Levy BD,Villani AC,Sade-Feldman M,Baron RM,Goldberg MB,Blainey PC,Hacohen N
Wed Jun 16 00:00:00 EDT 2021
DCIR and its ligand asialo-biantennary N-glycan regulate DC function and osteoclastogenesis.
The Journal of experimental medicine
Kaifu T,Yabe R,Maruhashi T,Chung SH,Tateno H,Fujikado N,Hirabayashi J,Iwakura Y
Mon Dec 06 00:00:00 EST 2021
The SIRPα-CD47 immune checkpoint in NK cells.
The Journal of experimental medicine
Deuse T,Hu X,Agbor-Enoh S,Jang MK,Alawi M,Saygi C,Gravina A,Tediashvili G,Nguyen VQ,Liu Y,Valantine H,Lanier LL,Schrepfer S
Mon Mar 01 00:00:00 EST 2021
A genetic link between risk for Alzheimer's disease and severe COVID-19 outcomes via the OAS1 gene.
Brain : a journal of neurology
Magusali N,Graham AC,Piers TM,Panichnantakul P,Yaman U,Shoai M,Reynolds RH,Botia JA,Brookes KJ,Guetta-Baranes T,Bellou E,Bayram S,Sokolova D,Ryten M,Sala Frigerio C,Escott-Price V,Morgan K,Pocock JM,Hardy J,Salih DA
Fri Dec 31 00:00:00 EST 2021
MEF2C regulates osteoclastogenesis and pathologic bone resorption via c-FOS.
Bone research
Fujii T,Murata K,Mun SH,Bae S,Lee YJ,Pannellini T,Kang K,Oliver D,Park-Min KH,Ivashkiv LB
Mon Jan 11 00:00:00 EST 2021
Kdm6a suppresses the alternative activation of macrophages and impairs energy expenditure in obesity.
Cell death and differentiation
Chen J,Xu X,Li Y,Li F,Zhang J,Xu Q,Chen W,Wei Y,Wang X
300-25 was used in Cell Culture to study whether the Kdm6a pathway in adipose tissue macrophages (ATMs), which are involved in metabolic inflammation in obesity, regulate energy homeostasis.
Sat May 01 00:00:00 EDT 2021
Transnasal transplantation of human induced pluripotent stem cell-derived microglia to the brain of immunocompetent mice.
Glia
Parajuli B,Saito H,Shinozaki Y,Shigetomi E,Miwa H,Yoneda S,Tanimura M,Omachi S,Asaki T,Takahashi K,Fujita M,Nakashima K,Koizumi S
Fri Oct 01 00:00:00 EDT 2021
Mantle cell lymphoma polarizes tumor-associated macrophages into M2-like macrophages, which in turn promote tumorigenesis.
Blood advances
Le K,Sun J,Khawaja H,Shibata M,Maggirwar SB,Smith MR,Gupta M
Tue Jul 27 00:00:00 EDT 2021
The selection of variable regions affects effector mechanisms of IgA antibodies against CD20.
Blood advances
Evers M,Rösner T,Dünkel A,Jansen JHM,Baumann N,Ten Broeke T,Nederend M,Eichholz K,Klausz K,Reiding K,Schewe DM,Kellner C,Peipp M,Leusen JHW,Valerius T
Tue Oct 12 00:00:00 EDT 2021
MED1 Deficiency in Macrophages Accelerates Intimal Hyperplasia via ROS Generation and Inflammation.
Oxidative medicine and cellular longevity
Zhang Y,Fu Y,Zhang C,Jia L,Yao N,Lin Y,Dong Y,Fatima N,Alam N,Wang R,Wang W,Bai L,Zhao S,Liu E
Tue Feb 22 00:00:00 EST 2022
Mutations in Profilin 1 Cause Early-Onset Paget's Disease of Bone With Giant Cell Tumors.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wei Z,Li S,Tao X,Zhu G,Sun Z,Wei Z,Jiao Q,Zhang H,Chen L,Li B,Zhang Z,Yue H
Tue Jun 01 00:00:00 EDT 2021
Mutations in Profilin 1 Cause Early-Onset Paget's Disease of Bone With Giant Cell Tumors.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Wei Z,Li S,Tao X,Zhu G,Sun Z,Wei Z,Jiao Q,Zhang H,Chen L,Li B,Zhang Z,Yue H
Tue Jun 01 00:00:00 EDT 2021
Human induced pluripotent stem cell-derived macrophages ameliorate liver fibrosis.
Stem cells (Dayton, Ohio)
Pouyanfard S,Meshgin N,Cruz LS,Diggle K,Hashemi H,Pham TV,Fierro M,Tamayo P,Fanjul A,Kisseleva T,Kaufman DS
Wed Dec 01 00:00:00 EST 2021
Plinabulin, a Distinct Microtubule-Targeting Chemotherapy, Promotes M1-Like Macrophage Polarization and Anti-tumor Immunity.
Frontiers in oncology
Natoli M,Herzig P,Pishali Bejestani E,Buchi M,Ritschard R,Lloyd GK,Mohanlal R,Tonra JR,Huang L,Heinzelmann V,Trüb M,Zippelius A,Kashyap AS
300-25 was used in Cell Culture to investigate plinabulin and the effects on dendritic cell maturation and anti-tumor immunity in mice.
Tue Mar 23 00:00:00 EDT 2021
IRF5 regulates airway macrophage metabolic responses.
Clinical and experimental immunology
Albers GJ,Iwasaki J,McErlean P,Ogger PP,Ghai P,Khoyratty TE,Udalova IA,Lloyd CM,Byrne AJ
Thu Apr 01 00:00:00 EDT 2021
STAT3 Gain-of-Function Mutations Underlie Deficiency in Human Nonclassical CD16+ Monocytes and CD141+ Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Korenfeld D,Roussak K,Dinkel S,Vogel TP,Pollack H,Levy J,Leiding JW,Milner J,Cooper M,Klechevsky E
Mon Nov 15 00:00:00 EST 2021
HLA DR Genome Editing with TALENs in Human iPSCs Produced Immune-Tolerant Dendritic Cells.
Stem cells international
Kwon YW,Ahn HS,Lee JW,Yang HM,Cho HJ,Kim SJ,Lee SH,Yang HM,Jang HD,Kim SJ,Kim HS
Tue Jun 08 00:00:00 EDT 2021
Medulloblastoma recurrence and metastatic spread are independent of colony-stimulating factor 1 receptor signaling and macrophage survival.
Journal of neuro-oncology
Crotty EE,Smith SMC,Brasel K,Pakiam F,Girard EJ,Connor YD,Zindy F,Mhyre AJ,Roussel MF,Olson JM
300-25 was used in Cell Culture to investigate the role of tumour-associated macrophage infiltration in cancer progression.
Tue Jun 01 00:00:00 EDT 2021
Type I interferon decreases macrophage energy metabolism during mycobacterial infection.
Cell reports
Olson GS,Murray TA,Jahn AN,Mai D,Diercks AH,Gold ES,Aderem A
Tue Jun 01 00:00:00 EDT 2021
FABP4 deactivates NF-κB-IL1α pathway by ubiquitinating ATPB in tumor-associated macrophages and promotes neuroblastoma progression.
Clinical and translational medicine
Miao L,Zhuo Z,Tang J,Huang X,Liu J,Wang HY,Xia H,He J
Thu Apr 01 00:00:00 EDT 2021
RSPO2 inhibits BMP signaling to promote self-renewal in acute myeloid leukemia.
Cell reports
Sun R,He L,Lee H,Glinka A,Andresen C,Hübschmann D,Jeremias I,Müller-Decker K,Pabst C,Niehrs C
Tue Aug 17 00:00:00 EDT 2021
Adenosine deaminase 2 produced by infiltrative monocytes promotes liver fibrosis in nonalcoholic fatty liver disease.
Cell reports
Tiwari-Heckler S,Yee EU,Yalcin Y,Park J,Nguyen DT,Gao W,Csizmadia E,Afdhal N,Mukamal KJ,Robson SC,Lai M,Schwartz RE,Jiang ZG
Tue Oct 26 00:00:00 EDT 2021
Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.
iScience
Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y
300-25 was used in Cell Culture to optimize the in vitro liver fibrotic niches and subsequently harvest their bioactive ingredients as niche extracts (NEs) so that pathology-relevant and tissue-specific NEs provide innovative and generalizable strategies for the discovery of optimal cellular niche and bioactive niche compositions.
Fri Nov 19 00:00:00 EST 2021
Synthetic liver fibrotic niche extracts achieve in vitro hepatoblasts phenotype enhancement and expansion.
iScience
Zhang Y,Guo A,Lyu C,Bi R,Wu Z,Li W,Zhao P,Niu Y,Na J,Xi JJ,Du Y
300-25 was used in Cell Culture to optimize the in vitro liver fibrotic niches and subsequently harvest their bioactive ingredients as niche extracts (NEs) so that pathology-relevant and tissue-specific NEs provide innovative and generalizable strategies for the discovery of optimal cellular niche and bioactive niche compositions.
Fri Nov 19 00:00:00 EST 2021
EGR1 is a gatekeeper of inflammatory enhancers in human macrophages.
Science advances
Trizzino M,Zucco A,Deliard S,Wang F,Barbieri E,Veglia F,Gabrilovich D,Gardini A
Fri Jan 01 00:00:00 EST 2021
Nanovibrational stimulation inhibits osteoclastogenesis and enhances osteogenesis in co-cultures.
Scientific reports
Kennedy JW,Tsimbouri PM,Campsie P,Sood S,Childs PG,Reid S,Young PS,Meek DRM,Goodyear CS,Dalby MJ
Tue Nov 23 00:00:00 EST 2021
HIV Increases the Inhibitory Impact of Morphine and Antiretrovirals on Autophagy in Primary Human Macrophages: Contributions to Neuropathogenesis.
Cells
Barbaro JM,Cuervo AM,Berman JW
300-25 was used in Sample Prep (ELISA) to indicate that inhibition of autophagy, both in bulk and selective, in CNS macrophages may mediate neurocognitive dysfunction in PWH using opioids.
Tue Aug 24 00:00:00 EDT 2021
Enhanced epigenetic profiling of classical human monocytes reveals a specific signature of healthy aging in the DNA methylome.
Nature aging
Shchukina I,Bagaitkar J,Shpynov O,Loginicheva E,Porter S,Mogilenko DA,Wolin E,Collins P,Demidov G,Artomov M,Zaitsev K,Sidorov S,Camell C,Bambouskova M,Arthur L,Swain A,Panteleeva A,Dievskii A,Kurbatsky E,Tsurinov P,Chernyatchik R,Dixit VD,Jovanovic M,Stewart SA,Daly MJ,Dmitriev S,Oltz EM,Artyomov MN
300-25 was used in Sample Preparation (PCR) to study the characterization of healthy aging in human classical monocytes, with a focus on epigenomic, transcriptomic, and proteomic alterations, as well as the corresponding proteomic and metabolomic data for plasma, using healthy cohorts of 20 young and 20 older males.
Fri Jan 01 00:00:00 EST 2021
Stem-cell-derived human microglia transplanted into mouse brain to study human disease.
Nature protocols
Fattorelli N,Martinez-Muriana A,Wolfs L,Geric I,De Strooper B,Mancuso R
300-25 was used in Sample Preparation to explain the step-by-step workflow that includes in vitro microglia differentiation from human PSCs, transplantation into the mouse brain and quantitative analysis of engraftment. This approach is more optimized and more efficient approach that yields up to 80% chimerism when compared to current differentiation and xenotransplantation protocols.
Mon Feb 01 00:00:00 EST 2021
Human Serum Enhances Biomimicry of Engineered Tissue Models of Bone and Cancer.
Frontiers in bioengineering and biotechnology
Villasante A,Robinson ST,Cohen AR,Lock R,Guo XE,Vunjak-Novakovic G
300-25 was used in Cell Culture to support the utility of human serum for bioengineering of bone and bone cancers.
Tue Feb 14 00:00:00 EST 2023
The miR-424(322)/503 gene cluster regulates pro- versus anti-inflammatory skin DC subset differentiation by modulating TGF-β signaling.
Cell reports
Zyulina V,Yan KK,Ju B,Schwarzenberger E,Passegger C,Tam-Amersdorfer C,Pan Q,Sconocchia T,Pollack C,Shaner B,Zebisch A,Easton J,Yu J,Silva JM,Strobl H
Tue Apr 27 00:00:00 EDT 2021
Improved modeling of human AD with an automated culturing platform for iPSC neurons, astrocytes and microglia.
Nature communications
Bassil R,Shields K,Granger K,Zein I,Ng S,Chih B
Wed Sep 01 00:00:00 EDT 2021
MYC-mediated early glycolysis negatively regulates proinflammatory responses by controlling IRF4 in inflammatory macrophages.
Cell reports
Bae S,Park PSU,Lee Y,Mun SH,Giannopoulou E,Fujii T,Lee KP,Violante SN,Cross JR,Park-Min KH
Tue Jun 15 00:00:00 EDT 2021
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma.
Nature communications
Xu B,Tian L,Chen J,Wang J,Ma R,Dong W,Li A,Zhang J,Antonio Chiocca E,Kaur B,Feng M,Caligiuri MA,Yu J
Fri Oct 08 00:00:00 EDT 2021
Evidence for additive and synergistic action of mammalian enhancers during cell fate determination.
eLife
Choi J,Lysakovskaia K,Stik G,Demel C,Söding J,Tian TV,Graf T,Cramer P
300-25 was used in In vitro experiments to investigate enhancer cooperation during transdifferentiation of human leukemia B-cells to macrophages.
Fri Mar 26 00:00:00 EDT 2021
Ligand-dependent kinase activity of MERTK drives efferocytosis in human iPSC-derived macrophages.
Cell death & disease
Wanke F,Gutbier S,Rümmelin A,Steinberg M,Hughes LD,Koenen M,Komuczki J,Regan-Komito D,Wagage S,Hesselmann J,Thoma R,Brugger D,Christopeit T,Wang H,Point F,Hallet R,Ghosh S,Rothlin CV,Patsch C,Geering B
Tue May 25 00:00:00 EDT 2021
Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance.
Cell reports
Li X,Zhang X,Xia J,Zhang L,Chen B,Lian G,Yun C,Yang J,Yan Y,Wang P,Wang X,Liu B,Liu H,Liang H,Pang Y,Wang X,Jiang C
Tue Aug 24 00:00:00 EDT 2021
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.
Nature communications
Wang YC,Wang X,Yu J,Ma F,Li Z,Zhou Y,Zeng S,Ma X,Li YR,Neal A,Huang J,To A,Clarke N,Memarzadeh S,Pellegrini M,Yang L
Thu Jun 10 00:00:00 EDT 2021
Targeting monoamine oxidase A-regulated tumor-associated macrophage polarization for cancer immunotherapy.
Nature communications
Wang YC,Wang X,Yu J,Ma F,Li Z,Zhou Y,Zeng S,Ma X,Li YR,Neal A,Huang J,To A,Clarke N,Memarzadeh S,Pellegrini M,Yang L
Thu Jun 10 00:00:00 EDT 2021
Ionizing Radiation Curtails Immunosuppressive Effects From Cancer-Associated Fibroblasts on Dendritic Cells.
Frontiers in immunology
Berzaghi R,Tornaas S,Lode K,Hellevik T,Martinez-Zubiaurre I
300-25 was used in Sample Preparation (FC/FACS) to study immunomodulatory functions of cancer-associated fibroblasts (CAFs) during/after radiotherapy by studying the effects of ionizing radiation on CAF-mediated regulation of dendritic cells (DCs) to demonstrate hat CAFs interfere with DC immune functions and unveil that certain radiation regimens may reverse CAF-mediated immunosuppressive effects.
Thu Oct 14 00:00:00 EDT 2021
Regulatory B Cells (Bregs) Inhibit Osteoclastogenesis and Play a Potential Role in Ameliorating Ovariectomy-Induced Bone Loss.
Frontiers in immunology
Sapra L,Bhardwaj A,Mishra PK,Garg B,Verma B,Mishra GC,Srivastava RK
300-25 was used in Cell Culture to suggest that modulations in the percentage of Bregs population along with its reduced potential to produce IL-10 might further exacerbate the observed bone loss in ovx mice.
Thu Nov 04 00:00:00 EDT 2021
On-target IgG hexamerisation driven by a C-terminal IgM tail-piece fusion variant confers augmented complement activation.
Communications biology
Sopp JM,Peters SJ,Rowley TF,Oldham RJ,James S,Mockridge I,French RR,Turner A,Beers SA,Humphreys DP,Cragg MS
Thu Sep 02 00:00:00 EDT 2021
Identification of adipocytes as target cells for Leishmania infantum parasites.
Scientific reports
Schwing A,Pisani DF,Pomares C,Majoor A,Lacas-Gervais S,Jager J,Lemichez E,Marty P,Boyer L,Michel G
Thu Oct 28 00:00:00 EDT 2021
Lactobacillus rhamnosus attenuates bone loss and maintains bone health by skewing Treg-Th17 cell balance in Ovx mice.
Scientific reports
Sapra L,Dar HY,Bhardwaj A,Pandey A,Kumari S,Azam Z,Upmanyu V,Anwar A,Shukla P,Mishra PK,Saini C,Verma B,Srivastava RK
Tue Jan 19 00:00:00 EST 2021
Regulatory T cells induce polarization of pro-repair macrophages by secreting sFGL2 into the endometriotic milieu.
Communications biology
Hou XX,Wang XQ,Zhou WJ,Li DJ
Fri Apr 23 00:00:00 EDT 2021
Loss of fragile site-associated tumor suppressor promotes antitumor immunity via macrophage polarization.
Nature communications
Zhang L,Zhang K,Zhang J,Zhu J,Xi Q,Wang H,Zhang Z,Cheng Y,Yang G,Liu H,Guo X,Zhou D,Xue Z,Li Y,Zhang Q,Da Y,Liu L,Yin Z,Yao Z,Zhang R
300-25 was used in In vitro experiments to report a function of FATS in tumor development via regulation of tumor immunity.
Wed Jul 14 00:00:00 EDT 2021
Itaconate confers tolerance to late NLRP3 inflammasome activation.
Cell reports
Bambouskova M,Potuckova L,Paulenda T,Kerndl M,Mogilenko DA,Lizotte K,Swain A,Hayes S,Sheldon RD,Kim H,Kapadnis U,Ellis AE,Isaguirre C,Burdess S,Laha A,Amarasinghe GK,Chubukov V,Roddy TP,Diamond MS,Jones RG,Simons DM,Artyomov MN
Tue Mar 09 00:00:00 EST 2021
Activation of (pro)renin by (pro)renin receptor in extracellular vesicles from osteoclasts.
Scientific reports
Murray JB,Mikhael C,Han G,de Faria LP,Rody WJ,Holliday LS
Wed Apr 28 00:00:00 EDT 2021
Active hematopoiesis triggers exosomal release of PRDX2 that promotes osteoclast formation.
Physiological reports
Sadvakassova G,Tiedemann K,Steer KJD,Mikolajewicz N,Stavnichuk M,In-Kyung Lee I,Sabirova Z,Schranzhofer M,Komarova SV
Mon Feb 01 00:00:00 EST 2021
Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles.
Journal of extracellular vesicles
Benet S,Gálvez C,Drobniewski F,Kontsevaya I,Arias L,Monguió-Tortajada M,Erkizia I,Urrea V,Ong RY,Luquin M,Dupont M,Chojnacki J,Dalmau J,Cardona P,Neyrolles O,Lugo-Villarino G,Vérollet C,Julián E,Furrer H,Günthard HF,Crocker PR,Tapia G,Borràs FE,Fellay J,McLaren PJ,Telenti A,Cardona PJ,Clotet B,Vilaplana C,Martinez-Picado J,Izquierdo-Useros N
Fri Jan 01 00:00:00 EST 2021
The neurorepellent, Slit2, prevents macrophage lipid loading by inhibiting CD36-dependent binding and internalization of oxidized low-density lipoprotein.
Scientific reports
Yusuf B,Mukovozov I,Patel S,Huang YW,Liu GY,Reddy EC,Skrtic M,Glogauer M,Robinson LA
Thu Feb 11 00:00:00 EST 2021
Identification of leukemic and pre-leukemic stem cells by clonal tracking from single-cell transcriptomics.
Nature communications
Velten L,Story BA,Hernández-Malmierca P,Raffel S,Leonce DR,Milbank J,Paulsen M,Demir A,Szu-Tu C,Frömel R,Lutz C,Nowak D,Jann JC,Pabst C,Boch T,Hofmann WK,Müller-Tidow C,Trumpp A,Haas S,Steinmetz LM
Mon Mar 01 00:00:00 EST 2021
Regulatory protein HilD stimulates Salmonella Typhimurium invasiveness by promoting smooth swimming via the methyl-accepting chemotaxis protein McpC.
Nature communications
Cooper KG,Chong A,Kari L,Jeffrey B,Starr T,Martens C,McClurg M,Posada VR,Laughlin RC,Whitfield-Cargile C,Garry Adams L,Bryan LK,Little SV,Krath M,Lawhon SD,Steele-Mortimer O
Wed Jan 13 00:00:00 EST 2021
B7-H3 regulates osteoclast differentiation via type I interferon-dependent IDO induction.
Cell death & disease
Oh Y,Park R,Kim SY,Park SH,Jo S,Kim TH,Ji JD
Wed Oct 20 00:00:00 EDT 2021
High-throughput phenotypic screen and transcriptional analysis identify new compounds and targets for macrophage reprogramming.
Nature communications
Hu G,Su Y,Kang BH,Fan Z,Dong T,Brown DR,Cheah J,Wittrup KD,Chen J
Wed Feb 03 00:00:00 EST 2021
PD-1 Affects the Immunosuppressive Function of Group 2 Innate Lymphoid Cells in Human Non-Small Cell Lung Cancer.
Frontiers in immunology
Shen C,Liu C,Zhang Z,Ping Y,Shao J,Tian Y,Yu W,Qin G,Liu S,Wang L,Zhang Y
300-25 was used in Sample Preparation (FC/FACS) to show that ILC2s are enriched in NSCLC patients and upregulate PD-1 expression.
Mon Oct 25 00:00:00 EDT 2021
Preclinical efficacy and toxicity studies of a highly specific chimeric anti-CD47 antibody.
FEBS open bio
Xu Z,Gao J,Yao J,Yang T,Wang D,Dai C,Ding Y
Mon Mar 01 00:00:00 EST 2021
An epigenetic GPI anchor defect impairs TLR4 signaling in the B cell transdifferentiation model for primary human monocytes BLaER1.
Scientific reports
Wegner J,Zillinger T,Schlee-Guimaraes TM,Bartok E,Schlee M
Thu Jul 22 00:00:00 EDT 2021
Understanding LRRK2 kinase activity in preclinical models and human subjects through quantitative analysis of LRRK2 and pT73 Rab10.
Scientific reports
Wang X,Negrou E,Maloney MT,Bondar VV,Andrews SV,Montalban M,Llapashtica C,Maciuca R,Nguyen H,Solanoy H,Arguello A,Przybyla L,Moerke NJ,Huntwork-Rodriguez S,Henry AG
Fri Jun 18 00:00:00 EDT 2021
Mitochondrial C5aR1 activity in macrophages controls IL-1β production underlying sterile inflammation.
Science immunology
Niyonzima N,Rahman J,Kunz N,West EE,Freiwald T,Desai JV,Merle NS,Gidon A,Sporsheim B,Lionakis MS,Evensen K,Lindberg B,Skagen K,Skjelland M,Singh P,Haug M,Ruseva MM,Kolev M,Bibby J,Marshall O,O'Brien B,Deeks N,Afzali B,Clark RJ,Woodruff TM,Pryor M,Yang ZH,Remaley AT,Mollnes TE,Hewitt SM,Yan B,Kazemian M,Kiss MG,Binder CJ,Halvorsen B,Espevik T,Kemper C
300-25 was used in Sample Preparation (Western Blotting) to suggest that the complosome is a contributor to the biologic processes underlying sterile inflammation and indicate that targeting this system could be beneficial in macrophage-dependent diseases, such as atherosclerosis.
Fri Dec 24 00:00:00 EST 2021
Microglia Require CD4 T Cells to Complete the Fetal-to-Adult Transition.
Cell
Pasciuto E,Burton OT,Roca CP,Lagou V,Rajan WD,Theys T,Mancuso R,Tito RY,Kouser L,Callaerts-Vegh Z,de la Fuente AG,Prezzemolo T,Mascali LG,Brajic A,Whyte CE,Yshii L,Martinez-Muriana A,Naughton M,Young A,Moudra A,Lemaitre P,Poovathingal S,Raes J,De Strooper B,Fitzgerald DC,Dooley J,Liston A
Thu Aug 06 00:00:00 EDT 2020
FAMIN Is a Multifunctional Purine Enzyme Enabling the Purine Nucleotide Cycle.
Cell
Cader MZ,de Almeida Rodrigues RP,West JA,Sewell GW,Md-Ibrahim MN,Reikine S,Sirago G,Unger LW,Iglesias-Romero AB,Ramshorn K,Haag LM,Saveljeva S,Ebel JF,Rosenstiel P,Kaneider NC,Lee JC,Lawley TD,Bradley A,Dougan G,Modis Y,Griffin JL,Kaser A
Thu Jan 23 00:00:00 EST 2020
Single-Cell Analyses Inform Mechanisms of Myeloid-Targeted Therapies in Colon Cancer.
Cell
Zhang L,Li Z,Skrzypczynska KM,Fang Q,Zhang W,O'Brien SA,He Y,Wang L,Zhang Q,Kim A,Gao R,Orf J,Wang T,Sawant D,Kang J,Bhatt D,Lu D,Li CM,Rapaport AS,Perez K,Ye Y,Wang S,Hu X,Ren X,Ouyang W,Shen Z,Egen JG,Zhang Z,Yu X
Thu Apr 16 00:00:00 EDT 2020
Translocation of Viable Gut Microbiota to Mesenteric Adipose Drives Formation of Creeping Fat in Humans.
Cell
Ha CWY,Martin A,Sepich-Poore GD,Shi B,Wang Y,Gouin K,Humphrey G,Sanders K,Ratnayake Y,Chan KSL,Hendrick G,Caldera JR,Arias C,Moskowitz JE,Ho Sui SJ,Yang S,Underhill D,Brady MJ,Knott S,Kaihara K,Steinbaugh MJ,Li H,McGovern DPB,Knight R,Fleshner P,Devkota S
Thu Oct 29 00:00:00 EDT 2020
Tumor-Derived Retinoic Acid Regulates Intratumoral Monocyte Differentiation to Promote Immune Suppression.
Cell
Devalaraja S,To TKJ,Folkert IW,Natesan R,Alam MZ,Li M,Tada Y,Budagyan K,Dang MT,Zhai L,Lobel GP,Ciotti GE,Eisinger-Mathason TSK,Asangani IA,Weber K,Simon MC,Haldar M
300-25 was used in In vitro experiments to find that the TME induces tumor cells to produce retinoic acid (RA), which polarizes intratumoral monocyte differentiation toward TAMs and away from DCs via suppression of DC-promoting transcription factor Irf4.
Thu Mar 19 00:00:00 EDT 2020
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
300-25 was used in Cell Culture to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.
Mon Jul 13 00:00:00 EDT 2020
Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion.
Cancer cell
Su R,Dong L,Li Y,Gao M,Han L,Wunderlich M,Deng X,Li H,Huang Y,Gao L,Li C,Zhao Z,Robinson S,Tan B,Qing Y,Qin X,Prince E,Xie J,Qin H,Li W,Shen C,Sun J,Kulkarni P,Weng H,Huang H,Chen Z,Zhang B,Wu X,Olsen MJ,Müschen M,Marcucci G,Salgia R,Li L,Fathi AT,Li Z,Mulloy JC,Wei M,Horne D,Chen J
300-25 was used in Cell Culture to demonstrate if fat mass and obesity-associated protein plays critical roles in cancer stem cell self-renewal and immune evasion.
Mon Jul 13 00:00:00 EDT 2020
Insulin-like growth factor 1-induced enolase 2 deacetylation by HDAC3 promotes metastasis of pancreatic cancer.
Signal transduction and targeted therapy
Zheng Y,Wu C,Yang J,Zhao Y,Jia H,Xue M,Xu D,Yang F,Fu D,Wang C,Hu B,Zhang Z,Li T,Yan S,Wang X,Nelson PJ,Bruns C,Qin L,Dong Q
Wed May 13 00:00:00 EDT 2020
Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury.
Cell metabolism
Yurdagul A,Subramanian M,Wang X,Crown SB,Ilkayeva OR,Darville L,Kolluru GK,Rymond CC,Gerlach BD,Zheng Z,Kuriakose G,Kevil CG,Koomen JM,Cleveland JL,Muoio DM,Tabas I
300-25 was used in Cell Culture to conclude that macrophage metabolism of AC-derived metabolites allows for optimal continual efferocytosis and resolution of injury.
Tue Mar 03 00:00:00 EST 2020
Macrophage hypophagia as a mechanism of innate immune exhaustion in mAb-induced cell clearance.
Blood
Pinney JJ,Rivera-Escalera F,Chu CC,Whitehead HE,VanDerMeid KR,Nelson AM,Barbeau MC,Zent CS,Elliott MR
Thu Oct 29 00:00:00 EDT 2020
Bone marrow-derived myeloid progenitors as driver mutation carriers in high- and low-risk Langerhans cell histiocytosis.
Blood
Xiao Y,van Halteren AGS,Lei X,Borst J,Steenwijk E,de Wit T,Grabowska J,Voogd R,Kemps P,Picarsic J,van den Bos C,Borst J
Thu Nov 05 00:00:00 EST 2020
Osteocyte necrosis triggers osteoclast-mediated bone loss through macrophage-inducible C-type lectin.
The Journal of clinical investigation
Andreev D,Liu M,Weidner D,Kachler K,Faas M,Grüneboom A,Schlötzer-Schrehardt U,Muñoz LE,Steffen U,Grötsch B,Killy B,Krönke G,Luebke AM,Niemeier A,Wehrhan F,Lang R,Schett G,Bozec A
Tue Sep 01 00:00:00 EDT 2020
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer.
The Journal of clinical investigation
Liu M,Tong Z,Ding C,Luo F,Wu S,Wu C,Albeituni S,He L,Hu X,Tieri D,Rouchka EC,Hamada M,Takahashi S,Gibb AA,Kloecker G,Zhang HG,Bousamra M,Hill BG,Zhang X,Yan J
Wed Apr 01 00:00:00 EDT 2020
Transcription factor c-Maf is a checkpoint that programs macrophages in lung cancer.
The Journal of clinical investigation
Liu M,Tong Z,Ding C,Luo F,Wu S,Wu C,Albeituni S,He L,Hu X,Tieri D,Rouchka EC,Hamada M,Takahashi S,Gibb AA,Kloecker G,Zhang HG,Bousamra M,Hill BG,Zhang X,Yan J
Wed Apr 01 00:00:00 EDT 2020
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Neuron
Nugent AA,Lin K,van Lengerich B,Lianoglou S,Przybyla L,Davis SS,Llapashtica C,Wang J,Kim DJ,Xia D,Lucas A,Baskaran S,Haddick PCG,Lenser M,Earr TK,Shi J,Dugas JC,Andreone BJ,Logan T,Solanoy HO,Chen H,Srivastava A,Poda SB,Sanchez PE,Watts RJ,Sandmann T,Astarita G,Lewcock JW,Monroe KM,Di Paolo G
Wed Mar 04 00:00:00 EST 2020
Efficient gene knockout in primary human and murine myeloid cells by non-viral delivery of CRISPR-Cas9.
The Journal of experimental medicine
Freund EC,Lock JY,Oh J,Maculins T,Delamarre L,Bohlen CJ,Haley B,Murthy A
Mon Jul 06 00:00:00 EDT 2020
Multi-omic comparison of Alzheimer's variants in human ESC-derived microglia reveals convergence at APOE.
The Journal of experimental medicine
Liu T,Zhu B,Liu Y,Zhang X,Yin J,Li X,Jiang L,Hodges AP,Rosenthal SB,Zhou L,Yancey J,McQuade A,Blurton-Jones M,Tanzi RE,Huang TY,Xu H
Mon Dec 07 00:00:00 EST 2020
Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway.
EMBO molecular medicine
Wilcz-Villega E,Carter E,Ironside A,Xu R,Mataloni I,Holdsworth J,Jones W,Moreno Béjar R,Uhlik L,Bentham RB,Godinho SA,Dalli J,Grose R,Szabadkai G,Jones L,Hodivala-Dilke K,Bianchi K
Fri Feb 07 00:00:00 EST 2020
Evasion of MAIT cell recognition by the African Salmonella Typhimurium ST313 pathovar that causes invasive disease.
Proceedings of the National Academy of Sciences of the United States of America
Preciado-Llanes L,Aulicino A,Canals R,Moynihan PJ,Zhu X,Jambo N,Nyirenda TS,Kadwala I,Sousa Gerós A,Owen SV,Jambo KC,Kumwenda B,Veerapen N,Besra GS,Gordon MA,Hinton JCD,Napolitani G,Salio M,Simmons A
Tue Aug 25 00:00:00 EDT 2020
Breast cancer-associated macrophages promote tumorigenesis by suppressing succinate dehydrogenase in tumor cells.
Science signaling
Gómez V,Eykyn TR,Mustapha R,Flores-Borja F,Male V,Barber PR,Patsialou A,Green R,Panagaki F,Li CW,Fruhwirth GO,Ros S,Brindle KM,Ng T
Tue Oct 06 00:00:00 EDT 2020
KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression.
British journal of cancer
Gilardini Montani MS,Falcinelli L,Santarelli R,Granato M,Romeo MA,Cecere N,Gonnella R,D'Orazi G,Faggioni A,Cirone M
300-25 was used in Cell Culture to suggest that manipulation of unfolded protein response (UPR) could be exploited to prevent or improve the treatment of KSHV-associated malignancies.
Wed Jul 01 00:00:00 EDT 2020
Targeting a membrane-proximal epitope on mesothelin increases the tumoricidal activity of a bispecific antibody blocking CD47 on mesothelin-positive tumors.
mAbs
Hatterer E,Chauchet X,Richard F,Barba L,Moine V,Chatel L,Broyer L,Pontini G,Bautzova T,Juan F,Calloud S,Bosson N,Charreton M,Masternak K,Buatois V,Shang L
300-25 was used in Cell Culture to show that MSLN targeted by bispecific antibodies (bsAbs)optimized ADCC activity by augmenting FcγR-IIIA activation and enhanced ADCP via a more efficient blockade of the CD47/SIRPα axis.
Fri Feb 12 00:00:00 EST 2021
Regulatory network mediated by RBP-J/NFATc1-miR182 controls inflammatory bone resorption.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Inoue K,Hu X,Zhao B
Sat Feb 01 00:00:00 EST 2020
IgA Triggers Cell Death of Neutrophils When Primed by Inflammatory Mediators.
Journal of immunology (Baltimore, Md. : 1950)
Wehrli M,Schneider C,Cortinas-Elizondo F,Verschoor D,Frias Boligan K,Adams OJ,Hlushchuk R,Engelmann C,Daudel F,Villiger PM,Seibold F,Yawalkar N,Vonarburg C,Miescher S,Lötscher M,Kaufmann T,Münz C,Mueller C,Djonov V,Simon HU,von Gunten S
Sun Nov 15 00:00:00 EST 2020
Anti-Inflammatory and Proresolving Effects of the Omega-6 Polyunsaturated Fatty Acid Adrenic Acid.
Journal of immunology (Baltimore, Md. : 1950)
Brouwers H,Jónasdóttir HS,Kuipers ME,Kwekkeboom JC,Auger JL,Gonzalez-Torres M,López-Vicario C,Clària J,Freysdottir J,Hardardottir I,Garrido-Mesa J,Norling LV,Perretti M,Huizinga TWJ,Kloppenburg M,Toes REM,Binstadt B,Giera M,Ioan-Facsinay A
Sun Nov 15 00:00:00 EST 2020
IL-10 Dampens an IL-17-Mediated Periodontitis-Associated Inflammatory Network.
Journal of immunology (Baltimore, Md. : 1950)
Sun L,Girnary M,Wang L,Jiao Y,Zeng E,Mercer K,Zhang J,Marchesan JT,Yu N,Moss K,Lei YL,Offenbacher S,Zhang S
Wed Apr 15 00:00:00 EDT 2020
Constitutive Expression of CCL22 Is Mediated by T Cell-Derived GM-CSF.
Journal of immunology (Baltimore, Md. : 1950)
Piseddu I,Röhrle N,Knott MML,Moder S,Eiber S,Schnell K,Vetter V,Meyer B,Layritz P,Kühnemuth B,Wiedemann GM,Gruen J,Perleberg C,Rapp M,Endres S,Anz D
Thu Oct 15 00:00:00 EDT 2020
Immune Complex-Driven Generation of Human Macrophages with Anti-Inflammatory and Growth-Promoting Activity.
Journal of immunology (Baltimore, Md. : 1950)
Dalby E,Christensen SM,Wang J,Hamidzadeh K,Chandrasekaran P,Hughitt VK,Tafuri WL,Arantes RME,Rodrigues IA,Herbst R,El-Sayed NM,Sims GP,Mosser DM
Wed Jul 01 00:00:00 EDT 2020
Siglec-15 on Osteoclasts Is Crucial for Bone Erosion in Serum-Transfer Arthritis.
Journal of immunology (Baltimore, Md. : 1950)
Korn MA,Schmitt H,Angermüller S,Chambers D,Seeling M,Lux UT,Brey S,Royzman D,Brückner C,Popp V,Percivalle E,Bäuerle T,Zinser E,Winkler TH,Steinkasserer A,Nimmerjahn F,Nitschke L
Sun Nov 15 00:00:00 EST 2020
LncRNA-mRNA expression profiles and functional networks in osteoclast differentiation.
Journal of cellular and molecular medicine
Liu W,Li Z,Cai Z,Xie Z,Li J,Li M,Cen S,Tang S,Zheng G,Ye G,Su H,Wang S,Wang P,Shen H,Wu Y
Tue Sep 01 00:00:00 EDT 2020
LncRNA-mRNA expression profiles and functional networks in osteoclast differentiation.
Journal of cellular and molecular medicine
Liu W,Li Z,Cai Z,Xie Z,Li J,Li M,Cen S,Tang S,Zheng G,Ye G,Su H,Wang S,Wang P,Shen H,Wu Y
Tue Sep 01 00:00:00 EDT 2020
Osteoidosis leads to altered differentiation and function of osteoclasts.
Journal of cellular and molecular medicine
Grünherz L,Prein C,Winkler T,Kirsch M,Hopfner U,Streichert T,Clausen-Schaumann H,Zustin J,Kirchhof K,Morlock MM,Machens HG,Schilling AF
Fri May 01 00:00:00 EDT 2020
Lentiviral gene therapy rescues p47phox chronic granulomatous disease and the ability to fight Salmonella infection in mice.
Gene therapy
Schejtman A,Aragão-Filho WC,Clare S,Zinicola M,Weisser M,Burns SO,Booth C,Gaspar HB,Thomas DC,Condino-Neto A,Thrasher AJ,Santilli G
Tue Sep 01 00:00:00 EDT 2020
Small extracellular vesicles derived from human MSCs prevent allergic airway inflammation via immunomodulation on pulmonary macrophages.
Cell death & disease
Fang SB,Zhang HY,Meng XC,Wang C,He BX,Peng YQ,Xu ZB,Fan XL,Wu ZJ,Wu ZC,Zheng SG,Fu QL
Mon Jun 01 00:00:00 EDT 2020
Therapeutic senescence via GPCR activation in synovial fibroblasts facilitates resolution of arthritis.
Nature communications
Montero-Melendez T,Nagano A,Chelala C,Filer A,Buckley CD,Perretti M
Thu Feb 06 00:00:00 EST 2020
Redox Regulator GLRX Is Associated With Tumor Immunity in Glioma.
Frontiers in immunology
Chang Y,Li G,Zhai Y,Huang L,Feng Y,Wang D,Zhang W,Hu H
300-25 was used in Cell Culture to investigate glutaredoxin regulation of glioma.
Mon Jun 21 00:00:00 EDT 2021
Glycogen metabolism regulates macrophage-mediated acute inflammatory responses.
Nature communications
Ma J,Wei K,Liu J,Tang K,Zhang H,Zhu L,Chen J,Li F,Xu P,Chen J,Liu J,Fang H,Tang L,Wang D,Zeng L,Sun W,Xie J,Liu Y,Huang B
Tue Apr 14 00:00:00 EDT 2020
Targeting the STING pathway in tumor-associated macrophages regulates innate immune sensing of gastric cancer cells.
Theranostics
Miao L,Qi J,Zhao Q,Wu QN,Wei DL,Wei XL,Liu J,Chen J,Zeng ZL,Ju HQ,Luo HY,Xu RH
300-25 was used in In vitro experiments to unveil a novel function of STING to activate the IL6R-JAK-IL24 pathway in macrophages.
Wed Apr 21 00:00:00 EDT 2021
A versatile and customizable low-cost 3D-printed open standard for microscopic imaging.
Nature communications
Diederich B,Lachmann R,Carlstedt S,Marsikova B,Wang H,Uwurukundo X,Mosig AS,Heintzmann R
Wed Nov 25 00:00:00 EST 2020
Interactions of Monocytes, HIV, and ART Identified by an Innovative scRNAseq Pipeline: Pathways to Reservoirs and HIV-Associated Comorbidities.
mBio
León-Rivera R,Morsey B,Niu M,Fox HS,Berman JW
300-25 was used in Cell Culture to develop an innovative single cell RNA sequencing (scRNAseq) pipeline that detects HIV and host transcripts simultaneously, enabling us to examine differences between HIV+ and exposed cells (HIVexp) mature monocytes.
Tue Jul 28 00:00:00 EDT 2020
Accumulation of synovial fluid CD19+CD24hiCD27+ B cells was associated with bone destruction in rheumatoid arthritis.
Scientific reports
Guo X,Xu T,Zheng J,Cui X,Li M,Wang K,Su M,Zhang H,Zheng K,Sun C,Song S,Liu H
Tue Sep 01 00:00:00 EDT 2020
Multiparametric Profiling of Engineered Nanomaterials: Unmasking the Surface Coating Effect.
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
Gallud A,Delaval M,Kinaret P,Marwah VS,Fortino V,Ytterberg J,Zubarev R,Skoog T,Kere J,Correia M,Loeschner K,Al-Ahmady Z,Kostarelos K,Ruiz J,Astruc D,Monopoli M,Handy R,Moya S,Savolainen K,Alenius H,Greco D,Fadeel B
Sun Nov 01 00:00:00 EDT 2020
Phosphoproteomics identifies microglial Siglec-F inflammatory response during neurodegeneration.
Molecular systems biology
Morshed N,Ralvenius WT,Nott A,Watson LA,Rodriguez FH,Akay LA,Joughin BA,Pao PC,Penney J,LaRocque L,Mastroeni D,Tsai LH,White FM
Tue Dec 01 00:00:00 EST 2020
Distinct macrophage phenotypes skewed by local granulocyte macrophage colony-stimulating factor (GM-CSF) and macrophage colony-stimulating factor (M-CSF) are associated with tissue destruction and intimal hyperplasia in giant cell arteritis.
Clinical & translational immunology
Jiemy WF,van Sleen Y,van der Geest KS,Ten Berge HA,Abdulahad WH,Sandovici M,Boots AM,Heeringa P,Brouwer E
Sat Apr 16 00:00:00 EDT 2022
The long non-coding RNA LUCAT1 is a negative feedback regulator of interferon responses in humans.
Nature communications
Agarwal S,Vierbuchen T,Ghosh S,Chan J,Jiang Z,Kandasamy RK,Ricci E,Fitzgerald KA
Fri Dec 11 00:00:00 EST 2020
Staphylococcus aureus-Derived α-Hemolysin Evokes Generation of Specialized Pro-resolving Mediators Promoting Inflammation Resolution.
Cell reports
Jordan PM,Gerstmeier J,Pace S,Bilancia R,Rao Z,Börner F,Miek L,Gutiérrez-Gutiérrez Ó,Arakandy V,Rossi A,Ialenti A,González-Estévez C,Löffler B,Tuchscherr L,Serhan CN,Werz O
300-25 was used in In vitro experiments to investigate the role of α-hemolysin from Staphylococcus aureus in the activation of specialized pro-resolving mediators.
Tue Oct 13 00:00:00 EDT 2020
Differentiation of Human Induced Pluripotent Stem Cells (hiPSCs) into Osteoclasts.
Bio-protocol
Chen IP
300-25 was used in Cell Culture to study efficient differentiation of hiPSCs into osteoclasts using a three-stage protocol which does not require a co-culture system; induces EBs into mesoderm differentiation in a homogenous manner; uses less cytokines for differentiation; requires only a short time for osteoclast maturation and produces sufficient numbers of osteoclasts for subsequent molecular analyses.
Sun Dec 20 00:00:00 EST 2020
RPTPε promotes M2-polarized macrophage migration through ROCK2 signaling and podosome formation.
Journal of cell science
Lapointe F,Turcotte S,Roy J,Bissonnette E,Rola-Pleszczynski M,Stankova J
300-25 was used in Cell Culture to show that differentiation and polarization of monocytes into M2-polarized hMDMs modulates the expression of PTPε isoforms and RPTPε is involved in podosome distribution, ROCK2 activation and migration in response to LTD4.
Tue Jan 21 00:00:00 EST 2020
Vorinostat in the acute neuroinflammatory form of X-linked adrenoleukodystrophy.
Annals of clinical and translational neurology
Zierfuss B,Weinhofer I,Kühl JS,Köhler W,Bley A,Zauner K,Binder J,Martinović K,Seiser C,Hertzberg C,Kemp S,Egger G,Leitner G,Bauer J,Wiesinger C,Kunze M,Forss-Petter S,Berger J
Fri May 01 00:00:00 EDT 2020
SLIT2/ROBO1-signaling inhibits macropinocytosis by opposing cortical cytoskeletal remodeling.
Nature communications
Bhosle VK,Mukherjee T,Huang YW,Patel S,Pang BWF,Liu GY,Glogauer M,Wu JY,Philpott DJ,Grinstein S,Robinson LA
Mon Aug 17 00:00:00 EDT 2020
Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages.
eLife
Dupont M,Souriant S,Balboa L,Vu Manh TP,Pingris K,Rousset S,Cougoule C,Rombouts Y,Poincloux R,Ben Neji M,Allers C,Kaushal D,Kuroda MJ,Benet S,Martinez-Picado J,Izquierdo-Useros N,Sasiain MDC,Maridonneau-Parini I,Neyrolles O,Vérollet C,Lugo-Villarino G
300-25 was used in Cell Culture to uncover a deleterious role for Siglec-1 in TB-HIV-1 co-infection and open new avenues to understand TNT biology.
Mon Mar 30 00:00:00 EDT 2020
Establishment and validation of an in vitro co-culture model for oral cell lines using human PBMC-derived osteoclasts, osteoblasts, fibroblasts and keratinocytes.
Scientific reports
Steller D,Scheibert A,Sturmheit T,Hakim SG
Thu Oct 08 00:00:00 EDT 2020
Neutrophil extracellular trap-associated RNA and LL37 enable self-amplifying inflammation in psoriasis.
Nature communications
Herster F,Bittner Z,Archer NK,Dickhöfer S,Eisel D,Eigenbrod T,Knorpp T,Schneiderhan-Marra N,Löffler MW,Kalbacher H,Vierbuchen T,Heine H,Miller LS,Hartl D,Freund L,Schäkel K,Heister M,Ghoreschi K,Weber ANR
Wed Jan 08 00:00:00 EST 2020
SMAC mimetics induce autophagy-dependent apoptosis of HIV-1-infected macrophages.
Cell death & disease
Campbell GR,To RK,Zhang G,Spector SA
Mon Jul 27 00:00:00 EDT 2020
Novel elvitegravir nanoformulation for drug delivery across the blood-brain barrier to achieve HIV-1 suppression in the CNS macrophages.
Scientific reports
Gong Y,Chowdhury P,Nagesh PKB,Rahman MA,Zhi K,Yallapu MM,Kumar S
Mon Mar 02 00:00:00 EST 2020
Neutrophil elastase promotes macrophage cell adhesion and cytokine production through the integrin-Src kinases pathway.
Scientific reports
Krotova K,Khodayari N,Oshins R,Aslanidi G,Brantly ML
Mon Sep 28 00:00:00 EDT 2020
IgA subclasses have different effector functions associated with distinct glycosylation profiles.
Nature communications
Steffen U,Koeleman CA,Sokolova MV,Bang H,Kleyer A,Rech J,Unterweger H,Schicht M,Garreis F,Hahn J,Andes FT,Hartmann F,Hahn M,Mahajan A,Paulsen F,Hoffmann M,Lochnit G,Muñoz LE,Wuhrer M,Falck D,Herrmann M,Schett G
Wed Jan 08 00:00:00 EST 2020
Regional Activation of Myosin II in Cancer Cells Drives Tumor Progression via a Secretory Cross-Talk with the Immune Microenvironment.
Cell
Georgouli M,Herraiz C,Crosas-Molist E,Fanshawe B,Maiques O,Perdrix A,Pandya P,Rodriguez-Hernandez I,Ilieva KM,Cantelli G,Karagiannis P,Mele S,Lam H,Josephs DH,Matias-Guiu X,Marti RM,Nestle FO,Orgaz JL,Malanchi I,Fruhwirth GO,Karagiannis SN,Sanz-Moreno V
Thu Feb 07 00:00:00 EST 2019
The Cytokine TNF Promotes Transcription Factor SREBP Activity and Binding to Inflammatory Genes to Activate Macrophages and Limit Tissue Repair.
Immunity
Kusnadi A,Park SH,Yuan R,Pannellini T,Giannopoulou E,Oliver D,Lu T,Park-Min KH,Ivashkiv LB
Tue Aug 20 00:00:00 EDT 2019
Anti-commensal IgG Drives Intestinal Inflammation and Type 17 Immunity in Ulcerative Colitis.
Immunity
Castro-Dopico T,Dennison TW,Ferdinand JR,Mathews RJ,Fleming A,Clift D,Stewart BJ,Jing C,Strongili K,Labzin LI,Monk EJM,Saeb-Parsy K,Bryant CE,Clare S,Parkes M,Clatworthy MR
Tue Apr 16 00:00:00 EDT 2019
The Short Chain Fatty Acid Butyrate Imprints an Antimicrobial Program in Macrophages.
Immunity
Schulthess J,Pandey S,Capitani M,Rue-Albrecht KC,Arnold I,Franchini F,Chomka A,Ilott NE,Johnston DGW,Pires E,McCullagh J,Sansom SN,Arancibia-Cárcamo CV,Uhlig HH,Powrie F
Tue Feb 19 00:00:00 EST 2019
CSF1R inhibitors exhibit antitumor activity in acute myeloid leukemia by blocking paracrine signals from support cells.
Blood
Edwards DK,Watanabe-Smith K,Rofelty A,Damnernsawad A,Laderas T,Lamble A,Lind EF,Kaempf A,Mori M,Rosenberg M,d'Almeida A,Long N,Agarwal A,Sweeney DT,Loriaux M,McWeeney SK,Tyner JW
Thu Feb 07 00:00:00 EST 2019
Low-dose chidamide restores immune tolerance in ITP in mice and humans.
Blood
Zhao HY,Ma YH,Li DQ,Sun T,Li LZ,Li P,Liu XG,Zhou H,Hou Y,Liu Y,Han PP,Zhao YJ,Jing FM,Peng J,Hou M
Thu Feb 14 00:00:00 EST 2019
IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion.
The Journal of clinical investigation
Chan LC,Li CW,Xia W,Hsu JM,Lee HH,Cha JH,Wang HL,Yang WH,Yen EY,Chang WC,Zha Z,Lim SO,Lai YJ,Liu C,Liu J,Dong Q,Yang Y,Sun L,Wei Y,Nie L,Hsu JL,Li H,Ye Q,Hassan MM,Amin HM,Kaseb AO,Lin X,Wang SC,Hung MC
Mon Jul 15 00:00:00 EDT 2019
Repurposing rotavirus vaccines for intratumoral immunotherapy can overcome resistance to immune checkpoint blockade.
Science translational medicine
Shekarian T,Sivado E,Jallas AC,Depil S,Kielbassa J,Janoueix-Lerosey I,Hutter G,Goutagny N,Bergeron C,Viari A,Valsesia-Wittmann S,Caux C,Marabelle A
300-25 was used in Sample Preparation (FC/FACS) to study whether anti-infectious disease vaccines could be used as a commercially available source of immunostimulatory agents for cancer immunotherapy.
Wed Oct 23 00:00:00 EDT 2019
Development of a Chimeric Model to Study and Manipulate Human Microglia In Vivo.
Neuron
Hasselmann J,Coburn MA,England W,Figueroa Velez DX,Kiani Shabestari S,Tu CH,McQuade A,Kolahdouzan M,Echeverria K,Claes C,Nakayama T,Azevedo R,Coufal NG,Han CZ,Cummings BJ,Davtyan H,Glass CK,Healy LM,Gandhi SP,Spitale RC,Blurton-Jones M
Wed Sep 25 00:00:00 EDT 2019
Streptococcus pyogenes evades adaptive immunity through specific IgG glycan hydrolysis.
The Journal of experimental medicine
Naegeli A,Bratanis E,Karlsson C,Shannon O,Kalluru R,Linder A,Malmström J,Collin M
Mon Jul 01 00:00:00 EDT 2019
A major role for ferroptosis in Mycobacterium tuberculosis-induced cell death and tissue necrosis.
The Journal of experimental medicine
Amaral EP,Costa DL,Namasivayam S,Riteau N,Kamenyeva O,Mittereder L,Mayer-Barber KD,Andrade BB,Sher A
Mon Mar 04 00:00:00 EST 2019
Calpain drives pyroptotic vimentin cleavage, intermediate filament loss, and cell rupture that mediates immunostimulation.
Proceedings of the National Academy of Sciences of the United States of America
Davis MA,Fairgrieve MR,Den Hartigh A,Yakovenko O,Duvvuri B,Lood C,Thomas WE,Fink SL,Gale M
Tue Mar 12 00:00:00 EDT 2019
Constitutive interferon signaling maintains critical threshold of MLKL expression to license necroptosis.
Cell death and differentiation
Sarhan J,Liu BC,Muendlein HI,Weindel CG,Smirnova I,Tang AY,Ilyukha V,Sorokin M,Buzdin A,Fitzgerald KA,Poltorak A
Tue Jan 01 00:00:00 EST 2019
Tumour cell-derived debris and IgG synergistically promote metastasis of pancreatic cancer by inducing inflammation via tumour-associated macrophages.
British journal of cancer
Chen Q,Wang J,Zhang Q,Zhang J,Lou Y,Yang J,Chen Y,Wei T,Zhang J,Fu Q,Ye M,Zhang X,Dang X,Liang T,Bai X
Tue Oct 01 00:00:00 EDT 2019
Mesenchymal Stromal Cell-Seeded Biomimetic Scaffolds as a Factory of Soluble RANKL in Rankl-Deficient Osteopetrosis.
Stem cells translational medicine
Menale C,Campodoni E,Palagano E,Mantero S,Erreni M,Inforzato A,Fontana E,Schena F,Van't Hof R,Sandri M,Tampieri A,Villa A,Sobacchi C
Tue Jan 01 00:00:00 EST 2019
Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages.
European journal of immunology
Maeda A,Digifico E,Andon FT,Mantovani A,Allavena P
Wed May 01 00:00:00 EDT 2019
A Human Gain-of-Function STING Mutation Causes Immunodeficiency and Gammaherpesvirus-Induced Pulmonary Fibrosis in Mice.
Journal of virology
Bennion BG,Ingle H,Ai TL,Miner CA,Platt DJ,Smith AM,Baldridge MT,Miner JJ
300-25 was used in Cell Culture to investigate STING N153S knock-in mice inflammatory response and pulmonary fibrosis.
Fri Feb 15 00:00:00 EST 2019
The mannose 6-phosphate/insulin-like growth factor 2 receptor mediates plasminogen-induced efferocytosis.
Journal of leukocyte biology
Ohradanova-Repic A,Machacek C,Donner C,Mühlgrabner V,Petrovčíková E,Zahradníková A,Vičíková K,Hořejší V,Stockinger H,Leksa V
Fri Mar 01 00:00:00 EST 2019
Citrullination Controls Dendritic Cell Transdifferentiation into Osteoclasts.
Journal of immunology (Baltimore, Md. : 1950)
Krishnamurthy A,Ytterberg AJ,Sun M,Sakuraba K,Steen J,Joshua V,Tarasova NK,Malmström V,Wähämaa H,Réthi B,Catrina AI
Sat Jun 01 00:00:00 EDT 2019
Growth Factor-like Gene Regulation Is Separable from Survival and Maturation in Antibody-Secreting Cells.
Journal of immunology (Baltimore, Md. : 1950)
Stephenson S,Care MA,Fan I,Zougman A,Westhead DR,Doody GM,Tooze RM
Fri Feb 15 00:00:00 EST 2019
Monocyte/Macrophage Abnormalities Specific to Rheumatoid Arthritis Are Linked to miR-155 and Are Differentially Modulated by Different TNF Inhibitors.
Journal of immunology (Baltimore, Md. : 1950)
Paoletti A,Rohmer J,Ly B,Pascaud J,Rivière E,Seror R,Le Goff B,Nocturne G,Mariette X
Tue Oct 01 00:00:00 EDT 2019
Identification of Neoantigen-Reactive Tumor-Infiltrating Lymphocytes in Primary Bladder Cancer.
Journal of immunology (Baltimore, Md. : 1950)
Leko V,McDuffie LA,Zheng Z,Gartner JJ,Prickett TD,Apolo AB,Agarwal PK,Rosenberg SA,Lu YC
Sat Jun 15 00:00:00 EDT 2019
Intra- and Extracellular Degradation of Neutrophil Extracellular Traps by Macrophages and Dendritic Cells.
Journal of immunology (Baltimore, Md. : 1950)
Lazzaretto B,Fadeel B
Tue Oct 15 00:00:00 EDT 2019
Dynamic gene regulation by nuclear colony-stimulating factor 1 receptor in human monocytes and macrophages.
Nature communications
Bencheikh L,Diop MK,Rivière J,Imanci A,Pierron G,Souquere S,Naimo A,Morabito M,Dussiot M,De Leeuw F,Lobry C,Solary E,Droin N
Fri Apr 26 00:00:00 EDT 2019
The three cytokines IL-1β, IL-18, and IL-1α share related but distinct secretory routes.
The Journal of biological chemistry
Tapia VS,Daniels MJD,Palazón-Riquelme P,Dewhurst M,Luheshi NM,Rivers-Auty J,Green J,Redondo-Castro E,Kaldis P,Lopez-Castejon G,Brough D
Fri May 24 00:00:00 EDT 2019
Mannan-Binding Lectin Attenuates Inflammatory Arthritis Through the Suppression of Osteoclastogenesis.
Frontiers in immunology
Dong L,Wu J,Chen K,Xie J,Wang Y,Li D,Liu Y,Yin A,Zhao Y,Han Y,Zhou J,Zhang L,Chen Z,Zuo D
300-25 was used in Cell Culture to investigate the role of mannan-binding lectin on murine adjuvant-induced arthritis.
Wed Oct 28 00:00:00 EDT 2020
Fibroblast-Mediated Immunoregulation of Macrophage Function Is Maintained after Irradiation.
Cancers
Berzaghi R,Ahktar MA,Islam A,Pedersen BD,Hellevik T,Martinez-Zubiaurre I
300-25 was used in Sample Cell Culture to study whether ionizing radiation alters the cancer-associated fibroblast-mediated immunoregulatory effects on macrophages.
Fri May 17 00:00:00 EDT 2019
Immunoregulatory role of exosomes derived from differentiating mesenchymal stromal cells on inflammation and osteogenesis.
Journal of tissue engineering and regenerative medicine
Wei F,Li Z,Crawford R,Xiao Y,Zhou Y
300-25 was used in Cell Culture to suggest that exosomes derived from differentiating mesenchymal stem/stromal cells play a unique osteoimmunomodulatory role in the regulation of bone dynamics.
Fri Nov 01 00:00:00 EDT 2019
G-protein Gα13 functions as a cytoskeletal and mitochondrial regulator to restrain osteoclast function.
Scientific reports
Nakano S,Inoue K,Xu C,Deng Z,Syrovatkina V,Vitone G,Zhao L,Huang XY,Zhao B
Tue Mar 12 00:00:00 EDT 2019
Monocarboxylate transporter 4 (MCT4) is a high affinity transporter capable of exporting lactate in high-lactate microenvironments.
The Journal of biological chemistry
Contreras-Baeza Y,Sandoval PY,Alarcón R,Galaz A,Cortés-Molina F,Alegría K,Baeza-Lehnert F,Arce-Molina R,Guequén A,Flores CA,San Martín A,Barros LF
Fri Dec 27 00:00:00 EST 2019
Tuberculosis Exacerbates HIV-1 Infection through IL-10/STAT3-Dependent Tunneling Nanotube Formation in Macrophages.
Cell reports
Souriant S,Balboa L,Dupont M,Pingris K,Kviatcovsky D,Cougoule C,Lastrucci C,Bah A,Gasser R,Poincloux R,Raynaud-Messina B,Al Saati T,Inwentarz S,Poggi S,Moraña EJ,González-Montaner P,Corti M,Lagane B,Vergne I,Allers C,Kaushal D,Kuroda MJ,Sasiain MDC,Neyrolles O,Maridonneau-Parini I,Lugo-Villarino G,Vérollet C
300-25 was used in Cell Culture to reveal that TNTs facilitate viral transfer and amplification, thereby promoting TNT formation as a mechanism to be explored in TB/AIDS potential therapeutics.
Tue Mar 26 00:00:00 EDT 2019
Enhanced Macrophage Pannexin 1 Expression and Hemichannel Activation Exacerbates Lethal Experimental Sepsis.
Scientific reports
Chen W,Zhu S,Wang Y,Li J,Qiang X,Zhao X,Yang H,D'Angelo J,Becker L,Wang P,Tracey KJ,Wang H
Thu Jan 17 00:00:00 EST 2019
Abnormal inhibition of osteoclastogenesis by mesenchymal stem cells through the miR-4284/CXCL5 axis in ankylosing spondylitis.
Cell death & disease
Liu W,Wang P,Xie Z,Wang S,Ma M,Li J,Li M,Cen S,Tang S,Zheng G,Ye G,Wu X,Wu Y,Shen H
Mon Feb 25 00:00:00 EST 2019
In-Depth Characterization of Monocyte-Derived Macrophages using a Mass Cytometry-Based Phagocytosis Assay.
Scientific reports
Schulz D,Severin Y,Zanotelli VRT,Bodenmiller B
Wed Feb 13 00:00:00 EST 2019
Metabolic Reprograming of Cystic Fibrosis Macrophages via the IRE1α Arm of the Unfolded Protein Response Results in Exacerbated Inflammation.
Frontiers in immunology
Lara-Reyna S,Scambler T,Holbrook J,Wong C,Jarosz-Griffiths HH,Martinon F,Savic S,Peckham D,McDermott MF
300-25 was used in Sample Preparation (FC/FACS) to investigate signalling pathways following cystic fibrosis transmembrane conductance regulator mutations.
Tue Oct 13 00:00:00 EDT 2020
Partial ligand-receptor engagement yields functional bias at the human complement receptor, C5aR1.
The Journal of biological chemistry
Pandey S,Li XX,Srivastava A,Baidya M,Kumari P,Dwivedi H,Chaturvedi M,Ghosh E,Woodruff TM,Shukla AK
Fri Jun 14 00:00:00 EDT 2019
Three cell deaths and a funeral: macrophage clearance of cells undergoing distinct modes of cell death.
Cell death discovery
Klöditz K,Fadeel B
Tue Sep 29 00:00:00 EDT 2020
Signal Integration and Transcriptional Regulation of the Inflammatory Response Mediated by the GM-/M-CSF Signaling Axis in Human Monocytes.
Cell reports
Rodriguez RM,Suarez-Alvarez B,Lavín JL,Ascensión AM,Gonzalez M,Lozano JJ,Raneros AB,Bulnes PD,Vidal-Castiñeira JR,Huidobro C,Martin-Martin C,Sanz AB,Ruiz-Ortega M,Puig-Kröger A,Corbí AL,Araúzo-Bravo MJ,Aransay AM,Lopez-Larrea C
300-25 was used in Cell Culture to study how cells integrate the macrophage colony-stimulating factor (M-CSF) and granulocyte-macrophage CSF (GM-CSF) cytokines signals which are opposing regulators of the inflammatory program.
Tue Oct 22 00:00:00 EDT 2019
PSEN1ΔE9, APPswe, and APOE4 Confer Disparate Phenotypes in Human iPSC-Derived Microglia.
Stem cell reports
Konttinen H,Cabral-da-Silva MEC,Ohtonen S,Wojciechowski S,Shakirzyanova A,Caligola S,Giugno R,Ishchenko Y,Hernández D,Fazaludeen MF,Eamen S,Budia MG,Fagerlund I,Scoyni F,Korhonen P,Huber N,Haapasalo A,Hewitt AW,Vickers J,Smith GC,Oksanen M,Graff C,Kanninen KM,Lehtonen S,Propson N,Schwartz MP,Pébay A,Koistinaho J,Ooi L,Malm T
Tue Oct 08 00:00:00 EDT 2019
MiR-146a is over-expressed and controls IL-6 production in cystic fibrosis macrophages.
Scientific reports
Luly FR,Lévêque M,Licursi V,Cimino G,Martin-Chouly C,Théret N,Negri R,Cavinato L,Ascenzioni F,Del Porto P
Thu Nov 07 00:00:00 EST 2019
ADP secreted by dying melanoma cells mediates chemotaxis and chemokine secretion of macrophages via the purinergic receptor P2Y12.
Cell death & disease
Kloss L,Dollt C,Schledzewski K,Krewer A,Melchers S,Manta C,Sticht C,Torre C,Utikal J,Umansky V,Schmieder A
Mon Oct 07 00:00:00 EDT 2019
Extracellular nicotinate phosphoribosyltransferase binds Toll like receptor 4 and mediates inflammation.
Nature communications
Managò A,Audrito V,Mazzola F,Sorci L,Gaudino F,Gizzi K,Vitale N,Incarnato D,Minazzato G,Ianniello A,Varriale A,D'Auria S,Mengozzi G,Politano G,Oliviero S,Raffaelli N,Deaglio S
Wed Sep 11 00:00:00 EDT 2019
Immune-centric network of cytokines and cells in disease context identified by computational mining of PubMed.
Nature biotechnology
Kveler K,Starosvetsky E,Ziv-Kenet A,Kalugny Y,Gorelik Y,Shalev-Malul G,Aizenbud-Reshef N,Dubovik T,Briller M,Campbell J,Rieckmann JC,Asbeh N,Rimar D,Meissner F,Wiser J,Shen-Orr SS
Wed Aug 01 00:00:00 EDT 2018
Intrinsic Immunity Shapes Viral Resistance of Stem Cells.
Cell
Wu X,Dao Thi VL,Huang Y,Billerbeck E,Saha D,Hoffmann HH,Wang Y,Silva LAV,Sarbanes S,Sun T,Andrus L,Yu Y,Quirk C,Li M,MacDonald MR,Schneider WM,An X,Rosenberg BR,Rice CM
Thu Jan 25 00:00:00 EST 2018
Trophoblast-derived CXCL16 induces M2 macrophage polarization that in turn inactivates NK cells at the maternal-fetal interface.
Cellular & molecular immunology
Wang XQ,Zhou WJ,Hou XX,Fu Q,Li DJ
Sat Dec 01 00:00:00 EST 2018
Blocking immunoinhibitory receptor LILRB2 reprograms tumor-associated myeloid cells and promotes antitumor immunity.
The Journal of clinical investigation
Chen HM,van der Touw W,Wang YS,Kang K,Mai S,Zhang J,Alsina-Beauchamp D,Duty JA,Mungamuri SK,Zhang B,Moran T,Flavell R,Aaronson S,Hu HM,Arase H,Ramanathan S,Flores R,Pan PY,Chen SH
Mon Dec 03 00:00:00 EST 2018
APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types.
Neuron
Lin YT,Seo J,Gao F,Feldman HM,Wen HL,Penney J,Cam HP,Gjoneska E,Raja WK,Cheng J,Rueda R,Kritskiy O,Abdurrob F,Peng Z,Milo B,Yu CJ,Elmsaouri S,Dey D,Ko T,Yankner BA,Tsai LH
Wed Jun 27 00:00:00 EDT 2018
A Combination of Ontogeny and CNS Environment Establishes Microglial Identity.
Neuron
Bennett FC,Bennett ML,Yaqoob F,Mulinyawe SB,Grant GA,Hayden Gephart M,Plowey ED,Barres BA
Wed Jun 27 00:00:00 EDT 2018
Human monocytes and macrophages regulate immune tolerance via integrin αvβ8-mediated TGFβ activation.
The Journal of experimental medicine
Kelly A,Gunaltay S,McEntee CP,Shuttleworth EE,Smedley C,Houston SA,Fenton TM,Levison S,Mann ER,Travis MA
Mon Nov 05 00:00:00 EST 2018
A Human IPS Model Implicates Embryonic B-Myeloid Fate Restriction as Developmental Susceptibility to B Acute Lymphoblastic Leukemia-Associated ETV6-RUNX1.
Developmental cell
Böiers C,Richardson SE,Laycock E,Zriwil A,Turati VA,Brown J,Wray JP,Wang D,James C,Herrero J,Sitnicka E,Karlsson S,Smith AJH,Jacobsen SEW,Enver T
300-25 was used in Cell Culture to explore the link between embryonic B-myeloid fate restriction and ETV6-RUNX1 mutant acute B-lymphoblastic leukaemia development.
Mon Feb 05 00:00:00 EST 2018
Enhancer variants reveal a conserved transcription factor network governed by PU.1 during osteoclast differentiation.
Bone research
Carey HA,Hildreth BE,Geisler JA,Nickel MC,Cabrera J,Ghosh S,Jiang Y,Yan J,Lee J,Makam S,Young NA,Valiente GR,Jarjour WN,Huang K,Rosol TJ,Toribio RE,Charles JF,Ostrowski MC,Sharma SM
Tue Sep 29 00:00:00 EDT 2020
Membrane-wrapped nanoparticles probe divergent roles of GM3 and phosphatidylserine in lipid-mediated viral entry pathways.
Proceedings of the National Academy of Sciences of the United States of America
Xu F,Bandara A,Akiyama H,Eshaghi B,Stelter D,Keyes T,Straub JE,Gummuluru S,Reinhard BM
Tue Sep 25 00:00:00 EDT 2018
USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation.
EMBO reports
Palazón-Riquelme P,Worboys JD,Green J,Valera A,Martín-Sánchez F,Pellegrini C,Brough D,López-Castejón G
Mon Oct 01 00:00:00 EDT 2018
Extracellular Purine Metabolism Is the Switchboard of Immunosuppressive Macrophages and a Novel Target to Treat Diseases With Macrophage Imbalances.
Frontiers in immunology
Ohradanova-Repic A,Machacek C,Charvet C,Lager F,Le Roux D,Platzer R,Leksa V,Mitulovic G,Burkard TR,Zlabinger GJ,Fischer MB,Feuillet V,Renault G,Blüml S,Benko M,Suchanek M,Huppa JB,Matsuyama T,Cavaco-Paulo A,Bismuth G,Stockinger H
Fri Jun 14 00:00:00 EDT 2019
Blockade of insulin-like growth factors increases efficacy of paclitaxel in metastatic breast cancer.
Oncogene
Ireland L,Santos A,Campbell F,Figueiredo C,Hammond D,Ellies LG,Weyer-Czernilofsky U,Bogenrieder T,Schmid M,Mielgo A
Sun Apr 01 00:00:00 EDT 2018
X-linked inhibitor of apoptosis inhibition sensitizes acute myeloid leukemia cell response to TRAIL and chemotherapy through potentiated induction of proapoptotic machinery.
Molecular oncology
Zhou J,Lu X,Tan TZ,Chng WJ
Mon Jan 01 00:00:00 EST 2018
ILDR2 Is a Novel B7-like Protein That Negatively Regulates T Cell Responses.
Journal of immunology (Baltimore, Md. : 1950)
Hecht I,Toporik A,Podojil JR,Vaknin I,Cojocaru G,Oren A,Aizman E,Liang SC,Leung L,Dicken Y,Novik A,Marbach-Bar N,Elmesmari A,Tange C,Gilmour A,McIntyre D,Kurowska-Stolarska M,McNamee K,Leitner J,Greenwald S,Dassa L,Levine Z,Steinberger P,Williams RO,Miller SD,McInnes IB,Neria E,Rotman G
Thu Mar 15 00:00:00 EDT 2018
Multiple Homozygous Variants in the STING-Encoding TMEM173 Gene in HIV Long-Term Nonprogressors.
Journal of immunology (Baltimore, Md. : 1950)
Nissen SK,Pedersen JG,Helleberg M,Kjær K,Thavachelvam K,Obel N,Tolstrup M,Jakobsen MR,Mogensen TH
Tue May 15 00:00:00 EDT 2018
IL-1β Induces Pathologically Activated Osteoclasts Bearing Extremely High Levels of Resorbing Activity: A Possible Pathological Subpopulation of Osteoclasts, Accompanied by Suppressed Expression of Kindlin-3 and Talin-1.
Journal of immunology (Baltimore, Md. : 1950)
Shiratori T,Kyumoto-Nakamura Y,Kukita A,Uehara N,Zhang J,Koda K,Kamiya M,Badawy T,Tomoda E,Xu X,Yamaza T,Urano Y,Koyano K,Kukita T
Mon Jan 01 00:00:00 EST 2018
The PI3Kδ-Selective Inhibitor Idelalisib Minimally Interferes with Immune Effector Function Mediated by Rituximab or Obinutuzumab and Significantly Augments B Cell Depletion In Vivo.
Journal of immunology (Baltimore, Md. : 1950)
Palazzo A,Herter S,Grosmaire L,Jones R,Frey CR,Limani F,Bacac M,Umana P,Oldham RJ,Marshall MJE,Cox KL,Turaj AH,Cragg MS,Klein C,Carter MJ,Tannheimer S
Sun Apr 01 00:00:00 EDT 2018
Efficacy and Mechanism of Antitumor Activity of an Antibody Targeting Transferrin Receptor 1 in Mouse Models of Human Multiple Myeloma.
Journal of immunology (Baltimore, Md. : 1950)
Leoh LS,Kim YK,Candelaria PV,Martínez-Maza O,Daniels-Wells TR,Penichet ML
Tue May 15 00:00:00 EDT 2018
Glatiramer Acetate Enhances Myeloid-Derived Suppressor Cell Function via Recognition of Paired Ig-like Receptor B.
Journal of immunology (Baltimore, Md. : 1950)
van der Touw W,Kang K,Luan Y,Ma G,Mai S,Qin L,Bian G,Zhang R,Mungamuri SK,Hu HM,Zhang CC,Aaronson SA,Feldmann M,Yang WC,Chen SH,Pan PY
Sat Sep 15 00:00:00 EDT 2018
BMP-2 induces human mononuclear cell chemotaxis and adhesion and modulates monocyte-to-macrophage differentiation.
Journal of cellular and molecular medicine
Pardali E,Makowski LM,Leffers M,Borgscheiper A,Waltenberger J
Thu Nov 01 00:00:00 EDT 2018
A High Content Screen in Macrophages Identifies Small Molecule Modulators of STING-IRF3 and NFkB Signaling.
ACS chemical biology
Koch PD,Miller HR,Yu G,Tallarico JA,Sorger PK,Wang Y,Feng Y,Thomas JR,Ross NT,Mitchison T
300-25 was used in In vitro experiments to study advancing IRF3 and NFkB pathway understanding and discovering probes for immunology research by screened a library of bioactive small molecules for activators and inhibitors of innate immune signaling through these pathways.
Fri Apr 20 00:00:00 EDT 2018
Characterizing replication kinetics and plaque production of type I feline infectious peritonitis virus in three feline cell lines.
Virology
O'Brien A,Mettelman RC,Volk A,André NM,Whittaker GR,Baker SC
300-25 was used in Cell Culture to characterize replication kinetics and plaque formation of a model type I strain FIPV Black in Fcwf-4 cells established at Cornell University (Fcwf-4 CU) to determine that the Fcwf-4 CU cells are morphologically distinct from feline bone marrow-derived macrophages and are less sensitive to exogenous type I interferon than Fcwf-4 cells purchased from ATCC.
Sat Dec 01 00:00:00 EST 2018
A correlative and quantitative imaging approach enabling characterization of primary cell-cell communication: Case of human CD4+ T cell-macrophage immunological synapses.
Scientific reports
Kasprowicz R,Rand E,O'Toole PJ,Signoret N
Tue May 22 00:00:00 EDT 2018
Bone protection by inhibition of microRNA-182.
Nature communications
Inoue K,Deng Z,Chen Y,Giannopoulou E,Xu R,Gong S,Greenblatt MB,Mangala LS,Lopez-Berestein G,Kirsch DG,Sood AK,Zhao L,Zhao B
Fri Oct 05 00:00:00 EDT 2018
Macrophage Cytokines Enhance Cell Proliferation of Normal Prostate Epithelial Cells through Activation of ERK and Akt.
Scientific reports
Dang T,Liou GY
Wed May 16 00:00:00 EDT 2018
Angiogenic factor-driven inflammation promotes extravasation of human proangiogenic monocytes to tumours.
Nature communications
Sidibe A,Ropraz P,Jemelin S,Emre Y,Poittevin M,Pocard M,Bradfield PF,Imhof BA
Wed Jan 24 00:00:00 EST 2018
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.
Cell death & disease
Lee CJ,Moon SJ,Jeong JH,Lee S,Lee MH,Yoo SM,Lee HS,Kang HC,Lee JY,Lee WS,Lee HJ,Kim EK,Jhun JY,Cho ML,Min JK,Cho YY
Wed Mar 14 00:00:00 EDT 2018
Kaempferol targeting on the fibroblast growth factor receptor 3-ribosomal S6 kinase 2 signaling axis prevents the development of rheumatoid arthritis.
Cell death & disease
Lee CJ,Moon SJ,Jeong JH,Lee S,Lee MH,Yoo SM,Lee HS,Kang HC,Lee JY,Lee WS,Lee HJ,Kim EK,Jhun JY,Cho ML,Min JK,Cho YY
Wed Mar 14 00:00:00 EDT 2018
NF-κB/MAPK activation underlies ACVR1-mediated inflammation in human heterotopic ossification.
JCI insight
Barruet E,Morales BM,Cain CJ,Ton AN,Wentworth KL,Chan TV,Moody TA,Haks MC,Ottenhoff TH,Hellman J,Nakamura MC,Hsiao EC
300-25 was used in In vitro experiments to examine the potential link between bone morphogenetic proteins and inflammation in patients with fibrodysplasia ossificans progressiva.
Thu Nov 15 00:00:00 EST 2018
Aluminum fluoride-18 labeled folate enables in vivo detection of atherosclerotic plaque inflammation by positron emission tomography.
Scientific reports
Silvola JMU,Li XG,Virta J,Marjamäki P,Liljenbäck H,Hytönen JP,Tarkia M,Saunavaara V,Hurme S,Palani S,Hakovirta H,Ylä-Herttuala S,Saukko P,Chen Q,Low PS,Knuuti J,Saraste A,Roivainen A
Tue Jun 26 00:00:00 EDT 2018
A proline deletion in IFNAR1 impairs IFN-signaling and underlies increased resistance to tuberculosis in humans.
Nature communications
Zhang G,deWeerd NA,Stifter SA,Liu L,Zhou B,Wang W,Zhou Y,Ying B,Hu X,Matthews AY,Ellis M,Triccas JA,Hertzog PJ,Britton WJ,Chen X,Feng CG
Mon Jan 08 00:00:00 EST 2018
Combination therapy with proteasome inhibitors and TLR agonists enhances tumour cell death and IL-1β production.
Cell death & disease
Tang AC,Rahavi SM,Fung SY,Lu HY,Yang H,Lim CJ,Reid GS,Turvey SE
Wed Feb 07 00:00:00 EST 2018
Effects of low molecular weight heparin on the polarization and cytokine profile of macrophages and T helper cells in vitro.
Scientific reports
Bruno V,Svensson-Arvelund J,Rubér M,Berg G,Piccione E,Jenmalm MC,Ernerudh J
Thu Mar 08 00:00:00 EST 2018
HIV-1 intron-containing RNA expression induces innate immune activation and T cell dysfunction.
Nature communications
Akiyama H,Miller CM,Ettinger CR,Belkina AC,Snyder-Cappione JE,Gummuluru S
Mon Aug 27 00:00:00 EDT 2018
Azithromycin promotes alternatively activated macrophage phenotype in systematic lupus erythematosus via PI3K/Akt signaling pathway.
Cell death & disease
Wang J,Xie L,Wang S,Lin J,Liang J,Xu J
Mon Oct 22 00:00:00 EDT 2018
Induction of autophagy by PI3K/MTOR and PI3K/MTOR/BRD4 inhibitors suppresses HIV-1 replication.
The Journal of biological chemistry
Campbell GR,Bruckman RS,Herns SD,Joshi S,Durden DL,Spector SA
Fri Apr 20 00:00:00 EDT 2018
A three-dimensional hybrid pacemaker electrode seamlessly integrates into engineered, functional human cardiac tissue in vitro.
Scientific reports
Weigel T,Schmitz T,Pfister T,Gaetzner S,Jannasch M,Al-Hijailan R,Schürlein S,Suliman S,Mustafa K,Hansmann J
Fri Sep 28 00:00:00 EDT 2018
The novel immunoglobulin super family receptor SLAMF9 identified in TAM of murine and human melanoma influences pro-inflammatory cytokine secretion and migration.
Cell death & disease
Dollt C,Michel J,Kloss L,Melchers S,Schledzewski K,Becker K,Sauer A,Krewer A,Koll F,Schmieder A
Wed Sep 19 00:00:00 EDT 2018
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages.
EBioMedicine
Rhys HI,Dell'Accio F,Pitzalis C,Moore A,Norling LV,Perretti M
300-25 was used in Cell Culture to present new mechanistic evidence underpinning the anti-inflammatory and anti-arthritic properties of neutrophil microvesicles.
Thu Mar 01 00:00:00 EST 2018
Integrin CD11b activation drives anti-tumor innate immunity.
Nature communications
Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA
Wed Dec 19 00:00:00 EST 2018
Integrin CD11b activation drives anti-tumor innate immunity.
Nature communications
Schmid MC,Khan SQ,Kaneda MM,Pathria P,Shepard R,Louis TL,Anand S,Woo G,Leem C,Faridi MH,Geraghty T,Rajagopalan A,Gupta S,Ahmed M,Vazquez-Padron RI,Cheresh DA,Gupta V,Varner JA
Wed Dec 19 00:00:00 EST 2018
Systematic RNA-interference in primary human monocyte-derived macrophages: A high-throughput platform to study foam cell formation.
Scientific reports
Domschke G,Linden F,Pawig L,Hafner A,Akhavanpoor M,Reymann J,Doesch AO,Erbel C,Weber C,Katus HA,Noels H,Erfle H,Gleissner CA,Runz H
Thu Jul 12 00:00:00 EDT 2018
Assessment of ATP8B1 Deficiency in Pediatric Patients With Cholestasis Using Peripheral Blood Monocyte-Derived Macrophages.
EBioMedicine
Hayashi H,Naoi S,Togawa T,Hirose Y,Kondou H,Hasegawa Y,Abukawa D,Sasaki M,Muroya K,Watanabe S,Nakano S,Minowa K,Inui A,Fukuda A,Kasahara M,Nagasaka H,Bessho K,Suzuki M,Kusuhara H
300-25 was used in Cell Culture to show that ATP8B1 deficiency caused incomplete polarization of HMDM into M2c and that phenotypic analysis of M2c helps to identify PFIC1 patients with no apparent disease-causing mutations in ATP8B1.
Mon Jan 01 00:00:00 EST 2018
Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia.
Stem cell reports
Brownjohn PW,Smith J,Solanki R,Lohmann E,Houlden H,Hardy J,Dietmann S,Livesey FJ
Tue Apr 10 00:00:00 EDT 2018
oxLDL inhibits differentiation and functional activity of osteoclasts via scavenger receptor-A mediated autophagy and cathepsin K secretion.
Scientific reports
Dawodu D,Patecki M,Hegermann J,Dumler I,Haller H,Kiyan Y
Thu Aug 02 00:00:00 EDT 2018
Macrophages are exploited from an innate wound healing response to facilitate cancer metastasis.
Nature communications
Muliaditan T,Caron J,Okesola M,Opzoomer JW,Kosti P,Georgouli M,Gordon P,Lall S,Kuzeva DM,Pedro L,Shields JD,Gillett CE,Diebold SS,Sanz-Moreno V,Ng T,Hoste E,Arnold JN
Fri Jul 27 00:00:00 EDT 2018
Bioreactor-based mass production of human iPSC-derived macrophages enables immunotherapies against bacterial airway infections.
Nature communications
Ackermann M,Kempf H,Hetzel M,Hesse C,Hashtchin AR,Brinkert K,Schott JW,Haake K,Kühnel MP,Glage S,Figueiredo C,Jonigk D,Sewald K,Schambach A,Wronski S,Moritz T,Martin U,Zweigerdt R,Munder A,Lachmann N
Fri Nov 30 00:00:00 EST 2018
Functionally distinct disease-associated fibroblast subsets in rheumatoid arthritis.
Nature communications
Mizoguchi F,Slowikowski K,Wei K,Marshall JL,Rao DA,Chang SK,Nguyen HN,Noss EH,Turner JD,Earp BE,Blazar PE,Wright J,Simmons BP,Donlin LT,Kalliolias GD,Goodman SM,Bykerk VP,Ivashkiv LB,Lederer JA,Hacohen N,Nigrovic PA,Filer A,Buckley CD,Raychaudhuri S,Brenner MB
Fri Feb 23 00:00:00 EST 2018
RNA-seq of macrophages of amoeboid or mesenchymal migratory phenotype due to specific structure of environment.
Scientific data
Čermák V,Gandalovičová A,Merta L,Fučíková J,Špíšek R,Rösel D,Brábek J
Tue Oct 02 00:00:00 EDT 2018
Macrophage-secreted interleukin-35 regulates cancer cell plasticity to facilitate metastatic colonization.
Nature communications
Lee CC,Lin JC,Hwang WL,Kuo YJ,Chen HK,Tai SK,Lin CC,Yang MH
Fri Sep 14 00:00:00 EDT 2018
IL-1R8 is a checkpoint in NK cells regulating anti-tumour and anti-viral activity.
Nature
Molgora M,Bonavita E,Ponzetta A,Riva F,Barbagallo M,Jaillon S,Popović B,Bernardini G,Magrini E,Gianni F,Zelenay S,Jonjić S,Santoni A,Garlanda C,Mantovani A
Thu Nov 02 00:00:00 EDT 2017
Methyltransferase SETD2-Mediated Methylation of STAT1 Is Critical for Interferon Antiviral Activity.
Cell
Chen K,Liu J,Liu S,Xia M,Zhang X,Han D,Jiang Y,Wang C,Cao X
300-25 was used in Cell Culture to identify STAT1 methylation on K525 catalyzed by the methyltransferase SETD2 as an essential signaling event for IFNα-dependent antiviral immunity and indicates potential of SETD2 in controlling viral infections.
Thu Jul 27 00:00:00 EDT 2017
The DNA Inflammasome in Human Myeloid Cells Is Initiated by a STING-Cell Death Program Upstream of NLRP3.
Cell
Gaidt MM,Ebert TS,Chauhan D,Ramshorn K,Pinci F,Zuber S,O'Duill F,Schmid-Burgk JL,Hoss F,Buhmann R,Wittmann G,Latz E,Subklewe M,Hornung V
Thu Nov 16 00:00:00 EST 2017
Renal Sodium Gradient Orchestrates a Dynamic Antibacterial Defense Zone.
Cell
Berry MR,Mathews RJ,Ferdinand JR,Jing C,Loudon KW,Wlodek E,Dennison TW,Kuper C,Neuhofer W,Clatworthy MR
Thu Aug 24 00:00:00 EDT 2017
An Immune Atlas of Clear Cell Renal Cell Carcinoma.
Cell
Chevrier S,Levine JH,Zanotelli VRT,Silina K,Schulz D,Bacac M,Ries CH,Ailles L,Jewett MAS,Moch H,van den Broek M,Beisel C,Stadler MB,Gedye C,Reis B,Pe'er D,Bodenmiller B
Thu May 04 00:00:00 EDT 2017
Interferon-γ Represses M2 Gene Expression in Human Macrophages by Disassembling Enhancers Bound by the Transcription Factor MAF.
Immunity
Kang K,Park SH,Chen J,Qiao Y,Giannopoulou E,Berg K,Hanidu A,Li J,Nabozny G,Kang K,Park-Min KH,Ivashkiv LB
Tue Aug 15 00:00:00 EDT 2017
Hypoxia-Sensitive COMMD1 Integrates Signaling and Cellular Metabolism in Human Macrophages and Suppresses Osteoclastogenesis.
Immunity
Murata K,Fang C,Terao C,Giannopoulou EG,Lee YJ,Lee MJ,Mun SH,Bae S,Qiao Y,Yuan R,Furu M,Ito H,Ohmura K,Matsuda S,Mimori T,Matsuda F,Park-Min KH,Ivashkiv LB
Tue Jul 18 00:00:00 EDT 2017
MYC-dependent oxidative metabolism regulates osteoclastogenesis via nuclear receptor ERRα.
The Journal of clinical investigation
Bae S,Lee MJ,Mun SH,Giannopoulou EG,Yong-Gonzalez V,Cross JR,Murata K,Giguère V,van der Meulen M,Park-Min KH
Fri Jun 30 00:00:00 EDT 2017
Macrophage-Dependent Cytoplasmic Transfer during Melanoma Invasion In Vivo.
Developmental cell
Roh-Johnson M,Shah AN,Stonick JA,Poudel KR,Kargl J,Yang GH,di Martino J,Hernandez RE,Gast CE,Zarour LR,Antoku S,Houghton AM,Bravo-Cordero JJ,Wong MH,Condeelis J,Moens CB
300-25 was used in Cell Culture to study and visualise tumour cells and their interactions with macrophages in zebrafish.
Mon Dec 04 00:00:00 EST 2017
Environment Tunes Propagation of Cell-to-Cell Variation in the Human Macrophage Gene Network.
Cell systems
Martins AJ,Narayanan M,Prüstel T,Fixsen B,Park K,Gottschalk RA,Lu Y,Andrews-Pfannkoch C,Lau WW,Wendelsdorf KV,Tsang JS
300-25 was used in In vitro experiments to explore context-dependent noise propagation among genes in human macrophages.
Wed Apr 26 00:00:00 EDT 2017
Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt.
Frontiers in cell and developmental biology
Tiedemann K,Le Nihouannen D,Fong JE,Hussein O,Barralet JE,Komarova SV
300-25 was used in Cell Culture to investigate TOR effects on osteoclast differentiation.
Tue Sep 29 00:00:00 EDT 2020
Ku70 Senses HTLV-1 DNA and Modulates HTLV-1 Replication.
Journal of immunology (Baltimore, Md. : 1950)
Wang J,Kang L,Song D,Liu L,Yang S,Ma L,Guo Z,Ding H,Wang H,Yang B
Sun Oct 01 00:00:00 EDT 2017
Complement Protein C1q Enhances Macrophage Foam Cell Survival and Efferocytosis.
Journal of immunology (Baltimore, Md. : 1950)
Pulanco MC,Cosman J,Ho MM,Huynh J,Fing K,Turcu J,Fraser DA
Sun Jan 01 00:00:00 EST 2017
Imatinib and Nilotinib Off-Target Effects on Human NK Cells, Monocytes, and M2 Macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Bellora F,Dondero A,Corrias MV,Casu B,Regis S,Caliendo F,Moretta A,Cazzola M,Elena C,Vinti L,Locatelli F,Bottino C,Castriconi R
Tue Aug 15 00:00:00 EDT 2017
The Role of Shed PrPc in the Neuropathogenesis of HIV Infection.
Journal of immunology (Baltimore, Md. : 1950)
Megra BW,Eugenin EA,Berman JW
Sat Jul 01 00:00:00 EDT 2017
Tissue-Engineered Model of Human Osteolytic Bone Tumor.
Tissue engineering. Part C, Methods
Villasante A,Marturano-Kruik A,Robinson ST,Liu Z,Guo XE,Vunjak-Novakovic G
300-25 was used in Cell Culture to study a novel bioengineered model of Ewing's sarcoma (ES) that incorporates the osteolytic process which can be used to investigate how tumor cells invade bone.
Wed Feb 01 00:00:00 EST 2017
Participation of 3-O-sulfated heparan sulfates in the protection of macrophages by herpes simplex virus-1 glycoprotein D and cyclophilin B against apoptosis.
FEBS open bio
Delos M,Hellec C,Foulquier F,Carpentier M,Allain F,Denys A
Wed Feb 01 00:00:00 EST 2017
KSRP specifies monocytic and granulocytic differentiation through regulating miR-129 biogenesis and RUNX1 expression.
Nature communications
Zhao H,Wang X,Yi P,Si Y,Tan P,He J,Yu S,Ren Y,Ma Y,Zhang J,Wang D,Wang F,Yu J
Fri Nov 10 00:00:00 EST 2017
DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation.
Nature communications
Kim HS,Nam ST,Mun SH,Lee SK,Kim HW,Park YH,Kim B,Won KJ,Kim HR,Park YM,Kim HS,Beaven MA,Kim YM,Choi WS
Wed Nov 15 00:00:00 EST 2017
Mapping tenascin-C interaction with toll-like receptor 4 reveals a new subset of endogenous inflammatory triggers.
Nature communications
Zuliani-Alvarez L,Marzeda AM,Deligne C,Schwenzer A,McCann FE,Marsden BD,Piccinini AM,Midwood KS
Fri Nov 17 00:00:00 EST 2017
RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages.
Scientific reports
Pujantell M,Riveira-Muñoz E,Badia R,Castellví M,Garcia-Vidal E,Sirera G,Puig T,Ramirez C,Clotet B,Esté JA,Ballana E
Tue Oct 17 00:00:00 EDT 2017
RNA editing by ADAR1 regulates innate and antiviral immune functions in primary macrophages.
Scientific reports
Pujantell M,Riveira-Muñoz E,Badia R,Castellví M,Garcia-Vidal E,Sirera G,Puig T,Ramirez C,Clotet B,Esté JA,Ballana E
Tue Oct 17 00:00:00 EDT 2017
Wiskott-Aldrich syndrome protein regulates autophagy and inflammasome activity in innate immune cells.
Nature communications
Lee PP,Lobato-Márquez D,Pramanik N,Sirianni A,Daza-Cajigal V,Rivers E,Cavazza A,Bouma G,Moulding D,Hultenby K,Westerberg LS,Hollinshead M,Lau YL,Burns SO,Mostowy S,Bajaj-Elliott M,Thrasher AJ
Fri Nov 17 00:00:00 EST 2017
Glucocorticoid-induced phosphorylation by CDK9 modulates the coactivator functions of transcriptional cofactor GRIP1 in macrophages.
Nature communications
Rollins DA,Kharlyngdoh JB,Coppo M,Tharmalingam B,Mimouna S,Guo Z,Sacta MA,Pufall MA,Fisher RP,Hu X,Chinenov Y,Rogatsky I
Thu Nov 23 00:00:00 EST 2017
Tunneling nanotubes (TNT) mediate long-range gap junctional communication: Implications for HIV cell to cell spread.
Scientific reports
Okafo G,Prevedel L,Eugenin E
Thu Nov 30 00:00:00 EST 2017
Caspase-1 cleaves PPARγ for potentiating the pro-tumor action of TAMs.
Nature communications
Niu Z,Shi Q,Zhang W,Shu Y,Yang N,Chen B,Wang Q,Zhao X,Chen J,Cheng N,Feng X,Hua Z,Ji J,Shen P
Tue Oct 03 00:00:00 EDT 2017
Classification of M1/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis.
Scientific reports
Bertani FR,Mozetic P,Fioramonti M,Iuliani M,Ribelli G,Pantano F,Santini D,Tonini G,Trombetta M,Businaro L,Selci S,Rainer A
Mon Aug 21 00:00:00 EDT 2017
Blood vessel control of macrophage maturation promotes arteriogenesis in ischemia.
Nature communications
Krishnasamy K,Limbourg A,Kapanadze T,Gamrekelashvili J,Beger C,Häger C,Lozanovski VJ,Falk CS,Napp LC,Bauersachs J,Mack M,Haller H,Weber C,Adams RH,Limbourg FP
Mon Oct 16 00:00:00 EDT 2017
Mucosa-associated lymphoid tissue lymphoma translocation 1 as a novel therapeutic target for rheumatoid arthritis.
Scientific reports
Lee CH,Bae SJ,Kim M
Tue Sep 19 00:00:00 EDT 2017
DNA methylation governs the dynamic regulation of inflammation by apoptotic cells during efferocytosis.
Scientific reports
Notley CA,Jordan CK,McGovern JL,Brown MA,Ehrenstein MR
Tue Feb 07 00:00:00 EST 2017
Phospholipase C-related, but catalytically inactive protein (PRIP) up-regulates osteoclast differentiation via calcium-calcineurin-NFATc1 signaling.
The Journal of biological chemistry
Murakami A,Matsuda M,Harada Y,Hirata M
Fri May 12 00:00:00 EDT 2017
Integrins Form an Expanding Diffusional Barrier that Coordinates Phagocytosis.
Cell
Freeman SA,Goyette J,Furuya W,Woods EC,Bertozzi CR,Bergmeier W,Hinz B,van der Merwe PA,Das R,Grinstein S
Thu Jan 14 00:00:00 EST 2016
Human Monocytes Engage an Alternative Inflammasome Pathway.
Immunity
Gaidt MM,Ebert TS,Chauhan D,Schmidt T,Schmid-Burgk JL,Rapino F,Robertson AA,Cooper MA,Graf T,Hornung V
Tue Apr 19 00:00:00 EDT 2016
Genetically distinct leukemic stem cells in human CD34- acute myeloid leukemia are arrested at a hemopoietic precursor-like stage.
The Journal of experimental medicine
Quek L,Otto GW,Garnett C,Lhermitte L,Karamitros D,Stoilova B,Lau IJ,Doondeea J,Usukhbayar B,Kennedy A,Metzner M,Goardon N,Ivey A,Allen C,Gale R,Davies B,Sternberg A,Killick S,Hunter H,Cahalin P,Price A,Carr A,Griffiths M,Virgo P,Mackinnon S,Grimwade D,Freeman S,Russell N,Craddock C,Mead A,Peniket A,Porcher C,Vyas P
Mon Jul 25 00:00:00 EDT 2016
Mesenchymal Stem Cells are Recruited and Activated into Carcinoma-Associated Fibroblasts by Prostate Cancer Microenvironment-Derived TGF-β1.
Stem cells (Dayton, Ohio)
Barcellos-de-Souza P,Comito G,Pons-Segura C,Taddei ML,Gori V,Becherucci V,Bambi F,Margheri F,Laurenzana A,Del Rosso M,Chiarugi P
Sat Oct 01 00:00:00 EDT 2016
Folate Receptor β Regulates Integrin CD11b/CD18 Adhesion of a Macrophage Subset to Collagen.
Journal of immunology (Baltimore, Md. : 1950)
Machacek C,Supper V,Leksa V,Mitulovic G,Spittler A,Drbal K,Suchanek M,Ohradanova-Repic A,Stockinger H
Thu Sep 15 00:00:00 EDT 2016
MSX1 Modulates RLR-Mediated Innate Antiviral Signaling by Facilitating Assembly of TBK1-Associated Complexes.
Journal of immunology (Baltimore, Md. : 1950)
Chen LT,Hu MM,Xu ZS,Liu Y,Shu HB
Fri Jul 01 00:00:00 EDT 2016
Transmembrane TNF-α Reverse Signaling Inhibits Lipopolysaccharide-Induced Proinflammatory Cytokine Formation in Macrophages by Inducing TGF-β: Therapeutic Implications.
Journal of immunology (Baltimore, Md. : 1950)
Pallai A,Kiss B,Vereb G,Armaka M,Kollias G,Szekanecz Z,Szondy Z
Mon Feb 01 00:00:00 EST 2016
The IL-12 Response of Primary Human Dendritic Cells and Monocytes to Toxoplasma gondii Is Stimulated by Phagocytosis of Live Parasites Rather Than Host Cell Invasion.
Journal of immunology (Baltimore, Md. : 1950)
Tosh KW,Mittereder L,Bonne-Annee S,Hieny S,Nutman TB,Singer SM,Sher A,Jankovic D
Fri Jan 01 00:00:00 EST 2016
Development by Genetic Immunization of Monovalent Antibodies (Nanobodies) Behaving as Antagonists of the Human ChemR23 Receptor.
Journal of immunology (Baltimore, Md. : 1950)
Peyrassol X,Laeremans T,Gouwy M,Lahura V,Debulpaep M,Van Damme J,Steyaert J,Parmentier M,Langer I
Tue Mar 15 00:00:00 EDT 2016
Anti-myeloma effect of pharmacological inhibition of Notch/gamma-secretase with RO4929097 is mediated by modulation of tumor microenvironment.
Cancer biology & therapy
Pisklakova A,Grigson E,Ozerova M,Chen F,Sullivan DM,Nefedova Y
300-25 was used in Cell Culture to study how targeting the Notch pathway, suggested to be implicated in growth and chemoresistance, could be beneficial for the treatment of multiple myeloma (MM).
Tue May 03 00:00:00 EDT 2016
Differential regulation of aldose reductase expression during macrophage polarization depends on hyperglycemia.
Innate immunity
Erbel C,Rupp G,Domschke G,Linden F,Akhavanpoor M,Doesch AO,Katus HA,Gleissner CA
300-25 was used in Cell Culture to show that aldose reductase (AR) expression in macrophages is associated with atherosclerosis and diabetes, and that AR expression is increased under hyperglycaemic conditions.
Fri Apr 01 00:00:00 EDT 2016
Rabbit M1 and M2 macrophages can be induced by human recombinant GM-CSF and M-CSF.
FEBS open bio
Yamane K,Leung KP
Thu Sep 01 00:00:00 EDT 2016
MiR-142-3p is a RANKL-dependent inducer of cell death in osteoclasts.
Scientific reports
Fordham JB,Guilfoyle K,Naqvi AR,Nares S
Tue Apr 26 00:00:00 EDT 2016
Stroma-derived but not tumor ADAMTS1 is a main driver of tumor growth and metastasis.
Oncotarget
Fernández-Rodríguez R,Rodríguez-Baena FJ,Martino-Echarri E,Peris-Torres C,Del Carmen Plaza-Calonge M,Rodríguez-Manzaneque JC
300-25 was used in In vitro experiments to provide the first genetic evidence that supports the pro-tumorigenic role of stromal ADAMTS1.
Tue Jun 07 00:00:00 EDT 2016
IFN-γ Induces Histone 3 Lysine 27 Trimethylation in a Small Subset of Promoters to Stably Silence Gene Expression in Human Macrophages.
Cell reports
Qiao Y,Kang K,Giannopoulou E,Fang C,Ivashkiv LB
300-25 was used in Cell Culture to investigate signalling activation of immune response.
Tue Sep 20 00:00:00 EDT 2016
Receptor residence time trumps drug-likeness and oral bioavailability in determining efficacy of complement C5a antagonists.
Scientific reports
Seow V,Lim J,Cotterell AJ,Yau MK,Xu W,Lohman RJ,Kok WM,Stoermer MJ,Sweet MJ,Reid RC,Suen JY,Fairlie DP
Wed Apr 20 00:00:00 EDT 2016
Opposing regulation of the late phase TNF response by mTORC1-IL-10 signaling and hypoxia in human macrophages.
Scientific reports
Huynh L,Kusnadi A,Park SH,Murata K,Park-Min KH,Ivashkiv LB
Thu Aug 25 00:00:00 EDT 2016
Osteoclast-derived exosomal miR-214-3p inhibits osteoblastic bone formation.
Nature communications
Li D,Liu J,Guo B,Liang C,Dang L,Lu C,He X,Cheung HY,Xu L,Lu C,He B,Liu B,Shaikh AB,Li F,Wang L,Yang Z,Au DW,Peng S,Zhang Z,Zhang BT,Pan X,Qian A,Shang P,Xiao L,Jiang B,Wong CK,Xu J,Bian Z,Liang Z,Guo DA,Zhu H,Tan W,Lu A,Zhang G
Mon Mar 07 00:00:00 EST 2016
Sorting nexin 10 acting as a novel regulator of macrophage polarization mediates inflammatory response in experimental mouse colitis.
Scientific reports
You Y,Zhou C,Li D,Cao ZL,Shen W,Li WZ,Zhang S,Hu B,Shen X
Tue Feb 09 00:00:00 EST 2016
Kelch-like Protein 21 (KLHL21) Targets IκB Kinase-β to Regulate Nuclear Factor κ-Light Chain Enhancer of Activated B Cells (NF-κB) Signaling Negatively.
The Journal of biological chemistry
Mei ZZ,Chen XY,Hu SW,Wang N,Ou XL,Wang J,Luo HH,Liu J,Jiang Y
Fri Aug 26 00:00:00 EDT 2016
miRNA let-7b modulates macrophage polarization and enhances tumor-associated macrophages to promote angiogenesis and mobility in prostate cancer.
Scientific reports
Wang Z,Xu L,Hu Y,Huang Y,Zhang Y,Zheng X,Wang S,Wang Y,Yu Y,Zhang M,Yuan K,Min W
Mon May 09 00:00:00 EDT 2016
Cancer Cell-derived Exosomes Induce Mitogen-activated Protein Kinase-dependent Monocyte Survival by Transport of Functional Receptor Tyrosine Kinases.
The Journal of biological chemistry
Song X,Ding Y,Liu G,Yang X,Zhao R,Zhang Y,Zhao X,Anderson GJ,Nie G
Fri Apr 15 00:00:00 EDT 2016
Monocyte-derived macrophages exhibit distinct and more restricted HIV-1 integration site repertoire than CD4(+) T cells.
Scientific reports
Kok YL,Vongrad V,Shilaih M,Di Giallonardo F,Kuster H,Kouyos R,Günthard HF,Metzner KJ
Tue Apr 12 00:00:00 EDT 2016
Expression of the innate immune receptor LILRB5 on monocytes is associated with mycobacteria exposure.
Scientific reports
Hogan LE,Jones DC,Allen RL
Wed Feb 24 00:00:00 EST 2016
Pyk2 activates the NLRP3 inflammasome by directly phosphorylating ASC and contributes to inflammasome-dependent peritonitis.
Scientific reports
Chung IC,OuYang CN,Yuan SN,Li HP,Chen JT,Shieh HR,Chen YJ,Ojcius DM,Chu CL,Yu JS,Chang YS,Chen LC
Mon Oct 31 00:00:00 EDT 2016
miR-24, miR-30b and miR-142-3p interfere with antigen processing and presentation by primary macrophages and dendritic cells.
Scientific reports
Naqvi AR,Fordham JB,Ganesh B,Nares S
Fri Sep 09 00:00:00 EDT 2016
Transcriptional and functional characterization of CD137L-dendritic cells identifies a novel dendritic cell phenotype.
Scientific reports
Harfuddin Z,Dharmadhikari B,Wong SC,Duan K,Poidinger M,Kwajah S,Schwarz H
Tue Jul 19 00:00:00 EDT 2016
Clearance of autophagy-associated dying retinal pigment epithelial cells - a possible source for inflammation in age-related macular degeneration.
Cell death & disease
Szatmári-Tóth M,Kristóf E,Veréb Z,Akhtar S,Facskó A,Fésüs L,Kauppinen A,Kaarniranta K,Petrovski G
Thu Sep 08 00:00:00 EDT 2016
Secreted Thrombospondin-1 Regulates Macrophage Interleukin-1β Production and Activation through CD47.
Scientific reports
Stein EV,Miller TW,Ivins-O'Keefe K,Kaur S,Roberts DD
Wed Jan 27 00:00:00 EST 2016
Calcium-sensing receptors signal constitutive macropinocytosis and facilitate the uptake of NOD2 ligands in macrophages.
Nature communications
Canton J,Schlam D,Breuer C,Gütschow M,Glogauer M,Grinstein S
Wed Apr 06 00:00:00 EDT 2016
Human iPSC-derived osteoblasts and osteoclasts together promote bone regeneration in 3D biomaterials.
Scientific reports
Jeon OH,Panicker LM,Lu Q,Chae JJ,Feldman RA,Elisseeff JH
Thu May 26 00:00:00 EDT 2016
Structural simulation of adenosine phosphate via plumbagin and zoledronic acid competitively targets JNK/Erk to synergistically attenuate osteoclastogenesis in a breast cancer model.
Cell death & disease
Qiao H,Wang TY,Yu ZF,Han XG,Liu XQ,Wang YG,Fan QM,Qin A,Tang TT
Thu Feb 11 00:00:00 EST 2016
Tuberculosis is associated with expansion of a motile, permissive and immunomodulatory CD16(+) monocyte population via the IL-10/STAT3 axis.
Cell research
Lastrucci C,Bénard A,Balboa L,Pingris K,Souriant S,Poincloux R,Al Saati T,Rasolofo V,González-Montaner P,Inwentarz S,Moraña EJ,Kondova I,Verreck FA,Sasiain Mdel C,Neyrolles O,Maridonneau-Parini I,Lugo-Villarino G,Cougoule C
Tue Dec 01 00:00:00 EST 2015
IRF8 acts in lineage-committed rather than oligopotent progenitors to control neutrophil vs monocyte production.
Blood
Yáñez A,Ng MY,Hassanzadeh-Kiabi N,Goodridge HS
Thu Feb 26 00:00:00 EST 2015
Broad-spectrum antibodies against self-antigens and cytokines in RAG deficiency.
The Journal of clinical investigation
Walter JE,Rosen LB,Csomos K,Rosenberg JM,Mathew D,Keszei M,Ujhazi B,Chen K,Lee YN,Tirosh I,Dobbs K,Al-Herz W,Cowan MJ,Puck J,Bleesing JJ,Grimley MS,Malech H,De Ravin SS,Gennery AR,Abraham RS,Joshi AY,Boyce TG,Butte MJ,Nadeau KC,Balboni I,Sullivan KE,Akhter J,Adeli M,El-Feky RA,El-Ghoneimy DH,Dbaibo G,Wakim R,Azzari C,Palma P,Cancrini C,Capuder K,Condino-Neto A,Costa-Carvalho BT,Oliveira JB,Roifman C,Buchbinder D,Kumanovics A,Franco JL,Niehues T,Schuetz C,Kuijpers T,Yee C,Chou J,Masaad MJ,Geha R,Uzel G,Gelman R,Holland SM,Recher M,Utz PJ,Browne SK,Notarangelo LD
Mon Nov 02 00:00:00 EST 2015
Sugar-based amphiphilic nanoparticles arrest atherosclerosis in vivo.
Proceedings of the National Academy of Sciences of the United States of America
Lewis DR,Petersen LK,York AW,Zablocki KR,Joseph LB,Kholodovych V,Prud'homme RK,Uhrich KE,Moghe PV
Tue Mar 03 00:00:00 EST 2015
Reprogramming of primary human Philadelphia chromosome-positive B cell acute lymphoblastic leukemia cells into nonleukemic macrophages.
Proceedings of the National Academy of Sciences of the United States of America
McClellan JS,Dove C,Gentles AJ,Ryan CE,Majeti R
Tue Mar 31 00:00:00 EDT 2015
Ionic imbalance, in addition to molecular crowding, abates cytoskeletal dynamics and vesicle motility during hypertonic stress.
Proceedings of the National Academy of Sciences of the United States of America
Nunes P,Roth I,Meda P,Féraille E,Brown D,Hasler U
Tue Jun 16 00:00:00 EDT 2015
Human pluripotent stem cell-derived neural constructs for predicting neural toxicity.
Proceedings of the National Academy of Sciences of the United States of America
Schwartz MP,Hou Z,Propson NE,Zhang J,Engstrom CJ,Santos Costa V,Jiang P,Nguyen BK,Bolin JM,Daly W,Wang Y,Stewart R,Page CD,Murphy WL,Thomson JA
Tue Oct 06 00:00:00 EDT 2015
Serum amyloid A inhibits RANKL-induced osteoclast formation.
Experimental & molecular medicine
Oh E,Lee HY,Kim HJ,Park YJ,Seo JK,Park JS,Bae YS
Fri Nov 13 00:00:00 EST 2015
Adseverin mediates RANKL-induced osteoclastogenesis by regulating NFATc1.
Experimental & molecular medicine
Song MK,Lee ZH,Kim HH
Fri Dec 18 00:00:00 EST 2015
Effective Small Interfering RNA Therapy to Treat CLCN7-dependent Autosomal Dominant Osteopetrosis Type 2.
Molecular therapy. Nucleic acids
Capulli M,Maurizi A,Ventura L,Rucci N,Teti A
300-25 was used in Cell Culture to investigate miRNA effects on autosomal dominant osteopetrosis type 2.
Tue Sep 01 00:00:00 EDT 2015
Effective Small Interfering RNA Therapy to Treat CLCN7-dependent Autosomal Dominant Osteopetrosis Type 2.
Molecular therapy. Nucleic acids
Capulli M,Maurizi A,Ventura L,Rucci N,Teti A
300-25 was used in Cell Culture to investigate miRNA effects on autosomal dominant osteopetrosis type 2.
Tue Sep 01 00:00:00 EDT 2015
The implication of cigarette smoking and cessation on macrophage cholesterol efflux in coronary artery disease patients.
Journal of lipid research
Song W,Wang W,Dou LY,Wang Y,Xu Y,Chen LF,Yan XW
Sun Mar 01 00:00:00 EST 2015
Lipocalin 2: a new mechanoresponding gene regulating bone homeostasis.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Rucci N,Capulli M,Piperni SG,Cappariello A,Lau P,Frings-Meuthen P,Heer M,Teti A
300-25 was used in Cell Culture to investigate mechanoresponding properties of LCN2 in mouse osteoblasts.
Sun Feb 01 00:00:00 EST 2015
Heme Oxygenase-1 Regulation of Matrix Metalloproteinase-1 Expression Underlies Distinct Disease Profiles in Tuberculosis.
Journal of immunology (Baltimore, Md. : 1950)
Andrade BB,Pavan Kumar N,Amaral EP,Riteau N,Mayer-Barber KD,Tosh KW,Maier N,Conceição EL,Kubler A,Sridhar R,Banurekha VV,Jawahar MS,Barbosa T,Manganiello VC,Moss J,Fontana JR,Marciano BE,Sampaio EP,Olivier KN,Holland SM,Jackson SH,Moayeri M,Leppla S,Sereti I,Barber DL,Nutman TB,Babu S,Sher A
Tue Sep 15 00:00:00 EDT 2015
The human fetal placenta promotes tolerance against the semiallogeneic fetus by inducing regulatory T cells and homeostatic M2 macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Svensson-Arvelund J,Mehta RB,Lindau R,Mirrasekhian E,Rodriguez-Martinez H,Berg G,Lash GE,Jenmalm MC,Ernerudh J
Sun Feb 15 00:00:00 EST 2015
Macrophage epoxygenase determines a profibrotic transcriptome signature.
Journal of immunology (Baltimore, Md. : 1950)
Behmoaras J,Diaz AG,Venda L,Ko JH,Srivastava P,Montoya A,Faull P,Webster Z,Moyon B,Pusey CD,Abraham DJ,Petretto E,Cook TH,Aitman TJ
Fri May 15 00:00:00 EDT 2015
Sos1 Regulates Macrophage Podosome Assembly and Macrophage Invasive Capacity.
Journal of immunology (Baltimore, Md. : 1950)
Baruzzi A,Remelli S,Lorenzetto E,Sega M,Chignola R,Berton G
Sun Nov 15 00:00:00 EST 2015
miR-24, miR-30b, and miR-142-3p regulate phagocytosis in myeloid inflammatory cells.
Journal of immunology (Baltimore, Md. : 1950)
Naqvi AR,Fordham JB,Nares S
Sun Feb 15 00:00:00 EST 2015
Contribution of MINCLE-SYK Signaling to Activation of Primary Human APCs by Mycobacterial Cord Factor and the Novel Adjuvant TDB.
Journal of immunology (Baltimore, Md. : 1950)
Ostrop J,Jozefowski K,Zimmermann S,Hofmann K,Strasser E,Lepenies B,Lang R
Tue Sep 01 00:00:00 EDT 2015
Application of IL-36 receptor antagonist weakens CCL20 expression and impairs recovery in the late phase of murine acetaminophen-induced liver injury.
Scientific reports
Scheiermann P,Bachmann M,Härdle L,Pleli T,Piiper A,Zwissler B,Pfeilschifter J,Mühl H
Tue Feb 17 00:00:00 EST 2015
Glycosylation of immunoglobulin G determines osteoclast differentiation and bone loss.
Nature communications
Harre U,Lang SC,Pfeifle R,Rombouts Y,Frühbeißer S,Amara K,Bang H,Lux A,Koeleman CA,Baum W,Dietel K,Gröhn F,Malmström V,Klareskog L,Krönke G,Kocijan R,Nimmerjahn F,Toes RE,Herrmann M,Scherer HU,Schett G
Tue Mar 31 00:00:00 EDT 2015
Osteoblast menin regulates bone mass in vivo.
The Journal of biological chemistry
Kanazawa I,Canaff L,Abi Rafeh J,Angrula A,Li J,Riddle RC,Boraschi-Diaz I,Komarova SV,Clemens TL,Murshed M,Hendy GN
300-25 was used in Cell Culture to conclude that osteoblast menin plays a key role in bone development, remodeling, and maintenance.
Fri Feb 13 00:00:00 EST 2015
IL-10 induces the development of immunosuppressive CD14(+)HLA-DR(low/-) monocytes in B-cell non-Hodgkin lymphoma.
Blood cancer journal
Xiu B,Lin Y,Grote DM,Ziesmer SC,Gustafson MP,Maas ML,Zhang Z,Dietz AB,Porrata LF,Novak AJ,Liang AB,Yang ZZ,Ansell SM
Fri Jul 31 00:00:00 EDT 2015
Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclasts.
The Journal of biological chemistry
Oh J,Kim JY,Kim HS,Oh JC,Cheon YH,Park J,Yoon KH,Lee MS,Youn BS
Fri Jan 23 00:00:00 EST 2015
Progranulin and a five transmembrane domain-containing receptor-like gene are the key components in receptor activator of nuclear factor κB (RANK)-dependent formation of multinucleated osteoclasts.
The Journal of biological chemistry
Oh J,Kim JY,Kim HS,Oh JC,Cheon YH,Park J,Yoon KH,Lee MS,Youn BS
Fri Jan 23 00:00:00 EST 2015
Integrated Transcriptomics Establish Macrophage Polarization Signatures and have Potential Applications for Clinical Health and Disease.
Scientific reports
Becker M,De Bastiani MA,Parisi MM,Guma FT,Markoski MM,Castro MA,Kaplan MH,Barbé-Tuana FM,Klamt F
Tue Aug 25 00:00:00 EDT 2015
Caveolin-1 regulates osteoclastogenesis and bone metabolism in a sex-dependent manner.
The Journal of biological chemistry
Lee YD,Yoon SH,Park CK,Lee J,Lee ZH,Kim HH
Fri Mar 06 00:00:00 EST 2015
Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.
Scientific reports
Zhang Y,Guan H,Li J,Fang Z,Chen W,Li F
Fri Sep 04 00:00:00 EDT 2015
Amlexanox Suppresses Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss.
Scientific reports
Zhang Y,Guan H,Li J,Fang Z,Chen W,Li F
Fri Sep 04 00:00:00 EDT 2015
The role of H4 flagella in Escherichia coli ST131 virulence.
Scientific reports
Kakkanat A,Totsika M,Schaale K,Duell BL,Lo AW,Phan MD,Moriel DG,Beatson SA,Sweet MJ,Ulett GC,Schembri MA
Mon Nov 09 00:00:00 EST 2015
AK2 deficiency compromises the mitochondrial energy metabolism required for differentiation of human neutrophil and lymphoid lineages.
Cell death & disease
Six E,Lagresle-Peyrou C,Susini S,De Chappedelaine C,Sigrist N,Sadek H,Chouteau M,Cagnard N,Fontenay M,Hermine O,Chomienne C,Reynier P,Fischer A,André-Schmutz I,Gueguen N,Cavazzana M
Thu Aug 13 00:00:00 EDT 2015
Monocyte-derived macrophage assisted breast cancer cell invasion as a personalized, predictive metric to score metastatic risk.
Scientific reports
Park KY,Li G,Platt MO
Wed Sep 09 00:00:00 EDT 2015
A Crohn's disease variant in Atg16l1 enhances its degradation by caspase 3.
Nature
Murthy A,Li Y,Peng I,Reichelt M,Katakam AK,Noubade R,Roose-Girma M,DeVoss J,Diehl L,Graham RR,van Lookeren Campagne M
Thu Feb 27 00:00:00 EST 2014
Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD.
Blood
Awojoodu AO,Keegan PM,Lane AR,Zhang Y,Lynch KR,Platt MO,Botchwey EA
Thu Sep 18 00:00:00 EDT 2014
Invariant NKT cells with chimeric antigen receptor provide a novel platform for safe and effective cancer immunotherapy.
Blood
Heczey A,Liu D,Tian G,Courtney AN,Wei J,Marinova E,Gao X,Guo L,Yvon E,Hicks J,Liu H,Dotti G,Metelitsa LS
Thu Oct 30 00:00:00 EDT 2014
Immunity induced by a broad class of inorganic crystalline materials is directly controlled by their chemistry.
The Journal of experimental medicine
Williams GR,Fierens K,Preston SG,Lunn D,Rysnik O,De Prijck S,Kool M,Buckley HC,Lambrecht BN,O'Hare D,Austyn JM
Mon Jun 02 00:00:00 EDT 2014
The phosphoinositide 3-kinase isoform PI3Kβ regulates osteoclast-mediated bone resorption in humans and mice.
Arthritis & rheumatology (Hoboken, N.J.)
Győri D,Csete D,Benkő S,Kulkarni S,Mandl P,Dobó-Nagy C,Vanhaesebroeck B,Stephens L,Hawkins PT,Mócsai A
Fri Aug 01 00:00:00 EDT 2014
The role, mechanism and potentially therapeutic application of microRNA-29 family in acute myeloid leukemia.
Cell death and differentiation
Gong JN,Yu J,Lin HS,Zhang XH,Yin XL,Xiao Z,Wang F,Wang XS,Su R,Shen C,Zhao HL,Ma YN,Zhang JW
Wed Jan 01 00:00:00 EST 2014
ABCG1-mediated generation of extracellular cholesterol microdomains.
Journal of lipid research
Freeman SR,Jin X,Anzinger JJ,Xu Q,Purushothaman S,Fessler MB,Addadi L,Kruth HS
Wed Jan 01 00:00:00 EST 2014
Cell cycle control and HIV-1 susceptibility are linked by CDK6-dependent CDK2 phosphorylation of SAMHD1 in myeloid and lymphoid cells.
Journal of immunology (Baltimore, Md. : 1950)
Pauls E,Ruiz A,Badia R,Permanyer M,Gubern A,Riveira-Muñoz E,Torres-Torronteras J,Alvarez M,Mothe B,Brander C,Crespo M,Menéndez-Arias L,Clotet B,Keppler OT,Martí R,Posas F,Ballana E,Esté JA
Fri Aug 15 00:00:00 EDT 2014
Glycoengineering of therapeutic antibodies enhances monocyte/macrophage-mediated phagocytosis and cytotoxicity.
Journal of immunology (Baltimore, Md. : 1950)
Herter S,Birk MC,Klein C,Gerdes C,Umana P,Bacac M
Sat Mar 01 00:00:00 EST 2014
Cell death triggered by Yersinia enterocolitica identifies processing of the proinflammatory signal adapter MyD88 as a general event in the execution of apoptosis.
Journal of immunology (Baltimore, Md. : 1950)
Novikova L,Czymmeck N,Deuretzbacher A,Buck F,Richter K,Weber AN,Aepfelbacher M,Ruckdeschel K
Sat Feb 01 00:00:00 EST 2014
Human IgA Fc receptor FcαRI (CD89) triggers different forms of neutrophil death depending on the inflammatory microenvironment.
Journal of immunology (Baltimore, Md. : 1950)
Wehrli M,Cortinas-Elizondo F,Hlushchuk R,Daudel F,Villiger PM,Miescher S,Zuercher AW,Djonov V,Simon HU,von Gunten S
Mon Dec 01 00:00:00 EST 2014
Modulation of TNF-induced macrophage polarization by synovial fibroblasts.
Journal of immunology (Baltimore, Md. : 1950)
Donlin LT,Jayatilleke A,Giannopoulou EG,Kalliolias GD,Ivashkiv LB
Mon Sep 01 00:00:00 EDT 2014
Pivotal role of protein tyrosine phosphatase 1B (PTP1B) in the macrophage response to pro-inflammatory and anti-inflammatory challenge.
Cell death & disease
Través PG,Pardo V,Pimentel-Santillana M,González-Rodríguez Á,Mojena M,Rico D,Montenegro Y,Calés C,Martín-Sanz P,Valverde AM,Boscá L
Thu Mar 13 00:00:00 EDT 2014
RelB-induced expression of Cot, an MAP3K family member, rescues RANKL-induced osteoclastogenesis in alymphoplasia mice by promoting NF-κB2 processing by IKKα.
The Journal of biological chemistry
Taniguchi R,Fukushima H,Osawa K,Maruyama T,Yasuda H,Weih F,Doi T,Maki K,Jimi E
Fri Mar 14 00:00:00 EDT 2014
Doxycycline inhibits polarization of macrophages to the proangiogenic M2-type and subsequent neovascularization.
The Journal of biological chemistry
He L,Marneros AG
Fri Mar 21 00:00:00 EDT 2014
HIV-1 infection induces interleukin-1β production via TLR8 protein-dependent and NLRP3 inflammasome mechanisms in human monocytes.
The Journal of biological chemistry
Guo H,Gao J,Taxman DJ,Ting JP,Su L
Fri Aug 01 00:00:00 EDT 2014
Characterization of the influence of mediator complex in HIV-1 transcription.
The Journal of biological chemistry
Ruiz A,Pauls E,Badia R,Riveira-Muñoz E,Clotet B,Ballana E,Esté JA
Fri Oct 03 00:00:00 EDT 2014
Comprehensive profiling analysis of actively resorbing osteoclasts identifies critical signaling pathways regulated by bone substrate.
Scientific reports
Purdue PE,Crotti TN,Shen Z,Swantek J,Li J,Hill J,Hanidu A,Dimock J,Nabozny G,Goldring SR,McHugh KP
Tue Dec 23 00:00:00 EST 2014
Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.
The Journal of biological chemistry
Levy-Apter E,Finkelshtein E,Vemulapalli V,Li SS,Bedford MT,Elson A
Fri Dec 26 00:00:00 EST 2014
Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ϵ in osteoclasts.
The Journal of biological chemistry
Levy-Apter E,Finkelshtein E,Vemulapalli V,Li SS,Bedford MT,Elson A
Fri Dec 26 00:00:00 EST 2014
Synergistic activation of inflammatory cytokine genes by interferon-γ-induced chromatin remodeling and toll-like receptor signaling.
Immunity
Qiao Y,Giannopoulou EG,Chan CH,Park SH,Gong S,Chen J,Hu X,Elemento O,Ivashkiv LB
Thu Sep 19 00:00:00 EDT 2013
Genetic programs expressed in resting and IL-4 alternatively activated mouse and human macrophages: similarities and differences.
Blood
Martinez FO,Helming L,Milde R,Varin A,Melgert BN,Draijer C,Thomas B,Fabbri M,Crawshaw A,Ho LP,Ten Hacken NH,Cobos Jiménez V,Kootstra NA,Hamann J,Greaves DR,Locati M,Mantovani A,Gordon S
Thu Feb 28 00:00:00 EST 2013
iRHOM2 is a critical pathogenic mediator of inflammatory arthritis.
The Journal of clinical investigation
Issuree PD,Maretzky T,McIlwain DR,Monette S,Qing X,Lang PA,Swendeman SL,Park-Min KH,Binder N,Kalliolias GD,Yarilina A,Horiuchi K,Ivashkiv LB,Mak TW,Salmon JE,Blobel CP
Fri Feb 01 00:00:00 EST 2013
Identification of human CCR8 as a CCL18 receptor.
The Journal of experimental medicine
Islam SA,Ling MF,Leung J,Shreffler WG,Luster AD
Mon Sep 23 00:00:00 EDT 2013
Preclinical activity of the type II CD20 antibody GA101 (obinutuzumab) compared with rituximab and ofatumumab in vitro and in xenograft models.
Molecular cancer therapeutics
Herter S,Herting F,Mundigl O,Waldhauer I,Weinzierl T,Fauti T,Muth G,Ziegler-Landesberger D,Van Puijenbroek E,Lang S,Duong MN,Reslan L,Gerdes CA,Friess T,Baer U,Burtscher H,Weidner M,Dumontet C,Umana P,Niederfellner G,Bacac M,Klein C
300-25 was used in Sample Preparation (FC/FACS) to show that the glyoengineered type II CD20 antibody GA101 is differentiated from the two approved type I CD20 antibodies rituximab and ofatumumab by its overall preclinical activity, further supporting its clinical investigation.
Tue Oct 01 00:00:00 EDT 2013
Selective impairment of P2Y signaling by prostaglandin E2 in macrophages: implications for Ca2+-dependent responses.
Journal of immunology (Baltimore, Md. : 1950)
Través PG,Pimentel-Santillana M,Carrasquero LM,Pérez-Sen R,Delicado EG,Luque A,Izquierdo M,Martín-Sanz P,Miras-Portugal MT,Boscá L
Mon Apr 15 00:00:00 EDT 2013
Inflammatory responses induced by lipopolysaccharide are amplified in primary human monocytes but suppressed in macrophages by complement protein C5a.
Journal of immunology (Baltimore, Md. : 1950)
Seow V,Lim J,Iyer A,Suen JY,Ariffin JK,Hohenhaus DM,Sweet MJ,Fairlie DP
Tue Oct 15 00:00:00 EDT 2013
Systemic circulation and bone recruitment of osteoclast precursors tracked by using fluorescent imaging techniques.
Journal of immunology (Baltimore, Md. : 1950)
Kotani M,Kikuta J,Klauschen F,Chino T,Kobayashi Y,Yasuda H,Tamai K,Miyawaki A,Kanagawa O,Tomura M,Ishii M
Tue Jan 15 00:00:00 EST 2013
Restriction of HIV-1 replication in primary macrophages by IL-12 and IL-18 through the upregulation of SAMHD1.
Journal of immunology (Baltimore, Md. : 1950)
Pauls E,Jimenez E,Ruiz A,Permanyer M,Ballana E,Costa H,Nascimiento R,Parkhouse RM,Peña R,Riveiro-Muñoz E,Martinez MA,Clotet B,Esté JA,Bofill M
Wed May 01 00:00:00 EDT 2013
IL-17 stimulates differentiation of human anti-inflammatory macrophages and phagocytosis of apoptotic neutrophils in response to IL-10 and glucocorticoids.
Journal of immunology (Baltimore, Md. : 1950)
Zizzo G,Cohen PL
Wed May 15 00:00:00 EDT 2013
An HLA-DRB1-coded signal transduction ligand facilitates inflammatory arthritis: a new mechanism of autoimmunity.
Journal of immunology (Baltimore, Md. : 1950)
Holoshitz J,Liu Y,Fu J,Joseph J,Ling S,Colletta A,Sharma P,Begun D,Goldstein S,Taichman R
Tue Jan 01 00:00:00 EST 2013
Fibrillin-1 directly regulates osteoclast formation and function by a dual mechanism.
Journal of cell science
Tiedemann K,Boraschi-Diaz I,Rajakumar I,Kaur J,Roughley P,Reinhardt DP,Komarova SV
300-25 was used in Cell Culture to highlight a direct dual inhibitory role of N-terminal fibrillin-1 fragments in osteoclastogenesis, the sequestration of RANKL and the inhibition of NFATc1 signaling.
Sun Sep 15 00:00:00 EDT 2013
Moderate excess of pyruvate augments osteoclastogenesis.
Biology open
Fong JE,Le Nihouannen D,Tiedemann K,Sadvakassova G,Barralet JE,Komarova SV
300-25 was used in Cell Culture to study how the differentiation of bone-resorbing osteoclasts, large polykaryons formed through fusion and growth of cells of monocytic origin, is affected by excess of energy substrate pyruvate and how energy metabolism changes during osteoclast differentiation.
Mon Apr 15 00:00:00 EDT 2013
A recombinant fusion toxin based on enzymatic inactive C3bot1 selectively targets macrophages.
PloS one
Dmochewitz L,Förtsch C,Zwerger C,Vaeth M,Felder E,Huber-Lang M,Barth H
Fri Jul 19 00:00:00 EDT 2013
Molecular signaling pathways mediating osteoclastogenesis induced by prostate cancer cells.
BMC cancer
Rafiei S,Komarova SV
300-25 was used in Cell Culture to study the molecular mechanism of prostate cancer-induced osteoclastogenesis following metastasis.
Thu Dec 26 00:00:00 EST 2013
The cardioprotective protein apolipoprotein A1 promotes potent anti-tumorigenic effects.
The Journal of biological chemistry
Zamanian-Daryoush M,Lindner D,Tallant TC,Wang Z,Buffa J,Klipfell E,Parker Y,Hatala D,Parsons-Wingerter P,Rayman P,Yusufishaq MSS,Fisher EA,Smith JD,Finke J,DiDonato JA,Hazen SL
Fri Jul 19 00:00:00 EDT 2013
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells.
PloS one
Fossati-Jimack L,Ling GS,Cortini A,Szajna M,Malik TH,McDonald JU,Pickering MC,Cook HT,Taylor PR,Botto M
Fri Sep 27 00:00:00 EDT 2013
Purification of Human Monocytes and Lymphocyte Populations by Counter Current Elutriation- A Short Protocol.
Bio-protocol
Clarke EV,Benoit ME,Tenner AJ
300-25 was used in Cell Culture to outline human blood monocyte isolation with counterflow elutriation.
Thu Dec 05 00:00:00 EST 2013
Vav1 fine tunes p53 control of apoptosis versus proliferation in breast cancer.
PloS one
Sebban S,Farago M,Gashai D,Ilan L,Pikarsky E,Ben-Porath I,Katzav S
Fri Aug 02 00:00:00 EDT 2013
A FOXO3-IRF7 gene regulatory circuit limits inflammatory sequelae of antiviral responses.
Nature
Litvak V,Ratushny AV,Lampano AE,Schmitz F,Huang AC,Raman A,Rust AG,Bergthaler A,Aitchison JD,Aderem A
Thu Oct 18 00:00:00 EDT 2012
The rs1143679 (R77H) lupus associated variant of ITGAM (CD11b) impairs complement receptor 3 mediated functions in human monocytes.
Annals of the rheumatic diseases
Rhodes B,Fürnrohr BG,Roberts AL,Tzircotis G,Schett G,Spector TD,Vyse TJ
Sat Dec 01 00:00:00 EST 2012
Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice.
Blood
Wroblewska A,van Haren SD,Herczenik E,Kaijen P,Ruminska A,Jin SY,Zheng XL,van den Biggelaar M,ten Brinke A,Meijer AB,Voorberg J
Thu May 31 00:00:00 EDT 2012
Role of c-MYC in alternative activation of human macrophages and tumor-associated macrophage biology.
Blood
Pello OM,De Pizzol M,Mirolo M,Soucek L,Zammataro L,Amabile A,Doni A,Nebuloni M,Swigart LB,Evan GI,Mantovani A,Locati M
Thu Jan 12 00:00:00 EST 2012
Bruton tyrosine kinase inhibition is a novel therapeutic strategy targeting tumor in the bone marrow microenvironment in multiple myeloma.
Blood
Tai YT,Chang BY,Kong SY,Fulciniti M,Yang G,Calle Y,Hu Y,Lin J,Zhao JJ,Cagnetta A,Cea M,Sellitto MA,Zhong MY,Wang Q,Acharya C,Carrasco DR,Buggy JJ,Elias L,Treon SP,Matsui W,Richardson P,Munshi NC,Anderson KC
Thu Aug 30 00:00:00 EDT 2012
Dendritic cell-mediated activation-induced cytidine deaminase (AID)-dependent induction of genomic instability in human myeloma.
Blood
Koduru S,Wong E,Strowig T,Sundaram R,Zhang L,Strout MP,Flavell RA,Schatz DG,Dhodapkar KM,Dhodapkar MV
Thu Mar 08 00:00:00 EST 2012
ARHGAP25, a novel Rac GTPase-activating protein, regulates phagocytosis in human neutrophilic granulocytes.
Blood
Csépányi-Kömi R,Sirokmány G,Geiszt M,Ligeti E
Thu Jan 12 00:00:00 EST 2012
Induction of osteoclastogenesis and bone loss by human autoantibodies against citrullinated vimentin.
The Journal of clinical investigation
Harre U,Georgess D,Bang H,Bozec A,Axmann R,Ossipova E,Jakobsson PJ,Baum W,Nimmerjahn F,Szarka E,Sarmay G,Krumbholz G,Neumann E,Toes R,Scherer HU,Catrina AI,Klareskog L,Jurdic P,Schett G
Tue May 01 00:00:00 EDT 2012
C/EBPε mediates nicotinamide-enhanced clearance of Staphylococcus aureus in mice.
The Journal of clinical investigation
Kyme P,Thoennissen NH,Tseng CW,Thoennissen GB,Wolf AJ,Shimada K,Krug UO,Lee K,Müller-Tidow C,Berdel WE,Hardy WD,Gombart AF,Koeffler HP,Liu GY
Sat Sep 01 00:00:00 EDT 2012
Pre-B cell to macrophage transdifferentiation without significant promoter DNA methylation changes.
Nucleic acids research
Rodríguez-Ubreva J,Ciudad L,Gómez-Cabrero D,Parra M,Bussmann LH,di Tullio A,Kallin EM,Tegnér J,Graf T,Ballestar E
Thu Mar 01 00:00:00 EST 2012
Identification of Axl as a downstream effector of TGF-β1 during Langerhans cell differentiation and epidermal homeostasis.
The Journal of experimental medicine
Bauer T,Zagórska A,Jurkin J,Yasmin N,Köffel R,Richter S,Gesslbauer B,Lemke G,Strobl H
Mon Oct 22 00:00:00 EDT 2012
TNF-induced osteoclastogenesis and inflammatory bone resorption are inhibited by transcription factor RBP-J.
The Journal of experimental medicine
Zhao B,Grimes SN,Li S,Hu X,Ivashkiv LB
Mon Feb 13 00:00:00 EST 2012
A novel method for autophagy detection in primary cells: impaired levels of macroautophagy in immunosenescent T cells.
Autophagy
Phadwal K,Alegre-Abarrategui J,Watson AS,Pike L,Anbalagan S,Hammond EM,Wade-Martins R,McMichael A,Klenerman P,Simon AK
300-25 was used in In vitro experiments to demonstrate a method to measure autophagy levels in certain diseases, whilst determining the contribution of autophagy to the efficacy of drugs.
Sun Apr 01 00:00:00 EDT 2012
Cytosolic clearance of replication-deficient mutants reveals Francisella tularensis interactions with the autophagic pathway.
Autophagy
Chong A,Wehrly TD,Child R,Hansen B,Hwang S,Virgin HW,Celli J
300-25 was used in Cell Culture to demonstrate that replication-impaired strains of Francisella are cleared by autophagy, while replication-competent bacteria seem to interfere with autophagic recognition.
Sat Sep 01 00:00:00 EDT 2012
IL-10-induced microRNA-187 negatively regulates TNF-α, IL-6, and IL-12p40 production in TLR4-stimulated monocytes.
Proceedings of the National Academy of Sciences of the United States of America
Rossato M,Curtale G,Tamassia N,Castellucci M,Mori L,Gasperini S,Mariotti B,De Luca M,Mirolo M,Cassatella MA,Locati M,Bazzoni F
Tue Nov 06 00:00:00 EST 2012
Direct and immune mediated antibody targeting of ERBB receptors in a colorectal cancer cell-line panel.
Proceedings of the National Academy of Sciences of the United States of America
Ashraf SQ,Nicholls AM,Wilding JL,Ntouroupi TG,Mortensen NJ,Bodmer WF
Tue Dec 18 00:00:00 EST 2012
Spleen serves as a reservoir of osteoclast precursors through vitamin D-induced IL-34 expression in osteopetrotic op/op mice.
Proceedings of the National Academy of Sciences of the United States of America
Nakamichi Y,Mizoguchi T,Arai A,Kobayashi Y,Sato M,Penninger JM,Yasuda H,Kato S,DeLuca HF,Suda T,Udagawa N,Takahashi N
Tue Jun 19 00:00:00 EDT 2012
Paracrine interactions between primary human macrophages and human fibroblasts enhance murine mammary gland humanization in vivo.
Breast cancer research : BCR
Fleming JM,Miller TC,Kidacki M,Ginsburg E,Stuelten CH,Stewart DA,Troester MA,Vonderhaar BK
Mon Jun 25 00:00:00 EDT 2012
ABCC5 supports osteoclast formation and promotes breast cancer metastasis to bone.
Breast cancer research : BCR
Mourskaia AA,Amir E,Dong Z,Tiedemann K,Cory S,Omeroglu A,Bertos N,Ouellet V,Clemons M,Scheffer GL,Park M,Hallett M,Komarova SV,Siegel PM
300-25 was used in Cell Culture to investigate molecular mechanisms of bone metastasis.
Thu Nov 22 00:00:00 EST 2012
Interleukin-34 produced by human fibroblast-like synovial cells in rheumatoid arthritis supports osteoclastogenesis.
Arthritis research & therapy
Hwang SJ,Choi B,Kang SS,Chang JH,Kim YG,Chung YH,Sohn DH,So MW,Lee CK,Robinson WH,Chang EJ
Fri Jan 20 00:00:00 EST 2012
Purinergic receptors are required for HIV-1 infection of primary human macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Hazleton JE,Berman JW,Eugenin EA
Tue May 01 00:00:00 EDT 2012
Semaphorin 4A exerts a proangiogenic effect by enhancing vascular endothelial growth factor-A expression in macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Meda C,Molla F,De Pizzol M,Regano D,Maione F,Capano S,Locati M,Mantovani A,Latini R,Bussolino F,Giraudo E
Sun Apr 15 00:00:00 EDT 2012
ITAM-coupled receptors inhibit IFNAR signaling and alter macrophage responses to TLR4 and Listeria monocytogenes.
Journal of immunology (Baltimore, Md. : 1950)
Huynh L,Wang L,Shi C,Park-Min KH,Ivashkiv LB
Sun Apr 01 00:00:00 EDT 2012
HLA-DQA2 and HLA-DQB2 genes are specifically expressed in human Langerhans cells and encode a new HLA class II molecule.
Journal of immunology (Baltimore, Md. : 1950)
Lenormand C,Bausinger H,Gross F,Signorino-Gelo F,Koch S,Peressin M,Fricker D,Cazenave JP,Bieber T,Hanau D,de la Salle H,Tourne S
Sun Apr 15 00:00:00 EDT 2012
NLRC4 inflammasome-mediated production of IL-1β modulates mucosal immunity in the lung against gram-negative bacterial infection.
Journal of immunology (Baltimore, Md. : 1950)
Cai S,Batra S,Wakamatsu N,Pacher P,Jeyaseelan S
Fri Jun 01 00:00:00 EDT 2012
Production of TNF-α in macrophages activated by T cells, compared with lipopolysaccharide, uses distinct IL-10-dependent regulatory mechanism.
Journal of immunology (Baltimore, Md. : 1950)
Agbanoma G,Li C,Ennis D,Palfreeman AC,Williams LM,Brennan FM
Wed Feb 01 00:00:00 EST 2012
Complement protein C1q directs macrophage polarization and limits inflammasome activity during the uptake of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)
Benoit ME,Clarke EV,Morgado P,Fraser DA,Tenner AJ
Fri Jun 01 00:00:00 EDT 2012
Efficient clearance of early apoptotic cells by human macrophages requires M2c polarization and MerTK induction.
Journal of immunology (Baltimore, Md. : 1950)
Zizzo G,Hilliard BA,Monestier M,Cohen PL
Mon Oct 01 00:00:00 EDT 2012
Diesel exhaust particle exposure in vitro alters monocyte differentiation and function.
PloS one
Chaudhuri N,Jary H,Lea S,Khan N,Piddock KC,Dockrell DH,Donaldson K,Duffin R,Singh D,Parker LC,Sabroe I
Fri May 24 00:00:00 EDT 2013
TLT-1s, alternative transcripts of triggering receptor expressed on myeloid cell-like transcript-1 (TLT-1), Inhibits the triggering receptor expressed on myeloid cell-2 (TREM-2)-mediated signaling pathway during osteoclastogenesis.
The Journal of biological chemistry
Yoon SH,Lee YD,Ha J,Lee Y,Kim HH
Fri Aug 24 00:00:00 EDT 2012
Adipokines in psoriatic arthritis patients: the correlations with osteoclast precursors and bone erosions.
PloS one
Xue Y,Jiang L,Cheng Q,Chen H,Yu Y,Lin Y,Yang X,Kong N,Zhu X,Xu X,Wan W,Zou H
Tue Aug 26 00:00:00 EDT 2014
Promotion of human early embryonic development and blastocyst outgrowth in vitro using autocrine/paracrine growth factors.
PloS one
Kawamura K,Chen Y,Shu Y,Cheng Y,Qiao J,Behr B,Pera RA,Hsueh AJ
Tue May 07 00:00:00 EDT 2013
Prevention of bone growth defects, increased bone resorption and marrow adiposity with folinic acid in rats receiving long-term methotrexate.
PloS one
Fan CM,Foster BK,Hui SK,Xian CJ
Thu Apr 11 00:00:00 EDT 2013
Tailored enrichment strategy detects low abundant small noncoding RNAs in HIV-1 infected cells.
Retrovirology
Althaus CF,Vongrad V,Niederöst B,Joos B,Di Giallonardo F,Rieder P,Pavlovic J,Trkola A,Günthard HF,Metzner KJ,Fischer M
Thu Mar 29 00:00:00 EDT 2012
Characterization and function of the human macrophage dopaminergic system: implications for CNS disease and drug abuse.
Journal of neuroinflammation
Gaskill PJ,Carvallo L,Eugenin EA,Berman JW
Sat Aug 18 00:00:00 EDT 2012
Characterization of a mutated IgA2 antibody of the m(1) allotype against the epidermal growth factor receptor for the recruitment of monocytes and macrophages.
The Journal of biological chemistry
Lohse S,Brunke C,Derer S,Peipp M,Boross P,Kellner C,Beyer T,Dechant M,van der Winkel JG,Leusen JH,Valerius T
Fri Jul 20 00:00:00 EDT 2012
Induction of CD36 and thrombospondin-1 in macrophages by hypoxia-inducible factor 1 and its relevance in the inflammatory process.
PloS one
Ortiz-Masià D,Díez I,Calatayud S,Hernández C,Cosín-Roger J,Hinojosa J,Esplugues JV,Barrachina MD
Wed Apr 10 00:00:00 EDT 2013
Divergent resorbability and effects on osteoclast formation of commonly used bone substitutes in a human in vitro-assay.
PloS one
Keller J,Brink S,Busse B,Schilling AF,Schinke T,Amling M,Lange T
Tue Apr 02 00:00:00 EDT 2013
Macrophage mesenchymal migration requires podosome stabilization by filamin A.
The Journal of biological chemistry
Guiet R,Vérollet C,Lamsoul I,Cougoule C,Poincloux R,Labrousse A,Calderwood DA,Glogauer M,Lutz PG,Maridonneau-Parini I
Fri Apr 13 00:00:00 EDT 2012
MiniCD4 protein resistance mutations affect binding to the HIV-1 gp120 CD4 binding site and decrease entry efficiency.
Retrovirology
Grupping K,Selhorst P,Michiels J,Vereecken K,Heyndrickx L,Kessler P,Vanham G,Martin L,Ariën KK
Wed May 02 00:00:00 EDT 2012
The chemerin/ChemR23 system does not affect the pro-inflammatory response of mouse and human macrophages ex vivo.
PloS one
Bondue B,De Henau O,Luangsay S,Devosse T,de Nadaï P,Springael JY,Parmentier M,Vosters O
Tue Nov 27 00:00:00 EST 2012
Rho GTPase expression in human myeloid cells.
PloS one
van Helden SF,Anthony EC,Dee R,Hordijk PL
Wed May 15 00:00:00 EDT 2013
Monocytes contribute to differential immune pressure on R5 versus X4 HIV through the adipocytokine visfatin/NAMPT.
PloS one
Van den Bergh R,Morin S,Sass HJ,Grzesiek S,Vekemans M,Florence E,Tran HT,Imiru RG,Heyndrickx L,Vanham G,De Baetselier P,Raes G
Tue Sep 04 00:00:00 EDT 2012
Dasatinib as a bone-modifying agent: anabolic and anti-resorptive effects.
PloS one
Garcia-Gomez A,Ocio EM,Crusoe E,Santamaria C,Hernández-Campo P,Blanco JF,Sanchez-Guijo FM,Hernández-Iglesias T,Briñón JG,Fisac-Herrero RM,Lee FY,Pandiella A,San Miguel JF,Garayoa M
Mon Sep 10 00:00:00 EDT 2012
Innate and adaptive interferons suppress IL-1α and IL-1β production by distinct pulmonary myeloid subsets during Mycobacterium tuberculosis infection.
Immunity
Mayer-Barber KD,Andrade BB,Barber DL,Hieny S,Feng CG,Caspar P,Oland S,Gordon S,Sher A
Fri Dec 23 00:00:00 EST 2011
TLR2-dependent pathway of heterologous down-modulation for the CC chemokine receptors 1, 2, and 5 in human blood monocytes.
Blood
Fox JM,Letellier E,Oliphant CJ,Signoret N
Thu Feb 10 00:00:00 EST 2011
Osteoclast-gene expression profiling reveals osteoclast-derived CCR2 chemokines promoting myeloma cell migration.
Blood
Moreaux J,Hose D,Kassambara A,Reme T,Moine P,Requirand G,Goldschmidt H,Klein B
Thu Jan 27 00:00:00 EST 2011
Fc gamma receptor IIb on target B cells promotes rituximab internalization and reduces clinical efficacy.
Blood
Lim SH,Vaughan AT,Ashton-Key M,Williams EL,Dixon SV,Chan HT,Beers SA,French RR,Cox KL,Davies AJ,Potter KN,Mockridge CI,Oscier DG,Johnson PW,Cragg MS,Glennie MJ
Thu Sep 01 00:00:00 EDT 2011
Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions.
Blood
Klimchenko O,Di Stefano A,Geoerger B,Hamidi S,Opolon P,Robert T,Routhier M,El-Benna J,Delezoide AL,Boukour S,Lescure B,Solary E,Vainchenker W,Norol F
Thu Mar 17 00:00:00 EDT 2011
The homeobox transcription factor VentX controls human macrophage terminal differentiation and proinflammatory activation.
The Journal of clinical investigation
Wu X,Gao H,Ke W,Giese RW,Zhu Z
Fri Jul 01 00:00:00 EDT 2011
Plasma carboxypeptidase B downregulates inflammatory responses in autoimmune arthritis.
The Journal of clinical investigation
Song JJ,Hwang I,Cho KH,Garcia MA,Kim AJ,Wang TH,Lindstrom TM,Lee AT,Nishimura T,Zhao L,Morser J,Nesheim M,Goodman SB,Lee DM,Bridges SL,Gregersen PK,Leung LL,Robinson WH
Thu Sep 01 00:00:00 EDT 2011
Extracellular ATP acts on P2Y2 purinergic receptors to facilitate HIV-1 infection.
The Journal of experimental medicine
Séror C,Melki MT,Subra F,Raza SQ,Bras M,Saïdi H,Nardacci R,Voisin L,Paoletti A,Law F,Martins I,Amendola A,Abdul-Sater AA,Ciccosanti F,Delelis O,Niedergang F,Thierry S,Said-Sadier N,Lamaze C,Métivier D,Estaquier J,Fimia GM,Falasca L,Casetti R,Modjtahedi N,Kanellopoulos J,Mouscadet JF,Ojcius DM,Piacentini M,Gougeon ML,Kroemer G,Perfettini JL
Mon Aug 29 00:00:00 EDT 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
300-25 was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.
Tue Mar 01 00:00:00 EST 2011
Hematopoietic differentiation and production of mature myeloid cells from human pluripotent stem cells.
Nature protocols
Choi KD,Vodyanik M,Slukvin II
300-25 was used in Cell Culture to study how differentiation of myeloid progenitors into mature myeloid cells requires an additional 5-19 d of culture with cytokines, depending on the cell type.
Tue Mar 01 00:00:00 EST 2011
Resistance to regulatory T cell-mediated suppression in rheumatoid arthritis can be bypassed by ectopic foxp3 expression in pathogenic synovial T cells.
Proceedings of the National Academy of Sciences of the United States of America
Beavis PA,Gregory B,Green P,Cribbs AP,Kennedy A,Amjadi P,Palfreeman AC,Feldmann M,Brennan FM
Tue Oct 04 00:00:00 EDT 2011
TNF activates calcium-nuclear factor of activated T cells (NFAT)c1 signaling pathways in human macrophages.
Proceedings of the National Academy of Sciences of the United States of America
Yarilina A,Xu K,Chen J,Ivashkiv LB
Tue Jan 25 00:00:00 EST 2011
Systems analysis identifies an essential role for SHANK-associated RH domain-interacting protein (SHARPIN) in macrophage Toll-like receptor 2 (TLR2) responses.
Proceedings of the National Academy of Sciences of the United States of America
Zak DE,Schmitz F,Gold ES,Diercks AH,Peschon JJ,Valvo JS,Niemistö A,Podolsky I,Fallen SG,Suen R,Stolyar T,Johnson CD,Kennedy KA,Hamilton MK,Siggs OM,Beutler B,Aderem A
Tue Jul 12 00:00:00 EDT 2011
MMP-13 stimulates osteoclast differentiation and activation in tumour breast bone metastases.
Breast cancer research : BCR
Pivetta E,Scapolan M,Pecolo M,Wassermann B,Abu-Rumeileh I,Balestreri L,Borsatti E,Tripodo C,Colombatti A,Spessotto P
Thu Oct 27 00:00:00 EDT 2011
Human macrophage responses to clinical isolates from the Mycobacterium tuberculosis complex discriminate between ancient and modern lineages.
PLoS pathogens
Portevin D,Gagneux S,Comas I,Young D
Tue Mar 01 00:00:00 EST 2011
Macrophages at the fetal-maternal interface express markers of alternative activation and are induced by M-CSF and IL-10.
Journal of immunology (Baltimore, Md. : 1950)
Svensson J,Jenmalm MC,Matussek A,Geffers R,Berg G,Ernerudh J
Sat Oct 01 00:00:00 EDT 2011
β5 integrin is the major contributor to the αVintegrin-mediated blockade of HIV-1 replication.
Journal of immunology (Baltimore, Md. : 1950)
Ballana E,Pauls E,Clotet B,Perron-Sierra F,Tucker GC,Esté JA
Sat Jan 01 00:00:00 EST 2011
Transcriptional suppression of IL-27 production by Mycobacterium tuberculosis-activated p38 MAPK via inhibition of AP-1 binding.
Journal of immunology (Baltimore, Md. : 1950)
Zhang J,Qian X,Ning H,Eickhoff CS,Hoft DF,Liu J
Sun May 15 00:00:00 EDT 2011
Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Novikov A,Cardone M,Thompson R,Shenderov K,Kirschman KD,Mayer-Barber KD,Myers TG,Rabin RL,Trinchieri G,Sher A,Feng CG
Thu Sep 01 00:00:00 EDT 2011
Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis.
Journal of immunology (Baltimore, Md. : 1950)
Bruscia EM,Zhang PX,Satoh A,Caputo C,Medzhitov R,Shenoy A,Egan ME,Krause DS
Wed Jun 15 00:00:00 EDT 2011
Hck tyrosine kinase regulates TLR4-induced TNF and IL-6 production via AP-1.
Journal of immunology (Baltimore, Md. : 1950)
Smolinska MJ,Page TH,Urbaniak AM,Mutch BE,Horwood NJ
Thu Dec 01 00:00:00 EST 2011
IL-27 and IL-21 are associated with T cell IL-10 responses in human visceral leishmaniasis.
Journal of immunology (Baltimore, Md. : 1950)
Ansari NA,Kumar R,Gautam S,Nylén S,Singh OP,Sundar S,Sacks D
Fri Apr 01 00:00:00 EDT 2011
Degradation, bioactivity, and osteogenic potential of composites made of PLGA and two different sol-gel bioactive glasses.
Annals of biomedical engineering
Pamula E,Kokoszka J,Cholewa-Kowalska K,Laczka M,Kantor L,Niedzwiedzki L,Reilly GC,Filipowska J,Madej W,Kolodziejczyk M,Tylko G,Osyczka AM
Mon Aug 01 00:00:00 EDT 2011
Autologous serum improves yield and metabolic capacity of monocyte-derived hepatocyte-like cells: possible implication for cell transplantation.
Cell transplantation
Ehnert S,Seeliger C,Vester H,Schmitt A,Saidy-Rad S,Lin J,Neumaier M,Gillen S,Kleeff J,Friess H,Burkhart J,Stöckle U,Nüssler AK
Thu Mar 08 00:00:00 EST 2012
Flemingia macrophylla Extract Ameliorates Experimental Osteoporosis in Ovariectomized Rats.
Evidence-based complementary and alternative medicine : eCAM
Ho HY,Wu JB,Lin WC
Thu Aug 23 00:00:00 EDT 2012
Siglecs facilitate HIV-1 infection of macrophages through adhesion with viral sialic acids.
PloS one
Zou Z,Chastain A,Moir S,Ford J,Trandem K,Martinelli E,Cicala C,Crocker P,Arthos J,Sun PD
Fri Jun 08 00:00:00 EDT 2012
Differentiation and glucocorticoid regulated apopto-phagocytic gene expression patterns in human macrophages. Role of Mertk in enhanced phagocytosis.
PloS one
Zahuczky G,Kristóf E,Majai G,Fésüs L
Wed Nov 02 00:00:00 EDT 2011
Minocycline inhibition of monocyte activation correlates with neuronal protection in SIV neuroAIDS.
PloS one
Campbell JH,Burdo TH,Autissier P,Bombardier JP,Westmoreland SV,Soulas C,González RG,Ratai EM,Williams KC
Wed Apr 06 00:00:00 EDT 2011
Evaluation of transduction efficiency in macrophage colony-stimulating factor differentiated human macrophages using HIV-1 based lentiviral vectors.
BMC biotechnology
Leyva FJ,Anzinger JJ,McCoy JP,Kruth HS
Mon Jan 31 00:00:00 EST 2011
Distinct functions of the mitogen-activated protein kinase-activated protein (MAPKAP) kinases MK2 and MK3: MK2 mediates lipopolysaccharide-induced signal transducers and activators of transcription 3 (STAT3) activation by preventing negative regulatory effects of MK3.
The Journal of biological chemistry
Ehlting C,Ronkina N,Böhmer O,Albrecht U,Bode KA,Lang KS,Kotlyarov A,Radzioch D,Gaestel M,Häussinger D,Bode JG
Fri Jul 08 00:00:00 EDT 2011
Increased IL-10 mRNA expression in tumor-associated macrophage correlated with late stage of lung cancer.
Journal of experimental & clinical cancer research : CR
Wang R,Lu M,Zhang J,Chen S,Luo X,Qin Y,Chen H
Fri May 20 00:00:00 EDT 2011
Effects of naturally-arising HIV Nef mutations on cytotoxic T lymphocyte recognition and Nef's functionality in primary macrophages.
Retrovirology
Mwimanzi P,Hasan Z,Hassan R,Suzu S,Takiguchi M,Ueno T
Wed Jun 22 00:00:00 EDT 2011
Protein kinase Czeta mediates micro-opioid receptor-induced cross-desensitization of chemokine receptor CCR5.
The Journal of biological chemistry
Song C,Rahim RT,Davey PC,Bednar F,Bardi G,Zhang L,Zhang N,Oppenheim JJ,Rogers TJ
Fri Jun 10 00:00:00 EDT 2011
Plasma L-cystine/L-glutamate imbalance increases tumor necrosis factor-alpha from CD14+ circulating monocytes in patients with advanced cirrhosis.
PloS one
Kakazu E,Ueno Y,Kondo Y,Inoue J,Ninomiya M,Kimura O,Wakui Y,Fukushima K,Tamai K,Shimosegawa T
Wed Feb 15 00:00:00 EST 2012
The transient receptor potential ion channel TRPV6 is expressed at low levels in osteoblasts and has little role in osteoblast calcium uptake.
PloS one
Little R,Muimo R,Robson L,Harris K,Grabowski PS
Fri May 11 00:00:00 EDT 2012
HIV infection enhances TRAIL-induced cell death in macrophage by down-regulating decoy receptor expression and generation of reactive oxygen species.
PloS one
Zhu DM,Shi J,Liu S,Liu Y,Zheng D
Tue Apr 05 00:00:00 EDT 2011
Dysfunctional CFTR alters the bactericidal activity of human macrophages against Pseudomonas aeruginosa.
PloS one
Del Porto P,Cifani N,Guarnieri S,Di Domenico EG,Mariggiò MA,Spadaro F,Guglietta S,Anile M,Venuta F,Quattrucci S,Ascenzioni F
Mon Oct 17 00:00:00 EDT 2011
Genomic stability over 9 years of an isoniazid resistant Mycobacterium tuberculosis outbreak strain in Sweden.
PloS one
Sandegren L,Groenheit R,Koivula T,Ghebremichael S,Advani A,Castro E,Pennhag A,Hoffner S,Mazurek J,Pawlowski A,Kan B,Bruchfeld J,Melefors Ö,Källenius G
Mon Jan 31 00:00:00 EST 2011
IRF5 is required for late-phase TNF secretion by human dendritic cells.
Blood
Krausgruber T,Saliba D,Ryzhakov G,Lanfrancotti A,Blazek K,Udalova IA
Thu Jun 03 00:00:00 EDT 2010
Periostin advances atherosclerotic and rheumatic cardiac valve degeneration by inducing angiogenesis and MMP production in humans and rodents.
The Journal of clinical investigation
Hakuno D,Kimura N,Yoshioka M,Mukai M,Kimura T,Okada Y,Yozu R,Shukunami C,Hiraki Y,Kudo A,Ogawa S,Fukuda K
Thu Jul 01 00:00:00 EDT 2010
IFN-γ abrogates endotoxin tolerance by facilitating Toll-like receptor-induced chromatin remodeling.
Proceedings of the National Academy of Sciences of the United States of America
Chen J,Ivashkiv LB
Tue Nov 09 00:00:00 EST 2010
Important roles of PI3Kgamma in osteoclastogenesis and bone homeostasis.
Proceedings of the National Academy of Sciences of the United States of America
Kang H,Chang W,Hurley M,Vignery A,Wu D
Tue Jul 20 00:00:00 EDT 2010
PDGF-CC blockade inhibits pathological angiogenesis by acting on multiple cellular and molecular targets.
Proceedings of the National Academy of Sciences of the United States of America
Hou X,Kumar A,Lee C,Wang B,Arjunan P,Dong L,Maminishkis A,Tang Z,Li Y,Zhang F,Zhang SZ,Wardega P,Chakrabarty S,Liu B,Wu Z,Colosi P,Fariss RN,Lennartsson J,Nussenblatt R,Gutkind JS,Cao Y,Li X
Tue Jul 06 00:00:00 EDT 2010
Effective, broad spectrum control of virulent bacterial infections using cationic DNA liposome complexes combined with bacterial antigens.
PLoS pathogens
Ireland R,Olivares-Zavaleta N,Warawa JM,Gherardini FC,Jarrett C,Hinnebusch BJ,Belisle JT,Fairman J,Bosio CM
Thu May 27 00:00:00 EDT 2010
Human gingiva-derived mesenchymal stem cells elicit polarization of m2 macrophages and enhance cutaneous wound healing.
Stem cells (Dayton, Ohio)
Zhang QZ,Su WR,Shi SH,Wilder-Smith P,Xiang AP,Wong A,Nguyen AL,Kwon CW,Le AD
Fri Oct 01 00:00:00 EDT 2010
Development of a macromolecular prodrug for the treatment of inflammatory arthritis: mechanisms involved in arthrotropism and sustained therapeutic efficacy.
Arthritis research & therapy
Quan LD,Purdue PE,Liu XM,Boska MD,Lele SM,Thiele GM,Mikuls TR,Dou H,Goldring SR,Wang D
Thu Mar 31 00:00:00 EDT 2011
Autoamplification of Notch signaling in macrophages by TLR-induced and RBP-J-dependent induction of Jagged1.
Journal of immunology (Baltimore, Md. : 1950)
Foldi J,Chung AY,Xu H,Zhu J,Outtz HH,Kitajewski J,Li Y,Hu X,Ivashkiv LB
Mon Nov 01 00:00:00 EDT 2010
Matrix architecture dictates three-dimensional migration modes of human macrophages: differential involvement of proteases and podosome-like structures.
Journal of immunology (Baltimore, Md. : 1950)
Van Goethem E,Poincloux R,Gauffre F,Maridonneau-Parini I,Le Cabec V
Fri Jan 15 00:00:00 EST 2010
Phagocytosis of apoptotic cells by neutrophil granulocytes: diminished proinflammatory neutrophil functions in the presence of apoptotic cells.
Journal of immunology (Baltimore, Md. : 1950)
Esmann L,Idel C,Sarkar A,Hellberg L,Behnen M,Möller S,van Zandbergen G,Klinger M,Köhl J,Bussmeyer U,Solbach W,Laskay T
Fri Jan 01 00:00:00 EST 2010
Triptolide inhibits IL-12/IL-23 expression in APCs via CCAAT/enhancer-binding protein alpha.
Journal of immunology (Baltimore, Md. : 1950)
Zhang Y,Ma X
Thu Apr 01 00:00:00 EDT 2010
CXC chemokine ligand 4 induces a unique transcriptome in monocyte-derived macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gleissner CA,Shaked I,Little KM,Ley K
Sat May 01 00:00:00 EDT 2010
Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27.
Journal of immunology (Baltimore, Md. : 1950)
Kalliolias GD,Gordon RA,Ivashkiv LB
Wed Dec 01 00:00:00 EST 2010
Calcium-activated pathways and oxidative burst mediate zymosan-induced signaling and IL-10 production in human macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Kelly EK,Wang L,Ivashkiv LB
Sat May 15 00:00:00 EDT 2010
HIV-1 Nef triggers macrophage fusion in a p61Hck- and protease-dependent manner.
Journal of immunology (Baltimore, Md. : 1950)
Vérollet C,Zhang YM,Le Cabec V,Mazzolini J,Charrière G,Labrousse A,Bouchet J,Medina I,Biessen E,Niedergang F,Bénichou S,Maridonneau-Parini I
Tue Jun 15 00:00:00 EDT 2010
Tumor-conditioned macrophages secrete migration-stimulating factor: a new marker for M2-polarization, influencing tumor cell motility.
Journal of immunology (Baltimore, Md. : 1950)
Solinas G,Schiarea S,Liguori M,Fabbri M,Pesce S,Zammataro L,Pasqualini F,Nebuloni M,Chiabrando C,Mantovani A,Allavena P
Thu Jul 01 00:00:00 EDT 2010
Direct inhibition of human RANK+ osteoclast precursors identifies a homeostatic function of IL-1beta.
Journal of immunology (Baltimore, Md. : 1950)
Lee B,Kim TH,Jun JB,Yoo DH,Woo JH,Choi SJ,Lee YH,Song GG,Sohn J,Park-Min KH,Ivashkiv LB,Ji JD
Mon Nov 15 00:00:00 EST 2010
Innate immune proteins C1q and mannan-binding lectin enhance clearance of atherogenic lipoproteins by human monocytes and macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Fraser DA,Tenner AJ
Fri Oct 01 00:00:00 EDT 2010
The relative timing of exposure to phagocytosable particulates and to osteoclastogenic cytokines is critically important in the determination of myeloid cell fate.
Journal of immunology (Baltimore, Md. : 1950)
James DE,Nestor BJ,Sculco TP,Ivashkiv LB,Ross FP,Goldring SR,Purdue PE
Thu Jul 15 00:00:00 EDT 2010
miR-146a is differentially expressed by myeloid dendritic cell subsets and desensitizes cells to TLR2-dependent activation.
Journal of immunology (Baltimore, Md. : 1950)
Jurkin J,Schichl YM,Koeffel R,Bauer T,Richter S,Konradi S,Gesslbauer B,Strobl H
Sat May 01 00:00:00 EDT 2010
The chemorepellent Slit3 promotes monocyte migration.
Journal of immunology (Baltimore, Md. : 1950)
Geutskens SB,Hordijk PL,van Hennik PB
Wed Dec 15 00:00:00 EST 2010
Kinetics and specificity of feline leukemia virus subgroup C receptor (FLVCR) export function and its dependence on hemopexin.
The Journal of biological chemistry
Yang Z,Philips JD,Doty RT,Giraudi P,Ostrow JD,Tiribelli C,Smith A,Abkowitz JL
Fri Sep 10 00:00:00 EDT 2010
Bone is not essential for osteoclast activation.
PloS one
Fuller K,Ross JL,Szewczyk KA,Moss R,Chambers TJ
Fri Sep 17 00:00:00 EDT 2010
VEGF stimulates RCAN1.4 expression in endothelial cells via a pathway requiring Ca2+/calcineurin and protein kinase C-delta.
PloS one
Holmes K,Chapman E,See V,Cross MJ
Tue Jul 06 00:00:00 EDT 2010
Lysophosphatidic acid signals through multiple receptors in osteoclasts to elevate cytosolic calcium concentration, evoke retraction, and promote cell survival.
The Journal of biological chemistry
Lapierre DM,Tanabe N,Pereverzev A,Spencer M,Shugg RP,Dixon SJ,Sims SM
Fri Aug 13 00:00:00 EDT 2010
Distinct types of fibrocyte can differentiate from mononuclear cells in the presence and absence of serum.
PloS one
Curnow SJ,Fairclough M,Schmutz C,Kissane S,Denniston AK,Nash K,Buckley CD,Lord JM,Salmon M
Thu Mar 18 00:00:00 EDT 2010
Transcriptome analysis of monocyte-HIV interactions.
Retrovirology
Van den Bergh R,Florence E,Vlieghe E,Boonefaes T,Grooten J,Houthuys E,Tran HT,Gali Y,De Baetselier P,Vanham G,Raes G
Mon Jun 14 00:00:00 EDT 2010
Amorphigenin inhibits Osteoclast differentiation by suppressing c-Fos and nuclear factor of activated T cells.
Anatomy & cell biology
Kim BG,Kwak HB,Choi EY,Kim HS,Kim MH,Kim SH,Choi MK,Chun CH,Oh J,Kim JJ
Wed Dec 01 00:00:00 EST 2010
Hematopoietic differentiation: a coordinated dynamical process towards attractor stable states.
BMC systems biology
Felli N,Cianetti L,Pelosi E,Carè A,Liu CG,Calin GA,Rossi S,Peschle C,Marziali G,Giuliani A
Wed Jun 16 00:00:00 EDT 2010
Innate immune signaling induces high levels of TC-specific deaminase activity in primary monocyte-derived cells through expression of APOBEC3A isoforms.
The Journal of biological chemistry
Thielen BK,McNevin JP,McElrath MJ,Hunt BV,Klein KC,Lingappa JR
Fri Sep 03 00:00:00 EDT 2010
The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA.
Immunity
Zhong B,Zhang L,Lei C,Li Y,Mao AP,Yang Y,Wang YY,Zhang XL,Shu HB
Fri Mar 20 00:00:00 EDT 2009
Stabilization of snail by NF-kappaB is required for inflammation-induced cell migration and invasion.
Cancer cell
Wu Y,Deng J,Rychahou PG,Qiu S,Evers BM,Zhou BP
Tue May 05 00:00:00 EDT 2009
The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth.
Blood
Pennisi A,Ling W,Li X,Khan S,Shaughnessy JD,Barlogie B,Yaccoby S
Thu Aug 27 00:00:00 EDT 2009
ADA-deficient SCID is associated with a specific microenvironment and bone phenotype characterized by RANKL/OPG imbalance and osteoblast insufficiency.
Blood
Sauer AV,Mrak E,Hernandez RJ,Zacchi E,Cavani F,Casiraghi M,Grunebaum E,Roifman CM,Cervi MC,Ambrosi A,Carlucci F,Roncarolo MG,Villa A,Rubinacci A,Aiuti A
Thu Oct 08 00:00:00 EDT 2009
Cell adhesion through alphaV-containing integrins is required for efficient HIV-1 infection in macrophages.
Blood
Ballana E,Pauls E,Senserrich J,Clotet B,Perron-Sierra F,Tucker GC,Esté JA
Thu Feb 05 00:00:00 EST 2009
Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation.
Blood
Kandilci A,Grosveld GC
Thu Aug 20 00:00:00 EDT 2009
Dominant role of CD47-thrombospondin-1 interactions in myeloma-induced fusion of human dendritic cells: implications for bone disease.
Blood
Kukreja A,Radfar S,Sun BH,Insogna K,Dhodapkar MV
Thu Oct 15 00:00:00 EDT 2009
Nutlin-3 up-regulates the expression of Notch1 in both myeloid and lymphoid leukemic cells, as part of a negative feedback antiapoptotic mechanism.
Blood
Secchiero P,Melloni E,di Iasio MG,Tiribelli M,Rimondi E,Corallini F,Gattei V,Zauli G
Thu Apr 30 00:00:00 EDT 2009
cIAP1-dependent TRAF2 degradation regulates the differentiation of monocytes into macrophages and their response to CD40 ligand.
Blood
Dupoux A,Cartier J,Cathelin S,Filomenko R,Solary E,Dubrez-Daloz L
Thu Jan 01 00:00:00 EST 2009
Fluorescent pegylated nanoparticles demonstrate fluid-phase pinocytosis by macrophages in mouse atherosclerotic lesions.
The Journal of clinical investigation
Buono C,Anzinger JJ,Amar M,Kruth HS
Fri May 01 00:00:00 EDT 2009
A human IL10 BAC transgene reveals tissue-specific control of IL-10 expression and alters disease outcome.
Proceedings of the National Academy of Sciences of the United States of America
Ranatunga D,Hedrich CM,Wang F,McVicar DW,Nowak N,Joshi T,Feigenbaum L,Grant LR,Stäger S,Bream JH
Tue Oct 06 00:00:00 EDT 2009
The role of transposable elements in the regulation of IFN-lambda1 gene expression.
Proceedings of the National Academy of Sciences of the United States of America
Thomson SJ,Goh FG,Banks H,Krausgruber T,Kotenko SV,Foxwell BM,Udalova IA
Tue Jul 14 00:00:00 EDT 2009
A rapid crosstalk of human gammadelta T cells and monocytes drives the acute inflammation in bacterial infections.
PLoS pathogens
Eberl M,Roberts GW,Meuter S,Williams JD,Topley N,Moser B
Sun Feb 01 00:00:00 EST 2009
Aryl hydrocarbon receptor activation inhibits in vitro differentiation of human monocytes and Langerhans dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Platzer B,Richter S,Kneidinger D,Waltenberger D,Woisetschläger M,Strobl H
Wed Jul 01 00:00:00 EDT 2009
Identification of mycobacterial alpha-glucan as a novel ligand for DC-SIGN: involvement of mycobacterial capsular polysaccharides in host immune modulation.
Journal of immunology (Baltimore, Md. : 1950)
Geurtsen J,Chedammi S,Mesters J,Cot M,Driessen NN,Sambou T,Kakutani R,Ummels R,Maaskant J,Takata H,Baba O,Terashima T,Bovin N,Vandenbroucke-Grauls CM,Nigou J,Puzo G,Lemassu A,Daffé M,Appelmelk BJ
Thu Oct 15 00:00:00 EDT 2009
Differential use of CARD9 by dectin-1 in macrophages and dendritic cells.
Journal of immunology (Baltimore, Md. : 1950)
Goodridge HS,Shimada T,Wolf AJ,Hsu YM,Becker CA,Lin X,Underhill DM
Thu Jan 15 00:00:00 EST 2009
GM-CSF regulates fusion of mononuclear osteoclasts into bone-resorbing osteoclasts by activating the Ras/ERK pathway.
Journal of immunology (Baltimore, Md. : 1950)
Lee MS,Kim HS,Yeon JT,Choi SW,Chun CH,Kwak HB,Oh J
Tue Sep 01 00:00:00 EDT 2009
Interactions between human NK cells and macrophages in response to Salmonella infection.
Journal of immunology (Baltimore, Md. : 1950)
Lapaque N,Walzer T,Méresse S,Vivier E,Trowsdale J
Wed Apr 01 00:00:00 EDT 2009
Human B cells secrete granzyme B when recognizing viral antigens in the context of the acute phase cytokine IL-21.
Journal of immunology (Baltimore, Md. : 1950)
Hagn M,Schwesinger E,Ebel V,Sontheimer K,Maier J,Beyer T,Syrovets T,Laumonnier Y,Fabricius D,Simmet T,Jahrsdörfer B
Sat Aug 01 00:00:00 EDT 2009
IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression.
Journal of immunology (Baltimore, Md. : 1950)
Park-Min KH,Ji JD,Antoniv T,Reid AC,Silver RB,Humphrey MB,Nakamura M,Ivashkiv LB
Sat Aug 15 00:00:00 EDT 2009
Differential expression of adenosine A3 receptors controls adenosine A2A receptor-mediated inhibition of TLR responses in microglia.
Journal of immunology (Baltimore, Md. : 1950)
van der Putten C,Zuiderwijk-Sick EA,van Straalen L,de Geus ED,Boven LA,Kondova I,IJzerman AP,Bajramovic JJ
Mon Jun 15 00:00:00 EDT 2009
Identification of markers that distinguish monocyte-derived fibrocytes from monocytes, macrophages, and fibroblasts.
PloS one
Pilling D,Fan T,Huang D,Kaul B,Gomer RH
Fri Oct 16 00:00:00 EDT 2009
Negative feedback Inhibition of NFATc1 by DYRK1A regulates bone homeostasis.
The Journal of biological chemistry
Lee Y,Ha J,Kim HJ,Kim YS,Chang EJ,Song WJ,Kim HH
Fri Nov 27 00:00:00 EST 2009
Trolox prevents osteoclastogenesis by suppressing RANKL expression and signaling.
The Journal of biological chemistry
Lee JH,Kim HN,Yang D,Jung K,Kim HM,Kim HH,Ha H,Lee ZH
Fri May 15 00:00:00 EDT 2009
Breast cancer-derived factors stimulate osteoclastogenesis through the Ca2+/protein kinase C and transforming growth factor-beta/MAPK signaling pathways.
The Journal of biological chemistry
Tiedemann K,Hussein O,Sadvakassova G,Guo Y,Siegel PM,Komarova SV
Fri Nov 27 00:00:00 EST 2009
Integrated regulation of Toll-like receptor responses by Notch and interferon-gamma pathways.
Immunity
Hu X,Chung AY,Wu I,Foldi J,Chen J,Ji JD,Tateya T,Kang YJ,Han J,Gessler M,Kageyama R,Ivashkiv LB
Fri Nov 14 00:00:00 EST 2008
Human basophils activated by mast cell-derived IL-3 express retinaldehyde dehydrogenase-II and produce the immunoregulatory mediator retinoic acid.
Blood
Spiegl N,Didichenko S,McCaffery P,Langen H,Dahinden CA
Sat Nov 01 00:00:00 EDT 2008
Lipopolysaccharide-induced expression of matrix metalloproteinases in human monocytes is suppressed by IFN-gamma via superinduction of ATF-3 and suppression of AP-1.
Journal of immunology (Baltimore, Md. : 1950)
Ho HH,Antoniv TT,Ji JD,Ivashkiv LB
Wed Oct 01 00:00:00 EDT 2008
The angiogenic response of the aorta to injury and inflammatory cytokines requires macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Gelati M,Aplin AC,Fogel E,Smith KD,Nicosia RF
Wed Oct 15 00:00:00 EDT 2008
Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures.
Journal of immunology (Baltimore, Md. : 1950)
Sacre SM,Lo A,Gregory B,Simmonds RE,Williams L,Feldmann M,Brennan FM,Foxwell BM
Mon Dec 01 00:00:00 EST 2008
Induction of TRAIL- and TNF-alpha-dependent apoptosis in human monocyte-derived dendritic cells by microfilariae of Brugia malayi.
Journal of immunology (Baltimore, Md. : 1950)
Semnani RT,Venugopal PG,Mahapatra L,Skinner JA,Meylan F,Chien D,Dorward DW,Chaussabel D,Siegel RM,Nutman TB
Sat Nov 15 00:00:00 EST 2008
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
Journal of immunology (Baltimore, Md. : 1950)
Mori Y,Tsuji S,Inui M,Sakamoto Y,Endo S,Ito Y,Fujimura S,Koga T,Nakamura A,Takayanagi H,Itoi E,Takai T
Wed Oct 01 00:00:00 EDT 2008
Inhibitory immunoglobulin-like receptors LILRB and PIR-B negatively regulate osteoclast development.
Journal of immunology (Baltimore, Md. : 1950)
Mori Y,Tsuji S,Inui M,Sakamoto Y,Endo S,Ito Y,Fujimura S,Koga T,Nakamura A,Takayanagi H,Itoi E,Takai T
Wed Oct 01 00:00:00 EDT 2008
SOCS1 regulates the IFN but not NFkappaB pathway in TLR-stimulated human monocytes and macrophages.
Journal of immunology (Baltimore, Md. : 1950)
Prêle CM,Woodward EA,Bisley J,Keith-Magee A,Nicholson SE,Hart PH
Mon Dec 01 00:00:00 EST 2008
Expression of and role for ovarian cancer G-protein-coupled receptor 1 (OGR1) during osteoclastogenesis.
The Journal of biological chemistry
Yang M,Mailhot G,Birnbaum MJ,MacKay CA,Mason-Savas A,Odgren PR
Fri Aug 18 00:00:00 EDT 2006
MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes human osteoclast fusion, and rescues granulocyte macrophage colony-stimulating factor suppression of osteoclast formation.
The Journal of biological chemistry
Kim MS,Day CJ,Morrison NA
Fri Apr 22 00:00:00 EDT 2005
Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.
Blood
Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M
Thu Jul 01 00:00:00 EDT 2004
Selective recognition of fibroblast growth factor-2 by the long pentraxin PTX3 inhibits angiogenesis.
Blood
Rusnati M,Camozzi M,Moroni E,Bottazzi B,Peri G,Indraccolo S,Amadori A,Mantovani A,Presta M
Thu Jul 01 00:00:00 EDT 2004
Disabling of receptor activator of nuclear factor-kappaB (RANK) receptor complex by novel osteoprotegerin-like peptidomimetics restores bone loss in vivo.
The Journal of biological chemistry
Cheng X,Kinosaki M,Takami M,Choi Y,Zhang H,Murali R
Fri Feb 27 00:00:00 EST 2004
c-myc is required for osteoclast differentiation.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
Battaglino R,Kim D,Fu J,Vaage B,Fu XY,Stashenko P
300-25 was used in Cell Culture to demonstrate role of c-myc as a downstream target of RANKL involved in RANKL-induced osteoclastogenesis.
Wed May 01 00:00:00 EDT 2002